Clinical trials: Target Lesion
Neonatal Respiratory Distress, Very Low Birth Weight Infant
PRICO: OPTI Target Range
The aim of the study is to determine if a narrower SpO2 Target Range setting automated control of FiO2 (A-FiO2) is more effective than a wider SpO2 Target Range
- Trial name
- POSTR (NCT06207994)
- Testing
- Narrow TR, Shifted TR
- Where
- Czechia
- Volunteers
- 11 people
- Sponsor
- Czech Technical University in Prague
Gastric Cancer Stage IV
Conversion Surgery After Target Therapy or Immunotherapy in Stage IV Gastric Cancer
In this retrospective study, investigators conducted a comprehensive investigation of the factors influencing postoperative prognosis in patients with stage IV gastric cancer undergoing conversion surgery.
- Trial name
- NCT07009600
- Testing
- immune check point inhibitors (PD-1 inhibitors), target therapy (trastuzumab)
- Volunteers
- 124 people
- Sponsor
- Samsung Medical Center
Anesthesia
Bispectral Index Under Propofol Anesthesia in Children : a Study Between TIVA and TCI
In children, only a few studies have compared different modes of propofol infusion during a total intravenous anesthesia (TIVA) with propofol and remifentanil.
- Trial name
- NCT02637726
- Testing
- Propofol : TCI Schnider, Propofol : TCI Kataria, Propofol : TIVA
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Pr Isabelle CONSTANT
HER2-positive Breast Cancer
Taxane Combined Targeted Therapy for Low-risk HER2 Positive and Lymph Node Negative Breast Cancer
Human epidermal growth factor receptor 2 (HER2) positive breast cancer is a molecular subtype with high malignancy and high risk of recurrence and metastasis.
- Trial name
- TaxHER (NCT06711055)
- Where
- China
- Volunteers
- 285 people
- Sponsor
- Shu Wang
Generalized Convulsive Epilepsy
Study to Evaluate the Safety and Efficacy of Levetiracetam in Patients Suffering From Idiopathic Generalized Epilepsy With Primary Generalized Tonic-clonic Seizures
This study will assess the efficacy, safety, and tolerability of adjunctive treatment with LEV (3,000 mg/day or a target dose of 60 mg/kg/day in children) compared to placebo in reducing PGTC seizures in subjects (4 - 65 years)…
- Trial name
- NCT00160550
- Testing
- Levetiracetam
- Volunteers
- 154 people
- Sponsor
- UCB Pharma
Pediatric Obesity
Development of the DRIVE Curriculum to Address Childhood Obesity Risk Factors
The purpose of this study is to help overweight or obese children to maintain or reduce their body mass index (BMI) through the home-based parent training program the investigators developed called DRIVE.
- Trial name
- NCT02160847
- Testing
- DRIVE Program
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Georgia State University
Cervix Cancer
Dosimetric Planning Study Comparing Intensity Modulated Radiotherapy (IMRT) and 4-field Radiotherapy for Definitive Treatment of Cancer of the Cervix
A theoretical planning study to compare the normal tissue irradiation when using intensity modulated radiotherapy (IMRT) as opposed to standard radiotherapy for the definitive treatment of cervical cancer.
- Trial name
- NCT00981552
- Testing
- IMRT planning, 4-Field Radiation Planning
- Where
- Canada
- Volunteers
- 55 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cow Milk Allergy
Microbiota as Potential Target for Food Allergy
Food allergy (FA) derives from a dysregulation of oral tolerance mechanisms. Studies suggest a crucial role for enteric microflora in oral tolerance development.
- Trial name
- MATFA (NCT02087930)
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Federico II University
Prostate Cancer
Randomized Controlled Trial of MRI Target Biopsy: Transrectal vs. Transperineal
This prospective study of comparing between Transrectal and transperineal prostate MRI targeted biopsy to provide evidence for clinicians to select the appropriate biopsy approach under different conditions.
- Trial name
- NCT03650153
- Testing
- Trans-rectal MRI targeted Biopsy, Trans-perineal MRI targeted Biopsy
- Where
- Saudi Arabia
- Volunteers
- 165 people
- Sponsor
- Princess Al-Johara Al-Ibrahim Cancer Research Center
Vascular Access Complication, Restenosis, Vascular Graft
Drug-eluting Balloon vs. Conventional Balloon in the Treatment of (re)Stenosis (Dialysis Fistulae)
The purpose of this study is to determine whether the use of drug-eluting balloons is effective in the treatment of (re)stenosis in dialysis fistulae.
- Conditions
- Vascular Access Complication, Restenosis, Vascular Graft, Dialysis Related Complications
- Trial name
- DRECOREST2 (NCT03036241)
- Testing
- Conventional angioplasty, Angioplasty with drug-eluting balloon
- Volunteers
- 39 people
- Sponsor
- Helsinki University Central Hospital
General Anaesthesia, Propofol
Blood Propofol Measurement During Anaesthesia Using Propofol Target Controlled Infusion
Propofol is a commonly used agent for sedation and anaesthesia in the intensive care unit and the operating room. The pharmacokinetics of propofol are difficult to predict in patients not conforming to the norms in which the…
- Conditions
- General Anaesthesia, Propofol, Target Controlled Infusion, Pharmacokinetics
- Trial name
- NCT01549639
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Neuroblastoma
A Pilot Study on ALK Gene Mutations in Neuroblastoma
Neuroblastoma (NB) originates from the sympathetic nervous system and is one of the most common cancers in infants and children.
- Trial name
- NCT01986595
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Fever, Malaria
Innovative Public-private Partnership to Target Subsidized Antimalarials in the Retail Sector (Aim 2)
The overall objective of this study is to evaluate the public health impact of targeted antimalarials subsidies through scale-up by determining the community-wide effects of targeting an antimalarial subsidy through a partnership…
- Trial name
- NCT02461628
- Testing
- Malaria RDT & conditional voucher for ACT from retail sector
- Where
- Kenya
- Volunteers
- 40,340 people, healthy volunteers welcome
- Sponsor
- Duke University
Postnatal Growth Failure of Preterm Infants, Human Milk Fortification
Target Versus Standard Human Milk Fortification in Very Low Birth Weight Preterm Infants
The prevention of postnatal growth failure in very low birth weight (VLBW) preterm infants is of utmost importance. Standard fortification is the most commonly used supplementation practice but it does not consider the native…
- Trial name
- NCT02716337
- Testing
- Addition of human milk fortifiers according to human milk analysis
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Erythema Multiforme
Severe Erythema Multiforme - CORTICO
Erythema multiforme (EM) is an acute and often recurrent mucocutaneous disease. EM is considered a hypersensitivity immune-mediated reaction.
- Trial name
- SEMCORTICO (NCT06266221)
- Testing
- Prednisone 20 Mg, Methylprednisolone 120 Mg
- Volunteers
- 96 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lupus Nephritis, Remission
Trial of Belimumab Combined With Multi-target Induction Therapy in Lupus Nephritis
The goal of this single-center, prospective clinical trial is to test the safety and efficacy of belimumab combined with multi-target therapy in the treatment of severe lupus nephritis.
- Conditions
- Lupus Nephritis, Remission, Safety Issues
- Trial name
- BEAM (NCT05863936)
- Testing
- Methylprednisolone Injectable Suspension, Belimumab Injection, Immunosuppressive Agents
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Nanjing University School of Medicine
Neuroblastoma, Sarcoma
Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors
The purpose of this study is to test the manufacturing feasibility and safety of intravenous (IV) administration of B7-H3CART in children and young adult subjects with relapsed and/or refractory solid tumors expressing B7-H3…
- Conditions
- Neuroblastoma, Sarcoma, Osteosarcoma
- Trial name
- NCT06500819
- Testing
- B7-H3CART Dose (Intravenous)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
ADHD
Children With ADHD and ADHD-like Symptoms and Target Shooting Sport in Danish Shooting Associations.
Practising target shooting sport requires focused attention and motoric steadiness. Parental reports suggest that children with attention-deficit/hyperactivity disorder (ADHD) benefit from participating in target shooting sport…
- Trial name
- NCT02898532
- Testing
- Educational programmes
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- University of Southern Denmark
Autism Spectrum Disorder
Study of Neuroimaging Biomarkers of Social Cognition Deficits in Adolescents (Age 13-17) With Autism Spectrum Disorder and Effects of Gabapentin
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder that is increasing in prevalence, and is characterized by deficits in social communication and interaction across multiple contexts, and restricted, repetitive…
- Trial name
- NCT03589898
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Massachusetts, Worcester
Advanced Cancers
Phosphatidylinositol 3 Kinase and Mammalian Target of Rapamycin (PI3K-mTOR) in Advanced Cancer Patients
The goal of this clinical research study is to learn if temsirolimus can help to control advanced cancer in patients who also have a PI3K mutation and/or PTEN loss. The safety of this drug will also be tested.
- Trial name
- NCT00877773
- Testing
- Temsirolimus
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- M.D. Anderson Cancer Center