Clinical trials: Substance Use Disorder
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
Choline Supplementation in Children With Fetal Alcohol Spectrum Disorders
The purpose of this study is to determine whether choline supplementation can improve cognitive functioning of children with prenatal alcohol exposure.
- Conditions
- Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome, Partial Fetal Alcohol Syndrome, Alcohol-related Neurodevelopmental Disorder
- Trial name
- NCT01911299
- Testing
- Choline
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- San Diego State University
Assault by Handgun Discharge, Violence
Lithium Water in Gun Violence Prevention
The word lithium frequently conjures images of catatonic psychiatric patients and side effects so severe that premature death is commonplace. But naturally occurring lithium is a far cry from pharmaceutical grades.
- Conditions
- Assault by Handgun Discharge, Violence, Homicide, Sexual Assault by Bodily Force
- Trial name
- LWGVP (NCT02213614)
- Testing
- Lithium Water, natural spring water
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- American Society Of Thermalism And Climatology Inc
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Smoking, Nicotine Dependence
Project 1: Evaluating EHR-Based Health System Modifications for the Chronic Care of Smoking
Smoking is the leading preventable cause of cancer mortality in the US. Despite its profound health and economic costs, smoking treatment is infrequently provided in healthcare settings, and when provided, it is not sufficiently…
- Conditions
- Smoking, Nicotine Dependence, Electronic Health Records, Translational Research
- Trial name
- EHR Project (NCT02358330)
- Testing
- EHR Enhanced Clinic Intervention
- Where
- United States
- Volunteers
- 28,095 people
- Sponsor
- University of Wisconsin, Madison
Cannabis Use, Alcohol Use, Unspecified
CARS: Cannabis and Alcohol Reduction Study
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
- Conditions
- Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
- Trial name
- CARS (NCT05486234)
- Testing
- modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias, modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medical University of South Carolina
HIV/AIDS
Adapting and Evaluating an EBI to Prevent HIV/AIDS Risk Among Apache Youth
The investigators seek to adapt, implement and evaluate a randomized controlled trial of an evidence based intervention delivered by Apache interventionists to reduce HIV/AIDS risk, targeting Apache adolescents.
- Trial name
- NCT01910714
- Testing
- Focus On Youth, Health Education Control Condition
- Where
- United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Substance Use, Conduct Disorder
A Family Intervention for Adolescent Problem Behavior (AKA Project Alliance 2)
The goal of this project is to empirically refine and improve a comprehensive family-centered prevention strategy for reducing and preventing adolescent substance use and other problem behaviors.
- Conditions
- Substance Use, Conduct Disorder, Depression, Anxiety
- Trial name
- PAL-2 (NCT01490307)
- Testing
- Family Check-Up
- Where
- United States
- Volunteers
- 593 people
- Sponsor
- University of Oregon
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Nicotine Dependence, Smoking Cessation
Nicotine Replacement for Smoking Cessation During Pregnancy
This is a clinical trial to determine if the nicotine inhaler in combination with counseling will help pregnant women quit smoking, and whether it is safe when compared to placebo (an inactive inhaler).
- Trial name
- NCT01656733
- Testing
- Nicotrol Inhaler
- Where
- 2 sites in United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- UConn Health
Alcohol Abuse
Pilot Test of Computerized MET to Reduce Adolescent Alcohol Use
The goal of this project is to conduct a pilot study evaluating feasibility, acceptability, and estimating the effect size of a new computerized Motivational Enhancement Therapy (cMET) intervention for alcohol-involved adolescent…
- Trial name
- NCT01796158
- Testing
- cASBI+cMET, cASBI
- Where
- United States
- Sponsor
- Boston Children's Hospital
Substance Use
A Family-Centered Ojibwe Substance Abuse Prevention
This study will complete a multisite randomized controlled trial (RCT) of a family-centered alcohol and drug prevention program for Anishinabe (Ojibwe) pre-adolescents in 3rd or 4th grade (Fall 2017) or who are age 8-10 years on…
- Trial name
- BZDDD (NCT02700035)
- Testing
- Bii-Zin-Da-De-Dah (Listening to One Another)
- Volunteers
- 705 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Substance Use, Adolescent Behavior
Adolescents With Substance Use Disorders Transitioníng From Residential Treatment to the Community
Adolescents with substance use disorders (ASUD) in residential treatment have the most serious substance use disorders and the highest rates of psychological, motivational, behavioral, legal, environmental, and vocational…
- Trial name
- NCT03592186
- Testing
- Parenting Wisely+, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 122 people
- Sponsor
- Brown University
Alcohol Drinking, Alcohol Use Disorder
Contributing Factors of Solitary Drinking Among Adolescents and Young Adults
A convenience sample of 40 solitary drinkers aged between 10 and 24 will be invited to complete a structured questionnaire and a individual semi-structured interviews.
- Trial name
- NCT05337488
- Testing
- questionnaire with interview
- Volunteers
- 40 people
- Sponsor
- The Hong Kong Polytechnic University
E-cigarette Use, Substance Use
The Development and Evaluation of a Culturally Grounded ENDS Intervention for Rural Hawaiian Youth
The purpose of this research proposal is to develop and evaluate a culturally grounded, ENDS prevention intervention for rural Hawaiian youth. This will be accomplished through two specific aims.
- Trial name
- NCT06929520
- Testing
- ENDS Prevention Intervention (TBD)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Hawaii
Fetal Alcohol Spectrum Disorders
The Trajectory of Fetal Alcohol Spectrum Disorders (FASD) Across the Life Span: Continuing Prevention and Longitudinal Epidemiology
Screen women of childbearing age (15 - 44 years) for high risk drinking in antenatal clinics of the established research sites in the Western Cape Province of South Africa (SA).
- Trial name
- NCT04026620
- Testing
- Informational Pamphlet, Brief Motivational Enhancement Therapy (MET) Session
- Where
- South Africa
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Drug Use, Drug Abuse
Prevention of Post Sexual Assault Stress
The purpose of this study is to evaluate whether a brief intervention in video format, that includes education about reactions to assault and modeling of adaptive coping strategies, designed to reduce post assault drug use or…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01430624
- Testing
- PPRS, PIRI
- Where
- 2 sites in United States
- Volunteers
- 245 people
- Sponsor
- Medical University of South Carolina
Adolescent Drinking, Adolescent Problem Behavior
Mindfulness Mobile App to Reduce Adolescent Substance Use
Substance-abusing youth - especially those who are involved in the juvenile justice system - are at higher risk than nonusers for mental health problems, including depression, conduct problems, personality disorders, suicidal…
- Trial name
- Qlarity (NCT04027075)
- Testing
- Qlarity app users
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.
Delinquency, HIV Risk
The ProGirls Study
Girls in the juvenile justice system who have high rates of delinquency, drug abuse, and trauma are particularly at risk for engaging in risky sexual behavior and for contracting HIV/AIDS or other sexually transmitted infections…
- Conditions
- Delinquency, HIV Risk, Substance Use, Trauma Exposure
- Trial name
- NCT02112201
- Testing
- Integrated intervention for parents and adolescent girls
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Substance Use, Stress
Automating Peer Learning to Reduce Alcohol Use and Related Deviant Behavior in Secondary School
Deviant peer affiliation is one of the most important predictors of alcohol use in adolescence. These affiliations arise when socially marginalized youth self-aggregate and reinforce alcohol use and other deviant activity (i.e.…
- Conditions
- Substance Use, Stress, Relation, Interpersonal, Bullying
- Trial name
- PeerLearning (NCT04478240)
- Testing
- PeerLearning.net
- Where
- United States
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Oregon Research Behavioral Intervention Strategies, Inc.