Clinical trials: Syphilis Infection
Syphilis, Syphilis, Congenital
Congenital and Maternal Point of Care Rapid Testing for Syphilis Study, Uganda
Syphilis is an infection which affects about 1 in 25 pregnant women in Uganda. If the infection is not diagnosed and treated this can be a risk to the mother and unborn baby's health.
- Trial name
- COMPARTS (NCT07173764)
- Where
- Uganda
- Volunteers
- 24 people
- Sponsor
- St George's, University of London
Syphilis Infection
Syphilis Treatment of Partners Trial
2.1 Primary Study Hypothesis In sub-Saharan Africa, between 2.5-17% of pregnant women are infected with syphilis [1]. It is estimated that 53-82% of women with untreated syphilis had adverse outcomes compared to only 10-21% of…
- Trial name
- STOP (NCT02262390)
- Testing
- Partner Notification Reminders
- Where
- Uganda
- Volunteers
- 1,752 people
- Sponsor
- Makerere University
Syphilis
Evaluation of Enhanced Syphilis Screening Among HIV-positive Men
This study aims to enhance syphilis testing among HIV-positive men who have sex with men (MSM), so that more men will undergo testing, they will test more often, and more cases will be treated early.
- Trial name
- NCT02019043
- Testing
- Syphilis testing with routine HIV bloodwork
- Where
- 4 sites in Canada
- Volunteers
- 3,895 people
- Sponsor
- Unity Health Toronto
Gonorrhea, Chlamydia
Safer Sex Program for Young African-American Men
To evaluate the efficacy of the adapted program a randomized controlled trial enrolling 620 eligible African American men who have sex with men (MSM) will be conducted.
- Conditions
- Gonorrhea, Chlamydia, Trichomoniasis, Syphilis
- Trial name
- NCT01439503
- Testing
- Intervention
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Richard Crosby
Hiv, Syphilis
Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody Test
This study aims to validate the percent agreement of the INSTI Multiplex Human Immunodeficiency (HIV) 1/2 syphilis antibody (Ab) test (INSTI POCT) when used as a self-test by patients compared to conventional serologic testing.
- Trial name
- NCT06953024
- Testing
- INSTI HIV/syphilis Point of Care Self-Test Administration
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
HIV Infections, Sexually Transmitted Diseases
Trial of Male Circumcision: HIV, Sexually Transmitted Disease (STD) and Behavioral Effects in Men, Women and the Community
This randomized controlled trial conducted in Rakai District, Uganda, has enrolled 997 HIV positive men and 500 men who declined to learn HIV results (regardless of HIV status).
- Conditions
- HIV Infections, Sexually Transmitted Diseases, Papillomavirus Infections, Genital Herpes
- Trial name
- NCT00124878
- Testing
- Male circumcision
- Where
- Uganda
- Volunteers
- 5,200 people, healthy volunteers welcome
- Sponsor
- Wawer, Maria J., M.D.
Sarcoidosis, Tuberculosis
The Serum Angiotensin Converting Enzyme and Lysozyme Levels in Patients Non-infectious and Infectious Uveitis
This study evaluates the significance of differences in serum angiotensin converting enzyme and lysozyme levels of patients with ocular involvement of other autoimmune inflammatory and infectious diseases.
- Trial name
- uveitis (NCT02627209)
- Testing
- spectrophotometric assay, radial immunodiffusion
- Where
- Turkey (Türkiye)
- Volunteers
- 280 people
- Sponsor
- Ozlem Sahin
HIV Infections, Herpesvirus 2, Human
Male Circumcision for HIV Prevention in Rakai, Uganda
Circumcision in HIV unifected men may reduce the likelihood of becoming infected with HIV, reduce sexually transmitted infections (STIs) in men, not engender increases in sexual risk behaviors, and be acceptable to men as a…
- Conditions
- HIV Infections, Herpesvirus 2, Human, Syphilis, Genital Diseases, Male
- Trial name
- NCT00425984
- Testing
- Adult male circumcision
- Where
- Uganda
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Syphilis Infection, Gonorrhea
The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing STIs Among MSM in Bangkok, Thailand.
The objective of this research is to evaluate the efficacy and safety of doxycycline in MSM for preventing sexually transmitted infections (gonorrhea, chlamydia, and syphilis) in Thailand Participation in this study will last…
- Conditions
- Syphilis Infection, Gonorrhea, Chlamydia
- Trial name
- ThaiDoxyPEP (NCT07397403)
- Testing
- Doxycycline (200mg/day)
- Where
- Thailand
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Bangrak STIs Center
Syphilis, Congenital
Comprehensive Ambulatory Antibiotics for the Treatment of Congenital Syphilis
CARES-1 is a randomised, open-label, phase II pharmacokinetic (PK) and safety study of ambulatory antibiotics for the treatment of neonates with "all-risk" asymptomatic congenital syphilis.
- Trial name
- Cares-1 (NCT06921213)
- Testing
- Linezolid (LZD), Amoxicillin, Benzathine Penicillin G
- Where
- 3 sites in Indonesia, Malawi and 1 more
- Volunteers
- 90 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Syphilis, Congenital
Congenital Syphilis Prospective Cohort With Retrospective Evaluation
Syphilis is an infectious disease caused by Treponema pallidum. In children, there are two different forms of this disease; acquired syphilis and congenital syphilis, which results from transplacental transmission of spirochetes.
