Clinical trials: Sputum
Cystic Fibrosis
The Effect of Inhaled N-Acetylcysteine Compared to Normal Saline on Sputum Rheology and Lung Function
Inhalation treatment with mucolytics is one of the cornerstones of CF treatment for respiratory problems. The efficacy of inhalation treatment with recombinant DNAse and hypertonic saline is well established.
- Trial name
- NCT00996424
- Testing
- Acetylcysteine, normal saline
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University Hospital, Ghent
Tuberculosis
Improving the Outcomes of Children With Tuberculosis Through Innovative Diagnostics and Treatment Monitoring
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with…
- Trial name
- RoGer Pedi (NCT06815588)
- Where
- Romania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Research Center Borstel
Cystic Fibrosis
A Short-term Comparative Study of Aerosure for Airway Clearance in Patients With Cystic Fibrosis
This is a double-blind randomised controlled crossover study to investigate whether high frequency airflow oscillation (HFAO), delivered using Aerosure, improves sputum clearance in patients admitted to hospital with infective…
- Trial name
- NCT01923753
- Testing
- Aerosure at 15 Hz, Aerosure at 25 Hz
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Actegy Ltd.
Tuberculosis
Xpert MTB/Rif, a New Tool for the Diagnosis of Pulmonary Tuberculosis in Two Municipalities in Brazil
Diagnosis of tuberculosis (TB) is a challenge because sputum smear, the most rapid and inexpensive test, often fails to detect the disease, in around 20 to 30% of cases.
- Trial name
- NCT01363765
- Testing
- Xpert MTB/Rif, Smear microscopy
- Where
- Brazil
- Volunteers
- 34,758 people
- Sponsor
- Ataulpho de Paiva Foundation
Chronic Obstructive Pulmonary Disease
Effect of Tiotropium on Inflammation and Exacerbations in COPD
Patients with COPD experience exacerbations that are a major cause of morbidity. Exacerbations are associated with increased airway and systemic inflammation and those experiencing frequent exacerbations demonstrate increased…
- Trial name
- NCT00405236
- Testing
- tiotropium
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- Royal Free and University College Medical School
Pulmonary Candidiasis
Clinical Significance of Smear or Culture Positive for Candida Spp. From Sputum Three Times a Week
The definition of pulmonary candidiasis is still unclear.In China, isolation of candida spp. form sputum twice or three times a week has been regarded as the microbiological evidence of pulmonary candidiasis.
- Trial name
- NCT00537888
- Testing
- fluconazole
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Capital Medical University
Cystic Fibrosis in Children
Effectiveness of the Hippotherapy Simulator in Children and Adolescents with Cystic Fibrosis
Cystic fibrosis (CF) is a genetic disease that affects many organs and systems, especially respiratory system problems due to lung damage.
- Trial name
- NCT05027503
- Testing
- Exercise with hippotherapy simulator, Respiratory Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Istanbul University - Cerrahpasa
Asthma, Airway Hyperresponsiveness
Bronchospasm Associated With High Nitric Oxide
Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.
- Trial name
- NCT00666510
- Where
- Brazil
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Cystic Fibrosis
Pharmacokinetic Bioequivalence Study of Nebcinal® 150mg/3ml Administered by Aeroneb® Idehaler® Versus Tobi® 300mg/5ml Administered by Pari LC Plus®
Cystic fibrosis (CF) is a genetic disease characterized by mutations in CFTR (Cystic Fibrosis Transmembrane conductance Regulator) gene.
- Trial name
- NCT01288170
- Testing
- Nebcinal Tobi, Tobi Nebcinal
- Where
- 2 sites in France
- Volunteers
- 12 people
- Sponsor
- Erempharma
Malignant Brain Tumor
Rates DMBT1 ( Glycoprotein) in Sputum of CF Patients With Pseudomonas Aeruginosa
Rates of DMBT1 (Glycoprotein like) in Sputum of CF Patients with or without may be different according to their Pseudomonas Aeruginosa chronic colonization status.
- Trial name
- DMBT1 (NCT02880111)
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Cystic Fibrosis, Respiratory Infection
Sputum Validation for the Molecular Diagnosis of Respiratory Viral Infections in Cystic Fibrosis
The aim of this pilot study is to demonstrate the feasibility of viral biomolecular diagnosis in sputum compared to nasopharyngeal swab in cystic fibrosis acute respiratory infection.
