Clinical trials: Stratification
Opioid Use, Post Operative Pain
Assessment of the Development of Postoperative Persistent Postoperative Pain
During the postoperative period, it is possible to observe the development of acute pain, which lasts no longer than a week after surgery.
- Conditions
- Opioid Use, Post Operative Pain, Chronic Pain
- Trial name
- NCT05370924
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
ICD, Arrythmia
Genome-Wide Association Study With the Aim of Implantable Cardioverter Defibrillator Implantation Genophenotypic Risk Stratification
This clinical study will be conducted with funding from European Innovation Council(EIC) after approval of the fund grant and is part of our organization's European Pathfinder Project(Ref…
- Conditions
- ICD, Arrythmia, Sudden Cardiac Death
- Trial name
- ICDGPSS (NCT05582252)
- Testing
- Non-Invasive saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Selcuk University
Cardiomyopathy With Unknown Etiology
Risk Stratification of Heart Failure in Cardiomyopathies.
The investigators aimed to use CMR technique in helping diagnose the etiology of unknown cardiomyopathy. Try to make a risk stratification of susceptible heart failure based on the extent of myocardial impairment.
- Trial name
- EARLY-MYO-HF (NCT02941315)
- Testing
- etiologic treatment,anti-myocardial remodeling, anti-myocardial remodeling, anti-myocardial remodeling,anti-acute heart failure
- Where
- China
- Volunteers
- 150 people
- Sponsor
- RenJi Hospital
Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent
HEM-iSMART-C: Ruxolitinib + Venetoclax + Dexamethasone + Cyclophosphamide and Cytarabine in Pediatric Patients With Relapsed or Refractory Hematological Malignancies
HEM-iSMART is a master protocol which investigates multiple investigational medicinal products in children, adolescents and young adults (AYA) with relapsed/refractory (R/R) ALL and LBL.
- Conditions
- Acute Lymphoblastic Leukemia, in Relapse, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor T-Lymphoblastic Lymphoma/Leukaemia) Recurrent, Lymphoblastic Lymphoma (Precursor B-Lymphoblastic Lymphoma/Leukaemia) Refractory
- Trial name
- HEM-iSMART C (NCT05745714)
- Testing
- Ruxolitinib, Venetoclax, Dexamethasone
- Where
- 33 sites in Austria, Belgium and 12 more
- Volunteers
- 26 people
- Sponsor
- Princess Maxima Center for Pediatric Oncology
Hereditary Heart Diseases
Stratification of Arrhythmic Risk and/or Heart Failure Risk in Patients With Hereditary Heart Disease
Sudden cardiac death (SCD) is one of the leading causes of death in developed countries. These deaths (more than 5,000 per year in France) are due to hereditary arrhythmias or cardiomyopathies.
- Trial name
- PREVENT (NCT07257289)
- Testing
- Blood sample
- Where
- 15 sites in France, Martinique and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Nantes University Hospital
Lower Respiratory Tract Infection (LRTI), Pneumonia
Optimising Antibiotic Use for Paediatric Lower Respiratory Tract Infections in Africa
Lower respiratory tract infections (LRTIs) remain a leading cause of hospitalisation and death among young children in Africa. Although viral infections account for a substantial proportion of LRTIs, antibiotics are frequently…
- Conditions
- Lower Respiratory Tract Infection (LRTI), Pneumonia, Bronchopneumonia, Bronchiolitis
- Trial name
- BEACON (NCT07841691)
- Testing
- CRP- and PREPARE-guided Antibiotic Prescription
- Where
- South Africa
- Volunteers
- 400 people
- Sponsor
- University of Witwatersrand, South Africa
PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome
National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS)
Overgrowth syndromes are rare genetic disorders defined by tissue hypertrophy that can be either localized or generalized, affecting both latitudinal and longitudinal growth.
- Conditions
- PIK3CA-related Overgrowth Spectrum, CLOVES Syndrome, Klippel Trenaunay Syndrome, Megalencephaly
- Trial name
- COSY (NCT05563831)
- Testing
- national registry
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Glioma
Tessa Jowell BRAIN MATRIX - Platform Study
The main aim of the Tessa Jowell BRAIN MATRIX - Platform Study is to more precisely determine the exact type of tumour patients have by developing the essential infrastructure to provide rapid and accurate molecular diagnosis.
- Trial name
- BRAIN MATRIX (NCT04274283)
- Testing
- Matched Tumour and Blood Sample - Research Pathway, Matched Tumour and Blood Sample - NHS GMS pathway
- Where
- 14 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- University of Birmingham
Invasive Ventilation
Prediction of PaO2 Values Using the PRoPERLy II Database
Four prospective observational studies of ventilation in critically ill patients were harmonized and pooled.
- Trial name
- PRoPERLy-II (NCT06589427)
- Testing
- Invasive ventilation.
- Where
- Netherlands
- Volunteers
- 8,000 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cardiovascular Diseases, Cardiovascular Risk Factor
Stratification Protocols and Clinical, Physical and Biochemical Parameters to Forecast Cardiovascular Intercurrences.
Introduction: Despite the various beneficial effects, cardiovascular rehabilitation programs (CVRP) have been associated with the appearance of signs and symptoms.
- Trial name
- NCT03446742
- Testing
- Cardiovascular rehabilitation
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Danon Disease, Fabry Disease
Precision Diagnosis and Risk Stratification of Rare Cardiomyopathies Based on Novel Cardiac Magnetic Resonance Techniques
What is this study about? This research is focused on improving the care for people with rare heart muscle diseases, known as rare cardiomyopathies.
- Conditions
- Danon Disease, Fabry Disease, Cardiac Amyloidosis, Noonan Syndrome
- Trial name
- NCT07336394
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Myocarditis
The Role of Electrocardiograms in Risk Stratification and Analysis of the Characteristics of ST Elevation in Acute Myocarditis: a 2-centre Study
The purpose of the present study was to investigate ECG findings of patients with acute myocarditis, ECG findings associated with fulminant myocarditis, and the characteristics of ST-elevation on admission.
- Trial name
- NCT04498494
- Testing
- ECG
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Yuanli Lei
Colorectal Cancer, Lung Metastases
AI Prediction Model and Risk Stratification for Lung Metastasis in Colorectal Cancer
Background: To assist clinicians with diagnosis and optimal treatment decision-making, we attempted to develop and validate an artificial intelligence prediction model for lung metastasis (LM) in colorectal cancer (CRC) patients.
- Trial name
- NCT05816902
- Testing
- The location of the patient's treatment
- Volunteers
- 2,779 people
- Sponsor
- Peking Union Medical College
Idiopathic Scoliosis
Effects of Real-Time Feedback Assisted Self-Correction on the Posture of Scoliotic Patients
Scoliosis is a progressive three-dimensional deformation of the spine during growth, with a prevalence of 80% in girls. The treatments currently used are surgery and rigid brace, which aim to stabilize scoliosis evolution.
- Trial name
- COVIRSCOL (NCT03978273)
- Testing
- Night-time brace + virtual-brace, Night-time brace only
- Where
- France
- Volunteers
- 74 people
- Sponsor
- University Hospital, Grenoble
Long QT Syndrome, Brugada Syndrome
Impact on Risk Stratification of Overlap Syndrome Phenotype in Patients With E1784K Mutation in SCN5A
In patients expressing the SCN5A-E1784K mutation (Glu1784Lys), cardiovascular risk is difficult to define as the stratification of these patients is challenging.
- Conditions
- Long QT Syndrome, Brugada Syndrome, Cardiac Conduction System Disease, Arrhythmias, Cardiac
- Trial name
- RISKOVER (NCT05274646)
- Where
- Reunion
- Volunteers
- 47 people
- Sponsor
- Centre Hospitalier Universitaire de la Réunion
Peripheral Arterial Disease, Myocardial Injury
Cardiovascular Risk in Peripheral Artery Disease Patients Undergoing Endovascular Revascularisation
This study will investigate heart-related complications in patients with peripheral arterial disease (PAD) undergoing endovascular revascularization procedures to improve blood flow in the legs.
- Conditions
- Peripheral Arterial Disease, Myocardial Injury, Troponin, NT-proBNP
- Trial name
- RISK (NCT07599540)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Myocarditis, Inflammatory Cardiomyopathy
Cardiac MRI in Myocarditis and Inflammatory Cardiomyopathy
Myocarditis and inflammatory cardiomyopathy represent a broad spectrum of myocardial inflammatory disorders with highly variable clinical presentations and outcomes, ranging from spontaneous recovery to progressive heart failure…
- Trial name
- CMR-MYOINF-PRO (NCT07325968)
- Volunteers
- 5,000 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Sudden Cardiac Death
Predictive Risk Stratification Through T Variability in ICD Patients Without Pacing Indications
The aim of the study is to assess the negative predictive value of the T amplitude variance as a method for risk stratification for patients with an increased risk for SCD.
- Trial name
- Prediction (NCT00560768)
- Testing
- Ovatio VR 6250 or DR6550
- Where
- 30 sites in United States, Canada and 2 more
- Volunteers
- 198 people
- Sponsor
- LivaNova
PTLD, Posttransplant Lymphoproliferative Disorder
Risk Stratified Sequential Treatment for CD20-positive PTLD
This phase-II trial will investigate the efficacy, safety and the tolerability of a sequential therapy consisting of 4 courses of single agent rituximab followed by 4 courses of R-CHOP chemotherapy in patients with CD20+…
- Trial name
- PTLD-1/3 (NCT00590447)
- Testing
- rituximab monotherapy, sequential R-CHOP
- Where
- 7 sites in Australia, Belgium and 5 more
- Volunteers
- 152 people
- Sponsor
- Charite University, Berlin, Germany
Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension
Chinese PE Multimodality Imaging Artificial Intelligence Study
The CHinese pulmOnary Embolism Multimodality Imaging-artifiCial intelligencE Study (CHOICE) is a prospective observational multi-center study that will collect imaging text data and raw data of patients with pulmonary embolism…
- Conditions
- Pulmonary Embolism, Chronic Thromboembolic Pulmonary Hypertension, Chronic Thromboembolic Pulmonary Disease
- Trial name
- NCT06526468
- Testing
- Artificial Intelligence
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- China-Japan Friendship Hospital