Clinical trials: Surgical Procedures, Operative
Malocclusion, Angle Class III
Evaluation of Surgical Outcomes of Patients Treated With the Surgery First Approach and Aligners
The purpose of this prospective study is to compare treatment outcomes and the quality of life of skeletal Class III patients treated with conventional fixed appliances and aligners undergoing Surgery-first approach.
- Trial name
- NCT05822271
- Testing
- Orthognathic Surgery
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Desmoid Tumor
Vinblastine and Methotrexate in Treating Children With Desmoid Tumors
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003019
- Testing
- methotrexate, vinblastine sulfate
- Where
- 39 sites in United States, Australia and 1 more
- Volunteers
- 28 people
- Sponsor
- Children's Oncology Group
Surgical Smoke
The Effect of Masks on Surgical Smoke Exposure
Surgical smoke refers to the gaseous plume released into the air as a result of the thermal destruction of tissues by energy-based devices used in operating rooms.
- Trial name
- NCT07161609
- Testing
- Particle counter
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Mersin University
Splints
Development of Upper Aerodigestive Tract Splint
The study hypothesis is that a splint will improve access to the upper aerodigestive tract (UADT) for diagnosis and treatment.
- Trial name
- NCT04544800
- Testing
- Use of Splint for UADT Visualization
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Education, Medical
Perceptions of the Annual Review of Competence Progression (ARCP) in Surgical Training in the UK and Ireland
A Prospective Cross Sectional Questionnaire Study was conducted to evaluate surgical trainees' experiences of the ARCP process in order to identify areas for improvement.
- Trial name
- NCT03718481
- Testing
- ARCP Process
- Where
- United Kingdom
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University College Hospital Galway
Surgery
Device to Reduce Surgery Site Contamination
The objective of this study is to determine whether the Air Barrier System device reduces airborne particulate and airborne colony forming units present at a surgery site.
- Trial name
- NCT00972153
- Testing
- Air Barrier System Device
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Nimbic Systems, LLC
Wound Dehiscence, Incision
Pediatric Post-operative Abdominal Wound Dehiscence in Association With Midline vs Other Incisions: A Prospective Cohort Study
This study is designed to see different abdominal incisions complication among neonates, infants and children and to find risk factors for developing wound dehiscence
- Trial name
- NCT05963477
- Testing
- laparatomy
- Where
- Afghanistan
- Volunteers
- 270 people
- Sponsor
- French Medical Institute for Mothers and Children
Ingrown Toenail (Onychocryptosis)
Comparison of Two Surgical Methods (Winograd vs. Sleeve Method) in the Treatment of Ingrown Toenail.
This randomized clinical trial aims to compare the recurrence rates of two surgical techniques-Winograd procedure and sleeve (gutter) method-in the treatment of ingrown toenails (onychocryptosis).
- Trial name
- NCT07547241
- Testing
- Winograd Technique, Sleeve (Gutter) Method
- Where
- Pakistan
- Volunteers
- 312 people
- Sponsor
- Pakistan Institute of Medical Sciences
Primary Congenital Glaucoma, Developmental Glaucoma
Comparison of Surgical Treatment Options for Primary Congenital and Developmental Glaucomas
Newborn and children can be affected by two subgroups of this disease: (1) primary congenital glaucoma (PCG) or (2) developmental glaucoma (DG).
- Trial name
- STOP-Glaucoma (NCT04647929)
- Testing
- Santen PRESERFLO MicroShunt, Trabeculectomy
- Sponsor
- University of Zurich
Pain, Postoperative, Healing Surgical Wounds
Use of Cyanoacrylate in Healing and Pain in the Palatal Donor Site of Connective Tissue Grafts
Periodontal plastic surgery has been performed successfully for a long time in the treatment of gingival recessions and mucogingival defects.
- Trial name
- NCT06116539
- Testing
- Cyanoacrylate, Suture
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Alfonso X El Sabio University
Rectal Cancer
Quality of Life After Abdominoperineal Resection for Rectal Cancer, Comparing Two Surgical Techniques
The purpose of the study is to compare self-reported health related quality of life after two different operating techniques for low rectal cancer operated by rectal amputation, using a specific and detailed questionnaire.
- Trial name
- APR (NCT01323166)
- Testing
- Excision of the levator muscle
- Where
- Sweden
- Volunteers
- 75 people
- Sponsor
- Sahlgrenska University Hospital
Access to Emergency Surgery
Determinants of Access to Emergency Surgery at the University College Hospital, Ibadan
Access to surgery is reported to be significantly lower in low income countries like Nigeria, and upwards of 5 billion people globally lack safe access to surgery.
- Trial name
- NCT04487496
- Where
- Nigeria
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University College Hospital, Ibadan
Bleeding, Tooth Extraction
Effects of Tranexamic Acid Irrigation on Impacted Third Molar Surgery
Tranexamic acid (TXA) is an effective hemostatic agent used to reduce blood loss and the need for transfusion. It is a relatively safe drug with minimal significant side effects.
- Trial name
- NCT06806241
- Testing
- Tranexamic acid, saline irrigation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Neuroendocrine Tumors, Von Hippel-Lindau Syndrome
Evaluation of 68Gallium-DOTATATE PET/CT for Detecting Neuroendocrine Tumors
Background: Neuroendocrine tumors (NETs) are rare but have been more common over the past decade. The only treatment for NETs is surgery, but most are found when they are too advanced for surgery.
- Conditions
- Neuroendocrine Tumors, Von Hippel-Lindau Syndrome, Hippel-Lindau Disease
- Trial name
- NCT01967537
- Testing
- 68Gallium DOTATATE, Radio-guided surgery
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- National Cancer Institute (NCI)
Post-Operative Pain, Acute Pain
Clinical Study to Evaluate the Effectiveness, Safety, and Tolerability of Oxymorphone Immediate Release (IR) Oral Liquid in Post Surgical Pediatric Subjects
The purpose of the study is to evaluate the efficacy, tolerability, safety and pharmacokinetics of Oxymorphone HCl as an analgesic for acute moderate to severe post-operative pain in pediatric subjects.
- Trial name
- NCT02687451
- Testing
- Oxymorphone HCl
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Endo USA Inc., a Keenova Therapeutics Company
Surgical Site Infection
Surgical Site Infection in Caesarean Section Using Alexis O Compared to Metal Retractors
Objective: To investigate if the use of the newly designed Alexis O Retractor leads to improved intra-operative and post-operative surgical outcomes in the setting of planned elective Caesarean Sections.
- Trial name
- NCT02685696
- Testing
- Alexis O Retractor, Metal Retractor
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Breast Cancer
Local Surgery for Metastatic Breast Cancer
Primary treatments for metastatic breast cancer are chemotherapy and radiation therapy, and surgery is reserved for tumor related complications such as bleeding.
- Trial name
- NCT00557986
- Testing
- Primary surgery
- Where
- 7 sites in Turkey (Türkiye)
- Volunteers
- 281 people
- Sponsor
- Federation of Breast Diseases Societies
Renal Cell Carcinoma, Three-Dimensional
3D-biomodels for Surgical Planning in Patients With Renal Cancer and Vascular Involvement
Objectives: Apply 3D- printed biomodels in patients with renal cancer (RCa) and vascular involvement (VTT) to: (1) improve surgical planning, (2) upgrade surgical results, (3) facilitate communication with patients, (4) serve as…
- Conditions
- Renal Cell Carcinoma, Three-Dimensional, Venous Thromboses
- Trial name
- 3DUrologia (NCT03738488)
- Testing
- 3D printing + images, Images
- Where
- 2 sites in Spain
- Volunteers
- 10 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Hypoparathyroidism Postprocedural
Improving Safety in Pediatric Thyroidectomy by PTH Measurements
We implemented a previously reported algorithm based on intra-postoperative PTH measurements with selected cut-off values, both to predict post-thyroidectomy hypoparathyroid hypocalcemia, and to guide postsurgical management.
- Trial name
- NCT04690842
- Testing
- PTH measurements post-thyroidectomy (at 5 and 60 min post thyroid removal)
- Volunteers
- 66 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Metastatic Disease, Spinal Cord Injury
Negative Pressure Wound Therapy vs. Sterile Dressing for Patients Undergoing Thoracolumbar Spine Surgery
The purpose of this study is to determine if the use of the Prevena™ System decreases the rate of subcutaneous seroma, superficial wound dehiscence and infection.
- Conditions
- Metastatic Disease, Spinal Cord Injury, Spinal Degeneration, Spinal Deformity
- Trial name
- NCT03632005
- Testing
- Vacuum Assisted Closure, Sterile dressing
- Where
- Canada
- Volunteers
- 550 people
- Sponsor
- John Street
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