Clinical trials: Thrombolysis
Deep Vein Thrombosis, Venous Thrombosis
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
The purpose of this study is to determine if the use of adjunctive Pharmacomechanical Catheter Directed Thrombolysis, which includes the intrathrombus administration of rt-PA--Activase (Alteplase),can prevent the post-thrombotic…
- Conditions
- Deep Vein Thrombosis, Venous Thrombosis, Postphlebitic Syndrome, Venous Thromboembolism
- Trial name
- ATTRACT (NCT00790335)
- Testing
- Recombinant tissue plasminogen activator (rt-PA)
- Where
- 56 sites in United States
- Volunteers
- 692 people
- Sponsor
- Washington University School of Medicine
Acute Stroke
CT or MRI in Work up for i.v. Thrombolysis: a Single-centre Study
Acute stroke occurs in approximately 13.000 persons every year in Denmark, 10 - 15 % now receives intervenous thrombolytic therapy, which remains the most important acute treatment in ischaemic stroke.
- Trial name
- NCT02780843
- Testing
- Computerized Tomography, Magnetic Resonance Imaging
- Where
- Denmark
- Volunteers
- 499 people
- Sponsor
- Bispebjerg Hospital
Cerebrovascular Accident
Troponin- I Elevation Predicts Outcome After Thrombolysis in Stroke Patients
Elevated level of serum troponin (T-I) has been regarded as a prognostic biomarker of poor outcome in acute ischemic stroke. However, its role in outcome in thrombolysed ischemic stroke patients remains uncertain.
- Trial name
- NCT03925298
- Volunteers
- 81 people
- Sponsor
- Zagazig University
Thrombolytic Therapy, Acute Stroke
Improving In-hospital Stroke Service Utilisation in China
A cluster randomised controlled trial will be conducted, using hospital as randomisation unit. Hospitals in Zhejiang Province, China, will be randomised into two arms (1:1): an intervention arm and a control arm.
- Conditions
- Thrombolytic Therapy, Acute Stroke, Door to Treatment Time, Quality Improvement
- Trial name
- NCT03317639
- Testing
- Behaviour Change Wheel model guided intervention
- Where
- China
- Volunteers
- 1,634 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
STEMI
Erectile Dysfunction After Percutaneous Coronary Intervention Versus the Thrombolytic Therapy in Acute ST Elevation Myocardial Infarction
Erectile dysfunction is a common sexual problem affecting up to one-third of men throughout their life. It is now well recognized that risk factors for erectile dysfunction (ED) include the same risk factors as coronary artery…
- Trial name
- NCT03328156
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arterial Ischemic Stroke
National Retrospective Study Of Recanalization Treatments In Pediatric Arterial Ischemic Stroke
The purpose of this study is to evaluate recanalization treatments use, safety and efficacy at the acute phase of arterial ischemic stroke in pediatric patients
- Trial name
- KID-CLOT (NCT03887143)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Ischemic Stroke, Thrombolytic (t-PA) Treatment
Long-Term Survival After Ischaemic Stroke: Ebrictus Study
A number of large trials have confirmed the benefits of thrombolysis in acute stroke, but there are gender differences. The authors sought to examine the relationship between sex and outcome after thrombolysis.
- Conditions
- Ischemic Stroke, Thrombolytic (t-PA) Treatment, Gender Bias, Long Term Adverse Effects
- Trial name
- EBRICTUS (NCT03247036)
- Testing
- IV thrombolytic (t-PA) treatment vs not
- Where
- Spain
- Volunteers
- 21,000 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Stroke, Acute
Computer-based Online Database of Acute Stroke Patients for Stroke Management Quality Evaluation
In the past three decades, the burden of stroke has increased in China and has gradually become the leading cause of death. The data acquisition and medical quality management still need to be improved in China.
- Trial name
- NCT04487340
- Testing
- Education
- Where
- China
- Volunteers
- 200,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke
Finnish Telestroke Pilot 2007-2009
Objective is to describe two years experience from The Finnish Telestroke piloting between Helsinki University Central Hospital (HUCH), Department of Neurology, The Hub, and five hospitals, the spokes.
- Trial name
- NCT01136993
- Where
- Finland
- Volunteers
- 109 people
- Sponsor
- Helsinki University Central Hospital
Thrombolysis, Deep Vein Thrombosis
Contemporary Endovascular Therapies in Treatment of Acute Iliofemoral Deep Vein Thrombosis
The goal of this initial proof of principle single arm cohort trial is to determine if contemporary endovascular venous intervention, compared with a 1:1 propensity-matched medical therapy arm of the ATTRACT trial, significantly…
- Trial name
- CLEAR-DVT (NCT03901872)
- Testing
- Contemporary endovascular venous intervention by Zelante pharmacomechanical thrombolysis
- Where
- United Kingdom
- Volunteers
- 65 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Antiplatelet Therapy, Hemorrhagic Infarction
Early Antiplatelet Therapy After Hemorrhagic Infarction in Acute Ischemic Stroke Treated With Intravenous Thrombolysis (HITs)
Previous study showed that the proportions of hemorrhagic Infarction after intravenous thrombolysis were 24.2% and 32.5% in the control group and the alteplase group, and most of them were asymptomatic.
- Trial name
- NCT04624295
- Testing
- Early aspirin Therapy, Non-Early aspirin Therapy
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Cerebral Infarction
Study on Yangxue Nao Granules Reducing the Risk of Stroke
Objective: To explore the effectiveness of raising serum nao granules in reducing the risk of bleeding in patients with acute ischemic stroke treated with intravenous thrombolysis in the real world
- Trial name
- NCT04949906
- Testing
- Raise serum brain granules, No nourishing serum brain granules are used
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking University Third Hospital
Stroke, Acute
Registration of Intravenous Thrombolysis for Acute Ischemic Stroke in Southwestern China（IVTIS）
This study aims to observe the safety and effectiveness of intravenous thrombolysis for acute ischemic stroke in real-world clinical practice.
- Trial name
- IVTIS (NCT06131385)
- Testing
- intravenous thrombolysis
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Zhengzhou Yuan
Pharmacomechanical Thrombolysis, Deep Vein Thrombosis
The Study of Percutaneous Mechanical Thrombectomy Treating Acute Deep Vein Thrombosis of Lower Extremities
This study is a prospective, multicenter, real world, observational study intended to understand tmechanical thrombectomy in the treatment of acute deep venous thrombosis of lower extremities, It is estimated that 600 patients…
- Trial name
- NCT05356767
- Testing
- Pharmacomechanical thrombolysis
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Left Ventricular Thrombus
Relation of Laboratory Indices to Left Ventricular Thrombus Formation in Patients With Acute Anterior ST Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention or Thrombolytic Therapy
to find the relationship between the different hematological indices including platelet indices, and blood cell ratios, to the development of LV thrombus in acute anterior STEMI patients managed by primary percutaneous coronary…
- Trial name
- NCT06152939
- Testing
- Primary percutaneous coronary intervention or thrombolytic therapy
- Volunteers
- 400 people
- Sponsor
- Assiut University
Acute ST-elevation Myocardial Infarction
Detection and Significance of Heart Injury in ST Elevation Myocardial Infarction.
Heart imaging with magnetic resonance imaging (MRI) provides detailed insights into heart function and injury. The nature and significance of heart injury after a heart attack is incompletely understood.
- Trial name
- BHF MR-MI (NCT02072850)
- Testing
- Coronary pressure wire, Magnetic resonance imaging of the heart
- Where
- United Kingdom
- Volunteers
- 324 people
- Sponsor
- NHS National Waiting Times Centre Board
Infarction
Myocardial Infarction Safe Emergency Medicine Accompanying Study: Providing Reperfusion Therapy Within the Recommended Time Limits
The project is a prospective observational study with the aim of system improvement. It represents accompanying research in connection with the implementation of Safe Emergency Medicine , - an initiative under the auspices of the…
- Trial name
- NCT07092904
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University Hospital of North Norway
Pulmonary Embolism, Venous Thromboembolism
STRATEGY-PE: Real-World Treatment Strategies for Intermediate-High Risk Pulmonary Embolism
This study aims to compare the effectiveness and safety of three treatment strategies (Anticoagulation, Thrombolysis, and Mechanical Thrombectomy) for patients with intermediate-high risk acute pulmonary embolism (PE) in a…
- Trial name
- STRATEGY-PE (NCT07603700)
- Testing
- Anticoagulants, Thrombolytic Agents, Mechanical Thrombectomy Devices
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stroke
Thrombolysis in Pediatric Stroke (TIPS)
Thrombolysis in Pediatric Stroke (TIPS) is a five-year multi-center international safety and dose-finding study of intravenous (IV) tPA in children with acute ischemic stroke (AIS) to determine the maximal safe dose of…
- Trial name
- TIPS (NCT01591096)
- Testing
- Tissue plasminogen activator (Activase®)
- Where
- 15 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Seattle Children's Hospital
Stroke
Safety and Efficacy of the Penumbra™ System in Acute Middle Cerebral Artery (MCA) Stroke
Stroke prognosis is intimately related to reperfusion. Reperfusion in acute setting can be achieved with different strategies - varying from intravenous rtPA from mechanical thrombectomy.
- Trial name
- NCT01133223
- Testing
- Penumbra™ System, Recombinant tissue plasminogen activator
- Where
- Brazil
- Sponsor
- Hospital de Clinicas de Porto Alegre