Clinical trials: Second Trimester Abortion
Pain
Analgesia for 2nd Trimester Termination of Pregnancy
There has been very little investigation into the management of pain from 2nd trimester termination of pregnancy or unexpected fetal loss.
- Trial name
- NCT01563835
- Testing
- bupivacaine, fentanyl, fentanyl
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Legally Induced Abortion Without Mention of Complication
A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion
The primary goal of this study is to directly compare repeat doses of sublingual and buccal routes of 400 mcg misoprostol following mifepristone for second trimester abortion in order to determine if sublingual route confers an…
- Trial name
- NCT02708446
- Testing
- Mifepristone, Buccal misoprostol, Sublingual misoprostol
- Where
- 4 sites in Armenia, Nepal and 2 more
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Induced
Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14 - 21 Weeks LMP): A Randomized-controlled Double-blinded Trial
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00784186
- Testing
- mifepristone+misoprostol, misoprostol
- Where
- 2 sites in Vietnam
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Fibroid, Miscarriage in First Trimester
Fibroids and the Risk of Miscarriage: a Prospective Observational Study in an Early Pregnancy Population
The aim of this observational study is to whether fibroids increase the risk of miscarriage in women in our early pregnancy population.
- Conditions
- Fibroid, Miscarriage in First Trimester, Miscarriage in Second Trimester
- Trial name
- FiRM (NCT06986616)
- Where
- United Kingdom
- Volunteers
- 436 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Incomplete Abortion
Misoprostol Treatment of Mid Trimester Incomplete Abortion by Midwives and Doctors in Uganda.
It is estimated that 47,000 women die every year due to consequences of unsafe abortion globally. The majority of pregnancy related deaths occur in low income countries where induced abortion is restricted, unmet need for…
- Trial name
- NCT03622073
- Testing
- Misoprostol treatment by Midwife, Misoprostol treatment by Doctor
- Where
- 14 sites in Uganda
- Volunteers
- 1,191 people
- Sponsor
- Makerere University
Pregnancy
Techniques to Improve Efficacy of Second Trimester Medical Termination
Interruption of a pregnancy after 14 weeks gestation may be required when the fetus is dead, severely malformed or in cases of maternal illness.
- Trial name
- NCT00864799
- Testing
- Misoprostol
- Where
- Australia
- Volunteers
- 302 people
- Sponsor
- King Edward Memorial Hospital
Labor Induction
Factors Influencing the Abortion Interval of Second-trimester Termination of Pregnancy Using Misoprostol
This study aims to analyze the factors influencing the abortion interval of second-trimester termination of pregnancy using misoprostol.
- Trial name
- NCT01927822
- Where
- Taiwan
- Volunteers
- 101 people
- Sponsor
- Far Eastern Memorial Hospital
Abortion, Induced, Abortion, Second Trimester
Mifepristone and Mid-Trimester Termination of Pregnancy
Mid-second trimester medical terminations of pregnancy require admission to the hospital for the length of time it takes a woman to abort.
- Trial name
- NCT00382538
- Testing
- Addition of mifepristone 200 mg 24 hours before induction
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston University
Second Trimester Abortion
Second Trimester Pregnancy Termination in Women With Previous Caesarean Sections
it is a randomized controlled trial comparing the safety and efficacy of Vaginal Misoprostol versus combined Intracervical Foley's Catheter and Oxytocin Infusion for Second Trimester Pregnancy Termination.
- Trial name
- NCT04501809
- Testing
- compare misoprostol with combined oxytocin and cervical foly catheter
- Where
- 2 sites in Egypt
- Volunteers
- 158 people
- Sponsor
- Zagazig University
Induced Abortion, Second Trimester Abortion
Midlevel Versus Physician-provided Medical Abortion in the Second Trimester
The purpose of the study is to determine the safety and effectiveness of second trimester medical abortion when provided by nurse midwives compared with physicians.
