Clinical trials: Sexually Active
Tuberculosis, HIV/AIDS
TB Reduction Through ART and TB Screening Project
Tuberculosis (TB) has overtaken HIV as the leading infectious cause of death worldwide and requires a major policy shift for it to be controlled in line with the WHO Stop-TB goal to "end TB".
- Trial name
- TREATS (NCT03739736)
- Testing
- Combination of TB/HIV prevention activities (arm A), Combination of TB/HIV prevention activities (arm B), Standard of care (arm C)
- Where
- 2 sites in South Africa, Zambia
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Health Risk Behaviors
Sexually Active Adolescent Focused Education
SAAFE will be pilot tested in 2 geographically distinct areas (Washington, DC and Deep South) with 100 participants from each site to 1) primarily assess the efficacy of improved self-efficacy, knowledge about HIV/STIs and…
- Trial name
- SAAFE (NCT03646032)
- Testing
- SAAFE, Control
- Where
- 2 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Benten Technologies, Inc.
Teenager, Sex Behavior
Quantitative Study of Prevalence and Vulnerability Factors of Active Cyber Sexuality Among Teenagers in West Normandy
This study evaluates prevalence of active cybersexuality among teenagers (15-17 old) in West Normandy and find different factors of vulnerability that could induce this behaviour.
- Trial name
- NCT03662321
- Where
- 14 sites in France
- Volunteers
- 1,208 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Inactivity, Physical, Aging
Oral 'Breath Test' to Measure Anabolic Sensitivity to a Protein Meal Across the Age and Physical Activity Spectrum
The purpose of this study is to determine how anabolic sensitivity, in response to the ingestion of a liquid protein meal, differs across the lifespan, between biological sexes, and with varying physical activity levels.
- Conditions
- Inactivity, Physical, Aging, Healthy Aging, Growth & Development
- Trial name
- NFRF (NCT06744491)
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Exercise, Metabolism
Metabolic Responses to Exercise and Recovery
Exercise benefits health through diverse metabolic processes and is central to healthy ageing. However, intense exercise also challenges the body, causing cellular damage that must be repaired.
- Trial name
- NCT06088108
- Testing
- Cornell treadmill exercise protocol
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University College, London
Adolescent Behavior, Sex Behavior
Delaying Sexual Activity in African American Adolescent Girls
This study will evaluate the effectiveness of a program designed to prevent early sexual behavior in middle school-aged African American girls.
- Trial name
- NCT00058760
- Testing
- NIA intervention (after school health promotion didactic program)
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection as well as or…
- Trial name
- NCT07044297
- Testing
- MK-8527, FTC/TDF
- Where
- 81 sites in United States, Argentina and 14 more
- Volunteers
- 4,390 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Child Behavior, Adolescent Behavior
A Mother's Role in Delaying Onset of Sexual Activity in Her Children
The goal of this study is to enhance the mother's role in promoting avoidance of sexual risks and problem behaviors in 6- to 12-year-old children.
- Trial name
- NCT00060697
- Testing
- Adolescent sexual activity education for mothers
- Where
- United States
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV Infections
Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
The P-glycoprotein (P-gp) is a membranous transporter that modulates the intracellular concentrations of many drugs and plays thus a major role in the efficacy of the therapeutics that act within the lymphocytes, such as…
- Trial name
- Onto-Pgp (NCT00702013)
- Where
- France
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, HIV Infection
Safety and Anti-HIV Activity of Capravirine Alone and in Combination With Other Anti-HIV Drugs
This 2-part study will test the safety and anti-HIV activity of capravirine alone, and the safety, anti-HIV activity, and drug interactions of capravirine combined with other anti-HIV drugs.
- Trial name
- NCT00005673
- Testing
- Capravirine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV
An Assessment of an HIV Prevention Intervention (Project AIM) Among Junior Secondary School Students in Eastern Botswana
The purpose of this study is to examine the effectiveness of an HIV prevention intervention called Project AIM (Adult Identity Mentoring) to delay onset of sexual activity and reduce sexual risk behaviors among students…
- Trial name
- AIM (NCT02455583)
- Testing
- Project AIM (Adult Identity Mentoring)
- Where
- Botswana
- Volunteers
- 4,732 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Human Immunodeficiency Virus (HIV), HIV Pre-Exposure Prophylaxis
A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)
Researchers are looking for new medicines to prevent HIV-1 (Human Immunodeficiency Virus Type 1) infection. The goals of this study are to learn: If taking MK-8527 once a month works to prevent HIV-1 infection better than a…
- Trial name
- NCT07071623
- Testing
- MK-8527, Emtricitabine/tenofovir disoproxil (FTC/TDF)
- Where
- 30 sites in Kenya, South Africa and 1 more
- Volunteers
- 4,580 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Family Relations, Nutrition Disorders
Family Relationships and Nutrition in TGGD Youth and Young Adults
The purpose of this study is to assess how family relationships are related to health and nutrition behaviors among transgender and gender diverse youth and young adults.
- Conditions
- Family Relations, Nutrition Disorders, Health Behavior, Transgenderism
- Trial name
- NCT05163860
- Testing
- Survey
- Where
- United States
- Volunteers
- 714 people, healthy volunteers welcome
- Sponsor
- St. Louis University
Ankylosing Spondylitis, Sexual Dysfunction
Association of Erectile Dysfunction With Neuropathic Pain, Disease Activity, and Functional Status in Male Patients With Axial Spondyloarthritis: A Cross-Sectional Observational Study
tudy Description Definitions Use this module to describe the study protocol. Required § Required if Study Start Date is on or after January 18, 2017 [*] Conditionally required Brief Summary Use these resources to provide…
- Trial name
- NCT07453628
- Testing
- Anti-TNF agents, NSAIDs, No Treatment (Healthy Controls)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Altuğ Güner
Video Game Addiction, Gaming Disorder
Community-Based Intervention to Reduce Problematic Video Game Use in First-Year Secondary School Students: A Cluster Randomised Controlled Trial
This cluster randomised controlled trial will evaluate whether a community-based, multicomponent intervention can reduce problematic video game use and gaming disorder among first-year secondary school students in Pontevedra…
- Trial name
- AQJ (NCT07357792)
- Testing
- Community-Based Component, Adolescent Mindfulness Component, Adult Mindfulness Component
- Where
- Spain
- Volunteers
- 492 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
HIV Preexposure Prophylaxis
Oral Islatravir (MK-8591) Once-Monthly as Preexposure Prophylaxis (PrEP) in Men and Transgender Women Who Are at High Risk for HIV-1 Infection (MK-8591-024)
The main purpose of the study is to evaluate the safety and tolerability of oral Islatravir (ISL) once monthly (QM) as Preexposure Prophylaxis (PrEP) in cisgender men who have sex with men (MSM) and transgender women (TGW) who…
- Trial name
- Impower-024 (NCT04652700)
- Testing
- ISL, FTC/TDF, FTC/TAF
- Where
- 25 sites in United States, Brazil and 5 more
- Volunteers
- 494 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Sex Behavior, Child Behavior
The "Reach For Health" Program: Delaying Sexual Activity in Children
Working with multiple schools in Brooklyn, NY, this study will develop and evaluate school- and community-based strategies designed to reduce early sexual activity and risky sexual behavior in middle school-aged children.
- Trial name
- NCT00059241
- Testing
- Parent-child communication education, Service learning, Classroom health curriculum
- Where
- United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
HIV
Behavioral Activation and Risk Reduction for Stimulant Use Among Sexually Active Adolescents and Young Adults
The use of behavioral intervention to reduce stimulant use and concurrent HIV sexual transmission risk.
- Trial name
- IMPACT (NCT06444360)
- Testing
- IMPACT, eSOC
- Where
- 2 sites in United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Westat
Self Concept
Evaluation of a Youth Mentoring Program
This study will be used to determine the effectiveness of GirlPOWER!, an innovative mentoring program for adolescent minority girls living in urban areas.
- Trial name
- NCT00158353
- Testing
- GirlPOWER! mentoring program, Traditional mentoring
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago