Clinical trials: Spine Condition
Adolescent Idiopathic Scoliosis, Cerebral Palsy
Pain Assessment in Children Undergoing Spine Surgery
Musculoskeletal (MSK) pain is one of the most common types of pain among children and adolescents. Recurring episodes of MSK pain conditions have a major impact on the daily lives.
- Trial name
- NCT04244760
- Testing
- Pain assessment for verbal patients, Pain assessment for non-verbal patients
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- Catherine Ferland
Systemic Lupus Erythematosus
Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children
The purpose of this study is to compare healthy children to children who have systemic lupus erythematosus (SLE). SLE is a childhood disease that has high risk for low bone mass and vertebral compression fractures.
- Trial name
- NCT01330368
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis
Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries
This randomized phase II trial is studying zoledronate to see how well it works compared to observation in maintaining bone mineral density in patients who are undergoing surgery to remove both ovaries.
- Conditions
- Hereditary Breast and Ovarian Cancer Syndrome, Osteoporosis, Ovarian Carcinoma
- Trial name
- NCT00305695
- Testing
- Laboratory Biomarker Analysis, Zoledronic Acid
- Where
- 95 sites in United States
- Volunteers
- 160 people
- Sponsor
- Gynecologic Oncology Group
Early-Onset Scoliosis Deformity of Spine (Disorder), Idiopathic Scoliosis
Limited-efficacy Testing of Spring Distraction System (SDS) and Unilateral One-way Rod (MID-C) for Early Onset Scoliosis
The primary aim of this study is to investigate the limited efficacy of these innovative surgical solutions in treatment of Early Onset Scoliosis (EOS) in terms of maintaining reduction while maintaining spinal growth.
- Trial name
- UniPOWR (NCT04003233)
- Testing
- SDS, MID-C
- Where
- 2 sites in Netherlands
- Sponsor
- UMC Utrecht
Degenerative Spine Diseases
A Multicenter Observational Cohort of Degenerative Spine Diseases in China（DSDC）
Study type: The objectives of this observational study were to understand, analyze, and compare the treatment and prognosis of patients with degenerative spine diseases and to construct a risk warning model and an assisted…
- Trial name
- DSDC (NCT05867732)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Xiamen University
Acute Traumatic Spinal Cord Injury
Safety and Preliminary Efficacy of FAB117-HC in Patients With Acute Traumatic Spinal Cord Injury
The main objective of the study is the evaluation of the safety and tolerability of FAB117-HC (a medicinal product containing human allogeneic adipose derived adult mesenchymal stem cells expanded and pulsed with H2O2, HC016…
- Trial name
- SPINE (NCT02917291)
- Testing
- FAB117-HC, Control group
- Where
- 9 sites in Spain
- Volunteers
- 48 people
- Sponsor
- Ferrer Internacional S.A.
Pharmacological Action
The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.
In this randomized double blind placebo controlled study of tranexamic acid during minor spinal surgery, mean postoperative blood loss in the patients who received TXA was statistically significantly lower compared to placebo.
- Trial name
- NCT03714360
- Testing
- Tranexamic Acid, Sodium Chloride 0,9%
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Mikkel Østerheden Andersen
Neurologic Deficits
NeuroVision vs Standard Neuromonitoring
The purpose of this study is to perform a prospective, randomized, controlled clinical trial to assess the utility of IONM in patients undergoing primary, single or multilevel lateral spinal procedures.
- Trial name
- NCT04639297
- Testing
- NeuroVision® IONM, Hospital Based IONM
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Spinal Cord Cancer, Brain (Nervous System) Cancers
Cyberknife Precision Radiation Delivery System for Tumors of the Spine
The purpose of this study is to determine the usefulness of Cyberknife precision radiation in eliminating or preventing the further growth of spinal tumors and lesions.
- Trial name
- NCT00185666
- Testing
- Stereotactic radiosurgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Scoliosis, Adolescent Idiopathic Scoliosis (AIS)
Validation of a New Generation of Optimized Orthoses for Personalized Treatment of Adolescent Idiopathic Scoliosis
Adolescent Idiopathic scoliosis affects 3-4% of the Canadian population, of which about 10% will need a brace treatment during pubertal growth spurt.
- Trial name
- NCT02285621
- Testing
- Optimized brace versus conventional Boston brace
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- St. Justine's Hospital
Juvenile; Scoliosis, Scoliosis Idiopathic
Digital Health Psychosocial Intervention for Adolescent Spine Surgery Preparation and Recovery
This is a randomized controlled trial to test effectiveness of the SurgeryPal intervention vs. education control to improve acute and chronic pain and health outcomes in youth undergoing major musculoskeletal surgery.
- Conditions
- Juvenile; Scoliosis, Scoliosis Idiopathic, Scoliosis; Adolescence, Scoliosis;Congenital
- Trial name
- SurgeryPal (NCT04637802)
- Testing
- CBT (SurgeryPal), Education
- Where
- United States
- Volunteers
- 433 people
- Sponsor
- Seattle Children's Hospital
Trauma, Nervous System
Intrathecal Morphine on Transcranial Electric Motor-Evoked Potentials
Patients undergoing posterior spinal fusion (PSF) procedures for scoliosis are at risk for iatrogenic neurologic injury of the spinal cord and/or spinal nerve roots during surgical correction of the abnormal spinal curvature.
- Trial name
- EIM (NCT00596609)
- Testing
- Intrathecal Morphine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Children's Hospital of Philadelphia
Scoliosis Idiopathic
Acute Effects of Self-correcting Movement on the Balance and Spine of Patients With Scoliosis.
The purpose of this study is to evaluate the acute effects of the self-elongation movement on the balance of patients (aged 8-16 years) suffering from adolescent idiopathic scoliosis,
- Trial name
- NCT05039255
- Volunteers
- 35 people
- Sponsor
- University of Pavia
Scoliosis
Evaluate Initial Safety of the HemiBridge™ System in Guided Spinal Growth Treatment of Progressive Idiopathic Scoliosis
The purpose of this clinical trial is to study a new method of treatment for patients who are diagnosed with idiopathic scoliosis and have abnormal and increasing curvature of the spine.
- Trial name
- NCT01465295
- Testing
- Mechanical hemiepiphysiodesis using the HemiBridge System
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- SpineForm LLC
Burst Thoracic Spine Fractures
The Influence of the Ribs on the Gravity of Burst Thoracic Spine Fractures
The purpose of this study is to analyse the anatomic influence of the ribs related to the incidence and severity of burst spine fractures.
- Trial name
- NCT01544933
- Where
- Brazil
- Volunteers
- 2 people
- Sponsor
- Universidade de Passo Fundo
Spine Cancer, Anesthesia
Dexmedetomidine Infusion on Intraoperative Propofol,Fentanyl Requirements in Spine Surgery for Pediatric Cancer Patients
The purpose of this trial is to investigate whether the effect of a low-dose dexmedetomidine infusion will decrease propofol consumption or not through a double blinded randomized controlled trial done in children cancer hospital…
- Trial name
- NCT05493228
- Testing
- Precedex Injectable Product, Saline
- Where
- Egypt
- Volunteers
- 38 people
- Sponsor
- Children's Cancer Hospital Egypt 57357
Back Pain
Back and Neck Pain in Adolescence
To validate the German version of the Young Spine Questionnaire (G-YSQ) and to study back and neck pain in adolescents between 10 and 16 years during one year by means of G-YSQ.
- Trial name
- Youngback (NCT02955342)
- Testing
- no intervention
- Where
- Switzerland
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Scoliosis Idiopathic, Myopia
Zhejiang Adolescent Spine and Vision Health Cohort: A Longitudinal Database Analysis
The aim of study: 1. To investigate the prevalence of scoliosis, other spinal deformities, myopia, and visual impairments in adolescents (aged 6-18) in Zhejiang Province.
- Conditions
- Scoliosis Idiopathic, Myopia, Vision Disorders
- Trial name
- NCT06992622
- Where
- China
- Volunteers
- 73,000 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Scoliosis
Gait and Postural Stability Assessment in Children With Idiopathic Scoliosis Undergoing Posterior Spine Instrumentation
The goal of this study is to evaluate children and adolescents with idiopathic scoliosis who are undergoing spinal fusion using motion analysis, balance, and outcome questionnaires.
- Trial name
- NCT01109082
- Testing
- posterior spine fusion
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Shriners Hospitals for Children
Surgical Site Infection
Bacterial Contamination: Iodine vs Saline Irrigation in Pediatric Spine Surgery
This study will evaluate the safety of povidone-iodine irrigation in pediatric spinal patients by collecting pre- and post-operative safety labwork.
- Trial name
- NCT02527512
- Testing
- Povidone-Iodine, Normal Saline
- Where
- 2 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital