Clinical trials: Systemic Inflammation
Sepsis
Neonatal Sepsis Diagnosis: ; PCR Commercial Technique and Blood Culture
Although advances in neonatal care have improved survival and reduced complications in preterm infants, sepsis still contributes significantly to mortality and in Neonatal Intensive Care Units (NICUs), in particular for…
- Trial name
- NCT03884894
- Testing
- molecular assay, Blood culture
- Where
- Italy
- Volunteers
- 69 people
- Sponsor
- Francesca Garofoli
Meningococcal Infections, Septic Shock
Septic cArdiac Deficiency and MenIngococcal seveRe Sepsis
Use of brain natriuretic peptide to evaluate the cardiac function in the course of meningococcal septic shock or severe sepsis.
- Conditions
- Meningococcal Infections, Septic Shock, Severe Sepsis
- Trial name
- SAMIRA (NCT02041663)
- Testing
- BNP
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Neonatal Sepsis, Evaluation, Bangladesh
More than half of under-five deaths in Bangladesh occur in the first month of life (neonatal period), and a substantial proportion of these deaths are due to infections (sepsis).
- Trial name
- NCT01333982
- Testing
- Amoxycillin, Gentamicin, Counselling
- Where
- Bangladesh
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Severe Respiratory Failure, Acute Respiratory Distress Syndrome
Large Observational Study to UNderstand the Global Impact of Severe Acute Respiratory FailurE
We wish to prospectively assess the burden of, management and therapeutic approaches to, and outcomes from acute hypoxaemic respiratory failure requiring ventilatory support, during the winter months in both the northern and…
- Trial name
- LUNG-SAFE (NCT02010073)
- Where
- Belgium
- Volunteers
- 14,000 people
- Sponsor
- European Society of Intensive Care Medicine
Sepsis, Procalcitonin
Impact of a Procalcitonin Testing and Treatment Algorithm on Antibiotic Use and Outcomes in the Pediatric Intensive Care Unit
The timely use of antibiotics can reduce morbidity and mortality associated with bacterial infections, particularly in the intensive care unit setting (ICU).
- Conditions
- Sepsis, Procalcitonin, Antimicrobial Stewardship
- Trial name
- ProPICU (NCT03440918)
- Testing
- Procalcitonin-Guided Antimicrobial Stewardship, Baseline Antimicrobial Stewardship
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- Vanderbilt University Medical Center
Sepsis
Validation of Early Warning Score & Lactate in Prehospital Screening
Sepsis claims over 37,000 lives in the United Kingdom each year- more than lung cancer, and more than breast cancer, bowel cancer and HIV/AIDS combined. Less than two-thirds of patients who develop sepsis will survive.
- Trial name
- VELPS (NCT02189096)
- Testing
- NEWS and Sepsis Screening, Point of care lactate measurement
- Volunteers
- 705 people
- Sponsor
- University of the West of Scotland
Neonatal SEPSIS
Epidemiology of Neonatal Sepsis in Neonatal Intensive Care Unit in Assiut University Children Hospital
Neonatal sepsis is an important cause of morbidity and mortality in the pediatric age group . It is one of the leading causes of death in the first 28 days of life both in the developed and developing countries.
- Trial name
- NCT03354650
- Testing
- blood culture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis, Cancer, Heart Attack, Heart Failure, Abdominal Surgery, Trauma, Diabetes, Lung Disease, Gynaecology, Fertility, Cardiac Surgery,
Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals
An adverse event (AE) is defined as unintended injury or complication, which results in disability, death or prolongation of hospital stay, and is caused by healthcare management (including omissions) rather than the patient's…
- Trial name
- NCT02044718
- Where
- Belgium
- Volunteers
- 878 people
- Sponsor
- Hasselt University
Neonatal Sepsis
Clinical Value of Metagenomic Sequencing in Neonatal Sepsis
This study aimed to enroll 2000 neonatal patients with suspected sepsis or clinical diagnosed sepsis. These patients will undergo both conventional methods and metagenomics sequencing to detect the pathogenic microorganisms of…
- Trial name
- NCT05416918
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Children's Hospital of Fudan University
Infectious Disease, Fever
Validation of a Proteomic Signature and Assessment of Viremia in Children With Fever Without Source
The study is an observational blinded Validation study in pediatric patients below 3 years old with a diagnosis of Fever Without Source (FWS).
- Conditions
- Infectious Disease, Fever, Viremia
- Trial name
- NCT03224026
- Where
- Switzerland
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- MeMed Diagnostics Ltd.
Immune and Microbial Reconstitution, Systemic Viral Infection
Monitoring of Immune and Microbial Reconstitution in (HCT) and Novel Immunotherapies
This protocol serves as a mechanism to collect, store, and distribute bodily fluid and tissue samples obtained from Hematopoietic Cell Transplant (HCT) or novel immunotherapy patients and their donors at the Masonic Cancer Center…
- Conditions
- Immune and Microbial Reconstitution, Systemic Viral Infection, Acute-graft-versus-host Disease, Chronic Graft-versus-host-disease
- Trial name
- NCT03557749
- Testing
- Blood Sample, Stool Sample, Urine Sample
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Septic Shock
Effects of Continuous Haemofiltration vs Intermittent Haemodialysis on Microcirculatory Parameters in Septic Shock
The aim of the study was to investigate whether CVVH, in comparison to intermittent haemodialysis (IHD), is able to improve regional perfusion in septic shock patients studied by muscle microdialysis
- Trial name
- NCT02962700
- Testing
- muscle microdialysis
- Where
- Tunisia
- Volunteers
- 100 people
- Sponsor
- Military Hospital of Tunis
Septic Shock, Acute Respiratory Distress Syndrome
CytOSorb TreatMent Of Critically Ill PatientS Registry
Registry intended to provide a data repository and reporting infrastructure for the surveillance of CytoSorb device use in real-world critical care settings, and to serve as an objective, comprehensive, and scientifically-based…
- Conditions
- Septic Shock, Acute Respiratory Distress Syndrome, Trauma, Rhabdomyolysis
- Trial name
- COSMOS (NCT05146336)
- Testing
- CytoSorb
- Where
- 28 sites in Austria, Germany and 4 more
- Volunteers
- 3,000 people
- Sponsor
- CytoSorbents, Inc
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences
Vitamin A Deficiency, Vitamin D Deficiency
Effects of Fat-soluble Vitamins Supplementation on Common Complications and Neural Development in Very Low Birth Weight Infants
Vitamins A, D, and E play important roles in humans, such as vision function, immune function, bone metabolism, cell growth and differentiation and oxidation resistance.
- Conditions
- Vitamin A Deficiency, Vitamin D Deficiency, Vitamin E Deficiency, Very Low Birth Weight Infants
- Trial name
- NCT03876704
- Testing
- High dose of fat-Soluble Vitamin, Conventional dose of fat-Soluble Vitamin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Acute Lymphoblastic Leukemia, Bloodstream Infection
The Role of NK Cells to Detect Blood Infection in ALL.
1. Assess possibility of prediction of blood stream infections in ALL patients by profiling of NK cells using flow cytometry. 2. Assess the role of NK cells in development of drug resistance post chemotherapy.
- Trial name
- NCT06160115
- Testing
- Flow cytometry
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Assiut University
Meningitis, Meningococcal, Meningococcal Sepsis
Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.
A fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. A fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease.
- Conditions
- Meningitis, Meningococcal, Meningococcal Sepsis, Meningococcal Disease, Meningococcal Infections
- Trial name
- PIC (NCT03378258)
- Where
- United Kingdom
- Volunteers
- 1,329 people
- Sponsor
- Belfast Health and Social Care Trust
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Adenovirus, Anesthesia
Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care
Understudied drugs will be administered to children per standard of care as prescribed by their treating caregiver and only biological sample collection during the time of drug administration will be involved.
- Conditions
- Adenovirus, Anesthesia, Anxiety, Anxiolysis
- Trial name
- PTN_POPS (NCT01431326)
- Testing
- The POPS study is collecting PK data on children prescribed the following drugs of interest per standard of care:
- Where
- 52 sites in United States, Canada and 3 more
- Volunteers
- 3,520 people
- Sponsor
- Daniel Benjamin
Sepsis, Septic Shock
Immune Failure in Critical Therapy (INFECT) Study
Patients admitted to intensive care units (ICU) are at high risk of developing secondary infections, and this is in part due to dysfunction or failure of their 'germ killing' functions (the immune system).
- Trial name
- INFECT (NCT02186522)
- Where
- 4 sites in United Kingdom
- Volunteers
- 168 people
- Sponsor
- University of Edinburgh