Clinical trials: Spinal Diseases
Poliomyelitis
Clinic Trial to Evaluate the Safety and Immunogenicity by Different Sequential Schedules of bOPV and IPV
With the progress of the eradication of polio, bivalent oral attenuated live poliomyelitis vaccine against type 1 and 3 (bOPV) and inactivated poliomyelitis vaccine made by Sabin strain (sIPV) are required to use in the "Strategy…
- Trial name
- NCT03614702
- Testing
- 1-dose cIPV + 2-doses bOPV (Candy), 1-dose sIPV + 2-doses bOPV (Candy), 2-doses cIPV + 1-dose bOPV (Candy)
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Institute of Medical Biology, Chinese Academy of Medical Sciences
Healthy Volunteer, Muscular Atrophy, Spinal
Ability of Muscle Imaging and Motor Function Measure (MFM) to Detect Changes in Disease Progression in Ambulant Spinal Muscular Atrophy Patients Compared to Healthy Volunteers.
This non-drug, single center, 24-week, longitudinal study in ambulant spinal muscular atrophy (SMA) patients and in age- and gender-matched healthy volunteers will assess the detection of disease progression by magnetic resonance…
- Trial name
- NCT02044029
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Spinal Cord Injury at C5-Th10 Level With Complete Lesion, Spinal Cord Transection
Autologous Bulbar Olfactory Ensheathing Cells and Nerve Grafts for Treatment of Patients With Spinal Cord Transection
The purpose of this experimental therapy is to evaluate the safety and efficacy of transplantation of autologous olfactory ensheathing cells (OECs) and olfactory nerve fibroblasts (ONFs) obtained from the olfactory bulb with…
- Trial name
- NCT03933072
- Testing
- obtaining of autologous human olfactory bulb, autologous sural nerve preparation, production of Glial Neuropatch, microsurgical reconstruction of the transected spinal cord with autologous Glial Neuropatch-nerve bridges
- Where
- Poland
- Volunteers
- 2 people
- Sponsor
- Nicholls Spinal Injury Foundation
Spinal Deformity
Sagittal Balance Through Ages
The parameters of the sagittal balance of the cervical, thoracic and lumbar spine vary according to the types of spino-pelvic organization (types 1-4 according to Roussouly).
- Trial name
- ESTA (NCT04467775)
- Where
- France
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Strasbourg, France
HTLV-I-associated Myelopathy
The HAM Infliximab Study
An open-label, non-randomised, uncontrolled, proof-of-concept study of eight patients with 'definite' HTLV-I-associated myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
- Trial name
- HAM06 (NCT00823641)
- Testing
- Infliximab
- Where
- United Kingdom
- Volunteers
- 3 people
- Sponsor
- Imperial College London
Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA)
REDO-JAK: Dose Reduction of Janus Kinase Inhibitors in Patients With Inflammatory Rheumatic Diseases
The goal of this clinical trial is to assess the effectiveness of a disease activity guided dose reduction strategy of Janus kinase inhibitor (JAKi) compared to disease activity guided JAKi continuation in patients with…
- Conditions
- Rheumatoid Arthritis (RA), Psoriatic Arthritis (PsA), Axial Spondyloarthritis (AxSpA)
- Trial name
- REDO-JAK (NCT07160231)
- Testing
- JAKi dose reduction strategy, JAKi disease activity guided continuation of same dose strategy
- Where
- 7 sites in Netherlands
- Volunteers
- 200 people
- Sponsor
- Sint Maartenskliniek
Post Traumatic Induced Spasticity
Selective Dorsal Rhizotomy as a Cost Effective and Safe Procedure as a Alternative to Intrathecal Baclofen Pump in Patients With Post Traumatic Spasticity
The investigators will investigate the selective dorsal rhizotomy in post traumatic brain and spinal cord injury induced spasticity to evaluate the efficacy of this procedure in reducing the tone of the spastic muscle groups.
- Trial name
- NCT07583277
- Testing
- Selective dorsal rhizotomy with neuromonitoring
- Volunteers
- 32 people
- Sponsor
- Assiut University
Spinal Muscular Atrophy
An Open-label Safety, Tolerability, and Dose-range Finding Study of Nusinersen (ISIS 396443) in Participants With Spinal Muscular Atrophy (SMA)
This objectives of this study are to evaluate the safety, tolerability, and pharmacokinetics of a single dose of nusinersen (ISIS 396443) administered intrathecally to participants with Spinal Muscular Atrophy (SMA).
- Trial name
- SMNRx (NCT01494701)
- Testing
- nusinersen
- Where
- 4 sites in United States
- Volunteers
- 28 people
- Sponsor
- Biogen
Adolescent Idiopathic Scoliosis
Trials of Intelligent Nighttime Brace With Smart Padding to Treat of Adolescent Idiopathic Scoliosis
Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity usually associated with intervertebral rotation that takes place during adolescence.
