Clinical trials: Supportive Therapy
Pneumonia, Pediatric Respiratory Diseases
Supportive Treatment and Antibiotics for Mild Pediatric Pneumonia
National guidelines make two recommendations for treatment of young children with mild pneumonia - one to avoid routine antibiotics and another to use narrow-spectrum antibiotics.
- Conditions
- Pneumonia, Pediatric Respiratory Diseases, Antibiotic Use, Community-acquired Pneumonia
- Trial name
- STAMPP (NCT05726253)
- Testing
- Supportive Care + Amoxicillin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
HIV Infections
Connecting Youth and Young Adults to Optimize ART Adherence: YouTHrive Efficacy Trial
YouTHrive (YT) is a two-arm randomized control trial (RCT) to test the efficacy of an adapted version of the Thrive With Me (TWM) intervention for youth living with HIV (YLWH).
- Trial name
- NCT03149757
- Testing
- YouTHrive, Information-only Control
- Where
- 7 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Spinal Muscular Atrophy Type I, Spinal Muscular Atrophy Type II
Body Weight Support Harness System in Spinal Muscular Atrophy
The goal of this pilot interventional study is to learn about the use of an in-home harness system in children who have been treated for spinal muscular atrophy. The main questions it aims to answer are: 1.
- Trial name
- NCT05715749
- Testing
- In-home body weight support harness system
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Nationwide Children's Hospital
Dental Caries
Oral-Spray Bacillus Spore Probiotic in Preventing and Supporting Treatment of Dental Caries in Children
Despite advances in oral health care, cavities remain highly prevalent worldwide, especially among children. Conventional treatment methods focus on removing damaged tooth tissue but fail to completely eliminate or control…
- Trial name
- NCT07241052
- Testing
- oral-spray 0.9% NaCl physiological saline solution, Smile Care
- Where
- Vietnam
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Anabio R&D
Occlusal Analysis, Patient Satisfaction
3D Integration of Facial , Intraoral Scanning and CBCT on Patient Satisfaction and Occlusion of Temporary, Permanent Implant Supported Prosthesis
This study will aim to evaluate the effect of complete digital workflow for construction of temporary and permanent full arch implant supported screw retained restoration by the 3D integration of facial scanning, intraoral…
- Trial name
- NCT06846372
- Testing
- occluscence, patient satisfaction
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Human Immunodeficiency Virus (HIV)
Assessment of Group Peer Support to Children With HIV in Vietnam
This project aims to assess the effect of group peer support to children with HIV in relation to adherence, virological treatment failure as well as physical development.
- Trial name
- NCT02035969
- Testing
- Enhanced Treatment Support (ETS)
- Where
- Vietnam
- Volunteers
- 520 people
- Sponsor
- Karolinska Institutet
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Headache, Migraine, Migraine
Mind and Body Approaches to Pain Reduction in Youth With Migraine
The overarching objective of this protocol is to identify and understand the neural and pain processing mechanisms by which youth with migraine improve in response to preventive treatment.
- Conditions
- Headache, Migraine, Migraine, Migraine Disorders, Headache
- Trial name
- NCT03472092
- Testing
- Cognitive Behavioral Therapy (CBT), Amitriptyline, Biofeedback-Assisted Relaxation Training (BART)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Traumatic Injuries, Prehospital Emergency Care
Study of Pre Hospital Management of Polytrauma Patients by Medical Teams From a Department in the Parisian Region
To study the impact of prehospital management duration by SMUR teams in the Essonne department (91) on early patient mortality (within 24 hours) and to analyze the procedures performed on scene.
- Conditions
- Traumatic Injuries, Prehospital Emergency Care, Early Mortality
- Trial name
- DELTA-91 (NCT07414186)
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Centre Hospitalier Sud Francilien
Bronchiolitis, Bronchitis
Effect of AI-Assisted Discharge Education on Parents of Children With Bronchitis/Bronchiolitis
This randomized controlled trial aims to evaluate the effects of artificial intelligence-assisted discharge education on mothers of children hospitalized with bronchitis/bronchiolitis.
- Trial name
- NCT07774494
- Testing
- AI-Assisted Written Discharge Education, AI-Assisted Video Discharge Education, Routine Discharge Education
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Osmaniye Korkut Ata University
SARS-CoV-2
The Use of Peripheral Blood Specimens From Patients Suspected of Having SARS-CoV-2 Infections in Research Studies Intended to Support the Development of COVID-19 Detection Methods, Treatments, and/or Vaccines
Invivoscribe, Inc. and its wholly owned subsidiary LabPMM, LLC are collecting peripheral blood specimens from patients with suspected SARS-CoV-2 viral infections.
- Trial name
- NCT04391400
- Testing
- nasal pharyngeal (NP) swab samples, peripheral blood draw
- Volunteers
- 500 people
- Sponsor
- Invivoscribe, Inc.
Autism Spectrum Disorder
OCCUPATIONAL THERAPY INTERVENTIONS ON COGNITIVE PERFORMANCE IN CHILDREN WITH AUTISM SPECTRUM DISORDER
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by deficits in social communication and interaction, as well as restricted and repetitive patterns of behavior.
- Trial name
- COGNITIVE PERF (NCT07818538)
- Testing
- Virtual Reality-Supported Cognitive-Focused Occupational Therapy, Structured Occupational Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Biruni University
Thrombotic Microangiopathy
Study of Ravulizumab in Pediatric Participants With HSCT-TMA
This study will evaluate the safety, efficacy, pharmacokinetics, and pharmacodynamics of ravulizumab administered by intravenous infusion to pediatric participants, from 1 month to < 18 years of age, with HSCT-TMA.
- Trial name
- NCT04557735
- Testing
- Ravulizumab, Best Supportive Care
- Where
- 26 sites in United States, Israel and 5 more
- Volunteers
- 41 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Depression in Adolescence
Streamlined Treatment and Evidence-based Adolescent Counseling and Medication Support (STREAMS)
Combination interventions to address mental health and adherence to HIV care in low- and middle-income countries (LMICs), are crucial to achieving the UNAIDS 95-95-95 targets as one in four adolescents living with HIV (ALWHIV)…
- Trial name
- STREAMS (NCT07637058)
- Testing
- Streamlined Suubi+Adherence, Streamlined Interpersonal Psychotherapy Groups (IPT-G)
- Volunteers
- 588 people
- Sponsor
- City University of New York, School of Public Health
Very Preterm Infant, Very Low Birthweight
LIFT-UP: Randomized Controlled Trial of Fortification of Human Milk
The goal of the LIFT-UP randomized controlled trial is to evaluate the efficacy of feeding routinely and fortified human milk using a standardized clinical protocol to very low birthweight (VLBW) or very preterm (VPT) infants in…
- Trial name
- LIFT-UP RCT (NCT06765863)
- Testing
- Human Milk Fortifier, Volume targets
- Where
- 4 sites in India
- Volunteers
- 776 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Cytomegalovirus Infection
Dried Blood Spot Testing of CMV Detection in HCT Recipients
This is a randomized clinical trial to assess whether a subject centered, self-collection of Dried blood spots (DBS) samples will improve compliance with the clinical recommendation of weekly Cytomegalovirus (CMV) testing of…
- Trial name
- NCT03910478
- Testing
- DBS Self-Collection Kit, Standard Control Strategy
- Where
- 4 sites in United States
- Volunteers
- 622 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Malocclusion, Angle Class I, Malocclusion, Angle Class II
AI-Assisted Versus Conventional Orthodontic Diagnosis and Treatment Planning
This study compared an artificial intelligence-assisted orthodontic diagnostic workflow using WebCeph with a conventional clinician-based workflow.
- Conditions
- Malocclusion, Angle Class I, Malocclusion, Angle Class II, Malocclusion, Angle Class III
- Trial name
- AI-OrthoDx (NCT07690774)
- Where
- Yemen
- Volunteers
- 120 people
- Sponsor
- Ben Hafeed Dental Center