Clinical trials: Skin Sensitisation
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Sensitization to Legumes
Prevalence of Sensitization to Legumes in a Region From Southern France (Légumineuses)
The Mediterranean diet is a model for health. Indeed, according to some epidemiological studies, it would participate in the prevention of various diseases such as cardiovascular diseases, diabetes type 2, cancer and obesity.
- Trial name
- Légumineuses (NCT03686891)
- Testing
- Skin prick tests with four native legumes
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Food Allergy
Analysis of the Prevalence of Sensitization to Plants Containing Gibberellins Using Realistic Skin Prick Tests
Gibberellin-related proteins (GRPs) are proteins contained in both pollens and vegetables and are associated with an increased risk of severe food allergy reactions.
- Trial name
- GIBBERELLINES (NCT06183398)
- Testing
- Skin prick test
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Montpellier
Foramen Ovale, Patent, Nickel Sensitivity
Investigation of Nickel Sensitization After Percutaneous Implantation of Patent Foramen Ovale Occluder
Percutaneous PFO closure has been established as a first-line therapy for preventing recurrent strokes in selected patients. The devices used for the specific purpose contain and release nickel, which is considered as the most…
- Conditions
- Foramen Ovale, Patent, Nickel Sensitivity, Dermatitis Contact Irritant, Metal Allergy
- Trial name
- INSPIRE (NCT04713683)
- Testing
- Percutaneous Patent Foramen Ovale Closure
- Where
- Greece
- Volunteers
- 96 people
- Sponsor
- National and Kapodistrian University of Athens
Allergy, Asthma
Early Origins of Allergy and Asthma
Birth cohort study with recruitment during pregnancy to determine prenatal and perinatal conditions, as well as genetic and epigenetic factors, that participate in the early setting of immune responses, and the role of these in…
- Conditions
- Allergy, Asthma, Food Allergy, Allergic Sensitisation
- Trial name
- ARIES (NCT04186949)
- Where
- Chile
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Food Allergy, Food Allergy in Infants
The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy
The BAT Impact study is a prospective multicentre study in the UK using a biomarker-led study design to compare the incidence of adverse events (defined as allergic reactions during oral food challenges) in a…
- Conditions
- Food Allergy, Food Allergy in Infants, Food Allergy in Children, Food Allergen Sensitisation
- Trial name
- NCT05309772
- Testing
- Basophil activation test (BAT), Oral food challenge (OFC)
- Where
- 11 sites in United Kingdom
- Volunteers
- 398 people
- Sponsor
- King's College London
Joint Hypermobility Syndrome, Hypermobile Ehlers-Danlos Syndrome
Central Sensitization and Physical Activity in Adolescents With HSD/hEDS
Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.
- Trial name
- NCT05633225
- Testing
- Submax exercise test on a bicycle ergometer
- Where
- 2 sites in Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Allergic Conditions
Primary Prevention of Allergic Disease in Early Child by Lactobacillus Reuteri
An altered microbial exposure may be partly responsible for the increase of allergic diseases in populations with a western lifestyle.
- Trial name
- NCT01285830
- Testing
- Lactobacillus reuteri
- Where
- 3 sites in Sweden
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Eczema, Asthma
The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants
This is a phase III, single blind (outcome assessor is blinded), randomised controlled multicentre trial of the effect of EpiCeram emollient for improving and maintaining skin barrier function and reducing incidence of eczema and…
- Conditions
- Eczema, Asthma, Allergy;Food
- Trial name
- PEBBLES (NCT03667651)
- Testing
- EpiCeram
- Where
- 4 sites in Australia
- Volunteers
- 760 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Allergy to Shrimp, Immunotherapy
Immunological Response After Shrimp Oral Immunotherapy Treatment
Oral immunotherapy is effective in desensitized food allergy. Shrimp allergy is increasing in Thailand. So the purpose of our study is to determine level of specific immunoglobulin E antibodies to shrimp, Immunoglobulin G4 and…
- Trial name
- NCT04552522
- Testing
- shrimp allergy with intend to eat shrimp
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Mahidol University
Atopic Dermatitis
Prevention of Development of Transcutaneous Sensitization in Children With Atopic Dermatitis During Their First Year of Life
This experimental non-randomized clinical study is aimed at comparing the efficacy and safety assessment of the proposed topical therapy algorithms with the use of topical calcineurin inhibitors in reducing the severity of atopic…
- Trial name
- NCT04900948
- Testing
- Pimecrolimus cream 1%, cream 0.1% methylprednisolone aceponate
- Where
- Russia
- Volunteers
- 108 people
- Sponsor
- National Medical Research Center for Children's Health, Russian Federation
Asthma, Dermatitis, Atopic
Impact in Off-spring of Mothers After Perinatal Daily Intake of a Probiotic
A probiotic (Lactobacillus rhamnosus GG) supplement to pregnant women the last four weeks of pregnancy and three months after birth is expected to give a 40% reduction in risk of atopic sensitisation and allergic disease at two…
- Conditions
- Asthma, Dermatitis, Atopic, Rhinitis, Allergic, Perennial
- Trial name
- NCT00159523
- Testing
- Probiotic
- Where
- Norway
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Urticaria, Patch Testing
Evaluating for Contact Allergies in Patients With Chronic Urticaria
Hives affects 10-25% of the population worldwide at some time during their lifetime. Hives are itchy transient swellings of the skin lasting 4-36 hours.