- Conditions
- Induced Abortion, Second Trimester Abortion, Medical Abortion, Health Personnel
- Trial name
- NCT04181541
- Testing
- Provider type: Physicians, Provider type: Midlevel Providers
- Where
- Ethiopia
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Ipas
Termination of Pregnancy Second Trimester
Misoprostol for Second Trimester Termination of Pregnancy
To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.
- Trial name
- MIMIS (NCT00945997)
- Testing
- misoprostol
- Where
- Netherlands
- Volunteers
- 176 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Abortion, Induced
Mifepristone and Misoprostol Versus Misoprostol Alone for Mid-trimester Termination of Pregnancy (14-21 Weeks LMP)
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00957346
- Testing
- Mifepristone+misoprostol
- Where
- Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Induction of Second Trimester Abortion
Use of Ulipristal Acetate in Induction of Second Trimester Missed Abortion
The aim of this work is to assess the effectiveness and safety of Ulipristal Acetate in the management of 2nd trimester missed abortion along with misoprostol in pregnant women with previous caesarean section versus the use of…
- Trial name
- NCT04989400
- Testing
- Ulipristal Acetate, Misoprostol
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Abortion, Induced
Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction
Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions.
- Trial name
- NCT00383032
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Abortion in Second Trimester
Mifepristone and Misoprostol for Mid-trimester Termination of Pregnancy in Armenia
The primary goal of this study is to examine the efficacy and feasibility of a mifepristone combined with misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Armenia.
- Trial name
- NCT01766388
- Where
- 2 sites in Armenia
- Volunteers
- 120 people
- Sponsor
- Gynuity Health Projects
Medical; Abortion, Fetus
Mifepristone and Misoprostol for 2nd Trimester Termination of Pregnancy in Burkina Faso
The goal of this study is to examine the effectiveness and feasibility of a mifepristone-misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Burkina Faso.
- Trial name
- NCT03269279
- Testing
- Mifepristone, Misoprostol
- Where
- 4 sites in Burkina Faso
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Abortion, Induced
Misoprostol for Second Trimester Termination of Pregnancy
The purpose of this study is to compare the efficacy of 400 µg vaginal misoprostol per 3 hours to 400 µg buccal misoprostol per 3 hours in second trimester termination of viable pregnancy
- Trial name
- NCT02048098
- Testing
- Vaginal misoprostol, Buccal misoprostol
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Abortion, Second Trimester, Procedural Pain
Cervical Preparation for Same-Day Dilation & Evacuation
This is a noninferiority randomized control trial of two cervical preparation methods prior to same-day Dilation \& Evacuation (D\&E). Cervical preparation is a process that softens and dilates the cervix prior to a procedure.
- Conditions
- Abortion, Second Trimester, Procedural Pain, Procedural Complication
- Trial name
- NCT06799052
- Testing
- Transcervical single-balloon catheter, Synthetic osmotic dilators
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Boston Medical Center
Missed Abortion
Evening Primrose Oil to Misoprostol During Induction of Second-trimester Missed Miscarriage
Termination of pregnancy is an important subject that has complex and emotional controversies. The most common time of termination of pregnancy is the mid-trimester which has two-thirds of all serious abortion-related…
- Trial name
- NCT03584698
- Testing
- Misoprostol 100Mcg Tab, Evening Primrose Oil 1000 MG
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Assiut University
Abortion Early, Abortion, Complete
Clotting Parameters After Medical Abortion
Venous thromboembolism (VTE - blood clots that form in deep veins or in the lungs) has been identified as a leading cause of death in economically developed countries for pregnant and recently-pregnant women.
- Conditions
- Abortion Early, Abortion, Complete, Abortion, Second Trimester, Termination of Pregnancy Complicated by Embolism
- Trial name
- C-PLAN (NCT04824118)
- Testing
- Thromboelastometry, Clotting Studies, Full Blood Count
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- NHS Lothian