Clinical trials: Systemic Inflammatory Response
Morality, Risk Factor, Sepsis
Mathematical Modeling and Risk Factor Analysis for Mortality of Sepsis
The purpose of this study was to investigate the risk factors for mortality of sepsis and to create mathematical models to predict the survival rate based on electronic health records that extracted from hospital information…
- Conditions
- Morality, Risk Factor, Sepsis, Predictive Model
- Trial name
- NCT03883061
- Testing
- regular medical treatment
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Shanghai Tongji Hospital, Tongji University School of Medicine
Septic Shock, Severe Sepsis
Echocardiography in Septic Shock
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction and volume status during resuscitation of patients with sepsis and septic shock and guide intravenous vasopressor and fluid therapy.
- Trial name
- NCT02135796
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Intermountain Health Care, Inc.
Neonatal Late Onset Sepsis
Pentoxifylline Dose Optimization in Neonatal Sepsis
Sepsis is a very important cause of death and morbidity in preterm infants. There are strong indications that preterm neonates with sepsis could benefit, next to antibiotics, from treatment with pentoxifylline (PTX).
- Trial name
- NCT04152980
- Testing
- Pentoxifylline
- Where
- 2 sites in Netherlands, Poland
- Volunteers
- 30 people
- Sponsor
- Erasmus Medical Center
Late Onset Neonatal Sepsis
Lactoferrin for Prevention of Sepsis in Infants
The investigators propose a clinical trial in premature infants to determine the effect of orally-administered bovine lactoferrin on occurrence of severe infections and to determine whether as a result of decreased infections…
- Trial name
- NEOLACTO (NCT01525316)
- Testing
- Bovine Lactoferrin, Maltodextrin
- Where
- 3 sites in Peru
- Volunteers
- 414 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Early-Onset Neonatal Sepsis, Antibiotic Side Effect
Individualized Duration of Antibiotic Treatment in Early Onset Infection in Newborns.
A nationwide multicenter open label randomized controlled non-inferiority trial, including 18 departments. The study aims to compare an individualized antibiotic treatment duration with standard seven days of antibiotic treatment…
- Trial name
- DurATi-n (NCT05329701)
- Testing
- Individualized treatment duration strategy
- Where
- Denmark
- Volunteers
- 488 people
- Sponsor
- Ulrikka Nygaard
Septic Shock, Thrombocytopenia
Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children
The purpose of this study is to learn how blood clotting substances respond in children with septic shock, low platelet counts, and multiple organ failure (MOF) treated at different institutions.
- Conditions
- Septic Shock, Thrombocytopenia, Multiple Organ Failure
- Trial name
- TAMOF (NCT00118664)
- Where
- 12 sites in United States
- Volunteers
- 86 people
- Sponsor
- Children's Healthcare of Atlanta
Drug Resistance, Bacterial
Epidemiology of Antimicrobial-use and Antimicrobial-resistant Infections in Four Hospitals in Thailand
The main goal of this retrospective observational study is to understand how stepping down antibiotic treatment (called antibiotic de-escalation) affects patients who receive it compared to those who don't after received a…
- Conditions
- Drug Resistance, Bacterial, Bacteremia
- Trial name
- NCT07082465
- Where
- 4 sites in Thailand
- Volunteers
- 108,000 people
- Sponsor
- University of Oxford
Late Onset Neonatal Sepsis, Necrotizing Enterocolitis
Effects of Oral Probiotic Supplementation on the Clinical Status of Very-low-birth-weight Preterm Neonates.
The purpose of this study was to evaluate the safety of a probiotic foodstuff and its influence on emergence and development of natural intestinal flora and the clinical status of premature very low birth weight neonates.
- Conditions
- Late Onset Neonatal Sepsis, Necrotizing Enterocolitis, Infant, Very Low Birth Weight
- Trial name
- NCT02073214
- Testing
- Probiotic
- Volunteers
- 182 people
- Sponsor
- IBSS Biomed S.A.
