Clinical trials: Targeted Therapy
Skeletal Class III Malocclusion
Comparison of Ertty Gap III and Facemask Therapy for Skeletal Class III Correction
This single-center, parallel-group randomized clinical trial compared 2 orthopedic treatment approaches in growing patients with skeletal Class III malocclusion associated predominantly with maxillary deficiency: the Ertty Gap…
- Trial name
- NCT07771660
- Testing
- Ertty Gap III Appliance, Facemask Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Ankara University
Depression in Adolescence, Delayed Sleep Phase
Better Sleep Study
The overall aim of this proposal is a confirmatory efficacy trial sufficiently powered and designed to test the hypothesis that improving the relationship between biological circadian timing and waketime, a novel modifiable…
- Trial name
- NCT06139861
- Testing
- TranS-C, Psychoeducation
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Hospital Los Angeles
Solid Tumors, Quality of Life
Prospective Observational Study to Investigate the Added Value of the Health Related Quality of Life and Patient Reported Symptoms in the Identification of the Recommended Phase II Dose in Phase I Trials of Molecularly Targeted Therapies.
A prospective cohort of 250 patients with solid tumours included in phase I clinical trials of targeted agents will be enrolled.
- Trial name
- QoL Phase I (NCT02857699)
- Where
- 3 sites in France
- Volunteers
- 250 people
- Sponsor
- Institut Curie
Leukemia
Efficacy and Safety Evaluation of IM19 CAR-T Cell Therapy for MRD+ After Transplantation
Efficacy study about donor derived CD19-target T cell to treat B-ALL post hematopoietic stem cell transplantation
- Trial name
- NCT04336501
- Testing
- IM19 CAR-T
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Beijing Immunochina Medical Science & Technology Co., Ltd.
Neuroblastoma
3rd Generation GD-2 Chimeric Antigen Receptor and iCaspase Suicide Safety Switch, Neuroblastoma, GRAIN
Subjects that have relapsed or refractory neuroblastoma are invited to take part in this gene transfer research study. We have found from previous research that we can put a new gene called a chimeric antigen receptor (CAR) into…
- Trial name
- GRAIN (NCT01822652)
- Testing
- iC9-GD2 T Cells - frozen, iC9-GD2 T Cells - fresh, Cytoxan
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Inflammatory Myofibroblastic Tumor
Study of Crizotinib in Children and Adolescents With Myofibroblastic Tumors
Targeted therapy based on target identification by genetic examinations is a promising direction in the treatment of patients with a complicated course of inflammatory myofibroblastic tumor.
- Trial name
- NCT03874273
- Testing
- Crizotinib
- Where
- Russia
- Volunteers
- 25 people
- Sponsor
- Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Papillary Thyroid Cancer, Pediatric Cancer
Targeted Therapy to Increase RAI Uptake in Metastatic DTC
Papillary thyroid cancer (PTC) is a common type of differentiated thyroid cancer (DTC) in children and represents the second most common cancer in adolescent females.
- Conditions
- Papillary Thyroid Cancer, Pediatric Cancer, Differentiated Thyroid Cancer
- Trial name
- NCT05024929
- Testing
- Whole body scan
- Where
- 9 sites in United States, Australia
- Volunteers
- 32 people
- Sponsor
- Children's Hospital of Philadelphia
Hematopoietic Stem Cell Transplantation
Target Busulfan Exposure in Children With HSCT in China
Objectives To evaluate the correlation between BU exposure and post-transplant clinical results (efficacy and safety) to establish the optimal BU treatment window for myeloablative conditioning in Chinese pediatrics, provide…
- Trial name
- NCT04786002
- Testing
- Busulfan
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Soochow University
T-Acute Lymphoblastic Leukemia
Targeting CD5 CAR-T Cells in the Treatment of r/r CD5+ T-ALL
A Clinical Study on the Safety and Effectiveness of targeting CD5 CAR-T Cells in the treatment of r/r CD5+ T-ALL
- Trial name
- NCT06633354
- Testing
- CD5 CAR T-cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Zhejiang University
Malignant Solid Neoplasm
Testing Copanlisib as Potentially Targeting Treatment in Cancers With PTEN Loss (MATCH - Subprotocol Z1G)
The phase II MATCH treatment trial tests how well copanlisib works to treat patients with cancer with PTEN loss. Copanlisib may stop the growth of tumor cells and may kill them by blocking some of the enzymes needed for cell…
- Trial name
- NCT06360588
- Testing
- Biopsy Procedure, Biospecimen Collection, Copanlisib
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- National Cancer Institute (NCI)
Pediatric Tumor, Familial Cancer
Analyse of Tumour and Constitutional DNA for the Study of the Determinism in Child Neoplasia
Background. Cancer is the leading cause of death by disease in children. Most pediatric tumors differ from adult tumors in terms of biological and clinical characteristics.
