Clinical trials: Thermal Injury
Fractures, Bone
Hi-Res IR Thermography for the Diagnosis of Toddler's Fractures
This is a pilot proof of feasibility study to explore the efficacy of high resolution thermal imaging (HRTI) to screen for toddler's fractures.
- Trial name
- NCT05536622
- Testing
- High resolution infrared imaging
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Skin Wound, Burns
StrataGraft Safety, Tolerability and Efficacy in Pediatric Subjects
Autografting is a surgical procedure to transplant healthy skin (donor skin) from another part of the participant's own body (donor site) to the burned part. Autografting is the usual treatment for DPT burns.
- Conditions
- Skin Wound, Burns, Trauma-related Wound
- Trial name
- StrataSTEPS (NCT05517902)
- Testing
- StrataGraft
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Stratatech, a Mallinckrodt Company
Burns
Relationship Between Neutrophil Function and Sepsis in Adults and Children With Severe Thermal Injuries
The study aims to validate neutrophil function, immature granulocyte and plasma free DNA levels as predictive diagnostic biomarkers of sepsis in burn patients.
- Trial name
- SIFTI-2 (NCT04693442)
- Testing
- taking of blood, urine and blood samples and objective scar assessment
- Where
- United Kingdom
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry
Burns
Phase III Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
This multicentre phase III clinical trial will target adults and adolescents of 12 years and older with severe burns to confirm the efficacy and functionality of denovoSkin™ in achieving wound closure and reducing scarring in…
- Trial name
- NCT06745557
- Testing
- denovoSkin(TM), STSG
- Where
- 19 sites in Belgium, France and 7 more
- Volunteers
- 70 people
- Sponsor
- CUTISS AG
Burns Second Degree
Thermal Imaging and Pediatric Burns
The need to cover a burn with a skin graft is determined primarily by its depth. In fact only burns of the second deep degree or the third degree are likely to be grafted.
- Trial name
- FLIRPED (NCT03702972)
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Burns
Lipopolysaccharide Adsorption (Efferon LPS NEO) in Children With Thermal Burns
This observational pilot study aims to identify criteria for evaluating the effectiveness of hemoadsorption with the Efferon LPS NEO device in pediatric burn injury.
- Trial name
- NCT07248930
- Testing
- Efferon LPS NEO
- Where
- 2 sites in Russia
- Sponsor
- Efferon JSC
Burns
Effects of Therapy With Sulfamylon® 5% Topical Solution Compared to a Historical Control Group
The primary objective is to compare the effectiveness of treatment with Sulfamylon® solution as the initial topical moist dressing over meshed autografts following the initial graft procedure on preventing graft loss in a…
- Trial name
- NCT00634166
- Testing
- Sulfamylon® For 5 % Topical Solution, Topical Antimicrobial/Antifungal Medications
- Where
- 9 sites in United States
- Volunteers
- 220 people
- Sponsor
- Mylan Inc.
Heat Stress, Physiological Stress
Impact of Indoor Overheating on Physiological Strain in Children
Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children.
- Conditions
- Heat Stress, Physiological Stress, Cognitive Change
- Trial name
- NCT07261202
- Testing
- Simulated exposure to indoor overheating
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Burn Wound
Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds
The primary purpose of this first-in-human, early feasibility study is to assess safety and feasibility of the Low-Irradiance Monochromatic Biostimulation (LIMB) System as a phototherapeutic intervention for the management of…
- Trial name
- NCT03948360
- Testing
- Low-Irradiance Monochromatic Biostimulation (LIMB) Device, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rogers Sciences Inc.
Burns, Wound Heal
Burn Validation Study
The purpose of this study is to validate the algorithm for burn healing assessment by the Spectral MD DeepView device which would provide burn healing potential assessment.