Feeding Behavior, Late-Onset Neonatal Sepsis
Effectiveness of Oral Immunotherapy Among Preterm Babies
The aim of the study is to assess the effectiveness of OIT with colostrum on the feeding behavior and Clinical Outcome of Late-onset sepsis and Necrotizing enterocolitis
- Trial name
- NCT03633500
- Testing
- Sterile water, Breastmilk
- Where
- Kuwait
- Volunteers
- 48 people
- Sponsor
- Al Adan Hospital Kuwait
Sepsis, Septic Shock
PCT Guided Stopping of Antibiotic Therapy in Children With Sepsis
The investigators' objective is to compare the risk of treatment failure* in children admitted to the pediatric intensive care unit (PICU) with sepsis and managed by procalcitonin guided therapy for stopping of antibiotics ('PCT…
- Conditions
- Sepsis, Septic Shock, Antibiotic Use, Procalcitonin
- Trial name
- NCT03388944
- Testing
- PCT group
- Where
- 2 sites in India
- Volunteers
- 561 people
- Sponsor
- All India Institute of Medical Sciences
Neonatal Sepsis, Low Birth Weight
Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
The purpose of this study is to examine if single skin cleansing with 0.25% chlorhexidine affects skin condition, temperature, and bacterial colonization in stable preterm (28-36 weeks gestational age) low birth weight (1001-2000…
- Trial name
- NCT00947518
- Testing
- Chlorhexidine, Normal saline
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Neural Tube Defects, Newborn Sepsis
Is Neutrophil to Lymphocyte Ratio a Prognostic Factor of Sepsis in Newborns With Operated Neural Tube Defects?
We aimed to investigate whether Neutrophil Lymphocyte Ratio is a Prognostic Factor of Sepsis in Newborns with operated Neural Tube Defects?
- Trial name
- NCT04135274
- Testing
- Neutrophil to lymphocyte ratio
- Volunteers
- 57 people
- Sponsor
- Tepecik Training and Research Hospital
Sepsis
Statin for Immunomudulation in Sepsis
The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients
- Trial name
- NCT00452608
- Testing
- amido pill, atorvastatina
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Sepsis
Zinc and Inflammation in Sepsis
The purpose of the proposed project is to investigate measures of zinc status in relation to oxidative stress and inflammation in patients with sepsis.
- Trial name
- NCT01328509
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- University of Aberdeen
Sepsis, Critical Illness
Optimizing Vancomycin Therapy in Children
The purpose of Opt Vanc is to evaluate the feasibility of Bayesian dose adaptation, based on a previously-developed population pharmacokinetic (PK) model and a single optimally timed PK sample, to predict vancomycin area under…
- Conditions
- Sepsis, Critical Illness, Infections, Drug Toxicity
- Trial name
- Opt Vanc (NCT05691309)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Children's Hospital of Philadelphia
Supraventricular Arrhythmia, Septic Shock
Propafenone Versus Amiodarone in Septic Shock
Arrhythmias accompany septic shock in increased rates than in other ICU cohorts and their presence and management are related to patient´s prognosis.
- Trial name
- PRASE (NCT03029169)
- Testing
- Propafenone i.v., Amiodarone i.v.
- Where
- 2 sites in Czechia
- Volunteers
- 210 people
- Sponsor
- Charles University, Czech Republic
Staphylococcus Aureus Bacteremia
Early Infectious Disease Consultations in Staphylococcus Aureus Bacteremia
The primary objective is to determine if early infectious disease (ID) consultation (defined as within 48 hours of a positive blood culture) will reduce mortality rates from Staphylococcus aureus bacteremia (SAB).
- Trial name
- NCT00622882
- Testing
- infectious disease specialist consultation
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- National University Hospital, Singapore
Sepsis, Newborn Sepsis
T6A Biomarker for Detection of Bacterial Infection in Newborn Infants
This bi-center study aims to assess the efficacy of a new biomarker, N6-threonylcarbamoyladenosine (t6A), for the early diagnosis of Early-Onset Sepsis (EOS) in newborns.
- Conditions
- Sepsis, Newborn Sepsis, Biomarker Discovery
- Trial name
- T6ASepsis (NCT07670624)
- Where
- 2 sites in Austria, Poland
- Volunteers
- 210 people
- Sponsor
- Salzburger Landeskliniken
Sepsis Newborn
The Effect of Melatonin as an Adjuvant Therapy for Preterm Neonates With Sepsis
The goal of this clinical trial is to assess the effect of melatonin on MDA serum, IL-6, IL-8 levels, ANC, and sepsis score in preterm neonates with sepsis.
- Trial name
- NCT06191523
- Testing
- Control Group, Treatment Group
- Where
- Indonesia
- Volunteers
- 42 people
- Sponsor
- Universitas Sebelas Maret
Septic Shock
Right Ventricular Dysfunction in Septic Shock Patients in ICU
Assesment of right ventricular dysfunction in septic shock patients in intensive care unit.
- Trial name
- Septicshock (NCT05193682)
- Volunteers
- 25 people
- Sponsor
- Shimaa Hammad Ahmed