Clinical trials: Systemic Inflammatory Response
Infective Endocarditis
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study
Introduction. Comprehensive data on infective endocarditis in developing countries are scarce. Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis…
- Trial name
- EndoDev (NCT02128139)
- Where
- 6 sites in Fiji, Laos and 3 more
- Volunteers
- 300 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bacteremia
Surveillance of AMR in DRC
This study addresses knowledge gaps regarding antimicrobial resistance (AMR) in sub-Saharan Africa, focusing on evaluating the feasibility of AMR surveillance and enhancing local research capacity.
- Trial name
- SARKIN (NCT06821282)
- Where
- Democratic Republic of the Congo
- Volunteers
- 210 people
- Sponsor
- University of Oxford
Shock, Septic, Sepsis
Balanced Salt Solution VS. Normal Saline Solution in Septic Shock
The Purpose of this study is to determine the impact of balanced salt solution versus chloride rich solution on clinical outcomes in paediatric severe sepsis or septic shock
- Trial name
- NCT02336620
- Testing
- Ringer acetate, Normal saline
- Where
- Thailand
- Volunteers
- 60 people
- Sponsor
- Ramathibodi Hospital
Neonatal Sepsis, Low Birth Weight
Safety of Skin Cleansing With Chlorhexidine in Preterm Low Birth Weight Infants
The purpose of this study is to examine if single skin cleansing with 0.25% chlorhexidine affects skin condition, temperature, and bacterial colonization in stable preterm (28-36 weeks gestational age) low birth weight (1001-2000…
- Trial name
- NCT00947518
- Testing
- Chlorhexidine, Normal saline
- Volunteers
- 60 people
- Sponsor
- All India Institute of Medical Sciences
Sepsis
Biomarker-enhanced Artificial Intelligence Based Pediatric Sepsis Screening Tool
The overall objective of this proposed research is the derivation of a biomarker-enhanced artificial intelligence (AI)-based pediatric sepsis screening tool (PSCT) (software) that can be used in combination with the hospital's…
- Trial name
- NCT05311046
- Testing
- Pediatric sepsis screening tool (either algorithmic or manual)
- Where
- United States
- Volunteers
- 12,961 people
- Sponsor
- Computer Technology Associates, Inc.
Fungal Infection
Fluconazole Pharmacokinetics in Infants
The purpose of this study is to determine the pharmacokinetics of fluconazole in infants and evaluate the dose exposure relationship of current fluconazole dosing in infants who are receiving fluconazole for the prevention or…
- Trial name
- NCT00514358
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Children's Hospital of Philadelphia
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Postpartum Period, Sepsis
Correlation of Survival in Puerperae by Electrical Impedance Tomography
Introduction: Electrical Impedance Tomography (TIE) consists of an equipment that enables the visualization / quantification in real time of the regional distribution of ventilation and pulmonary perfusion, as well as of…
- Conditions
- Postpartum Period, Sepsis, Respiratory Distress Syndrome,Adult, HELLP Syndrome
- Trial name
- COSIPBEIT (NCT03715647)
- Testing
- Sepsis, HELLP Syndrome, Respiratory Distress Syndrome Adult
- Volunteers
- 30 people
- Sponsor
- Amazon University
Sepsis
Statin for Immunomudulation in Sepsis
The purpose of this study is to determine whether atorvastatin can improve the inflammatory answer in the septic patients
- Trial name
- NCT00452608
- Testing
- amido pill, atorvastatina
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Long-term Effects of Thymosin Alpha 1 Treatment
Long-term Prognosis of Patients With Sepsis After Immunotherapy
Current clinical studies of thymosin α1 for sepsis have focused on short-term outcomes (28-day or 90-day mortality), and lack of clinical data on long-term outcomes (3 year mortality) of patients with sepsis after immunotherapy.
- Trial name
- NCT04901104
- Testing
- Thymosin Alpha1
- Volunteers
- 900 people
- Sponsor
- Sun Yat-sen University
Sepsis, Septic Shock
IVC Collapsibility Index or CVP as a Predictor of Fluid Responsiveness in Pediatric Sepsis
Pediatric population who suffered from sepsis due to perforated viscus will receive fluid resuscitation guided by either central venous pressure or guided by IVC collapsibility index.
- Conditions
- Sepsis, Septic Shock, Perforated Viscus, Hospitalism in Children
- Trial name
- NCT06833333
- Testing
- Central venous catheter, IVC collapsibility index
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
Bacteremia, Enterobacteriaceae Infections
Ultra Rapid Culture Independent Detection of High-Priority Carbapenem Resistant Enterobacteriaceae Directly From Blood
The purpose of this study is to develop a new and very rapid diagnostic test for identifying a certain type of bacteria called Enterobacteriaceae in blood.
- Trial name
- NCT02482051
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Denver Health and Hospital Authority
Neonatal Sepsis
Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis
A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital
- Trial name
- NCT06113653
- Testing
- Prospective study
- Volunteers
- 50 people
- Sponsor
- Assiut University
Severe Sepsis, Organ Dysfunction Syndrome
Effect of Docosahexaenoic Acid on the Inflammatory Response and Clinical Outcomes From Surgical Patients
The purpose of this study is to evaluate if enteral docosahexaenoic acid (DHA) administration attenuates the inflammatory cytokines and improve clinical outcomes in neonates who underwent cardiovascular surgery
- Trial name
- DHA-IRCO (NCT01049529)
- Testing
- Docosahexaenoic acid
- Where
- Mexico
- Volunteers
- 55 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Sepsis
A Machine Learning Predictive Model for Sepsis
Timely and accurately predicting the occurrence of sepsis and actively intervening in treatment may effectively improve the survival and cure rate of patients with sepsis.
- Trial name
- NCT04771429
- Where
- China
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Septic Shock, Severe Sepsis
Echocardiography in Septic Shock
BACKGROUND: Echocardiography can provide evaluation of right or left ventricular dysfunction and volume status during resuscitation of patients with sepsis and septic shock and guide intravenous vasopressor and fluid therapy.
- Trial name
- NCT02135796
- Testing
- Echocardiography
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Intermountain Health Care, Inc.
Febrile Neutropenia (FN), Sepsis
Prophylaxis of Febrile Neutropenia With Lactoferrin in Oncohematologic Children Undergoing Induction Chemotherapy
Test, in a randomized phase II trial, the safety and efficacy of lactoferrin prophylaxis in preventing the occurrence of febrile neutropenia and sepsis, with particular regard to forms due to multidrug-resistant Gram-negative…
- Conditions
- Febrile Neutropenia (FN), Sepsis, Chemotherapy Treatment
- Trial name
- Lactoferrin (NCT07113314)
- Testing
- Lactoferrin Bovine
- Where
- Italy
- Volunteers
- 160 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Septic Shock, Nonchemotherapy Drug-induced Neutropenia
Russian Clinical Trial of Mesenchymal Cells in Patients With Septic Shock and Severe Neutropenia
Septic shock remains a significant clinical problem associated with high rates of mortality among neutropenic patient despite antimicrobial therapy and supportive care.
- Conditions
- Septic Shock, Nonchemotherapy Drug-induced Neutropenia, Neutropenia After Chemotherapy in Oncohematological Patients, Neutropenia in Patients With Aplastic Anemia
- Trial name
- NCT01849237
- Testing
- Mesenchymal stromal cells, Standard therapy of septic shock
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- National Research Center for Hematology, Russia
Septic Shock, Shock
Balanced Crystalloid vs. Saline in Children With Septic Shock
Fluid resuscitation is the cornerstone of pediatric shock management; current practices of fluid resuscitation in children are not evidence based.
- Trial name
- NCT02835157
- Testing
- Balanced crystalloid solution, 0.9%sodium chloride
- Where
- 4 sites in India
- Volunteers
- 708 people
- Sponsor
- All India Institute of Medical Sciences
Neonatal Sepsis
Treatment Outcome With Antibiotic Use and Its Resistance Pattern Among Patient With Neonatal Sepsis
Determine Treatment outcome with antibiotic use and its resistance pattern among neonatal sepsis patients
- Trial name
- NCT05742477
- Testing
- Antibiotic
- Volunteers
- 100 people
- Sponsor
- Assiut University