Clinical trials: Status Asthmaticus
Status Asthmaticus
Pleth Variability and Asthma Severity in Children
Research has shown that pleth variability can be used to assess asthma severity in children with status asthmaticus. The investigators would like to use an FDA-cleared monitor (Masimo Radical 7) which measures Pleth Variability…
- Trial name
- NCT02302261
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Northwell Health
Status Asthmaticus
Treating Exacerbations of Asthma With Oral Montelukast in Children
This research will establish a mg/kg dose for a future RCT to determine the efficacy of high-dose oral montelukast for children with moderate and severe acute asthma exacerbations.
- Trial name
- TEAM (NCT05819541)
- Testing
- Montelukast Oral Granules, Albuterol, Corticosteroid
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Vanderbilt University Medical Center
Status Asthmaticus, Asthma
Montelukast With Status Asthmaticus, Ages 2-5
The purpose of this study is to determine if montelukast, in addition to standard treatment is helpful in treating patients ages 2-5 who are in the hospital because of status asthmaticus.
- Trial name
- NCT00491790
- Testing
- Montelukast, Sterile water
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Asthma (Diagnosis)
Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma
Acute asthma exacerbation is caused by dysregulated pulmonary inflammatory pathways such that standard treatment includes prompt administration of exogenous systemic corticosteroids (SCs), but there remains an ongoing dialogue…
- Trial name
- PATCH (NCT07455396)
- Testing
- Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone
- Where
- United States
- Volunteers
- 159 people
- Sponsor
- Johns Hopkins All Children's Hospital
Asthma Childhood
Ideal Steroids for Asthma Treatment in the PICU
Determine if differences in (1) pediatric intensive care unit length of stay, (2) continuous nebulized albuterol duration, and (3) a composite outcome of advanced asthma therapy incidence including use of non-invasive ventilation…
- Trial name
- iSTAT PICU (NCT03900624)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Johns Hopkins All Children's Hospital
Childhood Asthma With Status Asthmaticus
Status Asthmaticus on the Intensive Care Prospective - STATIC PRO
This study will prospectively assess the impact and relevance of several risk factors for children with severe acute asthma (SAA) or acute wheeze that have been identified in retrospective studies.
- Trial name
- NCT02936778
- Where
- Netherlands
- Volunteers
- 221 people
- Sponsor
- Erasmus Medical Center
Asthma
Continuous Levalbuterol for Treatment of Status Asthmaticus in Children
This study will use a randomized, double-blind, controlled trial design in order to assess the safety and efficacy of levalbuterol (LEV) compared to racemic albuterol (RAC) when delivered continuously in a high-dose regimen for…
- Trial name
- NCT00124176
- Testing
- Racemic albuterol (R+S albuterol), Levalbuterol (R albuterol)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Children's Hospital of Philadelphia
Asthma in Children
Efficacy and Safety of Continuous Versus Intermittent Nebulization of Salbutamol in Acute Severe Asthma in Children Under 12 Years of Age
Asthma affects around 260 million people globally, causing around 0.5 million deaths annually. Pediatric asthma remains a major global public health challenge, significantly affecting the quality of life for many children.
- Trial name
- NCT06754631
- Testing
- Continuous Nebulization of Salbutamol, Intermittent Nebulization of Salbutamol
- Where
- 2 sites in Pakistan
- Volunteers
- 120 people
- Sponsor
- Muhammad Aamir Latif
Status Asthmaticus
Non Invasive Positive Pressure Ventilation in Status Asthmaticus
Status Asthmaticus is recognized as a common cause of morbidity in children in the United States (CDC). In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01403428
- Testing
- Noninvasive positive pressure ventilation
- Where
- United States
- Sponsor
- Southern Illinois University
Status Asthmaticus
Early Noninvasive Positive Pressure Ventilation in Children With Status Asthmaticus
Status asthmaticus is recognized as a common cause of morbidity in children in the United States. In recent years, hospitalization rates have reached an all time high.
- Trial name
- NCT01188473
- Testing
- NPPV plus standard of care
- Where
- United States
- Sponsor
- Southern Illinois University
Bronchial Asthma, Asthma
HFCWO in Hospitalized Asthmatic Children
To determine whether or not high frequency chest wall oscillation (in the form of the VestTM) is superior to regular asthma therapy in the management of children hospitalized with moderate to severe asthma.
- Conditions
- Bronchial Asthma, Asthma, Status Asthmaticus
- Trial name
- NCT00722020
- Testing
- VEST
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Hill-Rom
Asthma, Status Asthmaticus
Steroids in Children Hospitalized With Asthma
Asthma is the most common chronic disease of children. A short (3-5 day) course of a short-acting steroid such as Prednisone or Prednisolone has long been the standard of care for asthma exacerbation.
- Conditions
- Asthma, Status Asthmaticus, Wheezes
- Trial name
- NCT02780479
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Florida
Status Asthmaticus
Evaluation Montelukast in the Treatment of Status Asthmaticus
The purpose of this study is to evaluate the effectiveness of oral montelukast (Singulair) given with other standard asthma medications and treatments in the treatment of children with status asthmaticus.
- Trial name
- NCT01770899
- Testing
- Montelukast
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Corrie Fletcher
Asthmatic Crisis, Wheezing
Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT)
Vitamin D deficiency is highly prevalent in the UK. Research shows that vitamin D enhances the immune system and may help protect against chest infections that can cause wheezing illness or worsen asthma symptoms.
- Trial name
- OPTIVIT (NCT02880930)
- Testing
- Fultium-D3 drops (Internis)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Status Asthmaticus
Effectiveness and Cost Study Comparing Two Ways to Deliver Albuterol for the Treatment of Asthma in the Hospital
This study will be conducted as a randomized, double blinded, controlled trial. The control group will receive albuterol delivered by a nebulizer along with placebo treatments delivered by a metered dose inhaler (MDI) with a…
- Trial name
- NCT00623688
- Testing
- Metered Dose Inhaler & Optichamber Advantage Valve Holding Chamber (VHC), Airlife Sidestream High Efficiency Nebulizer
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Akron Children's Hospital
Status Asthmaticus
High Flow Nasal Cannula in Children With Status Asthmaticus
In France, over 2.5 million people suffer from asthma, including one-third of children. This is the chronic respiratory disease leading to the highest rate of hospitalization.
- Trial name
- CANULASTHM (NCT03157102)
- Testing
- HFNC, Standard Oxygen Treatment
- Where
- 14 sites in France
- Volunteers
- 272 people
- Sponsor
- Hospices Civils de Lyon
Asthma
Oral Glucocorticosteroid in the Treatment of Severe Asthma Exacerbation in Hospitalized Patients
A comparison of oral prednisolone administration with intravenous methylprednisolone infusion in the treatment of acute asthma exacerbation in hospitalized patients.
- Trial name
- NCT00627731
- Testing
- methylprednisolone sodium succinate (mPSL), prednisolone (PSL)
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Hamamatsu University
Status Asthmaticus
Heliox-Powered Albuterol Therapy in the Treatment of Children Admitted With Acute Asthma Exacerbation
The purpose of this study is to investigate whether heliox-powered albuterol nebulizer therapy will result in reduced inpatient length of stay in children hospitalized with acute asthma exacerbations.
- Trial name
- NCT00410150
- Testing
- Helium-oxygen-driven albuterol nebulizer, Oxygen
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Status Asthmaticus
Different Doses of Nebulized Magnesium Sulphate in Status Asthmaticus
In this study investigators will use magnesium sulphate in the nebulized form in children between 2 and 12 years of age as an acute reliever for acute severe asthma.
- Trial name
- NCT04929626
- Testing
- Magnesium Sulfate 500 mg/ml+ ventolin, Ventolin
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Ziauddin University
Status Asthmaticus
Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus
This study is a Phase I study to investigate the addition of inhaled Ipratropium bromide to standard therapy in the treatment of severe asthma attacks in children admitted to the Pediatric Intensive Care Unit.
- Trial name
- NCT02872597
- Testing
- Ipratropium, 0.9% Sodium Chloride, Albuterol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University Hospitals Cleveland Medical Center