Clinical trials: Skin Tear
Laceration of Skin, Anxiety
IN Midazolam vs IN Dexmedetomidine vs IN Ketamine During Minimal Procedures in Pediatric ED
Pain in young children has been universally under-recognized due to their inability to describe or localize pain. Improvements in pharmacological interventions are necessary to optimize patient and family experience and allow for…
- Conditions
- Laceration of Skin, Anxiety, Discharge Time
- Trial name
- NCT05934669
- Testing
- Intranasal Midazolam, Intranasal Dexmedetomidine, Intranasal Ketamine
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Procedural Anxiety, Laceration of Skin
Virtual Reality for Anxiolysis During Laceration Repair in the Pediatric Emergency Room
The investigators propose a pilot study to examine the feasibility of utilizing immersive virtual reality to reduce procedural anxiety in children undergoing non-facial laceration repair in the Pediatric Emergency Department.
- Trial name
- NCT03475901
- Testing
- Virtual Reality App
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Contusions, Incision
Dermal Wound Closure Using Silkam®
Assessment of performance of Silkam® suture material for skin closure. A prospective, single center, single arm, observational study in daily practice.
- Conditions
- Contusions, Incision, Laceration
- Trial name
- DERMASILK (NCT05225714)
- Where
- Spain
- Volunteers
- 161 people
- Sponsor
- Aesculap AG
Facial Laceration
Facial Lacerations Repaired With Dermabond Compared With Dermabond With Underlying Steristrips in Pediatric Patients
The purpose of the study is to compare cosmetic outcomes of simple facial lacerations in children repaired with Dermabond (skin glue) compared with Dermabond (skin glue) with underlying steristrips (skin adhesive strips).
- Trial name
- NCT03685565
- Testing
- Dermabond and steristrips, Dermabond
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Texas at Austin
Cough, Irritation in Throat
Effects of Pepper Gas Exposure in Non-combatant Bystanders.
Pepper sprays and pepper gas grenades are used by riot police at various places in the world for crowd control. Data about the acute effects based on human studies is extremely scarce.
- Conditions
- Cough, Irritation in Throat, Irritation in Skin, Lacrimation
- Trial name
- NCT01922700
- Where
- India
- Volunteers
- 298 people, healthy volunteers welcome
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Lacerations
Study to Show Equivalence of DERMABOND PROTAPE to DERMABOND HVD for Wound Closure
This is a multicenter, prospective, randomized controlled study for the purpose of comparing DERMABOND PROTAPE to DERMABOND HVD for closure of wounds in the Emergency Department.
- Trial name
- NCT00547638
- Testing
- cyanoacrylate with pressure sensitive mesh, cyanoacrylate
- Where
- 9 sites in United States
- Volunteers
- 216 people
- Sponsor
- Ethicon, Inc.
Aortopathies, Thoracic Aortic Aneurysm
Pathogenetic Basis of Aortopathy and Aortic Valve Disease
The main purpose of this study is to define the complex genetic and pathogenic basis of thoracic aortic aneurysm (TAA) and other forms of aortopathy and/or aortic valve disease by identifying novel disease-causing genes and by…
- Conditions
- Aortopathies, Thoracic Aortic Aneurysm, Aortic Valve Disease, Thoracic Aortic Disease
- Trial name
- TAA (NCT03440697)
- Where
- 2 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Yale University
Marfan Syndrome, FBN1 Mutation
Genome-wide Epistasis for Cardiovascular Severity in Marfan Study
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder with pleiotropic manifestations in the ocular, skeletal and cardiovascular systems.
- Trial name
- GEMS (NCT06257004)
- Testing
- Saliva collection (screening of all participants), Bloodsampling
- Where
- Belgium
- Volunteers
- 200 people
- Sponsor
- University Hospital, Antwerp
Laceration, Skin Wound
Comparison of microMend® Devices to Sutures in Closing Lacerations in Children
This study will gather information on the use of microMend® to repair lacerations in children and compare the efficacy of microMend® to sutures for laceration repair.
- Conditions
- Laceration, Skin Wound, Wound Heal
- Trial name
- NCT04557761
- Testing
- microMend®, Closure with Sutures
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Orange County
Chorioamnionitis, Pregnancy Complications, Infectious
Closure of Skin in ChorioAmnionitis Research Pilot Study
The purpose of the CSCAR pilot study is to improve the design of a full-scale trial by determining the patient recruitment rate and participation rate.
