Clinical trials: Surgical Procedures, Operative
Metopic Synostosis
Comparing Conservative to Surgical Treatment of Trigonocephaly Craniofacial Surgery in Children With Trigonocephaly: an Observational Cohort Study on Clinical Outcomes, Psychosocial Wellbeing, and Costs
RESEARCH QUESTION Is the effectiveness of conservative policy comparable to that of surgery in children with trigonocephaly, with regard to clinical outcomes and psychosocial functioning, stress for parents, and costs? DESIGN…
- Trial name
- Treat Trigono (NCT06069479)
- Testing
- craniofacial surgery
- Where
- Netherlands
- Volunteers
- 440 people
- Sponsor
- Erasmus Medical Center
Pain
Post-surgical Pain Assessment in Children: Roles of Skin Conductance and Genomics
Pain assessment in infants and toddlers is quite challenging since children in these populations are nonverbal or preverbal and cannot describe the presence and severity of pain that they perceive.
- Trial name
- NCT02534168
- Testing
- Skin conductance monitor for measuring skin conductance
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Milton S. Hershey Medical Center
Surgical Condition, Obstetrical Condition
Validity of Information Employed to Generate Standardized Mortality Ratios Using Hospital Administrative Databases (RNMH)
In a retrospective cross-sectional study, investigators aimed to valid the variables employed to generate standardized mortality ratio from hospital administrative databases.
- Conditions
- Surgical Condition, Obstetrical Condition, Hospitalization in Acute Care
- Trial name
- RNMH (NCT02816320)
- Testing
- Hospitalization
- Volunteers
- 715 people
- Sponsor
- Hospices Civils de Lyon
Pituitary Adenoma
Pre-operative Surgical Difficulty Stratification Using Predicted Tumor Perfusion and Consistency
Pituitary adenomas (PAs) are among the most prevalent lesions of the sella turcica, accounting for 10%-25% of all intracranial neoplasms. Pituitary macroadenomas (PMAs) are defined with a maximum diameter of over 1 cm.
- Trial name
- NCT06664190
- Testing
- Advanced sequences, such as arterial spin labeling (ASL) and diffusion-weighted imaging (DWI)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huashan Hospital
Adolescent Idiopathic Scoliosis
Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery
The Finnish Paediatric Orthopaedic Study Group will perform a prospective randomized, multicenter, clinical trial comparing Gelatin matrix with human derived thrombin (Floseal, Baxter) and without use of Floseal in adolescents…
- Trial name
- NCT01451788
- Testing
- Gelatin matrix with human derived thrombin (Floseal, Baxter)
- Where
- 3 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Turku University Hospital
Acute Kidney Injury
Acute Kidney Injury in Children Operated for Congenital Heart Disease
The purpose of this study was to investigate if repeated inflation of a blood pressure cuff applied around one leg causing mild ischemia ("remote ischemic preconditioning") could protect children operated for congenital heart…
- Trial name
- NCT01316497
- Testing
- Remote ischemic preconditioning (RIPC), Control
- Where
- Denmark
- Volunteers
- 105 people
- Sponsor
- University of Aarhus
Funnel Chest
Cardiorespiratory Assessment and Quality of Life After Surgical Correction of Congenital Wall Malformations
The main objective of this study is to characterize the cardiorespiratory functional gain in patients with pectus excavatum following corrective surgery.
- Trial name
- HeartSoar (NCT03770390)
- Testing
- Surgical correction of pectus excavatum
- Where
- France
- Volunteers
- 43 people
- Sponsor
- University Hospital, Montpellier
Persistent Atrial Fibrillation
Comparison Between One-stage Hybrid Ablation and Thoracoscopic Surgical Ablation for Intractable Atrial Fibrillation
Previous evidence indicated that the outcomes of both video-assisted thoracoscopic surgical ablation and percutaneous radiofrequency ablation therapy for persistent atrial fibrillation (AF) were unsatisfied.
- Trial name
- NCT03127423
- Testing
- Hybrid ablation, Thoracoscopic surgical ablation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Pediatric Brain Tumors
FET-PET/MRI for Surgical Assessment of Pediatric Brain Tumors
The primary objectives of this study are: 1. Determine the percentage of patients whose surgical plan would change with FET-PET/MRI compared to MRI alone. 2.
- Trial name
- NCT03451123
- Testing
- FET PET/MRI
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Alabama at Birmingham
Papillary Thyroid Microcarcinoma, Radiofrequency Ablation
10 Years' Follow-up Results of Ultrasound-guided Radiofrequency Ablation Versus Surgery for Low-risk Papillary Thyroid Micro-carcinoma
Papillary thyroid micro-carcinoma (PTMC) generally demonstrates favorable prognosis. However, the potential risk of disease progression requires careful therapeutic consideration.
