Clinical trials: Septal
Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery
Precision TOF-Guided Sugammadex Versus Spontaneous Recovery for Early Extubation in Minimally Invasive Pediatric Cardiac Surgery
This prospective observational cohort study evaluates a precision neuromuscular management strategy in pediatric patients undergoing minimally invasive cardiac surgery (MICS).
- Conditions
- Minimally Invasive Pediatric Cardiac Surgery, Pediatric Cardiac Surgery, Early Extubation Pathway, TOF-Guided Sugammadex Administration
- Trial name
- TOF (NCT07798011)
- Testing
- Sugammadex
- Where
- Vietnam
- Volunteers
- 80 people
- Sponsor
- Dr. Nguyen Thi Thu Hang
Patent Foramen Ovale, Stroke
PFO ACCESS Registry
Closure of Patent Foramen Ovale with the AMPLATZER® PFO OCCLUDER in patients with at least two cryptogenic strokes due to presumed paradoxical embolism through a patent foramen ovale and who have failed conventional therapy.
- Trial name
- NCT00583401
- Testing
- Device closure with the AMPLATZER PFO Occluder
- Sponsor
- Abbott Medical Devices
Septoplasty
Safety and Performance of ENTACT Septal Staple System for Septoplasty
This is a prospective, multi-center, single arm PMCF study to evaluate the safety and performance of the ENTACT (Next Generation) resorbable staple system for septoplasty in 40 subjects.
- Trial name
- NCT04392583
- Testing
- ENTACT Septal Staple system
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Smith & Nephew, Inc.
Pulmonary Hypertension
Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension
Pulmonary hypertension (PH) is a consequence of an increase in pulmonary vascular resistance (PVR), pulmonary blood flow, pulmonary venous pressure, or a combination of these elements.
- Trial name
- NCT02595541
- Testing
- milrinone, Sildenafil
- Volunteers
- 30 people
- Sponsor
- Assiut University
Ventricular Septal Defect
Immune Heterogeneity Before and After Cardiopulmonary Bypass in Children
The goal of this observational study is to learn about functional heterogeneity of immune cells before and after cardiopulmonary bypass (CPB) in children with congenital heart disease (CHD).
- Trial name
- NCT06214182
- Where
- China
- Volunteers
- 3 people
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Apical Hypertrophic Cardiomyopathy
Surgical Treatment of the Patients With Restrictive Phenotype of the Hypertrophic Cardiomyopathy Without LVOT Obstruction
Hypertrophic cardiomyopathy - is an inherited disease characterized by pronounced genetic and phenotypic heterogeneity. There are two most common anatomic variants of cardiac hypertrophy: subaortic and submitral phenotypes.
- Trial name
- NCT06977646
- Testing
- Surgical transaortic left ventricular cavity remodeling in patients with apical hypertrophic cardiomyopathy without left ventricular outflow tract obstruction
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Heart Defects, Congenital, Heart Septal Defects, Ventricular
Angiotensin Converting Enzyme Inhibition in Children With Mitral Regurgitation
This study will evaluate the efficacy and safety of angiotensin converting enzyme inhibition (ACE-I) therapy for the treatment of mitral regurgitation (MR).
- Conditions
- Heart Defects, Congenital, Heart Septal Defects, Ventricular, Heart Failure, Congestive
- Trial name
- AceiMR (NCT00113698)
- Testing
- Enalapril
- Where
- 7 sites in United States, Canada
- Volunteers
- 5 people
- Sponsor
- University of Utah
Congenital Heart Disease, Truncus Arteriosus
High Intensity Interval Training in Patients With a Right Ventricle to Pulmonary Artery Conduit
The goal of this clinical trial is to learn if a specific type of exercise training (high intensity interval training) can improve exercise capacity in people with a congenital heart defect that required the creation of a new…
- Conditions
- Congenital Heart Disease, Truncus Arteriosus, Pulmonary Atresia, Tetralogy of Fallot
- Trial name
- Right HIIT (NCT06771687)
- Testing
- High intensity interval training
- Where
- 2 sites in Netherlands
- Volunteers
- 38 people
- Sponsor
- Erasmus Medical Center
Atrial Fibrillation, Tachycardia, Supraventricular
Reducing Episodes by Septal Pacing Efficacy Confirmation Trial (RESPECT)
The purpose of this study is to find out if specialized programs in the AT500 and EnRhythm pacemakers will reduce the number of irregular heartbeat in the upper chamber of the heart and reduce symptoms (such as shortness of…
- Conditions
- Atrial Fibrillation, Tachycardia, Supraventricular, Arrhythmia, Bradycardia
- Trial name
- NCT00289289
- Testing
- Intervention Pacing Features
- Where
- 38 sites in United States, Canada
- Volunteers
- 400 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Heart Block After Surgery
Rhythm Disturbances After Ventricular Septal Defects
We would like to conduct a retrospective chart review examining the incidence of surgical heart block in children treated in the Cardiac Service Line at Children's Healthcare of Atlanta.
- Trial name
- NCT00208624
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Emory University
Ventricular Septal Defect, Pulmonary Hypertension
The Effect of Remote Ischemic Preconditioning on the Ischemic Reperfusion Injury in Infants With Ventricular Septal Defect and Pulmonary Hypertension
Intraoperative myocardial and pulmonary protection is important for better outcome after cardiac surgery. Ischemic preconditioning is one of organ protective strategies against ischemia-reperfusion injury by applying brief…
- Trial name
- NCT01313832
- Testing
- remote ischemic preconditioning (RIPC)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Atrial Septal Defects, Patent Ductus Arteriosus
Hyperion™ International Registry Trial
The purpose of this study is to determine the safety, performance and efficacy of the Hyperion™ Occluder Systems during treatment of ASD and PDA patients.
- Trial name
- COM-01 (NCT02220270)
- Testing
- ASD and PDA closure
- Where
- 10 sites in Algeria, China and 2 more
- Volunteers
- 200 people
- Sponsor
- European Cardiovascular Research Center
Congenital Disorders
Infant Weight Gain With Trisomy 21 and CAVC
Failure to thrive and difficulty gaining weight is a sign of uncompensated congestive heart failure (CHF). Infants with Trisomy 21 and complete atrioventricular canal defects (CAVC) frequently develop uncompensated CHF and weight…
- Trial name
- NCT00327951
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Children's Healthcare of Atlanta
Tetrology of Fallot, Pulmonary Stenosis
MASA Valve Early Feasibility Study
The MASA Valve Early Feasibility Study (MVEFS) multi-site interventional clinical trial within the United States of America with each center following a common protocol.The objective of the trial is to evaluate the safety and…
- Conditions
- Tetrology of Fallot, Pulmonary Stenosis, Truncus Arteriosus, Transposition of Great Vessels
- Trial name
- MVEFS (NCT05452720)
- Testing
- Surgical Right Ventricular Outflow Tract Reconstruction
- Where
- 5 sites in United States
- Volunteers
- 10 people
- Sponsor
- PECA Labs
Tetralogy of Fallot
Follow up of Post-repair Tetralogy of Fallot
Tetralogy of Fallot is the most frequent complex congenital heart malformation. Over the past five decades, surgical repair has been performed with respectable results. However, relevant postoperative residues frequently remain.
- Trial name
- NCT00266188
- Where
- 14 sites in Germany
- Volunteers
- 406 people
- Sponsor
- Competence Network for Congenital Heart Defects
Atrial Septal Defect
Safety and Efficacy of the AbsnowTM II Absorbable Atrial Septal Defect Closure System for Atrial Septal Defect Closure Therapy
A prospective, multicenter, randomized controlled, non-inferiority clinical trial to evaluate the safety and efficacy of the AbsnowTM II absorbable atrial septal defect occluder system for atrial septal defect closure therapy.
- Trial name
- NCT07529028
- Testing
- Absnow II Absorbable Atrial Septal Defect Occluder System, Cera Atrial Septal Defect Occluder
- Volunteers
- 236 people
- Sponsor
- Lifetech Scientific (Shenzhen) Co., Ltd.
Congenital Heart Disease (CHD), Ventricular Septal Defects (VSD)
Early Warning of Structural Complications in Perimembranous VSD
The goal of this observational study is to develop and test a AI-based prediction model for children with perimembranous ventricular septal defect, also called PMVSD.
- Trial name
- NCT07662343
- Where
- China
- Volunteers
- 11,683 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Hypothalamic Neoplasms, Pituitary Diseases
The Cardiovascular Changes Associated With Septal Local Anaesthesia
The purpose of this study is to determine the effects on the heart of injecting local anaesthetic into the nose prior to surgery on the pituitary gland?
- Conditions
- Hypothalamic Neoplasms, Pituitary Diseases, Anesthesia, Local
- Trial name
- NCT03137615
- Testing
- Pituitary surgery, local anaesthetic injection
- Volunteers
- 15 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Perimembranous Ventricular Septal Defect
Minimally Invasive Transthoracic Device Closure in Perimembranous Ventricular Septal Defect
The purpose of this study is to evaluate the efficacy and safety of minimally invasive transthoracic device closure of ventricular septal defect. This is a multi-center randomized controlled trial.
- Trial name
- NCT02644330
- Testing
- transthoracic device closure, surgical repair
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Congenital Heart Disease
French Observatory of Congenital Ventricular Septal Defect With Pulmonary Overload
Ventricular septal defects (VSD) are the most common cardiac congenital heart defect (about 1/3 of patients with congenital heart disease).
- Trial name
- FRANCISCO (NCT03363932)
- Where
- 4 sites in France
- Volunteers
- 218 people
- Sponsor
- French Cardiology Society