- Conditions
- Chorioamnionitis, Pregnancy Complications, Infectious, Complications; Cesarean Section, Postoperative Complications
- Trial name
- CSCAR (NCT01988168)
- Testing
- Suture closure, Staples closure
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Wounds and Injuries, Lacerations
A Clinical Study to Compare MAR-CUTIS With Dermabond Advanced
This was a randomized, open-label, multicenter, comparator-controlled clinical study to compare MAR-CUTIS with Dermabond Advanced in closure of surgical incisions and lacerations less than or equal to (<=)15 centimeter (cm).
- Conditions
- Wounds and Injuries, Lacerations, Surgical Incision
- Trial name
- NCT03688880
- Testing
- MAR-CUTIS, Dermabond Advanced
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 107 people
- Sponsor
- Grünenthal GmbH
Laceration of Skin
IN Ketamine vs IN Midazolam and Fentanyl for Laceration Repair
Often, repair of the cuts (laceration repair) proves to be traumatic for the children and the parents. Nasal spray (Intranasal/IN) approaches for procedural pain reduction, such as during dental work, have been demonstrated to…
- Trial name
- NCT03528512
- Testing
- Ketamine, Midazolam and fentanyl
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Corewell Health East
Laceration of Skin
Evaluation of Zip Device to Conventional Sutures for Laceration Repair in Pediatrics in an Emergency Department
A prospective, randomized, controlled post-market clinical investigation that will enroll pediatric subjects requiring laceration repair.
- Trial name
- ZIPPED (NCT04122859)
- Testing
- Zip Skin Closure Device
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- ZipLine Medical Inc.
Full-thickness Skin Defects, Degloving Injuries
RECELL® System Combined With Meshed Autograft for Reduction of Donor Skin Harvesting in Soft Tissue Reconstruction
A prospective randomized within-subject controlled study to compare the clinical performance of conventional autografting with and without the RECELL system on acute non-burn full-thickness skin defects.
- Conditions
- Full-thickness Skin Defects, Degloving Injuries, Crush Injuries, Laceration of Skin
- Trial name
- NCT04091672
- Testing
- Control Intervention (Conventional Autograft), Investigational Intervention (RECELL + more widely meshed autograft)
- Where
- 18 sites in United States
- Volunteers
- 65 people
- Sponsor
- Avita Medical
Laceration of Skin, Distress, Emotional
Anxiolysis for Laceration Repair in Children
This is a 3-arm adaptive clinical trial to the optimal light sedative for reducing distress during laceration repair in children.
- Trial name
- ALICE (NCT05383495)
- Testing
- Dexmedetomidine, Midazolam Nasal Spray, Nitrous oxide
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Skin Lacerations
Prospective Evaluation of Topical Anesthesia in Children
This study is designed to assess efficacy and comfort of LET solution vs. EMLA cream and topical infiltration of lidocaine.
- Trial name
- LET (NCT04378283)
- Testing
- LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%), EMLA plus infiltration as anesthetic for wound repair.
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Osteoarthritis, Dislocations
Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data
Surgery is a common treatment type for damaged joints, tendons and nerves in the upper limb where conservative measures are inappropriate or have failed.
- Conditions
- Osteoarthritis, Dislocations, Inflammatory Arthritis, Rotator Cuff Tear
- Trial name
- NCT03573765
- Testing
- Shoulder arthroplasty, Elbow arthroplasty, Hand and wrist arthroplasty
- Volunteers
- 8,308,821 people
- Sponsor
- University of Oxford
Episiotomy Wound
Simple Continuous, Subcuticular and Interrupted Skin Suturing of Episiotomy and 2nd-degree Perineal Tears
Millions of women worldwide undergo perineal suturing after childbirth and the type of repair may have an impact on pain and healing.
- Trial name
- NCT03611452
- Testing
- Episiotomy
- Volunteers
- 138 people
- Sponsor
- Assiut University
Laceration of Skin, Injury Skin
Assessment of DAFILON® Suture Material for Skin Closure
In this non-interventional study (NIS) a polyamide non-absorbable suture (Dafilon®) will be evaluated for skin closure in adult and pediatric patients.
- Trial name
- SKINDA (NCT04617041)
- Where
- 2 sites in Germany, Spain
- Volunteers
- 115 people
- Sponsor
- Aesculap AG
Cartilage Disease
Assessment of Outcome of Meniscus Repair With or Without Platelet Rich Plasma
The purpose of this investigation is to determine the clinical outcome of repair of meniscus tears located in the "red/white" region using a well-known suture technique combined, when indicated, with platelet-rich plasma to…
- Trial name
- NCT00961597
- Testing
- Meniscus repair for red/white tears without PRP, Meniscus repair with PRP
- Where
- United States
- Sponsor
- Sue Barber-Westin