Clinical trials: Systemic Inflammation
Hemolytic Disease of Newborn, Anemia of Neonates
Risk Factors and Clinical Outcomes of Neonatal Anemia in NICU
Risk Factors, and Clinical Outcomes of Neonatal Anemia in the NICU of a Tertiary Care Hospital
- Conditions
- Hemolytic Disease of Newborn, Anemia of Neonates, Sepsis
- Trial name
- NCT07188298
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Assiut University
Feeding Intolerance, Necrotizing Enterocolitis
Bovine Colostrum as a Human Milk Fortifier for Preterm Infants
Very preterm infants (<32 weeks gestation) show the immaturity of organs and have high nutrient requirements for growth and development.
- Conditions
- Feeding Intolerance, Necrotizing Enterocolitis, Postnatal Growth, Late-Onset Neonatal Sepsis
- Trial name
- FortiColos-Ⅱ (NCT03822104)
- Testing
- Bovine Colostrum, FM85
- Where
- 2 sites in China
- Volunteers
- 139 people
- Sponsor
- Per Torp Sangild
Sepsis, Severe Sepsis With Septic Shock
Wearable Sweat Sensor for High-Concentration Lactate Monitoring in Critically Ill Patients
Blood lactate level is closely associated with the prognosis of patients with sepsis and septic shock. Clinical guidelines explicitly recommend blood lactate monitoring in septic patients and lactate-guided fluid resuscitation…
- Conditions
- Sepsis, Severe Sepsis With Septic Shock, Severe Sepsis Without Septic Shock
- Trial name
- NCT07716371
- Testing
- High-Concentration Sweat Lactate Wearable Monitoring Device, Commercial Sweat Collection Device (HELA)
- Volunteers
- 86 people
- Sponsor
- Second Affiliated Hospital of Xi'an Jiaotong University
Obstetric and Perinatal Complications, Postpartum Hemorrhage
A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka
To evaluate the effectiveness of a First Referral Unit (FRU) Emergency Obstetric and Newborn Care (EmONC) skills and drills intervention, to estimate the appropriateness and effectiveness of referrals in intervention arm compared…
- Conditions
- Obstetric and Perinatal Complications, Postpartum Hemorrhage, Preeclampsia/Eclampsia, Obstructed/Prolonged Labor
- Trial name
- NCT01865656
- Testing
- Skills training, Emergency obstetric drills, Revised Case Sheets
- Volunteers
- 15,018 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Neonatal Sepsis
Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis
The present study was designed to evaluate the effectiveness of oral lactoferrin in prevention of neonatal sepsis with comparison early (1st day) versus late (48-72 hours) Lactoferrin administration, Secondary aim was to study…
- Trial name
- NCT02959229
- Testing
- Lactoferrin
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pancreatitis
Management of Pancreatitis: the Role of Supportive and Drainage Treatment
This study aims to investigate the natural clinical course, diagnostic possibilities and treatment modalities in moderately severe (MSAP) and severe acute pancreatitis (SAP).
- Trial name
- NCT02648815
- Testing
- Percutaneous catheter drainage, Abdominal paracentesis evacuation
- Volunteers
- 100 people
- Sponsor
- University Clinical Center Tuzla
Pulmonary Disease, Electrolyte Disorder
Comparison of Success Rates of Femoral Artery Catheterization
The use of USI has eased practical application of interventional procedures, and reduced complications and procedure durations. For vascular interventions with ultrasound imaging, short- or long-section imaging of vascular…
- Conditions
- Pulmonary Disease, Electrolyte Disorder, Metabolic Disease, Sepsis
- Trial name
- NCT02986542
- Testing
- Femoral artery catheterization
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Kahramanmaras Sutcu Imam University
COVID-19
Expanded Access Program of Ruxolitinib for the Emergency Treatment of Cytokine Storm From COVID-19 Infection
To provide ruxolitinib through an expanded access program for the treatment of cytokine storm due to COVID-19 in the United States to patients who are eligible but not able to be hospitalized or who are hospitalized with a…
- Trial name
- NCT04355793
- Testing
- Ruxolitinib
- Sponsor
- Incyte Corporation
Severe Sepsis
Characterization of Non-canonical Way in Inflammasome Monocytes of Patients With Severe Sepsis
Activation of caspase-4 and human caspase-5 (orthologs of caspase-11 in mice) in innate immune cells.
