Clinical trials: Systemic Inflammatory Response
Toxic Shock Syndrome
Efficacy of IntraVenous ImmunoGlobulins in Toxic Shock Syndromes: a Paediatric Pilot Study
Staphylococcus aureus and Streptococcus pyogenes produce many virulence factors. Some of them are responsible for severe infections in humans. Superantigen toxins synthesized by S. aureus or by S.
- Trial name
- IVIG (NCT02219165)
- Testing
- Intravenous human immunoglobulin, Albumin
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Critical Illness Sepsis, Severe
Treatment of IL-6 and Its Receptor Antagonists in Children's Severe Sepsis.
In severe infective patients who survive the initial inflammatory storm, the immune response often evolves toward a state of immunosuppression, which contributes to increased mortality and severe secondary hospital-acquired…
- Trial name
- NCT04850443
- Sponsor
- Children's Hospital of Fudan University
Blood Stream Infections, MRSA Infections
Testing Spread and Implementation of Novel Methicillin Resistant Staphylococcal Aureus (MRSA)-Reducing Practices
The purpose of this study is to implement strategies for improved efficiency and waste reduction ("Toyota Lean") and positive deviance, a social behavioral change process, utilizing frontline healthcare personnel to reduce…
- Trial name
- NCT01255943
- Testing
- healthcare staff processes for infection prevention
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- MaineHealth
Infection, Sepsis
A Study to Compare the Efficacy and Safety of Extended and Intermittent Infusion of Beta-lactams in Critically Ill Paediatric Patients
The goal of this clinical trial is to examine the success and safety of administering certain antibiotics (beta-lactams) given in a longer 3-hour infusion to children (0-17 years) who are critically ill and have severe infection.
- Conditions
- Infection, Sepsis, NICU, PICU
- Trial name
- PEBBLE (NCT07484633)
- Testing
- Extended infusion time of the following beta-lactam: meropenem, Short-term infusion time of the following beta-lactam: meropenem, Extended infusion time of the following beta-lactam: piperacillin/tazobactam
- Where
- 2 sites in Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Sepsis, Children, Only
The Impact of Sepsis on Long-term Outcomes in Critical Ill Children With Sepsis
This study is conducted in critically ill children with sepsis with a five years follow-up. We aim to investigate the impact of sepsis on long-term outcomes including growth, neurodevelopment, survival rate, quality of life.
- Trial name
- NCT06323226
- Where
- China
- Volunteers
- 300 people
- Sponsor
- West China Hospital
Meningitis, Meningococcal, Meningococcal Sepsis
Petechiae In Children (PIC) Study: Defining A Clinical Decision Rule for The Management Of Fever and Non-Blanching Rashes In Children Including The Role Of Point Of Care Testing For Procalcitonin & Neisseria Meningitidis DNA.
A fever and a non-blanching rash is a relatively common reason for a child to attend an emergency department. A fever and a non-blanching rash can be an early sign of a life-threatening infection known as meningococcal disease.
- Conditions
- Meningitis, Meningococcal, Meningococcal Sepsis, Meningococcal Disease, Meningococcal Infections
- Trial name
- PIC (NCT03378258)
- Where
- United Kingdom
- Volunteers
- 1,329 people
- Sponsor
- Belfast Health and Social Care Trust
Intraventricular Hemorrhage, Sepsis
Placental Transfusion Project for Preterm Infants
The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants.
- Conditions
- Intraventricular Hemorrhage, Sepsis, Necrotizing Enterocolitis
- Trial name
- NCT02400697
- Testing
- <30 wks gestation or 1500 grams
- Where
- United States
- Volunteers
- 2,856 people
- Sponsor
- Indiana University
Influenza, Human, Vaccination; Sepsis
Nudging for Vaccination : Efficacity and Acceptability Among Medical Students
Nudge is a set of methods aimed at helping people adopt a behavior by a gentle prompt, conscious or not. Classically, Nudges rely on heuristics and cognitive biases.
- Trial name
- NCT03768596
- Testing
- Nudge, vaccination form
- Where
- France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Adriaan Barbaroux
Systemic Inflammatory Response Syndrome
Conventional Ultrafiltration Versus Dilutional Ultrafiltration in Pediatric CPB Patients
The investigators will be comparing two different filtration methods on cardiopulmonary bypass for pediatric heart surgery patients.
