Clinical trials: T2D, open to volunteers
Diabetes Mellitus, Type 2, End Stage Renal Disease
Drug Interaction Potential of Pro-Inflammatory Conditions
Pro-inflammatory cytokines, which are elevated in pro-inflammatory disease states (e.g., type II diabetes mellitus [T2DM], irritable bowel diseases [IBD], and end stage renal disease [ESRD]) have been shown to inhibit hepatic…
- Conditions
- Diabetes Mellitus, Type 2, End Stage Renal Disease, Irritable Bowel Syndrome
- Trial name
- DIPPIC (NCT07360938)
- Testing
- None (Observational)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Indiana University
Diabetes Mellitus, Type 2
A Research Study to See How Much CagriSema Lowers Blood Sugar and Body Weight Compared to Placebo in Children and Adolescents With Type 2 Diabetes
The purpose of this clinical study is to look into how well a study medicine called CagriSema helps children and adolescents living with diabetes lower their blood sugar and body weight.
- Trial name
- REIMAGINEYOUNG (NCT07282613)
- Testing
- CagriSema (Cagrilintide B and Semaglutide I)
- Where
- 58 sites in United States, Argentina and 8 more
- Volunteers
- 80 people
- Sponsor
- Novo Nordisk A/S
Diabetes in Adolescence, Type 2 Diabetes
Pilot-Testing Strategies to Improve Outcomes for Youth With Type 2 Diabetes by Addressing Health-Related Social Needs
The goal of this clinical trial is to pilot test different strategies to address health related social needs (HRSN) experienced by adolescent and young adult patients with type 2 diabetes and their families.
- Conditions
- Diabetes in Adolescence, Type 2 Diabetes, Social Needs
- Trial name
- ONWARD (NCT07216118)
- Testing
- Tailored Resources, Universal Empowerment, Text Messages
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Type 2 Diabetes, Gestational Diabetes Mellitus (GDM)
Co-designing Enhanced Models of Care for First Nations Children at Risk for Childhood-onset Type 2 Diabetes
The overall objective: to co-design and implement targeted and timely community led strategies to improve the health of the Next Generation and end the intergenerational impact of T2D in this population.
- Trial name
- NCT07692321
- Testing
- Breastfeeding and perinatal education and support, Purchasing HbA1c machines for communities, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Type 2 Diabetes
Type 2 Continuous Glucose Monitoring Academy
The goal of this clinical trial is to evaluate the Impact of Continuous Glucose Monitoring Academy Education Curriculum Versus Standard Care on Glycemic Outcomes for Youth With Type 2 Diabetes (T2D): The first aim is to determine…
- Trial name
- NCT06516640
- Testing
- Continuous Glucose Monitoring Academy, Standard Education
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Children's Hospital Los Angeles
Diabetes Mellitus Type 2
Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only ~5 min/day and is thus ideal for youth with T2D…
- Trial name
- IMST (NCT06936670)
- Testing
- Inspiratory Muscle Strength Training (IMST)
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Seattle Children's Hospital
Obesity Type 2 Diabetes Mellitus, Obesity & Overweight
Eating Behaviour Before, During, and After Obesity Medication
This study will examine how eating behaviour changes during the first 18 months of treatment with obesity medications in patients attending the St Vincent's Healthcare Group obesity service.
- Trial name
- NCT07636395
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- University College Dublin
Diabetes, Alzheimer Disease
The Diabetes Prevention Program Outcomes Study AD/ADRD Project
The DPPOS AD/ADRD project will address the overarching question: What are the determinants and the nature of cognitive impairment among persons with pre-diabetes (PreD) and type 2 diabetes (T2D), who are a high-risk group for…
- Conditions
- Diabetes, Alzheimer Disease, Dementia, Vascular, Dementia
- Trial name
- DPPOS-4 (NCT05704309)
- Where
- 27 sites in United States
- Volunteers
- 1,976 people, healthy volunteers welcome
- Sponsor
- Marinella Temprosa
Diabetes Mellitus Type 2, Childhood-Onset
DISCOVERY of Risk Factors for Type 2 Diabetes in Youth
The goal of the DISCOVERY study is to provide innovative critical information regarding the unique natural history of glycemic control, insulin sensitivity, and β-cell function, and their mechanistic determinates, in obese…
- Trial name
- DISCOVERY (NCT06525259)
- Where
- 20 sites in United States
- Volunteers
- 3,600 people
- Sponsor
- George Washington University
Type 2 Diabetes Mellitus, Diabetic Kidney Disease
Puberty, Diabetes, and the Kidneys, When Eustress Becomes Distress (PANTHER Study)
Early diabetic kidney disease (DKD) occurs in 50-70% of youth with type 2 diabetes (T2D) and confers high lifetime risk of dialysis and premature death.
- Conditions
- Type 2 Diabetes Mellitus, Diabetic Kidney Disease, Adolescent Obesity, Pre Diabetes
- Trial name
- NCT05008276
- Testing
- Aminohippurate Sodium Inj 20%, Iohexol Inj 300 MG/ML, Dextran 40
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Petter Bjornstad
Diabetes Mellitus, Type 2
Effect of Nutrition Education Groups in the Treatment of Patients with Type 2 Diabetes
Every year there is an increase in people with diabetes all over the world. Because it is a disease associated with several comorbidities and is increasing, there is a need for more effective treatments.
- Trial name
- NCT05598203
- Testing
- Operative group of nutrition education
- Where
- 2 sites in Brazil
- Volunteers
- 252 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Type 2 Diabetes
Relationship Between Insulin Resistance and Vitamin D in Type 2 Diabetes Mellitus (DM)
The primary aim of the study is to evaluate the association between vitamin D levels and triglyceride-glucose index as a marker of insulin resistance in patients with type 2 DM.
- Trial name
- DM (NCT07467161)
- Volunteers
- 165 people
- Sponsor
- Assiut University
Type 2 Diabetes
More Fresh Fruit and Vegetable Prescription Program for Families With Type 2 Diabetes Mellitus
Rady Children's Hospital San Diego (RCHSD), UCSD Division of Child and Community Health and the Center for Community Health, and Northgate Gonzalez (NG) Markets will collaborate to create a Produce Prescription Program (Fruit and…
- Trial name
- NCT05138432
- Testing
- Fruit and Vegetable Prescription Voucher
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego
Insulin Resistance, Depression
Cognitive-Behavioral Therapy and Exercise Training in Adolescents At-Risk for Type 2 Diabetes
The investigators are doing this study to learn more about how to prevent type 2 diabetes in teenage girls. The purpose of this study is to find out if taking part in a cognitive-behavioral therapy group, exercise training group…
- Conditions
- Insulin Resistance, Depression, Depressive Disorder, Mood Disorders
- Trial name
- CBTeX (NCT05543083)
- Testing
- Cognitive-Behavioral Therapy followed by Exercise Training, Exercise Training followed by Cognitive-Behavioral Therapy, Cognitive-Behavioral Therapy Only
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Diabetes Mellitus Type 2, Glycemic Control for Diabetes Mellitus
Comparison Between Efficacy of Trelagliptin and Sitagliptin in Type II Diabetic Patients
The goal of this clinical trial is to find out if a medicine called Trelagliptin works as well as another medicine called Sitagliptin to lower blood sugar levels in people with type 2 diabetes who have not reached their target…
- Trial name
- NCT07073768
- Testing
- Trelagliptin 100 mg, Sitagliptin 100mg OD
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Khyber Medical College, Peshawar
Type 2 Diabetes, Diabetic Cardiomyopathy
NT-ProBNP-based Heart Failure Screening and Prevention Trial in Patients With Type 2 Diabetes: STRONG-DM Study
A pragmatic, randomized clinical trial to evaluate the effect of a heart failure (HF) risk assessment and prevention strategy incorporating HF clinical risk scores (WATCH-DM) with cardiac biomarker (NT-proBNP) paired with a…
- Conditions
- Type 2 Diabetes, Diabetic Cardiomyopathy, Heart Failure, Cardiometabolic Diseases
- Trial name
- STRONG-DM (NCT06593327)
- Testing
- Intensive Prevention Strategy
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetes Mellitus, Type 2, Genetics
Phenotyping Genetic Risk for Type 2 Diabetes
This study tests the hypothesis that non-diabetic individuals with a high genetic risk score for type 2 diabetes have impaired glucose tolerance and insulin resistance compared to those with a low genetic risk score for type 2…
- Trial name
- NCT04024631
- Testing
- 75g glucose beverage (Glucola, Trutol, or similar brand), DXA, whole body
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Obesity Type 2 Diabetes Mellitus
Chinese, Overweight or Obesity, Real-World Registry Study
This study will enroll 10,000 patients with obesity, with the participation of approximately 50 medical institutions nationwide.
- Trial name
- NCT07525037
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese PLA General Hospital
Diabetic, Laughter Yoga
The Effect of Laughter Yoga in Type 2 Diabetes Patients
The purpose of this study is to examine the effect of laughter yoga on self-management skills and comfort levels in patients with Type 2 diabetes.
- Conditions
- Diabetic, Laughter Yoga, Comfort
- Trial name
- NCT07271706
- Testing
- Laughter yoga
- Volunteers
- 80 people
- Sponsor
- Bozok University
Type 2 Diabetes Mellitus, Type 1 Diabetes Mellitus
Efficacy of the Omnipod® 6 System Compared With the Omnipod® 5 System
This multi-center, randomized, cross-over trial will evaluate the efficacy of the Omnipod 6 System compared with the Omnipod 5 System in individuals with type 1 or type 2 diabetes and suboptimal glycemia.
- Trial name
- STRIVE 2 (NCT07579702)
- Testing
- Omnipod 5 System, Omnipod 6 System
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- Insulet Corporation