- Trial name
- CASPASEs (NCT02539147)
- Testing
- blood samples
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Catecholamine-resistant Hypotension (CRH), Distributive Shock
A Study of LJPC-501 in Pediatric Patients With Hypotension
The objective of this study is to evaluate the effect of LJPC-501 infusion on mean arterial pressure (MAP) or reduction in sum norepinephrine (NE) equivalent dosing, at Hour 2 after the start of LJPC-501, in pediatric patients…
- Conditions
- Catecholamine-resistant Hypotension (CRH), Distributive Shock, High Output Shock, Sepsis
- Trial name
- NCT03431077
- Testing
- Angiotensin II
- Where
- 3 sites in United States
- Volunteers
- 2 people
- Sponsor
- La Jolla Pharmaceutical Company
Cytokine Release Syndrome
A Study of Itacitinib for the Prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy
"The purpose of this study is to assess the safety and efficacy of oral administration of itacitinib for the prevention of cytokine release syndrome (CRS) in male or female participants aged 12 years or older and who are planning…
- Trial name
- NCT04071366
- Testing
- Itacitinib, Immune effector cell therapy, Yescarta
- Where
- 10 sites in United States
- Volunteers
- 112 people
- Sponsor
- Incyte Corporation
Sepsis, Premature Birth
Predictors of Sepsis in Ex-Preterm Infants
The aims of this study are to: Assess whether ex-preterm infants have a persistently immature immune system, which may decrease their ability to respond to infections, when they reach term-corrected gestational age.
- Trial name
- NCT03433846
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Severe Sepsis
Pro-inflammatory Cytokines Profile and Mortality Rate of Critically Ill Septic Patients Following Plasmapheresis
Sepsis is one of the most prevalent and fatal diseases in intensive care units .unfortunately, therapeutic approach to sepsis has remained unchanged for many years.
- Trial name
- NCT01249222
- Testing
- plasmapheresis
- Where
- Iran
- Volunteers
- 27 people
- Sponsor
- Tehran University of Medical Sciences
Bacteremia, Antimicrobial Stewardship
Knowledge Attitude and Practice Regarding Bloodstream Bacterial Infections and Antibiotics Usage Among Doctors.
This study is designed to use a questionnaire to assess doctors' knowledge, attitudes, and practices regarding bloodstream bacterial infections and antibiotic use in Tawam and Al Ain tertiary Hospitals (both hospitals have the…
- Conditions
- Bacteremia, Antimicrobial Stewardship, Antibiotic Use, Antibiotic Abuse
- Trial name
- NCT06605677
- Testing
- Questionnaire
- Where
- United Arab Emirates
- Volunteers
- 100 people
- Sponsor
- Abu Dhabi Health Services Company
Sepsis, Blood Purification
Blood Purification in Septic Children
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality.
- Trial name
- NCT05595239
- Testing
- blood purification(CVVH), blood purification(TPE+CVVH), blood purification(HP+CVVH)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Sepsis, Urinary Tract Infections
A Study of Enterorenal Syndrome Assessed by Gastrointestinal Ultrasound Combined with Renal Artery Resistance Index
In this study, the patients with sepsis caused by abdominal infection were divided into survival group and death group by ultrasound examination of gastrointestinal function, superior mesenteric artery blood flow, and renal…
- Trial name
- NCT06505512
- Testing
- No intervention
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Zhangzhou Municipal Hospital
Severe Sepsis
Clinical Assessment of Fish Oil-based Lipid Emulsion Infusions in Critical Patients With Severe Sepsis
The purpose of this study is to determine whether a fish oil-based lipid emulsion, enriched with ω-3 fatty acids, reduce proinflammatory cytokines and mortality rate in critically ill patients with severe sepsis.
- Trial name
- NCT00634075
- Testing
- omega-3-fatty acids (Omegaven)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Li Shin Hospital
Systemic Inflammatory Response Syndrome (SIRS), Sepsis
Genotypes and Phenotypes in Pediatric SIRS and Sepsis
The aim of this investigation is to longitudinally quantify host gene expression and serum proteins in children with infectious and non-infectious SIRS.
- Trial name
- GAPPSS (NCT02728401)
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Seattle Children's Hospital
Acute Respiratory Distress Syndrome (ARDS)
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial
Acute respiratory distress syndrome (ARDS) is a major cause of acute hypoxemic respiratory failure in critically ill patients and is associated with substantial mortality.
- Trial name
- DEFEND (NCT07576660)
- Testing
- Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 1,704 people
- Sponsor
- Southeast University, China
Nosocomial Infections, Bloodstream Infection
Surveillance for Nosocomial Infections in Pediatric Cancer Patients
The Oncoped 2006 study implements a multicenter prospective surveillance module for nosocomial infections in pediatric cancer patients.
- Conditions
- Nosocomial Infections, Bloodstream Infection, Invasive Aspergillosis
- Trial name
- Oncoped2006 (NCT00843804)
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bonn