Clinical trials: Substance Abuse Disorder
Methamphetamine Abuse, Opioid-use Disorder
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
The investigators propose to develop and evaluate optimal combinations of evidence-based interventions to improve HIV outcomes and reduce methamphetamine use (hereafter: meth use) among people with opioid use disorder who are in…
- Conditions
- Methamphetamine Abuse, Opioid-use Disorder, HIV Seropositivity
- Trial name
- STAR-OM (NCT04706624)
- Testing
- Contingency management (12 weeks), Contingency management (6 weeks), SMS reminders
- Where
- 4 sites in Vietnam
- Volunteers
- 667 people
- Sponsor
- Hanoi Medical University
Opioid-use Disorder, Opioid Use
PRescribing INterventions for Chronic Pain Via the Electronic Health Record Study - Current Opioid-User Population
The objective of this research is to assess the effects of electronic health record (EHR)-based decision support tools on primary care provider (PCP) decision-making around pain treatment and opioid prescribing.
- Conditions
- Opioid-use Disorder, Opioid Use, Opioid Abuse
- Trial name
- PRINCE (NCT04601480)
- Testing
- Choice Architecture Nudge, PMP Integration & Nudge
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- University of Minnesota
Substance Use Disorders
Enhancing Adolescent Substance Abuse Treatment
The ultimate goal of this research is to facilitate rapid enhancement of youth substance abuse treatments by determining the key mechanisms of change (i.e., what to target more intensely to generate better outcomes).
- Trial name
- NCT03249350
- Testing
- Standard Contingency Management (CM), Enhanced Contingency Management (CM+)
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- Oregon Social Learning Center
Cannabis Dependence
An Open-Label Trial of N-Acetylcysteine in Cannabis Dependent Adolescents
The purpose of this pilot study is to determine the feasibility of conducting a trial of N-Acetylcysteine in cannabis dependent adolescents.
- Trial name
- NAC MJ Pilot (NCT00542750)
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Substance Abuse
Preventing Drug Abuse Among Sexual Minority Youth
The planned randomized clinical trial will longitudinally test a tailored, web-based drug abuse prevention program with a nationwide sample of 15- to 17-year-old sexual minority youth (youth who identify as gay, lesbian…
- Trial name
- NCT03954535
- Testing
- Free2b
- Where
- United States
- Volunteers
- 1,216 people, healthy volunteers welcome
- Sponsor
- Columbia University
Marijuana Abuse
Treatment for Adolescent Marijuana Abuse
Marijuana remains the most prevalent illicit substance used by adolescents and the number of adolescents receiving treatment for marijuana abuse more than tripled during the last decade.
- Trial name
- NCT00580671
- Testing
- MET/CBT, CM, BPT
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Substance Abuse
Increasing Caregiver Engagement in Juvenile Drug Courts
The purpose of this study is to test a prize-based contingency management intervention for increasing caregiver engagement in juvenile drug court and adolescent drug treatment, and for achieving the ultimate outcomes of reduced…
- Trial name
- NCT03051997
- Testing
- Caregiver Contingency Management + Usual Drug Court Treatment, Usual Drug Court Treatment
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Medical University of South Carolina
Attention Deficit Hyperactivity Disorder
Pilot Study of Vyvanse™ In ADHD Adolescents at Risk for Substance Abuse
This is an open label pilot study to obtain information on the best way to study young adolescents with Attention Deficit Hyperactivity Disorder (ADHD)who may also be at risk of developing substance abuse, in part because of…
- Trial name
- NCT00573534
- Testing
- Vyvanse
- Volunteers
- 8 people
- Sponsor
- New York State Psychiatric Institute
Cannabis Use
Feasibility and Acceptability of the Cannabis Awareness and Prevention Toolkit
The Stanford Smart Talk Cannabis Awareness and Prevention Curriculum includes 5 lessons, each providing activities, online quiz games, and worksheets in addition to presentations, resources, and other materials aimed at…
- Trial name
- NCT05521321
- Testing
- Stanford Smart Talk Cannabis Awareness and Prevention curriculum
- Where
- United States
- Volunteers
- 658 people, healthy volunteers welcome
- Sponsor
- Stanford University
Substance Related Disorders
Screening and Brief Advice to Reduce Teen Substance Use
The purpose of this study is to test the effectiveness of a brief intervention for alcohol and drug use in adolescents that a primary care doctor can give in his/her office.
- Trial name
- NCT00227877
- Testing
- cSBA - New England, USA, cSBA - Prague, CZR
- Where
- 6 sites in United States, Czechia
- Volunteers
- 2,695 people
- Sponsor
- Boston Children's Hospital
Diabetes, Cardiovascular Disease
Reverse Innovation and Patient Engagement to Improve Quality of Care and Patient Outcomes
Project CONNECT ("Community-based Organizations Neighborhood Network: Enhancing Capacity Together") is a randomized controlled trial that involves 22 community-based organizations (CBOs) located in Baltimore, MD.
- Conditions
- Diabetes, Cardiovascular Disease, Substance Abuse Disorder, Mental Health Disorder
- Trial name
- CONNECT (NCT02222909)
- Testing
- Co-developed IT intervention
- Where
- United States
- Volunteers
- 6,767 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Bipolar Disorder, Alcohol Abuse
Efficacy and Tolerability of Topiramate in Treatment of Bipolar Mania and Alcohol Use in Adolescents and Young Adults
The purpose of this research study is to study the effects (both good and bad) of combining quetiapine and topiramate for treating symptoms of bipolar mania (an illness with periods of elation, excessive excitement, irritability…
- Trial name
- NCT00550394
- Testing
- Quetiapine and Topiramate
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University of Cincinnati
Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development
Maternal Adversity, Vulnerability and Neurodevelopment
Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) project is a prospective community-based, pregnancy and birth cohort of Canadian mother-child dyads.
- Conditions
- Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse), Infant Development, Infant Behavior
- Trial name
- MAVAN (NCT03434457)
- Where
- Canada
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Alcohol Drinking, Smoking
An Effectiveness Trial of Project ALERT
The purpose of this study is to replicate a longitudinal evaluation of Project ALERT, a substance abuse prevention program that targets middle school students.
- Conditions
- Alcohol Drinking, Smoking, Marijuana Smoking
- Trial name
- NCT00650585
- Testing
- Project ALERT
- Where
- United States
- Volunteers
- 8,338 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Prevention Harmful Effects
Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care
The purpose of this study is to assess the psychometric properties of a brief screening questionnaire for alcohol problems among 9- to 18-year-old patients in pediatricians' offices, and to pilot test a personalized…
- Trial name
- cASCA (NCT02233946)
- Testing
- computer-facilitated brief intervention
- Where
- 5 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Prescription Drug Abuse (Not Dependent), Intentional Misuse
Preventing Prescription Stimulant Diversion and Medication Misuse Via a Web-Based Simulation Intervention
Half or nearly half of college students with prescriptions divert their stimulant medication, and a similarly high percentage misuse their medication or use someone else's prescription.
- Trial name
- NCT04885166
- Testing
- Web-based simulation active intervention
- Where
- 3 sites in United States
- Volunteers
- 249 people
- Sponsor
- Trinity College
Bipolar Disorder
Lithium and Divalproex for the Treatment of Comorbid Rapid Cycling Bipolar Disorder and Substance Abuse Disorder
This study will determine the efficacy and safety of combination therapy with divalproex and lithium for treating mania in people with rapid cycling bipolar disorder and a substance abuse disorder.
- Trial name
- NCT00194129
- Testing
- Lithium, Divalproex
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University Hospitals Cleveland Medical Center
Attention Deficit Hyperactivity Disorder, Substance Abuse
Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder
The purpose of this study is to find out whether atomoxetine (also called Strattera) helps teenagers (12-19) with Attention Deficit Hyperactivity Disorder (ADHD) and drug/alcohol problems.
- Trial name
- NCT00399763
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Denver Health and Hospital Authority
Antisocial Personality Disorder, Substance Use Disorder
Justice-Involved Veterans and Moral Reconation Therapy
The purpose of this study is to determine whether Moral Reconation Therapy (MRT) is effective for reducing risk of criminal recidivism and improving other health-related outcomes (substance use, mental health, housing, and…
- Trial name
- MRT (NCT02524171)
- Testing
- Moral Reconation Therapy (MRT)
- Where
- 3 sites in United States
- Volunteers
- 344 people
- Sponsor
- VA Office of Research and Development
Opioid-Related Disorders, Opiate Dependence
Treatment of Opioid Dependent Patients With Suboxone: Acceptability & Safety Data From Real Life Scenario (Study P05603)
The aim of this post marketing surveillance study is to investigate the retention rate after 12 months of drug dependence treatment with SUBOXONE® (buprenorphine plus naloxone) of opioid dependent patients under real life…
- Conditions
- Opioid-Related Disorders, Opiate Dependence, Drug Abuse
- Trial name
- NCT00723749
- Testing
- Buprenorphine/Naloxone
- Volunteers
- 384 people
- Sponsor
- Indivior Inc.