Clinical trials: Severe Neurologic Injury
Patients in Minimally Conscious State After a Severe Brain Injury
tDCS on Precuneus in MCS: Repeated Stimulations
In this study researchers will apply transcranial direct current stimulation (tDCS) for 5 consecutive days in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02702362
- Testing
- transcranial direct current stimulation
- Volunteers
- 33 people
- Sponsor
- Hangzhou Normal University
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Alzheimer Disease, Late Onset, Stroke
Explore the Sharing Model Intervene to Improve the Knowledge, Attitudes, Service Intentions and Service Start-up Effects of the Eight Major Non-cancer Disease End-stage Caregivers on Well-being and Palliative Care
Since September 1st, 2009, Taiwan has begun to pay attention to the care of patients with organ failure, dementia and the elderly, and brought eight of non-cancer terminal patients into health insurance subsidies to implement the…
- Conditions
- Alzheimer Disease, Late Onset, Stroke, Heart Failure, Pulmonary Disease, Chronic Obstructive
- Trial name
- NCT05407272
- Testing
- Health Education Manual, manual
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Wen-Shiou Pan
Traumatology, Wounds and Injury
Sufentanil Versus Ketamine Intranasally in the Management of Severe Acute Trauma-related Pain in Children.
Pain is one of the most common reasons for children to attend emergency departments, particularly following traumatic injuries such as fractures, sprains, or contusions.
- Conditions
- Traumatology, Wounds and Injury, Fractures Bone, Analgesia
- Trial name
- SUF-KET-PED (NCT06968546)
- Testing
- Intranasal Sufentanil, Intranasal Ketamine (IN)
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Fondation Lenval
Traumatic Brain Injury
Growth Hormone and Insulin Growth Factor 1 Deficiencies in Children/Adolescents Following Traumatic Brain Injury: The Impact on Growth and Neuropsychological Development
The purpose of this study is to look at the relationship between growth hormones, and recovery from a TBI - traumatic brain injury. It is believed that a TBI may interfere with the body's ability to produce growth hormones.
- Trial name
- NCT00929045
- Testing
- Growth Hormone Replacement
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Brain Injuries, Traumatic, Brain Injury Traumatic Moderate
A Prospective Outcome Study in Patients With Moderate to Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of death, disability and cognitive impairment in young people worldwide. The majority of the traumatic deaths in developed countries results directly from lesions in the central…
- Conditions
- Brain Injuries, Traumatic, Brain Injury Traumatic Moderate, Brain Injury Traumatic Severe
- Trial name
- TBI-PRO (NCT03810222)
- Testing
- N/A (Observational Study)
- Where
- Italy
- Volunteers
- 225 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Traumatic Brain Injury
Prediction of Neurological Outcome of Children After a Traumatic Brain Injury Based on an Integrated Predictive Model
This study aims to develop a integrated predictive model based on serum biomarkers, HRV, and an innovative computerized classifier output, to predict the patient long term neurological outcome after a moderate or severe TBI in…
- Trial name
- NCT04157634
- Testing
- Prognostication model
- Volunteers
- 70 people
- Sponsor
- St. Justine's Hospital
Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature (CANDLE), Juvenile Dermatomyositis (JDM)
Compassionate Use Protocol for the Treatment of Autoinflammatory Syndromes
The Requesting Physician/Investigator contacts Lilly when, based on their medical opinion, a patient meets the criteria for inclusion in the expanded access program.
- Conditions
- Chronic Atypical Neutrophilic Dermatosis With Lipodystrophy and Elevated Temperature (CANDLE), Juvenile Dermatomyositis (JDM), Stimulator of Interferon Genes (STING)-Associated Vasculopathy With Onset During Infancy (SAVI), Aicardi-Goutières Syndrome (AGS)
- Trial name
- NCT01724580
- Testing
- Baricitinib
- Where
- 3 sites in United States, United Kingdom
- Sponsor
- Eli Lilly and Company
Traumatic Brain Injury
Antisecretory Factor In Severe Traumatic Brain Injury
This study evaluates the addition of Salovum, an egg yolk powder enriched for antisecretory factor, to standard care of participants with severe traumatic brain injury.
- Trial name
- AFISTBI (NCT04117672)
- Testing
- Salovum
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Peter Siesjö
Acquired Brain Injury
Exploring the Use of the Cognitive Orientation to Daily Occupational Performance Approach (CO-OP) With Children, Teenagers and Young Adults With Executive Functions Deficits Following Severe Acquired Brain Injury
Acquired brain injury (ABI) in childhood are the cause of disabling motor, cognitive and behavioural disorders, with severe consequences on the later development of autonomy and learning, with long-term repercussions on…
- Trial name
- REFECO-OP (NCT04560777)
- Testing
- CO-OP intervention
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Hopitaux de Saint-Maurice
Sequelae of; Infection, Post Infection Glomerulonephritis
Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2
Post-acute sequelae of SARS-CoV-2 infection can cause multiple system function disorders, and complicated symptoms last for an extended period.
- Conditions
- Sequelae of; Infection, Post Infection Glomerulonephritis, Post-Infectious Peripheral Neuralgia, Post-Infectious Disorder (Disorder)
- Trial name
- sequelae (NCT04846010)
- Testing
- PurWet, FurFat, PurApo
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- All Natural Medicine Clinic, LLC
Brain Injury, Craniocerebral Trauma
PariS -TBI Study: Paris Severe Traumatic Brain Injury Study - 8 Years
The objective of the protocol is to pursue the long-term follow-up of a large cohort of severe traumatic brain injury patients. This outcome is to be described in terms of activity, participation, quality of life…
- Conditions
- Brain Injury, Craniocerebral Trauma, Trauma, Nervous System
- Trial name
- TCS8 (NCT02050633)
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Prehospital Traumatic Brain Injury
The aim of the study is to measure the effect of Finnish physician-staffed EMS unit treatment methods on traumatic brain injury (TBI) patient prognosis.
- Trial name
- NCT01454648
- Where
- Finland
- Volunteers
- 458 people
- Sponsor
- Tampere University Hospital
Traumatic Brain Injury
Comparison Between Different Types of Oxygen Treatment Following Traumatic Brain Injury
The purpose of this study is to study the effects of EARLY (no more than 24 four hours from injury) administration of extra amounts of oxygen on traumatic brain injury.
- Trial name
- NCT00170352
- Testing
- Hyperbaric Oxygen Treatment (HBOT), Enhanced Oxygen Treatment (Enhanced FiO2)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Hennepin Healthcare Research Institute
Traumatic Brain Injury (TBI)
Prognostic Model for Predicting Outcome After Moderate to Severe Paediatric Traumatic Brain Injury
Due to ethical and logistical challenges related to paediatric research, there is limited age-appropriate evidence for managing paediatric traumatic brain injury (pTBI).
- Trial name
- PROMPT (NCT07538440)
- Where
- United Kingdom
- Volunteers
- 2,000 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Moderate to Severe Traumatic Brain Injury
Ante-hypophyseal Dysfunctions in Children Following Moderate to Severe Traumatic Brain Injuries
Annual incidence of severe traumatic brain injuries (TBI) varies from 180 to 300 out of 100.000. Mortality or severe sequelae risk is increased 8 fold after a TBI.
- Trial name
- Endoc-TC (NCT01250132)
- Testing
- Biological and behavioral explorations
- Where
- 2 sites in France
- Volunteers
- 110 people
- Sponsor
- Hospices Civils de Lyon
Head Injuries, Closed
Head Injury Retrieval Trial
The study hypothesis is that advanced interventions as provided by a physician at an accident scene will decrease the death rate and the rate of severe disability in survivors of severe head injury.
- Trial name
- NCT00112398
- Testing
- Extended interventions by advanced level prehospital providers
- Where
- Australia
- Volunteers
- 338 people
- Sponsor
- CareFlight
TBI (Traumatic Brain Injury)
Studying Trends of Auto-Regulation in Severe Head Injury in Paediatrics
Children are known to have devastating impact from traumatic brain injury (TBI). The focus of treatment of severe TBI is to limit secondary insult which can aggravate brain injury and worsen outcome and is supported by monitoring…
- Trial name
- STARSHIP (NCT05688462)
- Testing
- Data Collection
- Where
- United Kingdom
- Volunteers
- 135 people
- Sponsor
- Shruti Agrawal
Brain Injuries, Traumatic
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
- Trial name
- NCT00134472
- Testing
- Therapeutic mild hypothermia
- Where
- 43 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Yamaguchi University Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Aquatic Sequential Preparatory Approach and Severe Traumatic Brain Injury
Traumatic brain injury (TBI) is an acquired insult to the brain from an external mechanical force. It is considered a major cause of mortality and of long-term disabilities in young adults, especially considering high-income…
- Trial name
- NCT04383405
- Testing
- Aquatic Training, Conventional Training
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia