Clinical trials: Subfertility
Intrauterine Abnormalities in Infertility
SIGnificance of Routine Hysteroscopy Prior to a First 'in Vitro Fertilization'(IVF) Treatment Cycle
BACKGROUND: Despite the numerous advances in the field of in vitro fertilisation/intracytoplasmic sperm injection (IVF/ICSI), there still exists a maximum implantation rate per embryo transferred of about 30%.
- Trial name
- inSIGHT (NCT01242852)
- Testing
- Office hysteroscopy (in combination with a 'Saline Infusion Sonography'(SIS))
- Where
- Netherlands
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Reproductive Issues, Subfertility
A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis
During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate.
- Conditions
- Reproductive Issues, Subfertility, IVF
- Trial name
- NCT05896709
- Testing
- MK-RS
- Where
- Hong Kong
- Volunteers
- 176 people
- Sponsor
- Chinese University of Hong Kong
Subfertility
Mild Versus Conventional Ovarian Stimulation Treatment for In Vitro Fertilization
In vitro fertilization (IVF) is an assisted reproductive technique to achieve pregnancy in subfertile couples of which the average success rate is only 25%.
- Trial name
- FOLFO (NCT00985062)
- Testing
- Mild Ovarian Stimulation Treatment, Conventional Ovarian Stimulation Treatment
- Where
- Netherlands
- Volunteers
- 54 people
- Sponsor
- Erasmus Medical Center
Male Subfertility
Role of Immunoglobulin in Male Infertility
to investigate the role of IVIG in male infertility and to determine its benefits in term of semen parameters and assisted reproduction outcome
- Trial name
- NCT06423989
- Testing
- IVIG
- Where
- Pakistan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Dr Salma kafeel Qureshi
Endometritis; Chronic, Subfertility
The FLORA-project: in Search for the Microbial Cause of Chronic Endometritis and the Most Appropriate Treatment to Obtain a Successful Pregnancy IVF/ICSI
Chronic endometritis is an inflammatory condition of the endometrium. This inflammation can negatively affect fertility and pregnancy. The pathology is frequently (+-10%) observed in women with fertility problems.
- Trial name
- FLORA (NCT05337072)
- Testing
- Microbiome study
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Hyperprolactinemia, Subfertility
Hyperprolactinaemia Management in Reproductive Services at University Hospital of Coventry and Warwickshire
Hyperprolactinaemia and thyroid disorders can significantly reduce fertility by causing ovulatory dysfunction. There is no evidence to suggest treatment of hyperprolactinaemia in the presence of regular ovulatory menstruation…
- Conditions
- Hyperprolactinemia, Subfertility, Subclinical hypothyroïdism
- Trial name
- NCT03569787
- Testing
- MRI Pituitary
- Where
- United Kingdom
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Endocrine Disease, Fertility Decreased Male
Sperm DNA Damage in β-thalassemia Major: Is There a Role for Antioxidants?
Accumulation of iron in patients with beta thalassemia major causes free radical formation which leads to damage of biological membranes. Sperm DNA damage may result from these generated antioxidants.
- Conditions
- Endocrine Disease, Fertility Decreased Male, DNA Damage
- Trial name
- NCT03014882
- Testing
- L-Carnitine and N-acetyl cysteine
- Where
- 3 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Male Infertility, Male Subfertility
Assessing the Correlation Between Phospholipase C Zeta Measurements and Semen Parameters
With declining fertility rates Worldwide, Assisted Reproductive Technology is seen as a viable solution for infertility, however, individual success rates following ART remain relatively low, rarely exceeding ~50%.
- Trial name
- PLCZeta (NCT07684339)
- Testing
- No Intervention: Observational Cohort
- Where
- 2 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Fakih IVF Fertility Center