- Trial name
- NCT07221630
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akron Children's Hospital
Sepsis
Dose Assessment of Melatonin in Sepsis Trial
DAMSEL 2 is a pilot Phase II study in patients with sepsis. Stage 1 will assess the pharmacokinetics of melatonin and its major metabolite after a single dose of 50 or 100mg exogenous melatonin in two small groups of patients…
- Trial name
- DAMSEL2 (NCT02319265)
- Testing
- Melatonin
- Where
- United Kingdom
- Sponsor
- University of Aberdeen
Pneumonia, Bacterial
Study Evaluating Streptococcus Pneumoniae Serotype Carriage Rate for Nasopharyngeal Carriage in Filipino Children
Evaluation of the carriage rate of Streptococcus pneumoniae in the nasopharynx of healthy children and the carriage rate and distribution of Streptococcus pneumoniae serotypes
- Trial name
- NCT00724828
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Preterm Membrane Rupture, Neonatal Sepsis
Comparison of the Effectiveness of Two Different Antibiotic Regimens of the Treatment of Pregnant Women With Preterm Rupture of Membranes
There is no consensus around the world on the treatment of preterm rupture of membranes, which is one of the important causes of early neonatal sepsis and one of the common causes of prematurity.
- Trial name
- NCT04528251
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Neonatal Sepsis
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital
- Trial name
- NCT06113653
- Testing
- Prospective study
- Volunteers
- 50 people
- Sponsor
- Assiut University
Necrotizing Enterocolitis, Sepsis
The Role of Lactobacillus Reuteri in Preventing Necrotizing Enterocolitis (NEC) in Pre-term Infants
The purpose of this study is to compare the effectiveness of L. Reuteri with placebo in prevention of NEC in children, as according to my knowledge, there is limited work is done nationally and internationally.
- Trial name
- NEC (NCT04541771)
- Testing
- Lactobacillus Reuteri DSM 17938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Hospital and Institute of Child Health, Multan
Sepsis
Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults
Trial design: Randomised controlled, two-arm, parallel, clinical trial to assess the efficacy and safety of sequential daily procalcitonin assessments to guide de-escalation of empirical antibiotic therapy in adult patients with…
- Trial name
- PROCALBAN (NCT05955612)
- Testing
- Procalcitonin measurement
- Where
- Bangladesh
- Volunteers
- 532 people
- Sponsor
- University of Oxford
Septic Shock, Multi Organ Failure
The Role of Blood Purification by Hemoadsorption as Adjunctive Treatment in Children With Septic Shock
Sepsis is a major healthcare problem and leading cause of death in the pediatric population. Despite advances in supportive care of critically ill patients, sepsis remains an important cause of death worldwide in children.
- Trial name
- NCT05401695
- Testing
- HA330 hemoadsorption technique
- Where
- Thailand
- Volunteers
- 10 people
- Sponsor
- Chulalongkorn University
Sepsis Newborn, Malaria
Immune Dysfunction in Newborn Sepsis
The aim of the project is to study neonatal immune dysfunction associated to the risk of newborn sepsis in a malaria endemic area in Benin.
- Conditions
- Sepsis Newborn, Malaria, Immune Responses
- Trial name
- RECIPAL (NCT03780712)
- Testing
- Non applicable
- Volunteers
- 585 people
- Sponsor
- BioMérieux
Sepsis, Blood Purification
Blood Purification in Septic Children
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality.
- Trial name
- NCT05595239
- Testing
- blood purification(CVVH), blood purification(TPE+CVVH), blood purification(HP+CVVH)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Children's Hospital of Fudan University
Late-Onset Neonatal Sepsis
Clinical Impact of Donor Milk Pasteurized by HTST Treatment in Preterm Infants
Randomized double-blind clinical trial to compare the incidence of microbiological proven late onset sepsis in extremely preterm infants (<1000 grams) that are supplemented with donor milk pasteurized by High Temperature Short…
- Trial name
- NCT04424667
- Testing
- donor milk
- Where
- 2 sites in Spain
- Volunteers
- 211 people
- Sponsor
- Carmen Rosa Pallas
Neonatal Sepsis
Using Machine Learning to Model Early-onset Neonatal Sepsis Risk in Uganda and Zimbabwe
The goal of this observational study is to develop a risk prediction model for early-onset neonatal sepsis in term and late preterm neonates in Uganda and Zimbabwe.
- Trial name
- NeoRisk (NCT06411405)
- Testing
- Maternal medical history
- Where
- 2 sites in Uganda, United Kingdom
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- St George's, University of London