Clinical trials: Sedation for Mechanical Ventilation
Analgesia
Lorazepam for the Analgosedation of Pediatric Patients in Mechanical Ventilation.
The aim of this study is to better define the pharmacokinetic and pharmacodynamic profile of lorazepam for the analgosedation in pediatric intensive care unit.
- Trial name
- NCT04646135
- Testing
- Lorazepam 4 mg/ml
- Volunteers
- 9 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
PreTerm Neonate, Sedation for Invasive Mechanical Ventilation
Efficacy of Dexmedetomidine Versus Midazolam Sedation on Extubation Time in Mechanically Ventilated Preterm Infants
Very preterm neonates (born before 32 weeks' gestation) often require invasive mechanical ventilation (IMV) to manage respiratory insufficiency.
- Conditions
- PreTerm Neonate, Sedation for Invasive Mechanical Ventilation, Very Preterm Neonates With Sedation for Invasive Mechanical Ventilation
- Trial name
- DEXPRE (NCT06878703)
- Testing
- Midazolam, Dexmedetomidine
- Where
- France
- Volunteers
- 380 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Critical Illness
Lorazepam Sedation for Critically Ill Children
This clinical trial is being performed under the Best Pharmaceuticals for Children Act, signed into law in 2002 in order to improve pediatric labeling for off-patent drugs.
- Trial name
- NCT00109395
- Testing
- Lorazepam, Midazolam, Lorazepam CI
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- The Emmes Company, LLC
Mechanical Ventilation
Rapip Study: Clinical Trial on Remifentanyl for Analgesia and Sedation of Ventilated Neonates and Infants
It shall be investigated whether ventilated neonates and infants with a remifentanyl based analgesia and sedation can be extubated faster after discontinuation of the opioid infusion compared to neonates and infants with a…
- Trial name
- NCT00419601
- Testing
- Remifentanyl, Fentanyl
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- University of Cologne
Mechanical Ventilation Complication
Reduce Pediatric Sedation to Reduce Mechanical Ventilation Complication in ICU
Mechanical ventilation is a common procedure used in pediatric intensive care units (ICU). Its use requires almost always the establishment of a sedation.
- Trial name
- PEDIASED (NCT02040168)
- Where
- France
- Volunteers
- 106 people
- Sponsor
- Nantes University Hospital
Critical Illness, Pain
Population Pharmacokinetics of Remifentanil in Low-Weight Critically Ill Patients
The goal of this prospective clinical study is to learn about the population pharmacokinetics (PopPK), safety, and efficacy of remifentanil in low-body-weight patients in the Intensive Care Unit (ICU) who require mechanical…
- Trial name
- NCT07301970
- Testing
- Remifentanil
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Fudan University
Respiratory Distress Syndrome
Remifentanil Versus Morphine for Sedation of Premature Neonates With Respiratory Distress Syndrome
In this randomised controlled study we intended to compared intubation conditions and the continuous infusion of remifentanil (n=10) and morphine (n=10) in mechanically ventilated premature neonates (28-34wk) regarding the time…
- Trial name
- NCT00391105
- Testing
- Remifentanil
- Sponsor
- Federal University of Minas Gerais
Mechanical Ventilation Complication
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
Critically ill infants and children who are mechanically ventilated are often given large doses of opiates and benzodiazepines to provide analgesia-sedation.
- Trial name
- NCT02249039
- Testing
- intermittent IV CLON
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Retinopathy
Anesthesia for Retinopathy of Prematurity
Premature infants experience more respiratory problems after surgical procedures. The investigators aimed to compare general anesthesia with sedation on the need for post-operative mechanical ventilation in infants undergoing…
- Trial name
- NCT01955135
- Testing
- Ketamine, Sevoflurane, propofol
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Critical Illness, Post Intensive Care Unit Syndrome
pEEG Monitoring Effect on Delirium, Ventilator Days, and PICS
The goal of this multi-site observational study is to compare delirium rates, days on mechanical ventilation, and Post Intensive Care Syndrome (PICS) rates in adult Intensive Care Unit (ICU) patients.
- Conditions
- Critical Illness, Post Intensive Care Unit Syndrome, Post Intensive Care Syndrome, Mechanical Ventilation Complication
- Trial name
- NCT06019078
- Testing
- SedLine
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Fraser Health
Analgesia, Sedation and Analgesia
Dexmedetomidine as an Adjunct to Fentanyl for Term Neonates on Mechanical Ventilation
Despite well conducted studies on pain management in mechanically ventilated neonates, there is still a need for exploration of appropriate and accurate pharmacological management strategies for this ongoing pain, and assessment…
- Conditions
- Analgesia, Sedation and Analgesia, Neonatal, Mechanical Ventilation in Neonates
- Trial name
- NCT07241351
- Testing
- Dexmedetomidine, fentanyl 1mcg/kg/hr, fentanyl 0.5 mcg/kg/hr
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Daily Sedative Interruption, Sedation Strategies
Pilot Study for Sedation Interruption in Children
The purpose of this study is to estimate the hypothesized benefit of sedation interruption protocol on mechanical ventilation duration and PICU length of stay.
- Conditions
- Daily Sedative Interruption, Sedation Strategies, Sedation Protocols, Mechanical Ventilation
- Trial name
- NCT02426320
- Testing
- Sedation Interruption Protocol, Standard Sedation Protocol
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Davinia Withington
Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication
Volatile Sedation for Patients With the Acute Respiratory Distress Syndrome
This study will investigate how different types of routine sedation may affect patient's breathing whilst on a ventilator in the Intensive Care Unit (ICU).
- Conditions
- Acute Respiratory Distress Syndrome, Mechanical Ventilation Complication, Sedation Complication
- Trial name
- ISO-DRIVE (NCT06014138)
- Testing
- Propofol, Isoflurane
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Dexmedetomidine, Mechanical Ventilation Complication
DOSE Trial of Opioid Sparing Effect
Multicenter, double blind randomized controlled trial of fentanyl vs. fentanyl + dexmedetomidine as the initial regimen for maintenance of sedation in mechanically-ventilated, critically ill children.
- Conditions
- Dexmedetomidine, Mechanical Ventilation Complication, Critically Ill
- Trial name
- DOSE (NCT03938857)
- Testing
- Fentanyl, Dexmedetomidine
- Where
- 19 sites in United States
- Volunteers
- 30 people
- Sponsor
- Duke University