Clinical trials: Synucleinopathies
Parkinson Disease, PD
Genetic Characterization of Parkinson's Disease
This study will explore the risks and causes of Parkinson's disease, a chronic progressive nervous system disorder. Patients typically have tremors, muscle weakness and a shuffling gait.
- Conditions
- Parkinson Disease, PD, Movement Disorder, Healthy Volunteer
- Trial name
- NCT00105131
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD)
An Observational Study of Subcutaneous Infusion of ABBV-951 to Assess Change in Disease Activity and Adverse Events In Adult Japanese Participants With Advanced Parkinson's Disease
Parkinson's disease (PD) is a neurological condition, which affects the brain. Some symptoms of PD are tremors, stiffness, and slowness of movement.
- Trial name
- NCT05916157
- Where
- 17 sites in Japan
- Volunteers
- 250 people
- Sponsor
- AbbVie
Parkinson Disease, Parkinson Disease, Secondary
Accelerated Temporal Interference Stimulation on Bilateral Subthalamic Nucleus for Parkinson's Disease and Secondary Parkinson's Syndrome
This clinical trial will evaluate the efficacy of accelerated Temporal Interference Stimulation (TIS) as a therapeutic intervention for individuals diagnosed with Parkinson's disease or secondary Parkinson's syndrome.
- Trial name
- NCT07568067
- Testing
- Temporal Interference Stimulation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ke Dong, MD
Alzheimer Disease, Early Onset, Lewy Body Disease
Patients With Alzheimer's Disease or Related Youth Disease
This study aims to determine factors related to diagnosis delay for patients with young onset dementia (first symptoms before 60 years old) who live in North of France.
- Conditions
- Alzheimer Disease, Early Onset, Lewy Body Disease, Frontotemporal Lobar Degeneration
- Trial name
- PARMAAJJ (NCT03508024)
- Where
- France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Lille
Parkinson Disease (PD)
Enhanced Tai Chi for Parkinson's Disease (Enhanced Tai Chi PD)
This pilot study evaluates whether a structured, Parkinson's disease-specific Tai Chi programme ("Enhanced Tai Chi") can improve motor and non-motor symptoms in people with Parkinson's disease (PD).
- Trial name
- ETC-PD (NCT07297368)
- Testing
- Enhanced Tai Chi (Enhanced-Tai-Chi-PD), Usual Treatment (Standard Clinical Care)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- King's College Hospital NHS Trust
Idiopathic Parkinson's Disease
Efficacy of Acupuncture and Bee Venom Acupuncture on Patients With Idiopathic Parkinson's Disease
The aim of this study is to evaluate the efficacy of acupuncture and bee venom acupuncture (BVA) for idiopathic Parkinson's disease (IPD) through a sham-controlled trial and investigate whether there is sustainability of…
- Trial name
- NCT01970813
- Testing
- acupuncture and bee venom acupuncture point injection
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Kyunghee University Medical Center
Parkinson Disease
Post Marketing Surveillance And Special Surveillance for Mirapex® Tablet in Patients With Idiopathic Parkinson's Disease
The objectives of this study are to investigate issues or questions about MIRAPEX Tablets as shown below through the Post Marketing Surveillance (PMS) study upon approval.
- Trial name
- NCT02248168
- Testing
- Pramipexole
- Volunteers
- 1,449 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease, Apathy
Study of Rivastigmine to Treat Parkinsonian Apathy Without Dementia
Apathy usually refers to a set of behavioural, emotional and cognitive features as a reduced interest and participation in main activities of daily life, a lack of initiative, a trend toward an early withdrawal from started…
- Conditions
- Parkinson's Disease, Apathy, no Dementia
- Trial name
- CHoPA-I (NCT00767091)
- Testing
- rivastigmine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease (PD), Multiple System Atrophy
Shanghai Clinical Cohort - Parkinson's Disease (Reserve)
The goal of this observational cohort studyis to establish a high-quality clinical cohort of Parkinson's disease (PD) and multiple system atrophy (MSA) patients in Shanghai, in order to improve early diagnosis, precise subtyping…
- Trial name
- NCT07353463
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Ruijin Hospital
Parkinson Disease
The Effect of Sifrol® on Tremor and Depression in Patients With Idiopathic Parkinson's Disease
Documentation of the effect of SIFROL® on tremor and depression as well as its tolerability in ambulatory patients suffering from idiopathic Parkinson's disease under routine conditions
- Trial name
- NCT02231294
- Testing
- Sifrol®
- Volunteers
- 1,464 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease
GALIG Gene Expression in Parkinson's Disease
Parkinson's disease (PD) is the most frequent neurodegenerative disorder after Alzheimer's disease. It is characterized by motor symptoms (rigidity, tremor, slowness of movements), and non-motor symptoms (neuropsychological…
- Trial name
- GALIGPARK (NCT02923297)
- Testing
- Blood sampling
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Parkinson Disease, Dexterity
Effectiveness of MIRT on Hand and Finger Dexterity in PD Patients
Aims of the study are (1) to evaluate the effectiveness of a specific OT treatment aimed to enhance finger and hand dexterity and (2) its impact on daily living autonomy of PD patients.
- Conditions
- Parkinson Disease, Dexterity, Rehabilitation
- Trial name
- H_F_ D_PD_MIRT (NCT03763955)
- Testing
- MIRT
- Volunteers
- 482 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease, Postural; Defect
Focal Muscle Vibration in Parkinson's Disease
Postural instability has a major impact on the mobility and daily life activities of Parkinson's disease (PD) patients as it often leads to reduced mobility, insecure stance and falls.
- Conditions
- Parkinson Disease, Postural; Defect, Rehabilitation
- Trial name
- NCT06278623
- Testing
- Focal Muscle Vibratory Energy (EVM) Treatment
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson Disease
Validation of a Non-Motor Fluctuation Assessment Instrument (NoMoFA) for Parkinson's Disease
Investigators have developed a comprehensive questionnaire that assesses the presence of non-motor fluctuations (NMFs) in individuals with Parkinson's disease (PD).
- Trial name
- NCT03845634
- Where
- Canada
- Volunteers
- 202 people
- Sponsor
- Assistive Technology Clinic, Canada
Parkinson Disease, Sexual Orientation
Perspectives on Healthcare Access and Equity of People With Parkinson's Disease Identifying as LGBTQ+
Study Rationale: Older adults who identify as lesbian, gay, bisexual, transgender, or queer (LGBTQ+) have worse health than non-LGBTQ+ older adults.
- Trial name
- LGBTQ+_PD (NCT05502055)
- Testing
- Individual interviews, Focus Groups, National Survey
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Creighton University
Parkinson Disease, MSA - Multiple System Atrophy
Exploring the Olfactory Mucosa, Blood and Urine for the Identification of Early Biomarkers of Parkinson's Disease, Atypical Parkinsonisms and Neurocognitive Disorders Due to Lewy Body Disease
Clinical diagnosis of Parkinson's disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) is challenging, especially in the early stages.
- Conditions
- Parkinson Disease, MSA - Multiple System Atrophy, Lewy Body Dementia (LBD), Neurodegenerative Disease
- Trial name
- EXTRAORDINARY (NCT06846658)
- Where
- 3 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson's Disease
ADAGIO Follow Up Study: Evaluation of the Long-Term Effects of Rasagiline in Parkinson's Disease Subjects
Eligible participants, who participated in the ADAGIO trial and who sign an approved informed consent form, will be enrolled into the study at their original study locations.
- Trial name
- NCT00936676
- Testing
- rasagiline mesylate
- Where
- 102 sites in United States, Argentina and 11 more
- Volunteers
- 684 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Parkinson Disease
Gender Differences in Parkinsonian Patients- a Swedish Register Study
BACKGROUND: The complex impact of gender has been studied in different perspectives of health and disease in the literature. However, few attempts have been made to compile data from systematic disease specific registrations…
- Trial name
- NCT04713306
- Where
- Sweden
- Volunteers
- 1,217 people
- Sponsor
- Region Jönköping County
Parkinson Disease
Deep Brain Stimulation in Parkinson's Disease: Motor and Functional Outcomes
Introduction: Parkinson's Disease (PD) is a progressive neurodegenerative condition characterized by classic motor symptoms, such as bradykinesia, rigidity, resting tremor, and postural instability, which directly compromise the…
- Trial name
- NCT07567599
- Testing
- Deep Brain Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Minas Gerais
Neurologic Disorders
Evaluation and Treatment of Neurosurgical Disorders
Objective: This protocol is designed to allow the Surgical Neurology Branch to evaluate and treat the neurosurgical disorders of protocol participants.
- Trial name
- NCT00060541
- Testing
- Laboratory tests, Radiological exams
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)