Clinical trials: Systemic Inflammation
Fungemia
Prospective Population Study on Candidemia in Spain
The aim of this study is to describe the epidemiology of fungal blood infections in Spain (with emphasis on the incidence, fungal species distribution and antifungal susceptibility).
- Trial name
- CANDIPOP (NCT01236261)
- Testing
- Non intervention
- Where
- 29 sites in Spain
- Volunteers
- 730 people
- Sponsor
- Fundacion SEIMC-GESIDA
Meningitis, Bacteremia
THiamine for Recovery In Vulnerable Early-life Infections
To determine if the addition of thiamine to standard-of-care treatment will improve neurodevelopmental outcomes for infants with meningitis or bacteremia
- Trial name
- THRIVE (NCT07868679)
- Testing
- thiamine hydrochloride 100 mg
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- Milton S. Hershey Medical Center
Sepsis
Vitamin A Status in Critically Ill Children With Sepsis and Its Association With Illness Severity
The primary purpose of this study is to assess the status of vitamin A in critically ill children with sepsis and its association with the ill severity.
- Trial name
- NCT03598127
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Malaria, Sepsis
Optimal Fluid Management in Adult Severe Malaria
Optimal fluid therapy in severe falciparum malaria has not been well defined, especially in resource poor settings where access to mechanical ventilation is limited.
- Trial name
- DRIPICCO (NCT01936766)
- Where
- Bangladesh
- Volunteers
- 156 people
- Sponsor
- University of Oxford
Sepsis
Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis
Neonatal bacterial sepsis is a major cause of mortality and morbidity and early antibiotic therapy is crucial for treatment success.
- Trial name
- NCT00926497
- Testing
- Procalcitonin-guided decision making
- Where
- Switzerland
- Volunteers
- 121 people
- Sponsor
- Luzerner Kantonsspital
Intraventricular Hemorrhage, Sepsis
Placental Transfusion Project for Preterm Infants
The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants.
- Conditions
- Intraventricular Hemorrhage, Sepsis, Necrotizing Enterocolitis
- Trial name
- NCT02400697
- Testing
- <30 wks gestation or 1500 grams
- Where
- United States
- Volunteers
- 2,856 people
- Sponsor
- Indiana University
Critically Ill Patients
Clearance of Vasoactive Metabolites With Blood Purification
Extracorporeal blood purification is a supportive therapy in the management of patients with sepsis or vasoplegic shock. The pathophysiology of sepsis is based on an inappropriate host response to infection.
- Trial name
- VITAL (NCT06109142)
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neonatal Sepsis
Neurodevelopmental Outcomes After Suspected or Proven Sepsis: Secondary Analysis of INIS Trial Database
Neonatal sepsis is an important determinant of adverse neurodevelopmental outcome. The investigators seek to investigate whether neurodevelopmental outcome following neonatal sepsis differs according to whether or not the…
- Trial name
- NCT02281890
- Testing
- Proven sepsis
- Volunteers
- 3,493 people
- Sponsor
- University of Edinburgh
Hypoxemia, Neonatal Disease
Evaluation of a Multi-country Medical Oxygen Program
REAL-MOXY is a set of 5 mixed methods studies designed to understand how oxygen and pulse oximetry are used (or not used) at a facility level, to identify opportunities and barriers for strengthening oxygen systems for…
- Conditions
- Hypoxemia, Neonatal Disease, Pneumonia, Sepsis
- Trial name
- REAL-MOXY (NCT06087315)
- Testing
- Multi-faceted oxygen systems strengthening interventions (different for each country)
- Where
- 3 sites in Cambodia, Nigeria and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Murdoch Childrens Research Institute
Pneumonia, Diarrhea
Impact of Daily Zinc Supplementation to Infants Born With Low Birth Weight on Death and Severe Disease
Title: Impact of daily zinc supplementation to infants born with low birth weight on mortality and severe disease requiring hospitalization Background: Zinc supplementation was shown to prevent diarrhea and pneumonia in 6 month…
- Conditions
- Pneumonia, Diarrhea, Meningitis, Sepsis
- Trial name
- NCT00495690
- Testing
- Oral zinc gluconate (5 mg elemental)
- Where
- India
- Volunteers
- 2,012 people
- Sponsor
- Society for Applied Studies
Sepsis
Construction of a Database for the Life-cycle Sepsis-specific Disease Cohort
Establish a structured clinical database for sepsis screening, and establish a special data set standard for sepsis throughout the life cycle.
- Trial name
- NCT04872010
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Neonatal SEPSIS
Safety and Efficacy of Oral Bovine Lactoferrin
Oral lactoferrin versus Placebo will be given to preterm neonates
- Trial name
- Lactoferrin (NCT04094597)
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sepsis
Simplified Antibiotic Regimens for Outpatient Treatment of Suspected Sepsis in Neonates and Young Infants in Bangladesh
The primary aim is to establish the non-inferiority of several simplified, home-based antibiotic regimens compared to the standard course of parenteral antibiotics for the empiric treatment of suspected sepsis in Bangladeshi…
- Trial name
- NCT00844337
- Testing
- Gentamicin & Amoxicillin x 7days, Penicillin & gentamicin x 2 d + Amoxicillin X 5 d, Standard reference therapy
- Where
- 3 sites in Bangladesh
- Volunteers
- 2,490 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Critical Illness, Sepsis
MICU Recovery Clinic
Summary: Emerging data demonstrate long-term morbidity and mortality in those who survive critical illness. However, there is no data regarding long-term follow-up for ICU survivors.
- Conditions
- Critical Illness, Sepsis, Respiratory Failure, ARDS
- Trial name
- NCT02560129
- Testing
- Questionnaires, Physical and Cognitive Function
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Wake Forest University Health Sciences
Sepsis
Long-term Quality of Life Among Survivors of Sepsis in China Assessed by EQ-5D
Sepsis is a common critical illness in Intensive Care Unit (ICU). With the continuous progress of severe medicine, the mortality rate of ICU hospitalization for sepsis has decreased, but the long-term prognosis is not satisfied.
- Trial name
- NCT04033653
- Where
- China
- Volunteers
- 1,368 people
- Sponsor
- Jianfeng Xie
Septic Shock
Lung Ultrasound-guided Fluid Resuscitation in Neonatal Septic Shock
object name: Lung ultrasound-guided fluid resuscitation in neonatal septic shock. type of study: prospective observational study.
- Trial name
- LUGFRINSS (NCT06144463)
- Testing
- lung ultrasound-guided fluid resuscitation
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Guangdong Second Provincial General Hospital
Breast Neoplasms, Fever
A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer
This is a prospective, randomized Phase III trial of FLAC chemotherapy with GM-CSF versus PIXY321 in advanced breast cancer. The primary endpoints of this study will be the duration of thrombocytopenia and the time to recovery of…
- Conditions
- Breast Neoplasms, Fever, Hematologic Diseases, Neutropenia
- Trial name
- NCT00001338
- Testing
- FLAC chemotherapy with GM-CSF
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Cancer Institute (NCI)
Critical Illness, Sepsis
Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients
Introduction- Hospital acquired infections (HAI) are a major cause of morbidity and mortality and increase health care costs. Critically ill patients are particularly susceptible to these infections and have an even higher…
- Conditions
- Critical Illness, Sepsis, Septic Shock, Ventilator Associated Pneumonia
- Trial name
- SuDDICU (NCT02389036)
- Testing
- SDD Oral Paste, SDD Gastric Suspension, Intravenous Antibiotic
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 20,010 people
- Sponsor
- The George Institute
Sepsis, Critical Illness
PF-Organized Corticosteroid-Associated Heterogeneity in Sepsis
This retrospective multicohort observational study evaluates whether the PaO2/FiO2 ratio (P/F ratio) organizes heterogeneity in the association between early systemic corticosteroid exposure and mortality among critically ill…
- Trial name
- NCT07913464
- Testing
- Systemic Corticosteroids
- Where
- China
- Volunteers
- 2,693 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Leukemia, Chronic Leukemia
Fungemia in Hematologic Malignancies
The purpose of this study is to determine the risk factors for fungemia in a population of patients diagnosed with hematologic malignancies and eligible for chemotherapy.
- Conditions
- Acute Leukemia, Chronic Leukemia, Multiple Myeloma, Lymphoma
- Trial name
- NCT02451592
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Sorveglianza Epidemiologica Infezioni Fungine Emopatie Maligne