Clinical trials: Septic Shock
Shock Hypovolemic, Shock, Septic
Management of Shock in Children With SAM or Severe Underweight and Diarrhea
Diarrhea is one of the leading causes of under-five childhood mortality and accounts for 8% of 5.4 million global under-5 deaths.
- Conditions
- Shock Hypovolemic, Shock, Septic, Blood Transfusion, Adrenaline
- Trial name
- NCT04750070
- Testing
- Blood and Dopamine, Blood and adrenaline
- Where
- Bangladesh
- Volunteers
- 135 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Septic Shock
Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock
OBJECTIVES: I. Examine adrenal cortical function and the incidence of adrenal dysfunction in children with septic shock. II. Examine the mortality, length of stay in the PICU, and incidence of multiorgan failure in children with…
- Trial name
- NCT00005890
- Testing
- corticotropin
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- National Center for Research Resources (NCRR)
Toxic Shock Syndrome
Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study
Staphylococcus aureus and Streptococcus pyogenes produce many virulence factors. Some of them are responsible for severe infections in humans. Superantigen toxins synthesized by S. aureus or by S.
- Trial name
- IVIG (NCT02219165)
- Testing
- Intravenous human immunoglobulin, Albumin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Septic Shock, Multi Organ Failure
The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock
Sepsis is a major healthcare problem and leading cause of death in the pediatric population. Despite advances in supportive care of critically ill patients, sepsis remains an important cause of death worldwide in children.
- Trial name
- NCT05401695
- Testing
- HA330 hemoadsorption technique
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Severe Sepsis, Persistent Hypotension
Epidemiology of Septic Shock in Medical or Polyvalent ICU in the North-East Region of France
The epidemiology of this study aims and outcome of patients with septic shock in the intensive care unit (or versatile) of the North-East region in france as well as the modalities of care.
- Trial name
- NCT01903746
- Volunteers
- 1,495 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Burn Shock
Effect of Pre-emptive Intravenous Immunoglobulin (IVIG) on the Incidence of Septic Episodes in Pediatric Burn Patients
Effect of pre-emptive intravenous immunoglobulin administration on the incidence of septic episodes in pediatric burn patients: A randomized controlled study.
- Trial name
- NCT05134792
- Testing
- intravenous immunoglobulin
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Renal Disease, Liver Diseases
Outcomes of Children After Hospitalization in Intensive Care Unit
More than 10,000 children are hospitalized in an PICU every year in Canada. While most of them will survive their PICU hospitalization and their critical illness, some children will not recover to their pre-illness level.
- Conditions
- Renal Disease, Liver Diseases, Heart Diseases, Trauma Injury
- Trial name
- APCI (NCT06124092)
- Testing
- neurocognitive tests
- Where
- 8 sites in Canada
- Volunteers
- 690 people
- Sponsor
- St. Justine's Hospital
Head Trauma, Polytrauma
Comparative Study for the Validity of Various Severity Scoring System
Scoring systems for use in intensive care unit (ICU) patients have been introduced and developed over the last 30 years. They allow an assessment of the severity of disease and provide an estimate of in-hospital mortality
- Conditions
- Head Trauma, Polytrauma, Pre-Eclampsia, Sepsis
- Trial name
- NCT04683094
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Aswan University Hospital
Septic Shock
Right Ventricular Dysfunction in Septic Shock Patients in ICU
Assesment of right ventricular dysfunction in septic shock patients in intensive care unit.
- Trial name
- Septicshock (NCT05193682)
- Volunteers
- 25 people
- Sponsor
- Shimaa Hammad Ahmed
Severe Sepsis With Septic Shock
Evaluating a CytoSorb Score in Septic Shock
Systemic hyperinflammatory states, e.g. triggered by infection/sepsis, represent a major challenge for modern medicine. After an initially localized onset, inflammation can extend to an excessive, uncontrolled inflammatory…
- Trial name
- ECSISS (NCT03977688)
- Testing
- Cytokin Adsorption
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- Klinikum Emden
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Septic Shock
Stress Hydrocortisone In Pediatric Septic Shock
SHIPSS is a multi-institutional, prospective, controlled, randomized, double-blinded interventional trial that will examine the potential benefits and risks of adjunctive hydrocortisone prescribed for children with fluid and…
- Trial name
- SHIPSS (NCT03401398)
- Testing
- Hydrocortisone, sodium succinate, Normal saline
- Where
- 44 sites in United States, Brazil and 8 more
- Volunteers
- 500 people
- Sponsor
- Jerry Zimmerman
Septic Shock, Pediatric Critical Illness
Randomized Control Study in REsuscitation of SEpsis Trial
Crystalloids vs. Synthetic Plasma for Fluid Resuscitation in Children with Sepsis - REsuscitation of SEpsis Trial (RESET): A Comparative and Feasibility Study This research study, called the REsuscitation of SEpsis Trial (RESET)…
- Trial name
- RESET (NCT07035509)
- Testing
- Pharmaceutical fresh frozen plasma, Normal Saline, Ringer lactate (RL)
- Where
- Colombia
- Volunteers
- 150 people
- Sponsor
- Fundación Cardioinfantil Instituto de Cardiología
Supraventricular Arrhythmia, Septic Shock
Propafenone Versus Amiodarone in Septic Shock
Arrhythmias accompany septic shock in increased rates than in other ICU cohorts and their presence and management are related to patient´s prognosis.
- Trial name
- PRASE (NCT03029169)
- Testing
- Propafenone i.v., Amiodarone i.v.
- Where
- 2 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Charles University, Czech Republic
Neonatal Sepsis, Shock, Septic
Intravenous Methylene Blue for Treating Refractory Neonatal Septic Shock
Preterm infants (born at less than 37 weeks of pregnancy) sometimes develop a serious blood infection leading to low blood pressure, which does not respond to saline or to the standard medicines for increasing blood pressure…
- Trial name
- NCT06306001
- Testing
- Methylene Blue
- Where
- India
- Volunteers
- 130 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Infection, Sepsis
Short-course Antimicrobial Therapy in Sepsis
The purpose of this study is to compare the effect of a short course antimicrobial therapy (5-days) versus a 10-days therapy on sepsis-related organ dysfunction.
- Conditions
- Infection, Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02899143
- Testing
- Antibiotic
- Where
- 4 sites in Italy
- Volunteers
- 320 people
- Sponsor
- Ospedale Santa Maria delle Croci
Septic Shock
Carotid Doppler and EEOT for Fluid Responsiveness Prediction
Fluid responsiveness prediction prior to fluid challenge administration is a topic of interest, which has been extensively investigated, but remains challenging.
- Trial name
- NCT04470856
- Testing
- End-expiratory occlusion test (EEOT)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Septic Shock, Fluid Resuscitation
Evolution of Tissue Perfusion and Venous Congestion Markers in Fluid-Responsive Septic Shock Patients
Septic shock remains a leading cause of mortality in intensive care, and while fluid resuscitation (FR) is a cornerstone of early management, its benefit-risk balance is highly variable.
- Conditions
- Septic Shock, Fluid Resuscitation, Congestion, Venous
- Trial name
- FLUID-IMPACT (NCT06958809)
- Testing
- Echography
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospital Ambroise Paré Paris
Septic Shock, Sepsis, Severe
As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR
The sepsis and septic shock remain major causes of child morbidity and mortality, despite the use of modern antibiotics and resuscitation therapies.
- Trial name
- suPAR (NCT04459572)
- Testing
- suPAR
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Ege University
Cancer, Septic Shock
Evaluation of Fluid Resuscitation in Children With Cancer With Severe Sepsis / Septic Shock
Retrospective study to evaluate the characteristics of patients and of fluid resuscitation during intensive care unit hospitalization of patients under septic chock.
- Conditions
- Cancer, Septic Shock, Other Fluid Overload
- Trial name
- NCT01304680
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Grupo de Apoio ao Adolescente e a Crianca com Cancer