Clinical trials: Seizures Disorders
Refractory Partial Seizures
Safety Study of Rufinamide Given as an add-on Therapy to Treat Patients With Seizures
This study will evaluate the efficacy and safety of Rufinamide in reducing seizure frequency in subjects with partial seizures not fully controlled despite treatment with 1 to 3 concomitant antiepileptic drugs.
- Trial name
- NCT04558580
- Testing
- Rufinamide
- Where
- United States
- Sponsor
- University of South Alabama
Epilepsy, Partial Onset Seizures
An Open Label Study of Levetiracetam Monotherapy in Patients With Newly Diagnosed Focal Epilepsy
The purpose of this study is to evaluate the efficacy of Levetiracetam (LEV) used as monotherapy, with efficacy measured as 6-month seizure freedom at the last evaluated dose in the LEV 1000 mg/day to 2000 mg/day group, in newly…
- Trial name
- NCT01506882
- Testing
- Levetiracetam (LEV)
- Where
- 27 sites in Japan
- Volunteers
- 71 people
- Sponsor
- UCB Japan Co. Ltd.
Epilepsies, Partial
Safety and Tolerability of Intravenous SPM 927 as Replacement for Oral SPM 927 in Subjects With Partial Seizures
Subjects enrolled in the SP615, SP756, or SP774 open-label extension (OLE) trials receiving oral SPM 927 for at least 8 weeks and a stable dose of up to 3 antiepileptic medications may participate in a research trial at…
- Trial name
- NCT00151879
- Testing
- SPM 927
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- UCB Pharma
Seizures
Comparing the Efficacy of Intranasal Midazolam Versus Intravenous Diazepam for Control of Seizures in Children
After approval , study will be conducted at the Children Hospital PIMS, Islamabad. Children 1-12 years presenting/admitted with seizures will be enrolled in the study after taking informed consent from the parents.
- Trial name
- NCT04885075
- Testing
- IV diazepam, I/N Midazolam
- Volunteers
- 60 people
- Sponsor
- Shaheed Zulfiqar Ali Bhutto Medical University
Tuberous Sclerosis Complex
Roll-over Study to Collect and Assess Long-term Safety of Everolimus in Patients With TSC and Refractory Seizures Who Have Completed the EXIST-3 Study [CRAD001M2304] and Who Are Benefitting From Continued Treatment
The purpose of this study is to evaluate the long-term safety in patients with TSC and refractory seizures who are currently receiving everolimus treatment in the Novartis-sponsored EXIST-3 study and who are determined to be…
- Trial name
- NCT02962414
- Testing
- everolimus
- Where
- 67 sites in United States, Australia and 16 more
- Volunteers
- 206 people
- Sponsor
- Novartis Pharmaceuticals
Epilepsy With Simple or Complex Partial Onset Seizures
Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects With Partial Epilepsy Not Well Controlled by Current Antiepileptic Drugs
This is an 18-week, double-blind, multicenter study with gradual conversion from previous antiepileptic therapy to eslicarbazepine acetate monotherapy in subjects with partial epilepsy.
- Trial name
- NCT00866775
- Testing
- Eslicarbazepine acetate
- Where
- 106 sites in United States, Canada
- Volunteers
- 193 people
- Sponsor
- Sumitomo Pharma America, Inc.
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Epilepsy, Seizures
Monitoring Patients With Uncontrolled Epilepsy
This study is designed to evaluate patients with uncontrolled seizures. Seizures can be associated with and monitored by abnormal electrical activity in the brain.
- Trial name
- NCT00001149
- Where
- United States
- Volunteers
- 900 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Epilepsy; Seizure
Deep Brain Stimulation vs. Vagus Nerve Stimulation for Epileptic Spasms
Deep Brain Stimulation vs. Vagus Nerve Stimulation for the Treatment of Drug-Resistant Epilepsy and Epileptic Spasms in Children: A Randomized Control Trial
- Trial name
- DBS-VNS-ES (NCT07010276)
- Testing
- DBS Arm, VNS arm
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- The Hospital for Sick Children
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Neonatal Seizure
What Are the Determinant Factors of Ceasing Anti-seizure Medication in Infants With Neonatal Seizures?
The investigators aimed to determine the factors for ceasing anti-seizure medication in infants who experienced seizures during the neonatal period.
- Trial name
- NCT06211192
- Testing
- retrospective data collection
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people
- Sponsor
- Balikesir University
Febrile Seizure
Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Febrile seizures are one of the most common clinical diseases in pediatric neurology. It occurs between 6 months and 6 years of age and occurs in ~2-5% of children.
- Trial name
- NCT05215366
- Testing
- copeptin biomarker in children with febrile seizures
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Tuberous Sclerosis Complex, Epilepsy
Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy (RESTOR-1)
This Phase 2, randomized, double-blind, placebo-controlled study will evaluate the safety, tolerability, and efficacy of oral AV078 in participants with refractory epilepsy due to tuberous sclerosis complex (TSC).
- Trial name
- RESTOR-1 (NCT07680322)
- Testing
- AV078
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Aeovian Pharmaceuticals, Inc.
Epilepsy; Seizure, Blood Pressure
Observational Study on Dynamic Changes of Blood Pressure During Post-epileptic Seizure Stage (OCBPS)
This article details a multicenter study on changes of blood pressure and heart rate during post-epileptic seizure stage.
- Trial name
- NCT06790810
- Where
- China
- Volunteers
- 1,100 people
- Sponsor
- Xuanwu Hospital, Beijing
Epilepsy, Epilepsy, Complex Partial
Effect of Vigabatrin on Brain Blood Flow and Glucose Metabolism
This study is designed to test the effects of vigabatrin (gamma-vinyl-GABA) an experimental drug used for the treatment of epilepsy.
- Trial name
- NCT00001489
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Drug Resistant Epilepsy
Effect of Magnesium Supplementation for Children With Drug Resistant Idiopathic Epilepsy
Effect of oral magnesium sulfate (Mg) supplementation will be studied. Children with drug resistant idiopathic epilepsy following up in Pediatric Neurology Clinic, Ain Shams University, will be randomized to either Mg add-on…
- Trial name
- NCT02982824
- Testing
- Magnesium
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Epilepsy, Epilepsies, Partial
A Study of the Effectiveness and Safety of Topiramate in the Treatment of Children With Epilepsy
The purpose of this study is to evaluate the safety and effectiveness of oral topiramate as add-on therapy in children with uncontrolled partial onset seizures who are taking one or two standard anti-epileptic drugs.
- Conditions
- Epilepsy, Epilepsies, Partial, Seizures
- Trial name
- NCT00236743
- Testing
- topiramate
- Volunteers
- 90 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Alcohol Withdrawal Delirium, Alcohol Withdrawal
Phenobarbital for Severe Acute Alcohol Withdrawal Syndrome
Severe acute alcohol withdrawal syndrome is a potentially life-threatening condition characterized by agitation, confusion, abnormal heart rhythms and seizures.
- Conditions
- Alcohol Withdrawal Delirium, Alcohol Withdrawal, Alcohol Withdrawal Seizures
- Trial name
- PHENOMANAL (NCT03586089)
- Testing
- Phenobarbital Sodium
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Unity Health Toronto
Malaria, Seizures
Aggressive Antipyretics for Fever Reduction in CNS Malaria
The study will examine whether prophylactic and scheduled treatment with acetaminophen and ibuprofen can decrease the maximum temperature experienced during the acute illness in children with CNS malaria.
- Conditions
- Malaria, Seizures, Coma, Parasitemia
- Trial name
- NCT03399318
- Testing
- Acetaminophen, Ibuprofen
- Where
- 3 sites in Malawi, Zambia
- Volunteers
- 256 people
- Sponsor
- University of Rochester
Epilepsy
Concomitant High-resolution Recording of Haemodynamic and Electrical Activities of Children With Typical or Atypical Absence Seizures
This study, conducted in children with typical or atypical "absence" epilepsy, will consist of noninvasive recording of the metabolic activity of the brain concomitantly with electroencephalographic recording during seizures…
- Trial name
- Absence (NCT02819427)
- Testing
- Near Infra Red Spectroscopy (NIRS), Electroencephalography (EEG)
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens