Clinical trials: Stress Disorders, open to volunteers
Major Depressive Disorder
Neural Correlates of Stress and Perceived Control in Adolescent Depression
Lack of perceived control, particularly during stress, has been critically implicated in major depressive disorder (MDD) and anhedonic symptoms, especially among female adolescents; yet the neural underpinnings of perceived…
- Trial name
- NCT04788524
- Testing
- Computer Task Manipulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Moral Distress
The Interplay Between Moral Distress, Moral Resilience, and Mental Health Outcomes Among Neonatal Care Providers
Due to highly specialized medical care neonatal care providers are faced with numerous responsibilities which makes neonatal care a particularly challenging and stressful work environment.
- Trial name
- MoD (NCT06836323)
- Where
- Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Preterm
Co-regulation and Interaction in the NICU
Preterm infants are exposed to multiple stressors each day, posing a risk of toxic stress that can impact their developing brains during a critical period of sensitivity.
- Trial name
- CORI (NCT06753435)
- Where
- Sweden
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Child Allergy, Anxiety
Using a Stress Ball on Fear, Anxiety, Pain, and Satisfaction During Allergy Testing
This randomized controlled trial aims to evaluate and compare the effects of watching cartoons and using a stress ball on levels of fear, anxiety, pain, and satisfaction among 90 children aged 4-10 undergoing skin prick testing…
- Conditions
- Child Allergy, Anxiety, Fear, Pain
- Trial name
- NCT07750236
- Testing
- cartoon-watching group, stress ball group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Tarsus University
Urinary Incontinence , Stress, Prostatectomy
Effect of High-Intensity Focused Electromagnetic (HIFEM) Technology in the Treatment of SUI in Chinese Men Undergone Robotic Radical Prostatectomy
This is a prospective, randomized trial to evaluate the efficacy and safety of High-Intensity Focused Electromagnetic (HIFEM) Technology in the treatment of stress urinary incontinence compared with standard of care in Chinese…
- Trial name
- NCT06589869
- Testing
- EM Chair, Standard of care
- Where
- Hong Kong
- Volunteers
- 184 people
- Sponsor
- Chinese University of Hong Kong
Type 1 Diabetes Mellitus, Diabetes Self-Management Education
DiaBuddy: AI-Enabled Digital Self-Management for Youth With Type 1 Diabetes
The goal of this clinical trial is to learn whether DiaBuddy, a digital self-management app, can help children and adolescents with Type 1 diabetes better manage their condition and reduce the burden experienced by their…
- Conditions
- Type 1 Diabetes Mellitus, Diabetes Self-Management Education, Caregiver Burden
- Trial name
- DiaBuddy (NCT07861373)
- Testing
- DiaBuddy: AI-Enabled Digital Self-Management Intervention, Usual Diabetes Care
- Volunteers
- 140 people
- Sponsor
- Dr. Juwayria Omar
Spondylolysis Lumbar
A Pilot Study on the Safety of Active Conservative Management of Low Grade Lumbar Stress Reactions in Adolescent Soccer Players
Introduction: The Background Prevalence: Low back pain (LBP) is very common in young athletes, and lumbar spondylolysis (an overuse injury of bones in the low back) is the leading cause.
- Trial name
- ActiveBack (NCT07430072)
- Testing
- Active rehabilitation protocol
- Where
- 3 sites in Norway
- Volunteers
- 40 people
- Sponsor
- Western Norway University of Applied Sciences
Congenital Heart Disease
The Efficacy of Systematic Oral Feeding Education Program
After the intervention of Systematic Oral Feeding Education Program: 1. The feeding techniques scores of the main caregivers in the experimental group will be higher than those in the control group. 2.
- Trial name
- SOFEP (NCT06763497)
- Testing
- Systematic Oral Feeding Education Program
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Stress
Effect of Audio Book applıcatıon on patıents Blood Pressure, Pulse Rate and anxıety Levels Before Total Knee Replacement Surgery
Before the TDP surgery, the anxiety levels of the patients in the experimental group will be measured by listening to an audio book.
- Trial name
- NCT06905899
- Testing
- audiobook app
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Beyza Yilmaz
Internet-based Intervention, Waiting List Control Group
RCT: the Effectiveness of LifeHack in Improving Mental Wellbeing in University Students.
Psychological issues are common among university students and affect mental wellbeing. The Caring Universities (CU) project, involving nine Dutch universities, aims to enhance students' mental health through an annual online…
- Conditions
- Internet-based Intervention, Waiting List Control Group, Depression, Anxiety
- Trial name
- NCT06423417
- Testing
- LifeHack
- Where
- 2 sites in Netherlands
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Universiteit Leiden
Cutaneous Metastatic Melanoma
Intratumoral Targeted Hyperthermia Therapy (THT) for Cutaneous Metastatic Melanoma
This device phase I/II, first in human, early feasibility study (EFS), open-label, single-arm trial aims to evaluate the safety, tolerability, and preliminary efficacy of Gold Nanorod (GNR)-enabled sub-ablative targeted…
- Trial name
- NCT06870994
- Testing
- Targeted Hyperthermia Therapy
- Volunteers
- 10 people
- Sponsor
- Sona Nanotech Inc
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Emotion Regulation, Depression
JoyPop Mobile Mental Health App With Youth
Youth in Canada are in need of novel, innovative approaches to support their mental health and wellbeing. Within this age group, research suggests rates of several mental health difficulties and related hospitalizations have…
- Conditions
- Emotion Regulation, Depression, Anxiety, Stress
- Trial name
- NCT06239519
- Testing
- Usual Practice + JoyPop
- Where
- Canada
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Lakehead University
Pediatric Obesity
The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity.
- Trial name
- FAME (NCT06391671)
- Testing
- Collection of anthropometric data, biological samples (stool, saliva and hair), questionnaires (demographic data, psychological data, medical data)
- Where
- 7 sites in Belgium
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- University Ghent
Type 1 Diabetes
Can Mindfulness and Virtual Reality Reduce Stress in Young Adults With Type 1 Diabetes?
The goal of this study is to learn if Mindfulness-Based Stress Reduction (MBSR) can be delivered using virtual reality (VR) technology to emerging adults (youth 16-20 years old) with type 1 diabetes and high levels of stress…
- Trial name
- MBSR-VR (NCT07793097)
- Testing
- Mindfulness-Based Stress Reduction - Virtual Reality, Stress tip sheet
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Wayne State University
Cerebral Palsy, Sleep Disorders
Sleep Quality, Caregiver Burden, Stress, and Self-Efficacy in Parents of Children With Spastic Diplegic Cerebral Palsy: A Comparison by Night Orthosis Use
This observational study aims to compare sleep quality, caregiver burden, stress, and self-efficacy between parents of children with spastic diplegic cerebral palsy who use night orthoses and those who do not.
- Conditions
- Cerebral Palsy, Sleep Disorders, Caregiver Burden
- Trial name
- NCT07846917
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Atılım University
Abdominal Pain, Isolated Extremity Fracture
Morphine or Ketamine for Analgesia
Pain is common in children presenting to the emergency department but is frequently undertreated, leading to both short- and long-term consequences.
- Conditions
- Abdominal Pain, Isolated Extremity Fracture, Pain, Pediatrics
- Trial name
- MoKA (NCT06835504)
- Testing
- Ketamine hydrochloride, Morphine sulphate
- Where
- 8 sites in United States
- Volunteers
- 1,010 people
- Sponsor
- Columbia University
Trauma, Posttraumatic Stress Disorder
Increasing Treatment Access in Trauma Exposed Children: Developing an Adapted Step One Intervention (Pilot)
One of the most common and widely disseminated trauma treatments is Trauma Focused Cognitive Behavioral Therapy (TF-CBT). TF-CBT is a therapist-led, structured and sequential intervention, with treatment organized around…
- Trial name
- NCT07396935
- Testing
- Personalized Stepped Care Cognitive Behavioral Therapy for Children after Trauma (pSC-CBT-CT)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Race-related Stress, Depression, Anxiety
Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease
The current study seeks to build on previous research that demonstrates the efficacy of Acceptance and Commitment Therapy in combating stigma by investigating the feasibility and acceptability of a protocol to support Black…
- Conditions
- Race-related Stress, Depression, Anxiety, Quality of Life, Stress Reaction
- Trial name
- ACT for SCD (NCT05685368)
- Testing
- ACT for SCD
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Children's Hospital Los Angeles
Dysfunctional Voiding, Stress Incontinence, Urinary
Case Control Study to Investigate the Use of Urethral Pressure Profile Measurement in Children
The bladder has a muscle that acts like a tap called the sphincter. Just like a tap, when pee is stored the sphincter muscle is closed and during peeing the sphincter opens.
- Trial name
- NCT04147793
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- King's College London