- Trial name
- NCT05790031
- Testing
- Intelligent Nighttime Brace
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Hong Kong Polytechnic University
Adolescent Idiopathic Scoliosis (AIS)
Investigation of Shoulder Position, Upper Extremity Proprioception, and Function in Adolescents With Idiopathic Scoliosis Using Braces
This study aims to investigate the effects of brace use on shoulder position, upper extremity proprioception, and upper extremity function in adolescents with idiopathic scoliosis.
- Trial name
- NCT06904157
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gözde Yagci (Gür)
Spinal Stenosis Occipito-Atlanto-Axial, Spinal Disease
Streamline Occipito-Cervico-Thoracic System Post-Market Clinical Follow-up
This is a multi-center, post-market, retrospective study design to collect safety and performance data for patients implanted with the Streamline OCT System.
- Conditions
- Spinal Stenosis Occipito-Atlanto-Axial, Spinal Disease, Spinal Stenosis Cervical, Spinal Stenosis Cervicothoracic Region
- Trial name
- OCT PMCF (NCT04171544)
- Testing
- Streamline Occipito-Cervico-Thoracic Spinal Fixation System
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- RTI Surgical
Traumatic Brain Injury
Rehabilitation Research and Training Center for Traumatic Brain Injury Interventions--Teen Online Problem Solving Study
This study will evaluate the effectiveness of an Internet-based psychosocial treatment in improving problem-solving, communication skills, stress management strategies, and coping among teens who have had a traumatic brain injury…
- Trial name
- RRTC--TOPS (NCT01042899)
- Testing
- Teen Online Problem Solving (TOPS), Teen Online Problem Solving--Teen Only (TOPS-TO), Internet Resources Comparison (IRC)
- Where
- 5 sites in United States
- Volunteers
- 153 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Scoliosis Idiopathic Adolescent, Scoliosis Idiopathic Adolescent Treatment
Scoliosis-Specific Exercises on Physical Fitness Parameters
Adolescent Idiopathic Scoliosis is a common musculoskeletal condition characterized by a three-dimensional spinal deformity, affecting approximately 2-4% of adolescents worldwide and occurring more frequently in girls.
- Trial name
- NCT07249502
- Testing
- Scoliosis-Specific Corrective Exercise Program, Postural Education and Basic Corrective Exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Istinye University
Parkinson Disease, Dystonia
Osteopathic Manual Treatment Parkinson's Disease and Truncal Dystonia
This study will determine if posture and heart rate variability will significantly improve in Parkinsons disease with camptocormia after osteopathic manual treatments dystonia.
- Conditions
- Parkinson Disease, Dystonia, Autonomic Dysreflexia
- Trial name
- NCT03307161
- Testing
- osteopathic manual therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- New York Institute of Technology
Spinal Cord Injury
Identify Training Strategies for Progressing Exoskeleton Users Towards Everyday Functional Ambulation
Many people with spinal cord injury are no longer able to walk and must use wheelchairs for mobility. These individuals experience greater rates of depression and lower quality of life.
- Trial name
- NCT02104622
- Testing
- ReWalk Rehabilitation 2.0
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Adolescent Idiopathic Scoliosis
The Effect of Exercise on Paravertebral Muscle Thickness and Quality of Life in Adolescent Idiopathic Scoliosis
The study population comprised patients with AIS who had applied to the outpatient clinic between January and June 2022. The patients were divided into two groups.
- Trial name
- NCT07250295
- Testing
- Exercise, Exercise for Lower Extremities
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Sisli Hamidiye Etfal Training and Research Hospital
Low Back Pain
The Effect Of Low Back Pain on Paraspinal Muscles
Low back pain is frequently seen in the adolescent age group, with a prevalence approaching that of the adult age group. The most common type is non-specific, self-limiting low back pain.
- Trial name
- NCT04555356
- Where
- Turkey (Türkiye)
- Volunteers
- 205 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Muscular Atrophy, Spinal
An Expanded Access Program for Risdiplam in Participants With Spinal Muscular Atrophy (SMA)
This expanded access program (EAP) will provide access to risdiplam for eligible participants with Type 1 or Type 2 spinal muscular atrophy (SMA) before it is commercially available in the United States for the indication of SMA.
- Trial name
- NCT04256265
- Testing
- Risdiplam
- Where
- 29 sites in United States
- Sponsor
- Genentech, Inc.
Spinal Cord Injury
Functional Electrical Stimulations With and Without Motor Priming Exercises in Spinal Cord Injury
As functional electrical stimulations has evident role in improving motor control in tenodesis function (power and precision grip) but its results are considered to be short term so addition of task oriented approach i.e.
- Trial name
- NCT05411692
- Testing
- Functional electrical stimulations and motor priming exercise, Functional electrical stimulations, Conventional physical therapy
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- Riphah International University
Scoliosis Idiopathic, Scoliosis; Juvenile
Ultrasound for Scoliosis Diagnostic Evaluation
Scoliosis is a complex 3-dimensional deformity of the spine. It may occur at any time throughout growth and development and is typically detected through x-ray imaging.
- Trial name
- NCT03222739
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's National Research Institute
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