Clinical trials: Sibling
Autism Spectrum Disorders
Structural Connectivity as Imaging Endophenotypes of Autism Spectrum Disorders
Autism spectrum disorders (ASD) is a highly hereditary neuropsychiatric disorder. In children and adolescents worldwide, the prevalence of ASD is estimated at 0.6%.
- Trial name
- NCT01513629
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Caesarean Section, Obesity
Obesity Among Young Adult Males Born With Cesarean Section.
Previous research has suggested that cesarean section may be associated with an increased risk of developing obesity in childhood, adolescence and adulthood.
- Conditions
- Caesarean Section, Obesity, Cesarean Section Complications
- Trial name
- NCT03918044
- Where
- Sweden
- Volunteers
- 97,291 people
- Sponsor
- Karolinska Institutet
Cystic Fibrosis in Children, Siblings
Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, Resource Program: How Does it Work?
The goal of the clinical trial is to test whether a mental health program that is delivered through the Internet works well for children and adolescents with cystic fibrosis (CF) and their healthy siblings.
- Conditions
- Cystic Fibrosis in Children, Siblings, Mental Health, Internet-based Intervention
- Trial name
- iCF-PWR (NCT06020274)
- Testing
- Internet-delivered Cystic Fibrosis Mental Health Prevention, Wellness, and Resource (iCF-PWR) program
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University of Regina
Acute Myeloid Leukemia
Allogeneic HCT Using Uniform Conditioning Regimen Regardless of Donors (MS, MU, or HF) for AML in Remission
The purpose of this study is to evaluate the effect of various clinical variables including HLA-disparity and NK cell-related variables, upon outcomes of allogeneic hematopoietic cell transplantation (HCT) using uniform…
- Trial name
- AML_AlloHCT (NCT03337568)
- Testing
- allogeneic hematopoietic cell transplantation
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Asan Medical Center
Autism Spectrum Disorders
The Development of Younger Siblings of Children With Autism Now at 10 Years of Age
Background: Autism is a complex developmental disorder involving difficulties in verbal and nonverbal communication, social-emotional functioning, and markedly restricted interests and activities.
- Trial name
- NCT00695812
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Sickle Cell Disease
Do Alemtuzumab Levels Predict T Cell Chimerism After MSD SCT for SCD?
Rationale: Non-myeloablative allogeneic stem cell transplantation (SCT) has become a feasible curative treatment option for sickle cell disease (SCD) patients with an available matched sibling donor.
- Trial name
- PREDICT (NCT05905770)
- Testing
- Alemtuzumab Injection [Campath]
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
The Genetic Variation of Type 1 Diabetes
PST Linkage Based Analysis in the Family of More Than Two Members With Type 1 Diabetes in Taiwan
The purpose of this study is to explore the susceptible genes for Type 1 diabetes in Taiwan through the new genetic study methods.
- Trial name
- PATT (NCT01955746)
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Chang Gung Memorial Hospital
Type1diabetes, Type1 Diabetes Mellitus
Modulation of Type 1 Diabetes Susceptibility Through the Use of Probiotics
Investigators aim to further the understanding of environmental factors that underlie the progression to Type 1 diabetes (T1D). Dysbiosis, defined as alterations in intestinal microbiota composition and function, has been…
- Trial name
- NCT03423589
- Testing
- VSL#3
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Autism Spectrum Disorder, Siblings
Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers
In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done.
- Conditions
- Autism Spectrum Disorder, Siblings, Neurodevelopmental Disorders
- Trial name
- FRATSA (NCT05512637)
- Testing
- Step 1 - Screening ; Step 2 - Clinical interview
- Where
- France
- Volunteers
- 384 people
- Sponsor
- University Hospital, Montpellier
Autism Spectrum Disorder, Autism
Faecal Microbiota Analysis in Neurotypical and Autism Syndrome Disorder Siblings
This study aims to accurately characterise the gut microbiota composition of faeces of children with ASD and compare it with the gut microbiota composition of their neurotypical siblings.
- Trial name
- FAMILY (NCT05794620)
- Testing
- Stool sample
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- East Suffolk and North Essex NHS Foundation Trust
Acute Lymphoid Leukemia, Acute Myeloid Leukemia
Prophylactic DLI-X for Leukemia Relapse After HCT
The primary objective of this proposal is to conduct the first-in-human randomized clinical trial evaluating prophylactic DLI-X (pro-DLI-X) for relapse prevention following matched sibling donor (MSD) or haploidentical (haplo)…
- Conditions
- Acute Lymphoid Leukemia, Acute Myeloid Leukemia, Acute Undifferentiated Leukemia (AUL), Myelodysplastic Syndrome
- Trial name
- NCT07254793
- Testing
- Exercise Mobilized Prophylactic DLI, Standard Prophylactic DLI
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Arizona
Malignant Haemopathy
Information and Accompaniment of Siblings Following the Announcement of a Cancer in Pediatric Hematology.