- Trial name
- EXPIRE (NCT03684759)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Brest
Bronchitis, Cough
Treatment of Respiratory Tract Infection and/or Acute Bronchitis With Ectoin Inhalation Solution
This observational, non-interventional multicentric study compares the inhalation therapy on patients suffering on respiratory tract infections and/or acute bronchitis between Ectoin inhalation solution and Pari NaCl (0.9%)…
- Conditions
- Bronchitis, Cough, Sputum, Cellular Atypia, Dyspnoea
- Trial name
- NCT02632851
- Where
- Germany
- Volunteers
- 135 people
- Sponsor
- Bitop AG
Cystic Fibrosis
Bronchial Inflammation of Small Airways in Patients With Cystic Fibrosis
In the planned study, 60 patients with mild cystic fibrosis (CF) with and without the involvement of small airways (small airway disease - SAD) are to be compared with a historical control group matched in age and gender.
- Trial name
- FRA-MUKO (NCT01479166)
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis,
Evaluation of Bronchial Inflammation in Allergic Bronchopulmonary Aspergillosis (ABPA)
Chronic bronchial inflammation is an important clinical feature in cystic fibrosis. Approximately 10% of patients with cystic fibrosis suffer from Allergic Bronchopulmonary Aspergillosis.
- Trial name
- ABPA (NCT00906568)
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cystic Fibrosis (CF), Bronchiectasis, Non-Cystic Fibrosis
Diagnostic Value of Oropharyngeal Suction and Effect of Respiratory Physiotherapy on the Detection of Microorganisms in the Pediatric Patient
The goal of this clinical trial is to determine the effectiveness of oropharyngeal suction in detecting microorganisms by comparing it with induced sputum and oropharyngeal swab samples.
- Trial name
- NCT07903792
- Testing
- Respiratory physiothperapy, Oropharyngeal suction, Oropharyngeal swab
- Where
- Spain
- Volunteers
- 196 people
- Sponsor
- Corporacion Parc Tauli
Cystic Fibrosis, Lung Inflammation
TAAI Erasmus Research Initiative to Fight CF: Monitoring Inflammation in CF Lung Disease Into a New Era
Progressive destruction of the lungs is the main cause of shortened life expectancy in people with cystic fibrosis (pwCF). Inflammation and respiratory infections play a key role in CF lung disease.
- Conditions
- Cystic Fibrosis, Lung Inflammation, Lung Infection, Lung Disease; Cystic
- Trial name
- TERRIFIC-MILE (NCT05752019)
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Erasmus Medical Center
Asthma, Chest Syndrome
Clinical Characteristics, Treatment and Prognosis of Chest Tightness Variant Asthma
Asthma, abbreviation for bronchial asthma, is one of the common chronic airways disease that threatens human health. Typical symptoms of asthma are recurrent wheezing, shortness of breath, chest tightness and cough, usually…
- Conditions
- Asthma, Chest Syndrome, Clinical Anxiety, Clinical Depression
- Trial name
- NCT03237221
- Testing
- Treat patient according to Global Initiative for Asthma (GINA) guideline
- Where
- 34 sites in China
- Volunteers
- 76 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Bronchiolitis Obliterans
Bronchial Inflammation in Patients With Bronchiolithis Obliterans
The investigators plan to study the variability of lung function parameters and bronchial inflammatory markers in 20 patients with bronchiolitis obliterans at the age of 6 to 25 years compared with an age- and sex-matched control…
- Trial name
- FRABO-02 (NCT01633385)
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Tuberculosis, Multi Drug Resistant Tuberculosis
Evaluation of PCR Using DNA Extract From Slides and Filter Paper for the Detection of Tuberculosis and MDR-tuberculosis
Specimen transport from peripheral health structures to the National TB reference laboratory for MDR-TB identification presents a big challenge in term of sample management, safety, contamination and delays.
- Trial name
- NCT03137875
- Where
- Uganda
- Volunteers
- 122 people
- Sponsor
- Epicentre
Pulmonary Tuberculosis
Improving Community Based Tuberculosis Care in Ethiopia
The purpose of this study is to see if involving community health workers improves tuberculosis case finding and treatment outcome.
- Trial name
- community (NCT00803322)
- Where
- Ethiopia
- Volunteers
- 318 people
- Sponsor
- University of Bergen