- Conditions
- Papillary Thyroid Microcarcinoma, Radiofrequency Ablation, Surgical Resection, Long-term Outcomes
- Trial name
- NCT07107503
- Testing
- Radiofrequency ablation alone, surgical resection
- Volunteers
- 757 people
- Sponsor
- Yi Mao
Intestinal Obstruction
Prospective Multicenter Validation of a Severity Score of Strangulated Small Bowel Occlusion
The purpose of this study is to apply and validate a clinicoradiological score for the prediction of severity of strangulated small bowel occlusion (SBO).
- Trial name
- NCT01125280
- Testing
- Conservative treatment versus surgical treatment
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University Hospital, Geneva
Liver Neoplasms, Liver/Hepatobiliary Cancer
CE-IOUS Impact on Surgical Strategy of Liver Tumours and Liver Metastases
Contrast-enhanced intraoperative ultrasound (CE-IOUS) plays an increasingly important role in the surgical therapy planning of primary liver lesions as well as liver metastases.
- Conditions
- Liver Neoplasms, Liver/Hepatobiliary Cancer, Colorectal Cancer Metastatic, Metastases
- Trial name
- NCT05261113
- Testing
- CE-IOUS
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Regensburg
Periodontal Diseases
Antimicrobial Photodynamic Therapy as an Adjunct Treatment for Periodontal Disease in Down's Syndrome Patients
The aim of this study was to evaluate the effectiveness of antimicrobial photodynamic therapy as an adjuvant of scaling and root planning for treatment of periodontal disease in patients with Down's Syndrome.
- Trial name
- NCT02938988
- Testing
- Antimicrobial photodynamic therapy, Scaling and root planning, red laser
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- University of Sao Paulo
Femoral Shaft Fracture
Titanium Elastic Nailing Versus Hip Spica Cast in Treatment of Femoral Fractures in Children
The purpose of this study is to determine which method is better for treatment of femoral fracture in children in outcomes.
- Trial name
- NCT01190696
- Testing
- titanium elastic nailing, Hip spica casting
- Where
- Iran
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Infants, Intensive Care Unit
Open Surgical, Modified Seldinger's and US Techniques for Jugular Central Line Insertion in Infants
The aim of this study was to compare the three approaches: open technique, modified Seldinger's technique and closed ultrasound-guided Central venous catheterization insertion for central line insertion in infancy as regards…
- Conditions
- Infants, Intensive Care Unit, Central Venous Catheterization
- Trial name
- NCT06862492
- Testing
- Open surgical cut down technique, Modified Seldinger's technique, Closed Ultrasound guided CVC insertion
- Where
- Egypt
- Volunteers
- 35 people
- Sponsor
- Tanta University
Medication Related Osteonecrosis of the Jaw
MRONJ and Polynucleotides-Hyaluronic Acid Hydrogel (Regenfast®)
Several circumstances or conditions, such as wound extension or disease, can affect the hard and soft tissue healing after surgical treatment of MRONJ. Supportive therapies are therefore needed to help tissues wound healing.
- Trial name
- REG-MRONJ-1 (NCT06984107)
- Testing
- MRONJ resection plus PN+HA
- Volunteers
- 10 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Heart Diseases, ASD - Atrial Septal Defect
Abbott Structural Heart Device Registry
The Abbott Structural Heart (SH) Registry is being conducted to confirm the safety and performance of Abbott's SH devices in a post-market, real-world setting.
- Conditions
- Heart Diseases, ASD - Atrial Septal Defect, VSD - Muscular Ventricular Septal Defect, PFO - Patent Foramen Ovale
- Trial name
- SH-Registry (NCT06590467)
- Testing
- Amplatzer™ Occlusion Devices, Epic™ Surgical Tissue Heart Valve devices
- Where
- 36 sites in United States, Denmark and 8 more
- Volunteers
- 2,500 people
- Sponsor
- Abbott Medical Devices
Surgical Bleeding
Safety and Efficacy of WoundClot Surgical
The goal of this clinical trial is to verify that WoundClot Surgical helps stop bleedings which may occur during surgery. It will also help learn more about the safety of WoundClot Surgical.
- Trial name
- WCS-1 (NCT06696092)
- Testing
- Hemostatic Agent
- Where
- 8 sites in Romania
- Volunteers
- 72 people
- Sponsor
- Core Scientific Creations Ltd.
Choledochal Cyst
Clinical Features and Prognosis of Asymptomatic Biliary Dilatation
This study is a multicenter, ambidirectional cohort study aiming to consecutively recruit asymptomatic biliary dilation patients incidentally discovered by imaging from 25 medical centers across China.
- Trial name
- NCT07028164
- Where
- China
- Volunteers
- 1,008 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
General Surgery, Anaesthesia
BIS Monitoring of the Depth of Anaesthesia in Children
General anaesthesia (GA) is, according to many definitions, the greatest gift presented to the medical art (S. B. Nuland). One of the aims of GA is to achieve the optimal depth of anaesthesia and rapid emergence from general…
- Trial name
- NCT02664142
- Testing
- BIS Group, Non-BIS Group, Anaesthetics
- Where
- Czechia
- Volunteers
- 220 people
- Sponsor
- University Hospital Ostrava
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