- Conditions
- Urticaria, Patch Testing, Dermatitis, Allergy
- Trial name
- NCT00868036
- Testing
- Patch Testing
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Tufts Medical Center
Edible Insect Allergy, Shrimp Allergy
Shrimp Sensitization and Allergy Among Patients With Edible Insect Allergy
This study aims to determine the prevalence of shrimp sensitization and clinical shrimp allergy among patients aged ≥7 years with confirmed allergy to edible insects, including silkworm, bamboo worm, and palm weevil.
- Conditions
- Edible Insect Allergy, Shrimp Allergy, Shrimp Sensitization
- Trial name
- NCT07857187
- Testing
- Edible Insect Oral Food Challenge, White Shrimp Oral Food Challenge
- Where
- Thailand
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Wheat Allergy, Children
Outcome of Specific IgE Level in Children With IgE-mediated Wheat Allergy After Stop Using Wheat Containing Skin Care
Wheat allergy is increasing in Thailand. Some studies show that cutaneous exposure of allergen may cause allergy and there are many wheat containing skin care products that are over-the-counter.
- Trial name
- NCT04013763
- Testing
- wheat containing skin care products
- Where
- Thailand
- Volunteers
- 7 people
- Sponsor
- Mahidol University
Allergic Reaction
Epidemiology of Pecan Nut Allergy
IgE-mediated food allergy can manifest with reactions ranging from hives to anaphylactic shock. The diagnosis is based on the confirmation of sensitization to the food allergen by skin tests (prick) and the determination of…
- Trial name
- PEC-ALL (NCT05185362)
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Food Allergy, Eczema
Treatment of IgE Associated Eczema With Omega-3 Long Chain Polyunsaturated Fatty Acids in Infancy and the Development of Bronchial Asthma in Childhood
Although some causal factors in allergy development such as allergen exposure and environmental pollution have decreased during recent years, the incidence of the allergic diseases has increased in the Western world.
- Conditions
- Food Allergy, Eczema, Sensitisation
- Trial name
- Omega-Treat (NCT01473823)
- Testing
- Omega-3 LCPUFA
- Where
- Sweden
- Volunteers
- 160 people
- Sponsor
- Ostergotland County Council, Sweden
Asthma, Allergic Sensitization
Promoting Tolerance to Common Allergens in High-Risk Children: Global Prevention of Asthma in Children (GPAC) Study
The purpose of this study is to determine whether early childhood exposure to common allergens (substances that can trigger allergies and asthma) can prevent the development of asthma in children at high risk for developing the…
- Trial name
- GPAC (NCT00346398)
- Testing
- Oral mucosal immunoprophylaxis (OMIP)
- Where
- 3 sites in United States, Australia
- Volunteers
- 51 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Exercise Training, Breast Cancer
Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study
The aim of this study was to evaluate the feasibility, safety, and acceptability of a supervised, combined moderate-intensity aerobic and resistance training program designed to reduce pain sensitization in BCS with persistent…
- Conditions
- Exercise Training, Breast Cancer, Pain Management
- Trial name
- NCT07128030
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Universidad Rey Juan Carlos
Osteoporosis, Postmenopausal
A Multiple-Dose Study to Evaluate Skin Irritation and Sensitization of Teriparatide Administered Transdermally in Healthy Postmenopausal Women
This study is a Phase 1, multi-center, 2-part, subject- and investigator-blind, randomized, placebo-controlled, multiple dose study of transdermal teriparatide (80-µg dose) in healthy postmenopausal women.
- Trial name
- NCT01250145
- Testing
- LY333334
- Where
- 5 sites in United States, Germany and 1 more
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company