Clinical trials: Testosterone
Cerebral Blood Flow, Cerebral Blood Flow Regulation
The Role of Estrogen and Testosterone in Determining Brain Blood Flow and Metabolic Regulation in Humans
Due to historical exclusion of females from research, there are gaps in the understanding of female physiology, how it differs from males, and how sex-specific hormones contribute.
- Conditions
- Cerebral Blood Flow, Cerebral Blood Flow Regulation, Sex Differences, Exercise
- Trial name
- NCT07212712
- Testing
- GnRH antagonist, Estradiol (E2), Testosterone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Health Services for Transgender Persons, Transgender Persons
Comparing Subcutaneous Testosterone to Intramuscular Testosterone in Gender Affirming Care of Transgender Male Adolescents
The trial studies the efficacy of subcutaneous (SQ) testosterone compared to intramuscular (IM) testosterone therapy during the first 6 months of pubertal induction in transgender male adolescents.
- Trial name
- NCT03864913
- Testing
- Testosterone injection, PedsQL questionnarie, Masculinizing effects questionnaire
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Fine Motor Skills, Testosterone Concentration
Effect of Exercise Training on Fine Motor Skills
Despite the importance of physical activity for adolescent physical development, the specific impact of different types of exercise training on fine motor skills and testosterone concentration is unknown.
- Trial name
- NCT04734964
- Testing
- exercise training
- Where
- Lithuania
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Hyperandrogenism
Sleep-wake Changes of Luteinizing Hormone Frequency in Pubertal Girls With and Without High Testosterone
The purpose of this study is to determine whether sleep-wake changes of luteinizing hormone pulse frequency are different in early pubertal girls with high testosterone levels compared to early pubertal girls with normal…
- Trial name
- CRM005 (NCT00930007)
- Testing
- Blood sampling
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Adolescent Depression
Adolescent Mood During Puberty and Testosterone
Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention…
- Trial name
- AMPT (NCT06072677)
- Testing
- Healthy Minds Program
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Transgender, Transgenderism
Cardiometabolic Health in Transgender Males
Transgender individuals are those with a gender identity opposite the sex they were assigned at birth. Approximately 1% of the population is transgender, equating to ~60,000 transgender Wisconsinites.
- Trial name
- NCT04977765
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Hypogonadism
Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement
There is evidence that suggests male sex hormones (androgens) play a significant role in brain (central nervous system) functioning.
- Trial name
- NCT00001412
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Menopause, Perimenopausal Disorder
A New Hormone Replacement Paradigm: Physiologic Restoration Study
This is a three-year, prospective, observational study looking at the benefits of rhythmically dosed, bio-identical hormones compounded in a carrier cream in 100 symptomatic peri and postmenopausal women.
- Conditions
- Menopause, Perimenopausal Disorder, Menopause Related Conditions
- Trial name
- NCT04190927
- Testing
- Compounded topical estradiol and compounded topical progesterone in a carrier cream
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Women's Hormone Network
Bipolar Disorder, Circadian Rhythm
Effects of Sex Hormones on Circadian Rhythm in Men and Women
For many years researchers have been trying to better understand the regulation of sleep and activity by studying circadian (daily) rhythms of human beings.
- Conditions
- Bipolar Disorder, Circadian Rhythm, Depressive Disorder
- Trial name
- NCT00001285
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Secondary Hypogonadism
The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups
The study is designed to answer the following questions: 1. Is there any difference between the compositions of the HDL cholesterol subpopulations of patients with hypogonadism and the healthy controls. 2.
- Trial name
- NCT01454011
- Testing
- Testosteron 250mg injection, Testosterone 50mg transdermal application
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Hypogonadism, Estrogens
Development and Validation of in Vitro Cell-based Bioassays for Nuclear Receptor Activation
This is a prospective biobank set up to collect serum from patients with disorders associated with changes in androgens, estrogens or sex hormone-binding globulin (SHBG), before and/or after treatment.
- Conditions
- Hypogonadism, Estrogens, Testosterone, Androgens
- Trial name
- NCT02434562
- Testing
- Serum (with or without urine) samples
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Puberty Delayed
Pubertal Replacement In Boys Study Nebido and Testoviron Depot Treatment
In this prospective open clinical study, Pubertal Replacement in Boys Study (PRIBS), boys 14-16 years with delayed puberty in terms of slow pubertal progression, were randomized to SoC treatment with TE: Testostoviron depot® 75…
- Trial name
- NCT05417035
- Testing
- Nebido
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- NU-Hospital Organization, Sweden
Anxiety Disorder, Depression
Evaluation of Association Between Testosterone Levels, Dementia, and Adverse Mental Health Outcomes
This study evaluates the association between testosterone levels and risk of dementia and adverse mental health outcomes (e.g. depression and anxiety).
- Conditions
- Anxiety Disorder, Depression, Genetic Disorder, Hematopoietic and Lymphoid Cell Neoplasm
- Trial name
- NCT04743466
- Testing
- Electronic Health Record Review
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
PCOS
Theca Cell Function in Adolescents With Polycystic Ovary Syndrome (PCOS)
In women with polycystic ovary syndrome (PCOS), the cardinal physiological abnormality is excessive ovarian androgen production marked by increased serum testosterone (T) and androstenedione (A) levels.
- Trial name
- NCT01154192
- Testing
- Dexamethasone, recombinant human chorionic gonadotropin (r-hCG)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Appetitive Behavior, Pediatric Obesity
The Acute Effect of Protein or Carbohydrate Intake on Testosterone Levels and Food Intake in Children and Adolescent Boys
The purpose of this study was to determine the effect of acute protein and glucose intake on testosterone levels measured in adolescent boys and determine whether changes in testosterone levels are associated with alterations in…
- Trial name
- NCT03412136
- Testing
- Control, Glucose, Protein
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Polycystic Ovary Syndrome
Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS)
The purpose of this study is to determine if the combination therapy of lifestyle intervention and use of Metformin together will improve ovulation induction and hyperandrogenemia in women with polycystic ovary syndrome, by…
- Trial name
- NCT00151411
- Testing
- Metformin, Lifestyle Intervention
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center