Clinical trials: Sensitization
Asthma
Mold Sensitization Associated Severe Asthma Exacerbation
Mold sensitization is associated with severe asthma exacerbation.
- Trial name
- NCT03690349
- Testing
- Skin test
- Volunteers
- 102 people
- Sponsor
- Mahidol University
Allergic Disorder, Food Hypersensitivity
Importance and Association of Gut Microbiota and Biochemical Metabolites on Children Allergic Disorder
Food allergies account for only a small percentage of all adverse reactions to foods and their prevalence has increased over the past 10-15 years, particularly in industrialized countries: 3-6% of children under 3 years of age…
- Conditions
- Allergic Disorder, Food Hypersensitivity, Food Allergy in Children
- Trial name
- NCT05442658
- Testing
- Microbiota
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Sensitization to Legumes
Prevalence of Sensitization to Legumes in a Region From Southern France (Légumineuses)
The Mediterranean diet is a model for health. Indeed, according to some epidemiological studies, it would participate in the prevention of various diseases such as cardiovascular diseases, diabetes type 2, cancer and obesity.
- Trial name
- Légumineuses (NCT03686891)
- Testing
- Skin prick tests with four native legumes
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Exercise Training, Breast Cancer
Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study
The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent…
- Conditions
- Exercise Training, Breast Cancer, Pain Management
- Trial name
- NCT07128030
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad Rey Juan Carlos
Abdominal Pain, Irritable Bowel Syndrome
Pain Processing and Pain Neuroscience Education in Children With Chronic Abdominal Pain
The primary scientific objective of the study entails examining whether altered endogenous pain inhibition is present in children with functional abdominal pain (FAP) and irritable bowel syndrome (IBS) compared with healthy…
- Trial name
- NCT02880332
- Testing
- Usual care, Pain Neuroscience education, Extra care
- Where
- Belgium
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Food Allergy in Children
Lupine Allergy in Children
All children sensitized to lupine who have performed an oral food challenge (OFC) to lupine between January 2017 and May 2024 in the Pediatric Allergy Unit of the University Hospital of Nancy were included.
- Trial name
- NCT06918249
- Testing
- No intervention
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Asthma, Dermatitis, Atopic
Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic
A probiotic (Lactobacillus rhamnosus GG) supplement to pregnant women the last four weeks of pregnancy and three months after birth is expected to give a 40% reduction in risk of atopic sensitisation and allergic disease at two…
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Allergic, Perennial
- Trial name
- NCT00159523
- Testing
- Probiotic
- Where
- Norway
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Atopic Dermatitis
Prevention of Development of Transcutaneous Sensitization in Children With Atopic Dermatitis During Their First Year of Life
This experimental non-randomized clinical study is aimed at comparing the efficacy and safety assessment of the proposed topical therapy algorithms with the use of topical calcineurin inhibitors in reducing the severity of atopic…
- Trial name
- NCT04900948
- Testing
- Pimecrolimus cream 1%, cream 0.1% methylprednisolone aceponate
- Where
- Russia
- Volunteers
- 108 people
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Chronic Pain
The Effect of Pain Education Group Therapy and Its Impact on Chronic Pain, Kinesiophobia, and Physical Activity
The goal of this clinical trial is to learn if pain knowledge group intervention among chronic pain patients would influence their level of physical activity, pain intensity, depression, kinesiophobia and central sensitization.
- Trial name
- NCT07491549
- Testing
- pain education
- Where
- Estonia
- Volunteers
- 50 people
- Sponsor
- University of Tartu
Mild or Moderate Asthma With Allergic Sensitization
5HTP Regulation Of Asthma In Children
The purpose of this study is to learn more about if taking a supplement called 5-hydroxytryptophan (5HTP) can improve breathing and anxiety symptoms related to asthma.
- Trial name
- NCT04160910
- Testing
- 5-Hydroxytryptophan
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Indiana University
New Daily Persistent Headache (NDPH)
Endogenous Modulation and Central Sensitization in New Daily Persistent Headache ( NDPH ) in Children
New daily persistent headache (NDPH) is a primary headache disorder characterized by the daily and unremitting headache pain patients experience with a distinct onset.
- Trial name
- EMCS-NDPH (NCT03447782)
- Testing
- Naltrexone HCl (Bulk) Powder
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Food Allergy in Children, Obesity, Childhood
The EAT-On Study: Sensitisation, Allergy and Child Health
The EAT Study showed a reduction in both sensitisation (to all foods) and clinical food allergy (to peanut and egg) among children who consumed allergenic food early compared with those who followed standard government feeding…
- Conditions
- Food Allergy in Children, Obesity, Childhood, Food Allergen Sensitisation
- Trial name
- NCT03495583
- Testing
- Early introduction
- Where
- United Kingdom
- Volunteers
- 1,235 people
- Sponsor
- King's College London
Surgery
Irritation and Sensitization of Chlorhexidine Gluconate (CHG) Cloth
Evaluating the irritation properties of CHG cloth. Some Subjects will also have the product applied to see if they become sensitized to repeated applications.
- Trial name
- NCT02224625
- Testing
- 2% CHG Cloth solution, Vehicle Cloth, Active Comparator
- Where
- United States
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Medline Industries
Allergy, Irritation
Cumulative Irritation Patch Test
A Cumulative Patch Test with a Challenge Phase is a test devised to ascertain if a chemical agent or agents have the potential to cause contact irritation or contact allergy in the skin.
- Conditions
- Allergy, Irritation, Sensitization
- Trial name
- NCT01842711
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Chattem, Inc.
Food Allergies
Endophenotyping for Plant-based Food Allergy Diagnosis, Tolerance Biomarkers, and Mechanisms in Microneedle Immunotherapy
In relation to the prognosis of vegetable FA (VFA), in contrast to other food allergies (FA), which disappear naturally with time, VFA tends to persist into adulthood and to the appearance of new sensitizations to other…
- Trial name
- NCT06997432
- Testing
- Dietary intervention
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Bronchial Asthma
House Dust Mites Sensitization and Level of Asthma Control and Severity in Children
In this study we aimed to assess the clinical and laboratory profile of some Egyptian asthmatic children who are sensitized to house dust mites and determine the association of HDM sensitization and severity of asthma according…
- Trial name
- NCT04958616
- Testing
- Skin prick test.
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University Children Hospital
Edible Insect Allergy, Shrimp Allergy
Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy
This study aims to determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients aged ≥7 years with confirmed allergy to edible insects, including silkworm, bamboo worm, and palm weevil.
- Conditions
- Edible Insect Allergy, Shrimp Allergy, Shrimp Sensitization
- Trial name
- NCT07857187
- Testing
- Edible Insect Oral Food Challenge, White Shrimp Oral Food Challenge
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Allergic Asthma
Prevention of Asthma and Allergy by Probiotic Lactobacillus GG
Given that asthma results from a complex interaction between genetic susceptibility and environmental factors and rates of childhood asthma are increasing, primary prevention has to focus on modifiable aspects such as nutrition.
- Trial name
- FRALAC (NCT00490425)
- Testing
- Lactobacillus rhamnosus strain GG ATCC 53103 (LGG, 1010 cfu)
- Where
- Germany
- Volunteers
- 131 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Eczema, Asthma
The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants
This is a phase III, single blind (outcome assessor is blinded), randomised controlled multicentre trial of the effect of EpiCeram emollient for improving and maintaining skin barrier function and reducing incidence of eczema and…
- Conditions
- Eczema, Asthma, Allergy;Food
- Trial name
- PEBBLES (NCT03667651)
- Testing
- EpiCeram
- Where
- 4 sites in Australia
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- University of Melbourne