Clinical trials: Spinal Puncture
Late Infantile Neuronal Ceroid Lipofuscinosis, Batten Disease
Collection of Cerebrospinal Fluid in Healthy Children
The purpose of this study is to obtain cerebrospinal fluid from healthy children already undergoing a lumbar puncture procedure at New York Presbyterian Hospital, to act as healthy controls when compared to children with late…
- Trial name
- NCT01698229
- Testing
- Group 1
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Traumatic Lumbar Puncture
Variability of Infant LP Insertion Site Based On Procedural Experience
The reported rate of unsuccessful traditional LP in children (defined as the inability to obtain cerebrospinal fluid or obtaining a traumatic puncture) is as high as 50%.
- Trial name
- NCT02949869
- Testing
- Spinal Sonography
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Lumbar Puncture, Topical Analgesia
Jet Injection of 1% Buffered Lidocaine Versus Topical EMLA for Local Anesthesia Before Lumbar Puncture in Children
The purpose of this study is to evaluate the effectiveness of a needle-free jet-injection system with 1% buffered lidocaine for local anesthesia for lumbar punctures compared to a topical anesthetic agent.
- Trial name
- JTIP (NCT01628874)
- Testing
- J-Tip, EMLA, Lidocaine
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pediatric Lumbar Puncture
Intravenous Fluid Administration's Effect on Pediatric Lumbar Puncture
The purpose of this project is to determine if administration of normal saline intravenous fluids prior to a lumbar puncture improves first time success of lumbar puncture in infants less than 3 months of age.
- Trial name
- NCT05302765
- Testing
- Normal Saline Intravenous Fluids
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- University of Alabama at Birmingham
Hunter Syndrome
Collection and Study of Cerebrospinal Fluid in Patients With Hunter Syndrome
The purpose of the study is to collect data on CSF biomarkers in patients with Hunter Syndrome that would serve as reference data for comparison with cognitively impaired patients with Hunter syndrome, patients with other…
- Trial name
- NCT01449240
- Testing
- No treatment
- Where
- 7 sites in United States, United Kingdom
- Volunteers
- 10 people
- Sponsor
- Shire
Spinal; Puncture, Complications
Ultrasound vs Palpation for Infant Lumbar Puncture
The purpose of this study is to determine if performing an ultrasound to identify the space to insert the needle before performing a lumbar puncture will improve success of the procedure and patient safety.
- Trial name
- NCT02373774
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Columbia University
Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8
Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-Small Cell Lung Cancer
This phase I trial assesses the use of lumbar punctures to detect whether there is circulating tumor deoxyribonucleic acid (ctDNA) in the fluid that surrounds the brain and spinal cord (cerebrospinal fluid) in patients with stage…
- Conditions
- Lung Non-Small Cell Carcinoma, Stage III Lung Cancer AJCC v8, Stage IV Lung Cancer AJCC v8
- Trial name
- NCT06816979
- Testing
- Biospecimen Collection, Lumbar Puncture, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Post-Lumbar Puncture Headache
Headache After Diagnostic Lumbar Puncture
The objectives of this study are to investigate the effects of needle design, needle size and stylet reinsertion on the risk for headache after diagnostic LP (lumbar puncture, Post-LP headache).
- Trial name
- HELPUmeå (NCT03960749)
- Testing
- Sprotte 25G needle, stylet reinserted, Sprotte 25G needle, stylet not reinserted, Sprotte 22G needle, stylet reinserted
- Volunteers
- 1,000 people
- Sponsor
- Jonatan Salzer
Infant ALL
Effect of Music Therapy Applied During Lumbar Puncture on Infants' Pain Perception
Bacterial meningitis is a serious infection that is more common in newborns is associated with significant morbidity and mortality.
- Trial name
- NCT06571006
- Testing
- music
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Erzurum Technical University
Attention Deficit and Disruptive Behavior Disorder, Attention Deficit Disorder With Hyperactivity
Biological Markers in Attention Deficit/Hyperactivity Disorder (ADHD)
The purpose of this study is to evaluate individuals with Attention Deficit/Hyperactivity Disorder (ADHD) to learn more about the genetics of the disease. This study is part of other ongoing studies of individuals with ADHD.
- Trial name
- NCT00001206
- Where
- United States
- Volunteers
- 347 people
- Sponsor
- National Institute of Mental Health (NIMH)
Consent
Lumbar Puncture Video Study
The purpose of this study is to improve the lumbar puncture (LP) consent process for pediatric patients. Though a commonly performed and safe procedure, LP can be anxiety-provoking for parents.
- Trial name
- NCT03677219
- Testing
- Educational Video
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Spinal and Epidural Anaesthesia-Induced Headache During Pregnancy
Establishment of a Predictive Model for Post-dural Puncture Headache
The goal of this clinical trial is to establish a predictive model for post-dural puncture headache. The main questions it aims to answer are: Changes in intracranial pressure after spinal puncture (or lumbar puncture).
- Trial name
- NCT06800859
- Testing
- Supplement fluids
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Yilin Zhao
Leukemia, Non Hodgkin Lymphoma
Evaluation of the Analgesy With Emla and/or Nitrous Oxide in Pediatric Patients for Lumbar Puncture
In this randomised controlled study the investigators intended to compare the analgesic effects of EMLA and\or nitrous oxide in children submitted to lumbar puncture.
- Trial name
- NCT00808171
- Testing
- Livopan, EMLA
- Where
- Brazil
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Leukemia-Lymphoma
Pain Control in Pediatric Oncology: Utility of EMLA Cream vs Lidocaine Injection in Lumbar Punctures
A common procedure in children with cancer is the spinal tap, or lumbar puncture (LP), in which a needle is inserted into the spinal canal.
- Trial name
- NCT04003012
- Testing
- EMLA, Lidocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- CAMC Health System
CerebroSpinal Fluid (CSF) Leak
The Freiburg Registry on SpontanEous IntercrAnial Hypotension (SIH) & Post-duraL Puncture Headache (PDPH)
Spinal CSF leaks are considered as rare disease. They cause a variety of symptoms, mainly culminating in a chronic headache syndrome. Crucially, yet often disregarded, the disease holds the potential for cure.
- Trial name
- SEAL (NCT06711731)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University Hospital Freiburg
Meningitis/Encephalitis
QIAstat-Dx® Meningitis/Encephalitis Panel Performance Evaluation Study
Study for performance evaluation of the QIAstat-Dx® Meningitis/Encephalitis Panel in comparison with other chosen comparator methods.
- Trial name
- NCT05155553
- Testing
- QIAstat-Dx® Meningitis/Encephalitis (ME) Panel
- Where
- United Kingdom
- Volunteers
- 1,524 people
- Sponsor
- QIAGEN Gaithersburg, Inc
Traumatic Lumbar Puncture
The Effect of Bedside Ultrasound Assistance on the Proportion of Successful Infant Spinal Taps
The reported rate of unsuccessful spinal taps in children, especially young infants, is high. Our hypothesis is that ultrasound assistance can improve the success rate of spinal taps.
- Trial name
- NCT02133066
- Testing
- Bedside Ultrasound-Assisted Site Marking, Mindray M7 Ultrasound, Routine lumbar puncture
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Traumatic Tap
Lumbar Puncture Stylet Technique in Children
Lumbar puncture (LP) is a procedure performed frequently among children in the emergency department (ED). Although it has been performed for decades, and for distinct indications, the technique itself can often lead to traumatic…
- Trial name
- LiPSTICk (NCT05009173)
- Testing
- Lumbar puncture using the stylet-in technique, Lumbar puncture using the stylet-out technique
- Where
- Canada
- Volunteers
- 395 people
- Sponsor
- St. Justine's Hospital
Anxiety and Fear
The Effect of Therapeutic Play on Children's Anxiety and Fear Before Lumbar Puncture
The study will be conducted with the randomized controlled experimental method. The children who attended the pediatric department will divide into two groups via randomization in the computer environment.
- Trial name
- NCT06199206
- Testing
- Theraputic Play
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Maltepe University