The primary objective is to evaluate the experience with the information received on the disease by the healthy brothers and sisters of childrens with malignant haemopathy at the Centre Hospitalier Régional et Universitaire of…
- Trial name
- NCT03541330
- Testing
- semi-directive interview
- Where
- France
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Acute Leukemia, Acute Lymphoblastic Leukemia
Anti-Covid-19 Vaccine in Children With Acute Leukemia and Their Siblings
Mortality in case of SARS-CoV-2 infection (Covid-19) during acute leukemia (AL) treatment is around 30%, i.e. more than 10 times the one of general population. Severe forms are reported in children receiving chemotherapy for AL.
- Conditions
- Acute Leukemia, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
- Trial name
- PACIFIC (NCT04969601)
- Testing
- vaccine COMIRNATY® (BNT162b2)
- Where
- 2 sites in France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Myeloid Leukemia, Acute Lymphocytic Leukemia
Haploidentical Stem Cell Transplantation Using Post-Transplant Cyclophosphamide
Historically, the best results of allogeneic SCT have been obtained when the stem cell donor is a human leukocyte antigen (HLA)-matched sibling, however, this is only available for approximately 30 percent of patients in need for…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphocytic Leukemia, Myelodysplastic Syndrome, Non-hodgkin Lymphoma
- Trial name
- NCT03088709
- Testing
- Cyclophosphamide, Tacrolimus, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Loyola University
Acute Lymphoid Leukemia
Donor-specific Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia (ALL)
[Study Objectives] To evaluate the efficacy of allogeneic hematopoietic cell transplantation (HCT) in patients with acute lymphoblastic leukemia (ALL) in the first or second complete remission (CR).
- Trial name
- AHCTALL (NCT01037764)
- Testing
- alloHCT
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Hematologic Neoplasms
Use of Haploidentical Related Donors for Patients Without Matched Sibling, Unrelated Donor or Cord Blood Units
The administration of high-dose chemotherapy followed by the infusion of blood or bone marrow stem cells (stem cell transplantation) from a matched donor has become standard treatment for patients with high-risk or relapsed…
- Trial name
- NCT02504047
- Testing
- T-Cell replete haplo-transplant
- Where
- 5 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Autism Spectrum Disorder, Infant Development
Experimental Techniques for Early Identification of Autism
This project deals with essential challenges in the context of Autism Spectrum Disorder, benefiting from a longitudinal design in infancy and a cutting-edge electroencephalogram/eye-tracking integrated approach.
- Trial name
- NCT05712512
- Testing
- Neurodevelopmental assessment, Electrophysiological and eyetracking recordings
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Eugenio Medea
Autism Spectrum Disorder
Sibling-Mediated Intervention on Literacy and Reciprocity for Children With Autism
Given the increasing prevalence of autism spectrum disorder (ASD), estimated to be 1 in 68 in the United States alone, ASD has become one of the fastest-growing pediatric concerns.
- Trial name
- NCT05098392
- Testing
- Sibling-mediated intervention
- Where
- 3 sites in United States, China
- Volunteers
- 8 people
- Sponsor
- Arizona State University
Acute Myeloid Leukemia (AML)
Allogeneic HCT Using Conditioning Regimen of BuFluATG for AML CR1
1. Study Objectives To evaluate the effect of various clinical variables including HLA-disparity and NK cell-related variables, upon outcomes of allogeneic hematopoietic cell transplantation (HCT) using uniform conditioning…
- Trial name
- NCT07155382
- Where
- South Korea
- Volunteers
- 98 people
- Sponsor
- Asan Medical Center
Siblings, Childhood Cancer
SibACCESS: Developing a Telehealth Intervention to Address Unmet Psychosocial Needs of Siblings of Children With Cancer
This study aims to address barriers to psychosocial care for siblings of children with cancer by piloting a group-based telehealth program for adolescent siblings of youth with cancer.
- Conditions
- Siblings, Childhood Cancer, Pediatric Cancer, Posttraumatic Stress Disorder
- Trial name
- R03 CA259898 (NCT04889755)
- Testing
- SibACCESS
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus