Clinical trials: Stepped Care
Obsessive Compulsive Disorder, Stepped Care Cognitive Behavioral Therapy
Stepped Care Cognitive Behavioral Therapy for Pediatric Obsessive Compulsive Disorder
The purpose of this research study is to determine how well children with OCD can be helped using therapy that requires less clinic visits.
- Trial name
- SC-CBT (NCT01981317)
- Testing
- Stepped Care Cognitive Behavioral Therapy, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Florida
Influenza, Respiratory Viral Infection
Test-and-treat for Influenza in Homeless Shelters
This study is a stepped-wedge cluster-randomized trial of on-site rapid testing and treatment for influenza in homeless shelters within the Seattle area to determine whether this strategy reduced the incidence of influenza in the…
- Trial name
- NCT04141917
- Testing
- Point-of-care molecular testing and treatment of influenza
- Where
- 9 sites in United States
- Volunteers
- 1,618 people
- Sponsor
- University of Washington
Depression Anxiety Disorder, Psychological Distress
Evaluating the Effectiveness of a School-based Stepped Care Treatment Model for Adolescent Depression in Pakistan
This study aims to test the effectiveness of a stepped-care model to reduce depressive symptoms in adolescents in school settings in Pakistan.
- Conditions
- Depression Anxiety Disorder, Psychological Distress, Well-Being, Psychological
- Trial name
- SMART-STEP (NCT07399314)
- Testing
- Universal Intervention & CBT-based Guided Self-Help Application
- Where
- Pakistan
- Volunteers
- 600 people
- Sponsor
- Global Institute of Human Development
Clinical High Risk for Psychosis, Ultra High Risk for Psychosis
Sacramento Clinical High Risk for Psychosis Stepped-Care Program
This is a dissemination and implementation study that is evaluating a stepped-care intervention for identifying and treating youths at clinical high-risk for psychosis within multiple community mental health centers.
- Trial name
- SCIP Step (NCT06640803)
- Testing
- Stepped-Care including Cognitive Behavioral Case Management
- Where
- 6 sites in United States
- Volunteers
- 223 people
- Sponsor
- University of California, Davis
Respiratory Infections in Children
Improving Antibiotic Stewardship for Children With Respiratory Illness Presenting to Village Health Workers in Uganda
This is a stepped wedge, cluster randomized study of a clinical algorithm that includes point-of-care C-reactive protein testing to inform antibiotic treatment decisions by village health workers for children presenting with…
- Trial name
- STAR (NCT05294510)
- Testing
- STAR Sick Child Job Aid
- Where
- Uganda
- Volunteers
- 1,280 people
- Sponsor
- University of North Carolina, Chapel Hill
Decreased Fetal Movements Affecting Care of Mother, Pregnancy
Promoting Awareness Fetal Movements to Reduce Fetal Mortality Stillbirth, a Stepped Wedge Cluster Randomised Trial.
Rates of stillbirth in Scotland are among the highest in resource rich countries. The majority of stillbirths occur in normally formed infants, with (retrospective) evidence of placental insufficiency being the commonest clinical…
- Conditions
- Decreased Fetal Movements Affecting Care of Mother, Pregnancy, Stillbirth
- Trial name
- AFFIRM (NCT01777022)
- Testing
- A package of interventions
- Where
- 29 sites in Ireland, United Kingdom
- Volunteers
- 430,830 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Psychotic Episode
Impact of an Early Identification Program for First-Episode Psychosis on the Duration of Untreated Psychosis
The First-Episode Psychosis (FPE) is a severe disorder that can include delusions, cognitive disorders and suicidal behavior. In the majority of cases (more than 80%) it evolves into schizophrenia.
- Trial name
- PRESTO (NCT05813457)
- Testing
- PRESTO Early Identification Program
- Where
- 6 sites in France
- Volunteers
- 416 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Cancer, Fertility Preservation
Evaluation of a Telehealth Oncofertility Care Intervention in Adolescent and Young Adult Cancer Patients
The purpose of this study is to evaluate the effectiveness of a multi-component intervention to improve young cancer survivors' engagement in goal-concordant oncofertility care, concurrently with observing and gathering…
- Trial name
- NCT05443737
- Testing
- Multi-component oncofertility care intervention
- Where
- 4 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- University of California, San Diego
Pregnancy, Neonatal Mortality
Scalable Public Health Empowerment, Research, and Education Sites (SPHERES)
SPHERES is a health service research trial in the Indonesian primary care system designed to improve health system performance using a structured data-driven action model.
- Conditions
- Pregnancy, Neonatal Mortality, Tuberculosis, Hepatitis B
- Trial name
- SPHERES (NCT07126041)
- Testing
- Prescription for Action (SPHERES Model)
- Where
- 2 sites in Indonesia
- Volunteers
- 1,750,000 people, healthy volunteers welcome
- Sponsor
- Oxford University Clinical Research Unit Indonesia
Asthma
Technology- Assisted Stepped Care Intervention Study
The overall goal of this project is to demonstrate the feasibility, implementation, and preliminary efficacy of a technology-assisted stepped care (TASC) adherence-promotion intervention in adolescents with asthma.
- Trial name
- TASC (NCT03733457)
- Testing
- Technology-assisted Stepped-care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cesarean Section Complications
Clean-CS: A Program to Improve the Safety of C-section
Executive summary: Cesarean delivery, or section (CS), is the single most common surgical procedure performed. Estimates indicate that in low resource settings, CS comprises up to 50% of more of the total volume of operations…
- Trial name
- Clean-CS (NCT04812522)
- Testing
- Clean Cut program
- Where
- 10 sites in Ethiopia
- Volunteers
- 10,506 people, healthy volunteers welcome
- Sponsor
- The Lifebox Foundation
Opioid Use Disorder, HIV
Expanded HIV Care in Opioid Substitution Treatment (EHOST) Trial
Opioid Substitution Treatment (OST) provides a critical opportunity for HIV testing and linkage to antiretroviral treatment. The EHOST study will evaluate a prescriber-focused intervention to increase HIV testing rates, and…
- Trial name
- EHOST (NCT02440256)
- Testing
- Expanded HIV care in Opioid Substitution Treatment
- Volunteers
- 49 people
- Sponsor
- Simon Fraser University
Traumatic Injury, Technology
Evaluation of Trauma Center-Based Intervention for Adolescent Traumatic Injury Survivors
Pediatric traumatic injury (i.e., injury of sudden onset and severity requiring immediate attention) is the leading cause of death and morbidity among US adolescents and are associated with mental health and health risk outcomes…
- Conditions
- Traumatic Injury, Technology, Posttraumatic Stress Disorder, Adolescents
- Trial name
- NCT05086757
- Testing
- TRRP, Enhanced Usual Care
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Anxiety
Stepped Care Versus Group Cognitive Behaviour Therapy for Paediatric Anxiety in Primary Care
Objectives: Over the past decade in Sweden, a novel approach to primary healthcare units, known as first-line mental health (FLMH), has been introduced to enhance mental health services for children and adolescents.
- Trial name
- NCT06212362
- Testing
- Step-by-step, Cool Kids
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Suicidal Behavior, Self-Harm, Deliberate
Randomized Trial of Stepped Care for Suicide Prevention in Teens and Young Adults
This randomized controlled trial will evaluate two approaches to achieving the aspirational goal of Zero Suicide within a health system: 1) Zero Suicide Best Practices initiated through a zero suicide quality improvement…
- Conditions
- Suicidal Behavior, Self-Harm, Deliberate, Suicidal Ideation, Suicide
- Trial name
- Step2Health (NCT03092271)
- Testing
- Stepped Care for Suicide Prevention, Zero Suicide Quality Improvement
- Where
- 2 sites in United States
- Volunteers
- 301 people
- Sponsor
- University of California, Los Angeles
Adolescent Behavior, Hiv
Data-informed Stepped Care (DiSC) to Improve Adolescent HIV Outcomes (UH3)
The investigators will conduct a Phase III cluster randomized controlled trial (cRCT) to evaluate the effectiveness of the implementation of a data-informed stepped care (DiSC) intervention for HIV treatment management among…
- Trial name
- NCT05007717
- Testing
- Data-informed Stepped Care (DiSC)
- Where
- 24 sites in Kenya
- Volunteers
- 1,911 people
- Sponsor
- University of Washington
Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care
SEPREVEN: a Stepped-wedge Randomised Controlled Trial
Adverse events are frequent in Neonatal Intensive Care Units' (NICU) patients and account for a high morbidity and mortality. Possible severe adverse events are central line associated bloodstream infections (CLABSI), ventilator…
- Conditions
- Intensive Care Units, Neonatal, Misadventures to Patients During Surgical and Medical Care, Catheter-related Bloodstream Infection (CRBSI) Nos, Quality of Healthcare
- Trial name
- SEPREVEN (NCT02598609)
- Testing
- Education program for NICU caregivers
- Where
- 12 sites in France
- Volunteers
- 8,000 people
- Sponsor
- Dr Caeymaex Laurence
Autism Spectrum Disorder
Stepped-care Telehealth for Young Children With ASD
This proof-of-concept study addresses the gap in the access to care literature by examining a stepped-care version of a telehealth naturalistic developmental behavioral intervention (NDBI), Online RIT.
- Trial name
- NCT04467073
- Testing
- Online RIT
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Cryptococcal Meningitis, Cryptococcus Neoformans
Operational Research for Cryptococcal Antigen Screening
This will be a stepped wedge randomized trial design to evaluate the implementation of cryptococcal antigen (CRAG) screening and preemptive anti-fungal therapy of HIV-infected persons entering antiretroviral therapy (ART)…
- Conditions
- Cryptococcal Meningitis, Cryptococcus Neoformans, Cryptococcosis
- Trial name
- ORCAS (NCT01535469)
- Testing
- Fluconazole
- Where
- 2 sites in Uganda
- Volunteers
- 3,049 people
- Sponsor
- University of Minnesota
Point-of-care Ultrasound (POCUS)
The POCUS in Practice Study
In a stepped-wedge cluster randomized trial, the effects of an educational intervention will be determined by estimating the uptake of point-of-care ultrasound by general practitioners (outcome P1), change in referral from…
- Trial name
- PIP (NCT05696821)
- Testing
- Educational intervention
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Aalborg University