- Conditions
- Burns, Wound Heal, Wounds and Injuries
- Trial name
- BVS (NCT06131203)
- Testing
- DeepView SnapShot Portable (DV-SSP)
- Where
- 21 sites in United States
- Volunteers
- 274 people
- Sponsor
- SpectralMD
Skin Burns
The Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns
Skin burns are one of the causes of disability, suffering and death in humans. Anecdotal, uncontrolled studies have shown the efficacy of povidone-iodine ointment in human skin burns, provided the preparation was applied shortly…
- Trial name
- NCT01350713
- Testing
- povidone iodine
- Where
- Israel
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Thermal Burn
Use of NexoBrid for Treatment of Acute Deep Partial and Full Thickness Burn Injuries
Enzymatic eschar removal with NexoBrid allows initiating and completing the phase of removal of the offending eschar earlier upon admission, enabling earlier visualization of the wound bed for assessment of burn wound depth as…
- Trial name
- NEXT (NCT04040660)
- Testing
- NexoBrid
- Where
- 28 sites in United States
- Sponsor
- MediWound Ltd
Burns
Study With an Autologous Dermo-epidermal Skin Substitute for the Treatment of Burns in Adults and Adolescents
This phase IIb trial aims to evaluate the efficacy and safety of EHSG-KF (synonym denovoSkin) in comparison to meshed STSG in adults and adolescents with partial deep dermal and full thickness burns.
- Trial name
- NCT03227146
- Testing
- EHSG-KF, STSG
- Where
- 6 sites in Italy, Netherlands and 1 more
- Volunteers
- 14 people
- Sponsor
- CUTISS AG
Burn
Study in the Use of Virtual Reality as an Adjunct to Pain Control in Burn Patients
The purpose of this study is to evaluate the use of Virtual Reality (VR) technology during Physical Therapy (PT) and/or Occupational Therapy (OT) for patients with burns.
- Trial name
- NCT00591448
- Testing
- Virtual Reality (VR)
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Thermal Burn, Wound
Biofilm Infection in Adults and Children Burn Injury
The objective of the study is to analyze the different implications (such as graft loss and conversion of indeterminate depth burns) of biofilm infections in burn patients.
- Trial name
- NCT03248154
- Testing
- Procellera
- Where
- 4 sites in United States
- Sponsor
- Gayle Gordillo
Fracture, Abuse Physical
Thermal Imaging Compared to Skeletal Survey in Children Below 2 Years
When a child less than 2 years old attends the Emergency Department (ED) with an injury, carers should offer an explanation. When there is no explanation or if the explanation is inconsistent \& because the child cannot say what…
- Trial name
- NCT04237454
- Testing
- Thermal Imaging Camera
- Where
- United Kingdom
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sheffield Children's NHS Foundation Trust
Risk of Heat Stress
Impact of Pre-cooling in Adolescent Tennis Athletes
Many tennis tournaments are played outdoors in hot and humid conditions, which poses a significant challenge particularly for children athletes.
- Trial name
- NCT04197375
- Testing
- Thermal stress and performance using a pre-cooling protocol, Thermal stress and performance without a pre-cooling protocol
- Where
- Greece
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Hypothermia, Newborn, Body Temperature Changes
Early Weaning From Incubator To Crib
The purpose of this study is to determine the safety and feasibility of weaning from the incubator at a lower post-natal weight at 1600 grams.
- Conditions
- Hypothermia, Newborn, Body Temperature Changes, Newborn Thermal Injury
- Trial name
- NCT06230172
- Testing
- Weaning incubator (heat) at an lower postnatal weight
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Augusta University
Appendicitis Acute, Safety Issues
Review of Efficacy of Used ultraSonic Energy Device
Single-use medical instruments are intended by the manufacturers for single-use only or for single-patient-use only. Nevertheless, single-use instruments are being reused more than once in many countries around the world.
- Conditions
- Appendicitis Acute, Safety Issues, Complication of Surgical Procedure, Device Induced Injury
- Trial name
- REUSED (NCT04226482)
- Testing
- New Device, Used Device
- Where
- 2 sites in Croatia
- Volunteers
- 100 people
- Sponsor
- University of Split, School of Medicine