Clinical trials: Standard Care Control
Laceration
Virtual Reality vs. Standard-of-Care for Comfort During Laceration Repair
Lacerations are a common reason for presentation to the Emergency Department and children needing laceration repair with sutures are experiencing pain and anxiety.
- Trial name
- NCT03681717
- Testing
- Virtual Reality
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Catheter-Related Infections
Comparison of Chlorhexidine Impregnated Dressing and Standard Dressing
Investigators have designed a single-center randomized controlled trial to compare chlorhexidine gluconate (CHG)-impregnated dressing and standard dressing with respect to their effects on the infection outcomes.
- Trial name
- NCT04794231
- Testing
- Standard dressing, Chlorhexidine gluconate -impregnated dressing group
- Where
- Turkey (Türkiye)
- Volunteers
- 307 people
- Sponsor
- Istanbul Medeniyet University
Prophylactic, Anticoagulation
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026…
- Trial name
- NCT07710482
- Testing
- Enoxaparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Minor Plastic Surgery
Virtual Reality vs. Standard-of-Care for Comfort During Minor Plastic Surgery Procedures in Children
Children often experience pain and anxiety during minor medical procedures. In addition to pain medication, distraction may help children cope with the pain. This may include interacting with books, TV, toys or videogames.
- Trial name
- NCT03681743
- Testing
- Virtual Reality
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Adolescent Idiopathic Scoliosis
Effect of a Postural Re-education Intervention Compared to Standard Care on Scoliosis Progression in Adolescent
The aim of this project is to verify the effect of the global postural reeducation (GPR) intervention used in physiotherapy on scoliosis progression (scoliosis angle), back pain, quality of life, respiratory function, trunk…
- Trial name
- RCT-RPG (NCT04568759)
- Testing
- Global postural re-education
- Where
- 2 sites in Canada
- Volunteers
- 47 people
- Sponsor
- St. Justine's Hospital
Acute Respiratory Distress Syndrome
KL₄Surfactant Treatment in Patients With ARDS
Lung wash with KL₄Surfactant of individual lung segments using a bronchoscope compared to usual care alone consisting primarily of assisted (mechanical) ventilation in patients with acute respiratory distress syndrome(ARDS).
- Trial name
- NCT00215553
- Testing
- A.1 Lucinactant, B.3 SoC, A.2 Lucinactant
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Windtree Therapeutics
Amblyopia
CURESIGHT BINOCULAR AMBLYOPIA TREATMENT STUDY
Screening A child is considered for the study after undergoing a standard of care and study specific eye examinations (by a study investigator as part of standard of care) that identifies amblyopia appearing to meet the…
- Trial name
- NCT04785690
- Testing
- CureSight, Patching
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- NovaSight
Chorioamnionitis, Early Onset Neonatal Sepsis
Chorioamnionitis: Observation of at Risk Infants vs Standard Care
This study evaluates the non-inferiority of a protocol of limited evaluation (complete blood count, blood culture) and clinical observation by standardized physical examination versus the algorithm suggested in the CDC's 2010…
- Conditions
- Chorioamnionitis, Early Onset Neonatal Sepsis, Sepsis of the Newborn
- Trial name
- CHORIS-RCT (NCT02886910)
- Testing
- Clinical observation, Standard management
- Where
- Italy
- Sponsor
- IRCCS Burlo Garofolo
Respiratory Failure, Shock
Comparing Post Cardiac Surgery Outcomes in ESRD Patient's With Early Dialysis Versus Standard Care
End-stage renal disease (ESRD) is an important risk factor for coronary and valvular cardiac disease leading to cardiac surgery.
- Conditions
- Respiratory Failure, Shock, Coagulopathy
- Trial name
- NCT04705701
- Testing
- Hemodialysis
- Sponsor
- Northwell Health
Psychosis, Major Depression
Peer Support for Severe Mental Disorders
The purpose of this study is to determine wether peer support is effective for the treatment of people with severe mental illness.
- Conditions
- Psychosis, Major Depression, Bipolar Disorder, Borderline Personality Disorder
- Trial name
- PEER (NCT02276469)
- Testing
- peer support
- Volunteers
- 200 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Intravenous Catheterization
Virtual Reality vs Standard-of-Care for Comfort During Intravenous Catheterization
Children often need an intravenous catheter placement for delivery of fluids and medications, a procedure associated with pain and anxiety. In the Emergency Department topical anesthetics are frequently used.
