Clinical trials: Systemic Inflammation
Sepsis, Septic Shock
Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock
Patients with severe infection can develop very low blood pressure. There are many mechanisms leading to this, and one of them appears to involve a hormone called vasopressin.
- Trial name
- VaCoSS (NCT00698048)
- Where
- Singapore
- Volunteers
- 136 people
- Sponsor
- Jan Hau Lee
Artificial Intelligence, Septic Shock
Artificial Intelligence for Sepsis Prediction in ICU
The development of sepsis prediction model in line with Chinese population, and extended to clinical, assist clinicians for early identification, early intervention, has a good application prospect.
- Conditions
- Artificial Intelligence, Septic Shock, Intensive Care Unit Psychosis
- Trial name
- AICUSepsis (NCT04913181)
- Testing
- Artificial intelligence sepsis prediction model
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Premature Birth, Late-onset Invasive Infection
Speed of Increasing Milk Feeds Trial
Survival of preterm infants has increased greatly over the years, so a major aim now is to improve the long term outlook for these babies and to avoid serious complications.
- Conditions
- Premature Birth, Late-onset Invasive Infection, Necrotizing Enterocolitis
- Trial name
- SIFT (NCT01727609)
- Testing
- Milk feed (breast milk or formula milk)
- Where
- 57 sites in Ireland, United Kingdom
- Volunteers
- 2,804 people
- Sponsor
- University of Oxford
Maternal Sepsis, Neonatal Sepsis
Smart Discharges for Mom & Baby
This study aims to build a predictive algorithm that identifies mother-newborn dyads most at risk of death or complications in the 6 weeks after birth.
- Trial name
- NCT05730387
- Testing
- Observational only
- Where
- Canada
- Volunteers
- 7,182 people
- Sponsor
- University of British Columbia
Late Onset Neonatal Sepsis
Lactoferrin for Prevention of Sepsis in Infants
The investigators propose a clinical trial in premature infants to determine the effect of orally-administered bovine lactoferrin on occurrence of severe infections and to determine whether as a result of decreased infections…
- Trial name
- NEOLACTO (NCT01525316)
- Testing
- Bovine Lactoferrin, Maltodextrin
- Where
- 3 sites in Peru
- Volunteers
- 414 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Catheter-Related Infections, Central Venous Catheters
Advanced Dressings for CVC Infection Prevention in PICU
Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections…
- Conditions
- Catheter-Related Infections, Central Venous Catheters, Bloodstream Infection, Pediatric Intensive Care Units
- Trial name
- NCT07175116
- Testing
- 3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated), Conventional transparent polyurethane dressing
- Where
- Spain
- Volunteers
- 250 people
- Sponsor
- University of Seville
Sepsis, Systemic Inflammatory Response Syndrome
PPV to Guide Fluid Management in the PICU
Children who are critically ill often require large amounts of fluid during their acute illness. It has been shown in multiple studies that appropriate administration of fluid decreases morbidity and mortality, but giving too…
- Trial name
- PPV (NCT02308371)
- Testing
- Automated Pulse Pressure Variation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Bacterial Infections, Urinary Tract Infections
Host RNA Profiles to Detect Infections in Young Infants
This study seeks to identify and test host RNA expression profiles as markers for infections in young infants. Preliminary studies have shown high sensitivity and specificity for the discrimination of bacterial from non-bacterial…
- Conditions
- Bacterial Infections, Urinary Tract Infections, Sepsis, Fever
- Trial name
- CHILD_YIC (NCT04823026)
- Where
- 4 sites in Denmark
- Volunteers
- 152 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Febrile Illness Acute, Meningitis, Bacterial
Febrile Infants Swedish Study
Approximately one million febrile infants aged ≤60 days present annually to pediatric emergency departments (PEDs) in Europe and the United States.
- Conditions
- Febrile Illness Acute, Meningitis, Bacterial, Urinary Tract Infection (Diagnosis), Invasive Bacterial Infection
- Trial name
- FISS (NCT07134751)
- Where
- 11 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Sepsis, Children, Only
The Impact of Sepsis on Long-term Outcomes in Critical Ill Children With Sepsis
This study is conducted in critically ill children with sepsis with a five years follow-up. We aim to investigate the impact of sepsis on long-term outcomes including growth, neurodevelopment, survival rate, quality of life.
- Trial name
- NCT06323226
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Congenital Heart Disease in Children, Inflammatory Response
STeroids to REduce Systemic Inflammation After Infant Heart Surgery
This study's objective is to determine the pharmacokinetics (PK)/pharmacodynamics (PD), safety and efficacy of methylprednisolone in infants undergoing heart surgery with cardiopulmonary bypass.
- Trial name
- STRESS (NCT03229538)
- Testing
- Methylprednisolone, Isotonic saline
- Where
- 23 sites in United States
- Volunteers
- 1,263 people
- Sponsor
- Kevin Hill
Neonatal Sepsis, Neonatal Mortality
Prevention of Nosocomial Bacteremia Among Zambian Neonates
The purpose of this study is to estimate the burden of disease, identify risk factors associated with nosocomial bacteremia among neonates and assess the efficacy of low-cost measures targeted to known and suspected nosocomial…
- Trial name
- NCT02386592
- Testing
- Chlorhexidine gluconate (CHG), Hand hygiene (HH), Infection control training
- Where
- Zambia
- Volunteers
- 9,410 people
- Sponsor
- Boston University
Group B Streptococcus, Sepsis
Management of Infants Born to Group B Streptococcus Positive Mothers.
Intrapartum antibiotic prophylaxis has greatly decreased but not abolished early-onset neonatal sepsis caused by GBS. According to current recommendations, the evaluation of infants at risk for GBS sepsis should include a…
- Conditions
- Group B Streptococcus, Sepsis, Infant, Newborn
- Trial name
- NCT00716781
- Volunteers
- 16,394 people
- Sponsor
- IRCCS Burlo Garofolo
Sepsis, Prematurity
An Open Label Study to Describe the Pharmacokinetics of Cefazolin in Preterm Neonates
This is a phase I open label multi-dose study to investigative the pharmacokinetics and safety of cefazolin in infants <121 days of age and < 28 weeks gestation with suspected sepsis.
- Trial name
- NCT00850122
- Testing
- cefazolin
- Where
- Brazil
- Volunteers
- 9 people
- Sponsor
- Phillip Brian Smith
Sepsis
Registration of Sepsis Patients in the Emergency Department
1) Establish a clinical data database for sepsis patients in the Emergency Department of the First Hospital of Jilin University.
- Trial name
- RSP (NCT06068192)
- Testing
- no intervention
- Volunteers
- 500 people
- Sponsor
- The First Hospital of Jilin University
Sepsis
Pilot Study: Lactoferrin for Prevention of Neonatal Sepsis
We will test the hypothesis that bovine lactoferrin supplementation prevents serious infections in preterm infants. We will conduct a randomized placebo-controlled double blind study in 190 premature infants <2500 gm in 5…
- Trial name
- NEOLACTO (NCT01264536)
- Testing
- lactoferrin, Maltodextrin
- Where
- 3 sites in Peru
- Volunteers
- 190 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Infections Resistant to Multiple Drugs, Bacterial Infections
Multi-Drug Resistant Organism Network
This study is specifically designed to provide observational data which can be used to help in the design of future randomized clinical trials on both therapeutics and diagnostics for MDRO infections.
- Trial name
- MDRO Network (NCT03646227)
- Testing
- Standard of Care
- Where
- 4 sites in United States, Australia and 2 more
- Volunteers
- 6,496 people
- Sponsor
- Duke University
Hematologic Diseases, Sepsis
Benefit of SeptiFast Multiplex PCR in the Etiologic Diagnosis and Therapeutic Approach for Onco-hematology Patients Presenting Sepsis
A SpetiFast multiplex PCR kit has recently been placed on the market witch can evidence the DNA of 90% of micro-organisms (bacteria and fungus) implicated in sepsis.
- Trial name
- SEPTIFAST (NCT00561639)
- Where
- France
- Volunteers
- 76 people
- Sponsor
- University Hospital, Grenoble
Sepsis, Infection
Maternal and Neonatal Outcomes After Membrane Sweeping
This study aim to estimate maternal and neonatal outcomes after membrane sweeping in different group of patients.
- Trial name
- Stripping (NCT01828853)
- Where
- Israel
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization