Clinical trials: Status Epilepticus
Status Epilepticus
LORA-PITA IV General Investigation
Secondary Data Collection:To confirm the effectiveness and safety profiles under the actual medical practice of LORA-PITA in Japan.
- Trial name
- NCT03905798
- Testing
- Lorazepam
- Where
- Japan
- Volunteers
- 206 people
- Sponsor
- Pfizer
Status Epilepticus, Anaphylaxis
Smartphone Apps for Pediatric Resuscitation
Medication errors are common in children. Characteristics of errors during critical situations in the Emergency Department are ill-defined and might be more frequent than previously thought.
- Trial name
- SMARTER (NCT02958605)
- Testing
- Smartphone apps, Handbook
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Epilepsy
A Survey of Midazolam in People With Status Epilepticus
This study is a survey in Japan of midazolam oromucosal solution used to treat people with status epilepticus. The study sponsor will not be involved in how the participants are treated but will provide instructions on how the…
- Trial name
- NCT05313308
- Testing
- Midazolam
- Where
- Japan
- Volunteers
- 50 people
- Sponsor
- Clinigen K.K.
Status Epilepticus, Dysimmune Encephalopathy
Study of Pathophysiology of Status Epilepticus and Dysimmune Encephalitis
COLETTE is an interventional study for which blood, cerebrospinal fluid and post-mortem tissues are collected in patients with status epilepticus or epilepsy associated to dysimmune encephalitis as well as in control patients, to…
- Trial name
- COLETTE (NCT04421846)
- Testing
- Blood sampling, cerebrospinal fluid , post-mortem cerebral tissues (NA for the Group 3), Blood sampling, cerebrospinal fluid, stool sampling post-mortem cerebral tissues (NA for the Group 3)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Status Epilepticus
Safety and Efficacy of Intravenous Valproate in Pediatric Status Epilepticus and Acute Repetitive Seizures
To evaluate the safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures as part of seizure treatment protocol in pediatric ER
- Trial name
- NCT01268904
- Testing
- Valproate
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hillel Yaffe Medical Center
Status Epilepticus
Efficacy and Safety Study Comparing Lorazepam and Diazepam for Children in the Emergency Department With Seizures (Status 2)
Children with seizures are frequently seen in the emergency department. The drug lorazepam, which is commonly used, is not labeled by the US Food and Drug Administration for children for this use.
- Trial name
- NCT00621478
- Testing
- lorazepam or diazepam
- Where
- 14 sites in United States, Canada
- Volunteers
- 259 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Status Epilepticus
Improving Emergency Management of Status Epilepticus
In the trial the effectiveness of pre-briefing physicians with the current guideline on Status epilepticus (SE) treatment or a consolidated "one page" guideline regarding quality enhancement of the physician's clinical…
- Trial name
- SESIM (NCT03883516)
- Testing
- Pre-briefing with the current SE treatment guidelines, Pre-briefing with a consolidated "one page" SE treatment guide, No Pre-briefing
- Where
- Switzerland
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Status Epilepticus
Ketamine in Refractory Convulsive Status Epilepticus
To evaluate the efficacy of intravenous administration of ketamine in the treatment of refractory convulsive status epilepticus in children compared to administration of midazolam at high doses, thiopental and / or propofol.
- Trial name
- KETASER01 (NCT02431663)
- Testing
- Ketamine
- Where
- Italy
- Volunteers
- 57 people
- Sponsor
- Meyer Children's Hospital IRCCS
Grand Mal Status Epilepticus, Non-convulsive Status Epilepticus
Refractory Status Epilepticus Treatment Study
Identify the most effective dose of valproic acid when used in combination with phenytoin for treatment of patients with refractory status epilepticus, which allow a better clinical course and prognosis of the disease.
- Trial name
- NCT01586208
- Testing
- valproic acid (VPA)
- Where
- Spain
- Volunteers
- 5 people
- Sponsor
- Hospital Universitari de Bellvitge
Landau-Kleffner Syndrome, Status Epilepticus, Electrographic
Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome
The purpose of this study is to compare the effectiveness of the medications acetazolamide and diazepam in the treatment of continuous spike wave in sleep (CSWS) and Landau-Kleffner syndrome (LKS).
- Trial name
- NCT02904265
- Testing
- Diazepam, Acetazolamide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Mayo Clinic
Status Epilepticus
Efficacy Comparison Between Levetiracetam and Valproic Acid in Pediatric Patients With Status Epilepticus
Since there is a significant degree of variability in the results of previous studies and there exists a thirst for local data regarding this topic, the current study was planned, with the objective of comparing the efficacy of…
- Trial name
- NCT07052136
- Testing
- Levetiracetam, Valproic acid
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- RESnTEC, Institute of Research
Status Epilepticus
Comparison of Intravenous Brivaracetam Versus Levetiracetam in the Management of Status Epilepticus
Brivaracetam is increasingly being studied in adult status epilepticus populations, evidence in pediatric patients remains sparse, with only limited case series and observational studies reporting favorable outcomes.
- Trial name
- NCT07163572
- Testing
- Intravenous brivaracetam, Intravenous levetiracetam
- Where
- Pakistan
- Volunteers
- 152 people
- Sponsor
- Muhammad Aamir Latif
Cardiac Arrest, Stroke
Prevalence of Acute Critical Neurological Disease in Children: a Global Epidemiological Assessment
PANGEA is an international prospective point prevalence study to describe the epidemiology, interventions, and outcomes in children with acute critical brain disease.
- Conditions
- Cardiac Arrest, Stroke, Traumatic Brain Injury, Brain Mass
- Trial name
- PANGEA (NCT02381977)
- Testing
- No intervention
- Volunteers
- 922 people
- Sponsor
- University of Pittsburgh
Epilepticus Status
Clonazepam in Children Status Epilepticus
•Background: Intravenous clonazepam is the most widely used first-line benzodiazepine in Europe for the initial management of status epilepticus in children.
- Trial name
- UHAPA (NCT04287361)
- Testing
- Efficacy of intravenous clonazepam
- Where
- France
- Volunteers
- 310 people
- Sponsor
- University Hospital, Montpellier
Altered Mental Status, Generalized Nonconvulsive Seizure Disorder
Putting Electroencephalography (EEG) in the Emergency Department
The aim of the proposed research is to compare the diagnostic accuracy of a portable wireless electroencephalography (EEG) device (Biosignal Micro-EEG) to standard EEG in identifying abnormal EEG patterns (mainly non-convulsive…
- Conditions
- Altered Mental Status, Generalized Nonconvulsive Seizure Disorder, Status-epilepticus
- Trial name
- NCT01355211
- Where
- United States
- Volunteers
- 261 people
- Sponsor
- Bio-Signal Group Corp.
Status Epilepticus
Management of Non Convulsive Status Epilepticus
Non convulsive status epilepticus is a persistent change in behavioural and or mental process from baseline associated with continuous epileptiform activity in electroencephalograph,it occur in about 50 percent in patients with…
- Trial name
- NCT03245099
- Testing
- cross sectional
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Status Epilepticus, Ketogenic Dieting
Ketogenic Diet for Status Epilepticus in Children Post Cessation of Convulsive Status Epilepticus
Ketogenic diet being started early in those with status epilepticus and frequent or abundant discharges in EEG in comparison to just standard therapy is being evaluated here for efficacy and adverse effects.
- Trial name
- NCT05591508
- Testing
- Ketogenic Diet
- Where
- India
- Volunteers
- 50 people
- Sponsor
- All India Institute of Medical Sciences
Epilepsy, Status Epilepticus
Lacosamide Intravenous Injection for Emergency Termination of Status Epilepticus
Status epilepticus (SE) is an acute and critical form of neurological and systemic diseases involving multiple clinical disciplines, with an annual incidence of (20-73) per 100,000 people and a clinical case fatality rate of 20%.
- Trial name
- NCT06966830
- Testing
- Lacosamide (LCM)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Status Epilepticus
Lorazepam for the Treatment of Status Epilepticus in Children
The purpose of this study is to gather the data to: 1) determine the best dose, and 2) evaluate its effectiveness and safety in stopping seizures.
- Trial name
- NCT00114569
- Testing
- lorazepam
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Generalized Convulsive Status Epilepticus
Combined Ketamine and Midazolam for Generalized Convulsive Status Epilepticus
Generalized convulsive status epilepticus (GCSE) is a common neurological emergency in children. Benzodiazepines are the recommended first line antiseizure medication (ASMs), but they fail to control seizures in a third of cases.
- Trial name
- Ket-Mid (NCT05779657)
- Testing
- Ketamine, Midazolam
- Where
- Egypt
- Volunteers
- 144 people
- Sponsor
- Sohag University