Clinical trials: Systemic Inflammatory Response Syndrome (SIRS)
Septic Shock, Methylene Blue
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
The goal of this clinical trial is to investigate whether methylene blue injection can safely and effectively improve the survival rate of patients with severe septic shock, shorten the duration of norepinephrine use, reduce the…
- Conditions
- Septic Shock, Methylene Blue, Sepsis
- Trial name
- NCT06481410
- Testing
- Methylene Blue Intervention Group, Normal Saline Control Group
- Where
- China
- Volunteers
- 488 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Infant, Newborn, Diseases, Sepsis
Prevention of Perinatal Sepsis (PoPS): Evaluation of Chlorhexidine Wipes of Birth Canal and Newborn
The purpose of this study is to evaluate whether use of the disinfectant chlorhexidine administered to the birth canal during labour and newborn at delivery can protect a woman and her baby from bacterial infections after birth.
- Conditions
- Infant, Newborn, Diseases, Sepsis, Puerperal Infection
- Trial name
- NCT00136370
- Testing
- Chlorhexidine, Birth canal wipe, sterile water external genital wipe
- Where
- South Africa
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Sepsis
LifeFlow Sepsis Study
This is a prospective, comparative, blinded, randomized study to prove the safety, efficacy and ease of use of the LifeFlow® device in pediatric patients presenting to an emergency department with concern for sepsis.
- Trial name
- NCT07191054
- Testing
- LifeFlow Rapid infuser, Push Pull
- Where
- United States
- Sponsor
- Phoenix Children's Hospital
Neonatal Sepsis, Neonatal Infection
Infection, Sepsis and Meningitis in Surinamese Neonates
Suriname is a small developing country in South America with a population of half a million people. Early neonatal death in Suriname is high with 16 per 1000 live births.
- Conditions
- Neonatal Sepsis, Neonatal Infection, Neonatal Meningitis
- Trial name
- InSepSur (NCT02486783)
- Where
- Suriname
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Academic Hospital Paramaribo
Bacteremia
BALANCE on the Wards: A Pilot RCT
The burden of bloodstream infections is large and increasing over time. Antibiotic overuse continues to drive increased rates of antimicrobial-resistant pathogens across Canada.
- Trial name
- BALANCE-Wards (NCT02917551)
- Testing
- 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment
- Where
- 6 sites in Canada
- Volunteers
- 134 people
- Sponsor
- Sunnybrook Health Sciences Centre
Sepsis, Pre-Term
Olive Oil Massage Effect for Reduction of Preterm Sepsis (OMEPS)
The OMEPS trial is a randomized clinical trial in the western region of Saudi Arabia. Conducted to assess the safety and feasibility of olive oil as massage for preterm infants and if associated with reduced risk of Late-Onset…
- Conditions
- Sepsis, Pre-Term, Late-Onset Neonatal Sepsis
- Trial name
- OMEPS (NCT04717037)
- Testing
- Olive Oil Massage
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 300 people
- Sponsor
- King Abdullah International Medical Research Center
Early-Onset Neonatal Sepsis, Antibiotic Stewardship
Efficacy And Safety Of Short Course Antibiotic Therapy In Preterm Neonates With Early Onset Sepsis
Objective of the study is to compare the efficacy and safety of 'Short duration antibiotic' (72hrs) and 'Standard duration antibiotic'(5 - 7days) in preterm neonates ( >28weeks and >1000grams ) with culture negative early onset…
- Trial name
- NCT06197269
- Testing
- Short duration antibiotics, Standard duration antibiotics
- Where
- India
- Volunteers
- 75 people
- Sponsor
- Lady Hardinge Medical College
Bacteremia
Ethanol Lock for the Salvage of Infected Long-term Vascular Access
Long-term venous devices (e.g.Ports, tunneled catheters,...) may become infected. Sometimes it is very difficult to treat the infection and it is necessary to remove the device.
- Trial name
- NCT01186172
- Testing
- Ethanol-lock therapy, Antibiotic-lock
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Infant, Premature, Hypoperfusion in Newborn
Monitoring of Systemic or Organ Perfusion for Preterm Infants
To investigate biomarker reflects systemic or specific organ perfusion well, we are going to the observational comparison study using several hemodynamic monitoring methods in the premature infants.
- Conditions
- Infant, Premature, Hypoperfusion in Newborn, Necrotizing Enterocolitis of Newborn, Sepsis Newborn
- Trial name
- NCT03136172
- Testing
- NIRS (near Infra-red spectroscopy)
- Where
- South Korea
- Volunteers
- 85 people
- Sponsor
- Inha University Hospital
Enterovirus, Clinical Syndrome
Neonatal Enterovirus Infections in Italy: Virological Characterization, Genomic and Clinical-epidemiological Insights on Echovirus 11
The Enterovirus genus, belonging to the Picornaviridae family, consists of positively polarized single-stranded RNA viruses classified into the species Enterovirus (EV, comprising Coxsackievirus, Echovirus and Poliovirus) A-J and…
- Conditions
- Enterovirus, Clinical Syndrome, Respiratory Complications, Gastrointestinal
- Trial name
- Entero-Neo (NCT07356583)
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Neonatal Sepsis
Serum Presepsin as Early Predictor for Neonatal Early-onset Sepsis
124 neonates aged ≤7 days with suspected EOS were clinically evaluated using SNAP-II and gave blood samples for BC, total leucocytic count (TLC), lymphocytic and neutrophil count, and ELISA estimation of serum levels of PSP…
- Trial name
- NCT05022043
- Testing
- Serum Presepsin
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Tanta University
Solid Tumor, Hematological Malignancy
Metoprolol Treatment for Cytokine Release Syndrome in Patients Treated With Chimeric Antigen Receptor T Cells
The aim of this prospective study is to evaluate the feasibility and efficacy of metoprolol, a beta-1 adrenergic receptor blocker, in the treatment of cytokine release syndrome (CRS) caused by chimeric antigen receptor T (CAR T)…
- Trial name
- NCT04082910
- Testing
- Metoprolol, metoprolol, infliximab, etanercept, tocilizumab and/or other agents
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Chinese PLA General Hospital
Hypoxemia, Neonatal Sepsis
Infant Pulse Oximetry in Pakistan Study
Hypoxemia is an abnormally low concentration of oxygen in the blood, and is an important sign of cardio-respiratory compromise in acutely ill patients.
- Conditions
- Hypoxemia, Neonatal Sepsis, Pneumonia
- Trial name
- iPOP (NCT01676610)
- Where
- 2 sites in Canada, Pakistan
- Volunteers
- 3,149 people
- Sponsor
- The Hospital for Sick Children
Bacterial Vaginosis, Premature Birth
Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
The trial intends to evaluate the efficacy of specially designed probiotics to prevent premature birth and related neonatal morbidity associated to intra-uterine infection.
- Conditions
- Bacterial Vaginosis, Premature Birth, Sepsis, Periventricular Leukomalacia
- Trial name
- NCT00303082
- Testing
- Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
- Where
- 2 sites in Brazil
- Volunteers
- 645 people
- Sponsor
- Oswaldo Cruz Foundation
Sepsis
Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket Trial
PALETTE is a perpetual adaptive platform to efficiently study sepsis interventions within 'treatable traits' in all-ages patients enabling prompt evaluation of pandemic treatments.
- Trial name
- PALETTE (NCT06381661)
- Testing
- Tocilizumab, Baricitinib, Anakinra
- Where
- 19 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sepsis
Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy
Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown.
- Trial name
- NCT00410111
- Where
- Switzerland
- Volunteers
- 23 people
- Sponsor
- University Hospital, Basel, Switzerland
Group B Streptococcus, Sepsis
Management of Infants Born to Group B Streptococcus Positive Mothers.
Intrapartum antibiotic prophylaxis has greatly decreased but not abolished early-onset neonatal sepsis caused by GBS. According to current recommendations, the evaluation of infants at risk for GBS sepsis should include a…
- Conditions
- Group B Streptococcus, Sepsis, Infant, Newborn
- Trial name
- NCT00716781
- Volunteers
- 16,394 people
- Sponsor
- IRCCS Burlo Garofolo
Sepsis
AN69ST Verse PS in CBP in Septic Children
In septic shock, dysregulated host responses to pathogens lead to cytokine storms that damage host tissues and organs, further contributing to the development of organ dysfunction and increased mortality.
- Trial name
- NCT05692011
- Testing
- blood purification(PS), blood purification(AN69ST)
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Children's Hospital of Fudan University
Sepsis
Glycocalyx and Microcirculation in Sepsis
The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis.
- Trial name
- NCT03960307
- Testing
- Microcirculation and Glycocalyx assessment
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Necrotizing Enterocolitis, Sepsis
Human Milk Fortification in Extremely Preterm Infants
This is a randomised controlled multi-centre trial comparing the effect of diet supplementation of a human breast milk-based nutrient fortifier (H2MF®) with standard bovine protein-based nutrient fortifier in 222 extremely…
- Conditions
- Necrotizing Enterocolitis, Sepsis, Mortality
- Trial name
- N-forte (NCT03797157)
- Testing
- H2MF, Bovine milk-based fortifier
- Where
- 5 sites in Sweden
- Volunteers
- 229 people
- Sponsor
- Thomas Abrahamsson, MD, PhD