Clinical trials: Swallowing Disorders
Cystic Fibrosis
The Prevalence and Significance of Gastro-oesophageal Reflux in Cystic Fibrosis Before and After Lung Transplantation
Gastro-oesophageal reflux (GOR) has been found to be prevalent in children with cystic fibrosis (CF)and may further worsen lung damage via reflex bronchospasm or pulmonary aspiration.
- Trial name
- NCT00164021
- Testing
- Physiotherapy, exercise, percutaneous gastrostomy feeds, Anti-reflux pharmacotherapy
- Where
- Australia
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Dysphagia, Esophageal, Esophageal Cancer
Validation of Instruments Used for Assessment of Dysphagia in Patients With Esophageal Cancer
This study validates 3 well known dysphagia scores for dysphagia due to malignancies of the oesophagus and gastro-oesophageal junction and to the Swedish language.
- Trial name
- NCT03066167
- Testing
- Validation of different dysphagia scores
- Where
- Sweden
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Dysphagia, Aspiration
Effect of Afferent Oropharyngeal Pharmacological and Electrical Stimulation on Swallow Response and on Activation of Human Cortex in Stroke Patients With Oropharyngeal Dysphagia
Oropharyngeal dysphagia (OD) is a major complaint among many patients with stroke and causes severe complications. There is no specific treatment for these patients.
- Conditions
- Dysphagia, Aspiration, Stroke
- Trial name
- NCT01777672
- Testing
- Dietary and oral hygiene recommendations, oral TRPV1 agonist, pharyngeal electrical stimulation
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital de Mataró
Gastroesophageal Reflux Disease
Transoral Incisionless Fundoplication Database Repository (TIF)
Collect data on individuals who have a transoral incisionless fundoplication (TIF) performed by physicians at Indiana University for the treatment of gastroesophageal reflux disease.
- Trial name
- TIF (NCT04306380)
- Testing
- no intervention, database study
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Indiana University
Hyperparathyroidism
Swalqol in Primary Hyperparathyroidism
Swallow related quality of life before and after parathyroidectomy will be evaluated in patients with primary hyperparathyridism.
- Trial name
- NCT03968510
- Testing
- parathyroidectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Uşak University
Oropharyngeal Dysphagia
Nursing Care Bundle on Oral Intake Among Critically Ill Children With Post-Extubation Dysphagia
the aim of this study is to evaluate the effect of Nursing care Bundle on Oral Intake among Critically Ill Children with Post-Extubation Dysphagia
- Trial name
- NCT06814457
- Testing
- a nursing care bundle on oral intake
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Gastroesophageal Reflux Disease
Cardiaplication: A Novel Antireflux Operation
Gastro-Esophageal Reflux is a commonly encountered problem in infants. After failure of medical therapy, many children are referred for surgical intervention.
- Trial name
- NCT02060500
- Testing
- Cardiaplication
- Volunteers
- 8 people
- Sponsor
- Emory University
Gastroesophageal Reflux Disease and Position
Car Safety Seat and Gastroesophageal Reflux Disease
What's known? Prone position is no longer a treatment option for GERD because of the association with SIDS. Originally, positioning in an infant seat was recommended for infants with GERD.
- Trial name
- NCT01266551
- Testing
- car safety seat
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Mitral Prosthetic Valve Stenosis and Regurgitation
Redo Surgery or Transcatheter Valve-in-Valve for Mitral Bioprosthetic Dysfunction (SURViV)
Transcatheter valve-in-valve implantation has emerged as a valid alternative to redo surgery for patients with surgical bioprosthetic dysfunction.
- Trial name
- SURVIV (NCT04402931)
- Testing
- Transcatheter Valve-in-Valve Intervention, Redo Mitral valve surgery
- Where
- 7 sites in Brazil
- Volunteers
- 150 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Gastro Esophageal Reflux
Effect of Magnesium Alginate in Infants With Gastroesophageal Reflux.
Recurrent regurgitation stress the infants and their parents and often results in an inappropirate use of PPI prescription in infancy.
- Trial name
- NCT03881722
- Testing
- Mg alginate
- Where
- Italy
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Swallow, Preterm Infant
Effect of Kinesio-taping Technique on Oral Feeding in Late Preterm Infants
Difficulty in feeding among late preterm infants is one of the most significant factors contributing to prolonged hospitalization and re-admissions.
- Conditions
- Swallow, Preterm Infant, Newborn, Kinesiotaping
- Trial name
- NCT06208228
- Testing
- Kinesiotaping
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people
- Sponsor
- Ondokuz Mayıs University
Gastroesophageal Reflux
Esophageal Bolus Transit in Newborns With Gastroesophageal Reflux Disease
Esophageal dysmotility due to immaturity could promote impaired bolus transit during esophageal swallow events,thus influencing gastroesophageal reflux (GER) clearance.
- Trial name
- NCT02167984
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- University of Turin, Italy
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Gastroesophageal Reflux in Children
Study on the Efficacy and Tolerance of a New Anti-regurgitation Infant Formula (STELLAR)
The aim of the study is to assess the effectiveness of this new formula on regurgitations and secondarily its effect on digestive tolerance through a randomized, controlled, double-blind trial against a comparator.
- Trial name
- STELLAR (NCT04358146)
- Testing
- Experimental Infant formula, Infant formula thickened with locust bean gum
- Where
- 12 sites in Belgium, France and 2 more
- Volunteers
- 346 people
- Sponsor
- United Pharmaceuticals
GERD
A Comparative Study of Proton-pump Inhibitor Tests for Chinese Reflux Patients in Relation to the CYP2C19 Genotypes
Backgrounds \& Aims: Proton-pump inhibitor (PPI) test has been proposed as a valuable tool in the diagnosis of gastroesophageal reflux disease (GERD) in Western populations.
- Trial name
- NCT00681005
- Testing
- rabeprazole, pantoprazole
- Volunteers
- 178 people
- Sponsor
- National Taiwan University Hospital
Microaspiration, Gastro Esophageal Reflux
Transpyloric Feeding for Prevention of Micro-aspiration
To determine the effect of transpyloric (TP) feeding on microaspiration and lung inflammation in ventilated preterm infants.
- Trial name
- NCT03646045
- Testing
- Transpyloric feeding
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Nemours Children's Clinic
Gastroesophageal Reflux Disease, Bronchopulmonary Dysplasia
The Role of Anti-Reflux Surgery for Gastroesophageal Reflux Disease in Premature Infants With Bronchopulmonary Dysplasia
The purpose of this study is to evaluate the efficacy of fundoplication in premature infants with GERD and BPD.
- Trial name
- GERD-BPD (NCT00926276)
- Testing
- Fundoplication
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cerebral Palsy
Stellate Ganglion Block in Cerebral Palsy
The goal of this clinical trial is to test the efficacy of stellate ganglion block in children with cerebral palsy and dysphagia.
- Trial name
- NCT06319508
- Testing
- routine rehabilitation treatment, Stellate ganglion block, Lidocaine hydrochloride
- Volunteers
- 80 people
- Sponsor
- Copka Sonpashan
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Gastroesophageal Reflux Disease
The Use of Lansoprazole to Treat Infants With Symptoms of Gastroesophageal Reflux
The purpose of this study is to assess the safety and efficacy of lansoprazole microgranules oral suspension, once daily (QD), in infants with gastroesophageal reflux symptoms during a 4-week treatment period.
- Trial name
- NCT00324974
- Testing
- Lansoprazole microgranules suspension
- Where
- 17 sites in United States, Poland
- Volunteers
- 162 people
- Sponsor
- Takeda