- Trial name
- NCT03681730
- Testing
- Virtual Reality
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- University of British Columbia
Asthma
Study of Efficacy and Safety of QAW039 When Added to Standard-of-care Asthma Therapy in Patients With Uncontrolled Asthma
A randomized, multicenter, double-blind, placebo- controlled parallel-group study to determine the efficacy and safety of QAW039, compared with placebo, when added to standard-of-care (SoC) asthma therapy in adult and adolescent…
- Trial name
- NCT03215758
- Testing
- QAW039
- Where
- 110 sites in United States, Argentina and 8 more
- Volunteers
- 675 people
- Sponsor
- Novartis Pharmaceuticals
Peripheral Venous Catheterization, Difficult Intravenous Access
TruVascular Access - Ultrasound-Guided Vascular Access Study
TruVascular Access - TVA-2026 is a prospective, randomized clinical study evaluating whether ultrasound-guided peripheral vascular access improves first-attempt cannulation success compared with conventional landmark…
- Conditions
- Peripheral Venous Catheterization, Difficult Intravenous Access, Catheterization, Peripheral
- Trial name
- TVA-2026 (NCT07798427)
- Testing
- Ultrasound-Guided Peripheral Vascular Access, Standard Peripheral Vascular Access, Point-of-Care Ultrasound System for Vascular Access Guidance
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Truway Health, Inc.
Hepatitis C
Ribavirin Pre-treatment Followed by Combined Standard Therapy in Hepatitis C Virus (HCV) Recipients
The results of antiviral therapy in patients with recurrent hepatitis C after liver transplantation are lower than standard. Ribavirin has immune-modulating effects and seems to be crucial to optimize viral treatment.
- Trial name
- RBV (NCT00993122)
- Testing
- ribavirin pre-treatment
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Roma La Sapienza
Catheter-related Infections
CATCH - Catheter Infections in Children
Most children admitted to paediatric intensive care units (PICU) need to have medicines given to them into their veins using a narrow tube, so they do not need repeated injections. This tube is called a central venous catheter.
- Trial name
- NCT01029717
- Testing
- Standard polyurethane Central Venous Catheter, Antibiotic impregnated polyurethane CVC (minocycline and rifampicin), Heparin bonded polyurethane CVC
- Where
- United Kingdom
- Volunteers
- 1,859 people
- Sponsor
- Institute of Child Health
Asthma
Efficacy and Safety Study of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
This study aimed to determine the efficacy and safety of QAW039 150 mg and QAW039 450 mg, compared with placebo, when added to GINA (Global Initiative for Asthma) steps 4 and 5 standard-of- care (SoC) asthma therapy (GINA 2016)…
- Trial name
- NCT02555683
- Testing
- QAW039
- Where
- 234 sites in United States, Argentina and 25 more
- Volunteers
- 894 people
- Sponsor
- Novartis Pharmaceuticals
Procedural Pain
Comparison of Virtual Reality, EMLA Cream, and Standard Care for Pain During Blood Draws in Children
This randomized controlled trial evaluates methods to reduce pain during venipuncture in children aged 3 to 15 years. The study compares three approaches: virtual reality distraction using a VR headset, topical anesthesia with…
- Trial name
- NCT07763132
- Testing
- Virtual Reality Distraction, Lidocaine-Prilocaine Cream
- Where
- Czechia
- Volunteers
- 450 people
- Sponsor
- Marie Lulková
Kangaroo-Mother Care, Preterm Infants
Early Kangaroo Care vs. Standard Neonatal Practices: Impact on Survival and Outcomes in Preterm Infants
This study aims to evaluate the efficacy of Early Kangaroo Mother Care (KMC) compared to standard neonatal nursing practices in improving survival rates and nursing outcomes among preterm infants weighing less than 2000 grams…
- Trial name
- NCT06707376
- Testing
- Early Kangaroo Mother Care
- Where
- Egypt
- Volunteers
- 240 people
- Sponsor
- Jouf University
Influenza A
A Study to Evaluate the Efficacy and Safety of Pimodivir in Combination With the Standard-of-Care Treatment in Adolescent, Adult, and Elderly Non-Hospitalized Participants With Influenza A Infection Who Are at Risk of Developing Complications
The purpose of this study is to evaluate the clinical and virologic benefit of pimodivir in combination with Standard-of-Care (SOC) treatment compared to placebo in combination with SOC treatment.
- Trial name
- NCT03381196
- Testing
- Pimodivir 600 mg, SOC Treatment
- Where
- 427 sites in United States, Argentina and 36 more
- Volunteers
- 553 people
- Sponsor
- Janssen Research & Development, LLC
Delivery of Health Care, Smoking Cessation
Increasing Smoking Cessation Counselling in Primary Care Using a Chronic Disease Management System
This pilot study will determine the feasibility of studying a new smoking cessation management module in an existing chronic disease management system.
- Trial name
- NCT01004276
- Testing
- New, improved smoking cessation management module
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University