Clinical trials: Systemic Inflammatory Response
Sepsis
EARLY-MYO-SEPSIS Registry
The diagnosis and pathophysiology of sepsis-induced cardiac dysfunction remain unknown. This registry is to evaluate characteristics of sepsis patients by multi-modalities imaging, including echocardiography, cardiovascular…
- Trial name
- NCT04513795
- Volunteers
- 300 people
- Sponsor
- RenJi Hospital
Cancer Pediatric, Neutropenia
Safety of Acupuncture and Intracutaneous Needles in Pediatric Cancer Patients: a Retrospective Study (ACUSAFE2021)
This study aims to demonstrate the safety of intracutaneous needles in pediatric cancer patients. For this, a two-year retrospective study will be carried out to determine the incidence of adverse effects related to acupuncture…
- Conditions
- Cancer Pediatric, Neutropenia, Thrombocytopenia, Bacteremia
- Trial name
- ACUSAFE2021 (NCT05585463)
- Testing
- acupuncture
- Where
- Spain
- Volunteers
- 460 people
- Sponsor
- Fundació Sant Joan de Déu
Invasive Candidiasis, Candidemia
Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia
To determine the efficacy and safety of micafungin (FK463) versus fluconazole (Diflucan) in treating patients with invasive candidiasis or candidaemia
- Trial name
- NCT00189709
- Testing
- Micafungin, fluconazole
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Astellas Pharma Inc
Infant, Newborn, Diseases, Sepsis
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
The purpose of this study is to evaluate whether use of the disinfectant chlorhexidine administered to the birth canal during labour and newborn at delivery can protect a woman and her baby from bacterial infections after birth.
- Conditions
- Infant, Newborn, Diseases, Sepsis, Puerperal Infection
- Trial name
- NCT00136370
- Testing
- Chlorhexidine, Birth canal wipe, sterile water external genital wipe
- Where
- South Africa
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Sepsis
Efficacy Of Zinc Towards The Outcome on Children With Sepsis
Sepsis is a life-threatening organ failure induced by a compromised immune response to infection. Sepsis is a leading cause of morbidity and mortality (50-60%) in children treated in inpatient and critical care units.
- Trial name
- NCT06556511
- Testing
- Zinc Sulfate
- Where
- Indonesia
- Volunteers
- 140 people
- Sponsor
- dr. Aldora Jesslyn Oentari
Severe Infection and Non-injury Death
SEPSIS Observational Cohort Study in Young Infants in Bangladesh
Globally, infectious diseases such as sepsis, meningitis and pneumonia are among the leading causes of neonatal deaths. A recent observational study in South Asia highlighted the contribution of both bacterial and viral…
- Trial name
- NCT04012190
- Where
- 2 sites in Bangladesh
- Volunteers
- 2,083 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Sepsis, Necrotizing Enterocolitis
Circulating Markers in Preterm Infants With Perinatal and Neonatal Inflammation
Circulating markers to diagnose complications (sepsis, necrotizing enterocolitis) in preterm infants are often inaccurate, partly due to the lack of comprehensive studies with temporal evaluation from birth until a disease onset.
- Conditions
- Sepsis, Necrotizing Enterocolitis, Chorioamnionitis, Feeding Intolerance
- Trial name
- NEOINFLAM (NCT03320785)
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Per Torp Sangild
Sepsis
Neonatal Procalcitonin Intervention Study
In neonates, clinical signs and symptoms associated with early-onset sepsis are non-specific and currently available tests have poor positive and negative predictive values.
- Trial name
- NeoPInS (NCT00854932)
- Testing
- Procalcitonin-guided decision making
- Where
- Switzerland
- Volunteers
- 1,600 people
- Sponsor
- Luzerner Kantonsspital
Sepsis
The Study of NT-proBNP Combined With HS-cTnT in Evaluating the Prognosis of Sepsis
To study the clinical value of combined detection of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-cTnT) in assessing the prognosis of patients with sepsis.
- Trial name
- NCT04963699
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Neonatal SEPSIS, Nosocomially Acquired Neonatal Sepsis
A Study on Ventilator-associated Pneumonia as a Risk for Nosocomial Infection in Mechanically Ventilated Neonates In NICU of Assiut University Children Hospital (Nicu Eta)
Abstract Background: Neonatal ventilator associated pneumonia (VAP) is a major hospital-acquired infection in acute care settings, associated with high mortality and poor outcome.
- Trial name
- nicu eta (NCT03310840)
- Testing
- others
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sepsis
Procalcitonin-Guided Decision Making to Shorten Antibiotic Therapy in Suspected Neonatal Early-Onset Sepsis
Neonatal bacterial sepsis is a major cause of mortality and morbidity and early antibiotic therapy is crucial for treatment success.
- Trial name
- NCT00926497
- Testing
- Procalcitonin-guided decision making
- Where
- Switzerland
- Volunteers
- 121 people
- Sponsor
- Luzerner Kantonsspital
Acute Myeloid Leukemia, Neutropenia
Home Away From Home - Medical Outcomes
Treatment for pediatric acute myeloid leukemia (AML) involves intensive chemotherapy regimens that result in periods of profound neutropenia leaving patients susceptible to severe infectious complications.
- Conditions
- Acute Myeloid Leukemia, Neutropenia, Bacteremia
- Trial name
- Aim 1 (NCT02774850)
- Where
- 17 sites in United States
- Volunteers
- 610 people
- Sponsor
- Children's Hospital of Philadelphia
Systemic Inflammatory Response Syndrome
Goal-directed Resuscitative Interventions During Pediatric Inter-facility Transport (The GRIPIT Trial)
Recent advances in critical care medicine have dramatically improved morbidity and mortality of critical illness. Goal-directed therapy protocols have been instrumental in this change.
- Trial name
- GRIPIT (NCT01293500)
- Testing
- Goal-directed Therapeutic Protocol
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Arkansas Children's Hospital Research Institute
Severe Sepsis, Malaria
Monitoring of Perfusion in Sepsis and Malaria
Sepsis and severe malaria together contribute to an estimated 13 million deaths annually, a great burden of which is in low-income countries.
- Trial name
- PERFuSE (NCT03641534)
- Testing
- Lung Ultrasound examination, Compression ultrasonography (CUS), Echocardiography
- Where
- Bangladesh
- Volunteers
- 103 people
- Sponsor
- University of Oxford
Sepsis, Acute Kidney Injury
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry.
- Conditions
- Sepsis, Acute Kidney Injury, Diabetic Ketoacidosis
- Trial name
- NCT04825639
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff and Vale University Health Board
Sepsis, Hemodynamic Instability
Therapeutic Drug Monitoring in Patients With Difficult-to-Treat Gram-Negative Bacterial Infections
A prospective, open-label, randomized controlled trial will be conducted to evaluate a novel TDM-guided therapy in management of DT-GNB infections.
- Conditions
- Sepsis, Hemodynamic Instability, Bacterial Infections, Therapeutic Drug Monitoring
- Trial name
- TDM-RCT (NCT05942157)
- Testing
- Therapeutic Drug Monitoring (TDM)
- Where
- Singapore
- Volunteers
- 810 people
- Sponsor
- Singapore General Hospital
Neonatal Sepsis
Early Versus Late Lactoferrin in Prevention of Neonatal Sepsis
The present study was designed to evaluate the effectiveness of oral lactoferrin in prevention of neonatal sepsis with comparison early (1st day) versus late (48-72 hours) Lactoferrin administration, Secondary aim was to study…
- Trial name
- NCT02959229
- Testing
- Lactoferrin
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Feeding Intolerance, Extrauterine Growth Retardation
Feeding Bovine Colostrum to Preterm Infants
Feeding preterm infants is of great challenge in the NICUs. Mother's own milk is considered as the best for the digestive system followed by donor milk.
- Conditions
- Feeding Intolerance, Extrauterine Growth Retardation, Necrotizing Enterocolitis, Sepsis
- Trial name
- PreColos (NCT02054091)
- Testing
- Bovine colostrum
- Where
- 4 sites in China, Denmark
- Volunteers
- 52 people
- Sponsor
- Per Torp Sangild
Severe Sepsis, Sepsis
Early Identification and Effective Management of Pediatric Sepsis
In patients diagnosed as sepsis on PICU admission, early and accurate identification of patients who will develop organ dysfunction (severe sepsis) is critical for effective management and positive outcome.
- Conditions
- Severe Sepsis, Sepsis, Septic Shock
- Trial name
- NCT03996720
- Where
- 4 sites in China
- Volunteers
- 175 people
- Sponsor
- Children's Hospital of Fudan University
Acute Lymphoblastic Leukemia, Immune System Diseases
Administration of Autologous CAR-T CD19 Antigen With Inducible Safety Switch in Patients With Relapsed/Refractory ALL
The body has different ways of fighting infection and disease. No single way is effective at fighting cancer. This research study combines two different ways of fighting disease: antibodies and T cells.
- Conditions
- Acute Lymphoblastic Leukemia, Immune System Diseases, Immunoproliferative Disorders
- Trial name
- NCT03016377
- Testing
- iC9-CAR19 cells, Rimiducid, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center