- Conditions
- Pediatric Tumor, Familial Cancer, Solid Tumor, Childhood, Hematological Tumor
- Trial name
- ALADIN (NCT04471961)
- Testing
- Exome sequencing in pediatrics cancers
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Leukemia, Leukemia, Acute
Precision Diagnosis Directing HDACi and TKI Target Therapy for Adult Ph-like ALL
Ph-like ALL is a recently recognized high-risk subgroup and the optimal therapeutic approaches are poorly characterized. Based on the pediatric-inspired, PEG-L-asparaginase-intensified and MRD-directed PDT-ALL-2016 protocol, this…
- Conditions
- Leukemia, Leukemia, Acute, Leukemia, Lymphoblastic, Leukemia, B-cell
- Trial name
- NCT03564470
- Testing
- Chidamide, Dasatinib
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Ulcerative Colitis
Microbiota-targeted Diet for Pediatric UC
Ulcerative colitis is a chronic inflammatory disease primarily involving the colon and has long been considered to be due to a dysregulated immune response targeting the colon, and involves unknown environmental factors.
- Trial name
- UCD (NCT02922881)
- Testing
- Ulcerative Colitis Diet (UCD)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Children's Hospital of Philadelphia
Dual-target CAR-T Cells, B ALL
Dual Target CAR-T Cells in B-cell Acute Lymphoblastic Leukemia
Prospectively evaluate the safety and effectiveness of CD19/CD22 dual-target CAR-T cells in the treatment of relapsed/refractory B-cell acute lymphoblastic leukemia.
- Conditions
- Dual-target CAR-T Cells, B ALL, Relapse, Refractory B Acute Lymphoblastic Leukemia
- Trial name
- CAR-T (NCT04723901)
- Testing
- Dual target CAR-T cell therapy
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shenzhen University General Hospital
Crohn Disease
Study of Factors and Mechanisms Influencing the Effects of Treatments in Crohn's Disease
The course of Crohn's disease (CD) varies considerably between patients, but reliable prognostic markers are not available in clinical practice.
- Trial name
- NCT04135027
- Testing
- no interventions
- Where
- 4 sites in China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Child Abuse, Self-control
Coaching Alternative Parenting Strategies (CAPS) Study
This is a randomized, controlled trial (RCT) of Parent-Child Interaction Therapy (PCIT) designed to test the effects of PCIT on self-regulation and behavior in child maltreating (CM) parents and their elementary-school children.
- Conditions
- Child Abuse, Self-control, Parenting
- Trial name
- CAPS (NCT02684903)
- Testing
- Parent Child Interaction Therapy
- Where
- United States
- Volunteers
- 408 people
- Sponsor
- University of Oregon
Dermatologic Diseases
Role of Angiogenesis in Dermatologic Diseases: A Potential Therapeutic Target
The researchers believe that pro-angiogenic factors are upregulated in a wide range of dermatologic diseases, including port wine stains, hemangiomas, angiofibromas, Kaposi's sarcoma, angiosarcoma, scars, rosacea, and psoriasis.
- Trial name
- NCT00842283
- Testing
- skin tissue sample
- Where
- 2 sites in United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Preterm Infants, Respiratory Distress Syndrome (Neonatal)
Pressure Targeting During High Flow Therapy in Premature Infants
The goal of this study is to see if a new approach to breathing support ('Pressure Targeted High Flow') is as effective as standard of care ('Continuous Positive Airway Pressure') in prematurely born infants.
- Conditions
- Preterm Infants, Respiratory Distress Syndrome (Neonatal), BPD - Bronchopulmonary Dysplasia
- Trial name
- NeoMATCH (NCT07418502)
- Testing
- Pressure Targeted High Flow, CPAP
- Where
- 2 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Texas at Austin
T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma
Universal 4SCAR7U Targeting CD7-positive Malignancies
The purpose of this clinical trial is to assess the feasibility, safety and efficacy of universal CAR T cells based on 4SCAR7U design against CD7-positive hematological malignancies using CD7 specific universal CAR T cells.
- Conditions
- T-cell Acute Lymphoblastic Leukemia, T-cell Acute Lymphoblastic Lymphoma, Acute Myeloid Leukemia, NK Cell Lymphoma
- Trial name
- NCT05995028
- Testing
- Universal CD7-specific CAR gene-engineered T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T ACI
A Feasibility and Safety Study of CD38 CAR-T Cell Immunotherapy for Relapsed B-cell Acute Lymphoblastic Leukemia After CD19 CAR-T Adoptive Cellular Immunotherapy
CD19-directed CAR-T cell therapy has shown promising results for the treatment of relapsed or refractory B-cell malignancies; however, a subset of patients relapse due to the loss of CD19 in tumor cells.
- Trial name
- NCT03754764
- Testing
- Specificity CD38 CAR-T Cells
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Chinese PLA General Hospital