- Trial name
- NCT04137601
- Where
- Argentina
- Volunteers
- 62 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Syphilis, HIV
Introduction Study of Dual HIV & Syphilis Rapid Diagnostic Tests in Antenatal Clinics in Colombia
Global and regional initiatives have been launched for the dual elimination of mother-to-child transmission (MTCT) of HIV and syphilis.
- Trial name
- NCT02454816
- Testing
- Single HIV RDT and single syphilis RDT, Dual HIV/syphilis RDT
- Where
- Colombia
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidad Nacional de Colombia
Point-of-Care Testing, HIV
Ayaangwaamiziwin Initiative: Carefulness and Preparedness
The goal of this clinical trial is to implement a test, treat, and connect intervention approach using HIV and syphilis rapid point-of-care (POC) testing in 3 Canadian Prairie provinces (Alberta, Manitoba, and Saskatchewan)…
- Conditions
- Point-of-Care Testing, HIV, Syphilis
- Trial name
- AI (NCT06893159)
- Testing
- INSTI HIV-1/2 Antibody Test, INSTI Multiplex HIV-1/2 Syphilis Antibody Test, Multiplo Complete Syphilis (TP/nTP) Antibody Test
- Where
- 8 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Syphilis, Treponema Pallidum
A Cross-sectional Investigational Study to Evaluate the Sensitivity, Specificity, and Utility of the MedMira Inc. Multiplo® Complete Syphilis (TP/nTP) Antibody Test (POCT) to Diagnose Infectious Syphilis in Participants Attending the Sexual Health Clinic in Ottawa, Ontario.
Due to the recent resurgence of infectious syphilis in Canada and the changing epidemiology of the disease to involve heterosexuals and females of child bearing age leading to a record number of congenital syphilis cases and…
- Trial name
- NCT06586905
- Testing
- Medical Device
- Where
- Canada
- Volunteers
- 1,300 people, healthy volunteers welcome
- Sponsor
- MedMira Laboratories Inc.
Chagas Disease, Syphilis
Implementation Strategy of Bio-molecular Techniques for Early Diagnose of Congenital Syphilis and Chagas Diseases
Chagas disease and syphilis are considered a mayor public health problem worldwide. Both pathologies affect socio-economic vulnerable population and they are both transmitted congenitally, causing an alarming increasing number of…
- Trial name
- NCT04084379
- Where
- Argentina
- Volunteers
- 560 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Congenital Syphilis
Preventing Congenital Syphilis
Nearly 1.5 million pregnant women are infected with syphilis each year, and it is estimated that half of them will have adverse birth outcomes.
- Trial name
- PCS (NCT02353117)
- Testing
- Congenital Syphilis Intervention Group
- Where
- 4 sites in United States, Argentina and 2 more
- Volunteers
- 60,386 people, healthy volunteers welcome
- Sponsor
- Tulane University School of Public Health and Tropical Medicine
Syphilis, Congenital
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates
The Investigator hypothesize that the treatment efficacy will be similar in both study arms. Secondary outcomes and endpoints will characterize safety by comparing adverse events (AEs), tolerability, and adherence to therapy in…
- Trial name
- NCT07457385
- Testing
- Benzathine Penicillin, Amoxicillin
- Where
- 11 sites in United States
- Volunteers
- 374 people
- Sponsor
- University of Alabama at Birmingham
Syphilis
Linezolid for Syphilis Pilot Study
The study aims to evaluate the efficacy of linezolid for the treatment of syphilis.
- Trial name
- NCT05548426
- Testing
- Group B, Linezolid 10d, Group A, Penicillin
- Where
- 5 sites in United States
- Volunteers
- 24 people
- Sponsor
- University of Southern California
Syphilis
Modernizing Perinatal Syphilis Testing
The purpose of this study is to determine the testing performance of real-time quantitative polymerase chain reaction and transcription mediated amplification by comparing test performance of these novel molecular tests to…
- Trial name
- NCT06082453
- Testing
- Quantitative polymerase chain reaction (qPCR) assay for detection of Treponema pallidum, Aptima Treponema pallidum transcription-mediated amplification (TMA) assay for detection of Treponema pallidum, Center for Disease Control (CDC) Sexually Transmitted Infections (STI) 2021 Treatment Guidelines for diagnosis of syphilis
- Where
- 9 sites in United States
- Volunteers
- 924 people
- Sponsor
- The University of Texas Health Science Center, Houston
Chlamydia Infections, Gonorrhea
Extraordinarily Fun Training Project in Compulsory Secondary Education - Sexually Transmitted Infections
Project FEDE-ITS will improve the STI knowledge and its treatment, of adolescents in the 1st and 2nd year of compulsory secondary education in the intervention group compared to compared to the control group, and will modify the…
- Conditions
- Chlamydia Infections, Gonorrhea, Syphilis Infection, Human Immunodeficiency Virus (HIV)
- Trial name
- FEDE-ITS (NCT05727033)
- Testing
- Participatory teaching group
- Where
- 4 sites in Spain
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina