Clinical trials: Tissue Plasminogen Activator
Ischemic Stroke, Thrombolytic (t-PA) Treatment
Long-Term Survival After Ischaemic Stroke: Ebrictus Study
A number of large trials have confirmed the benefits of thrombolysis in acute stroke, but there are gender differences. The authors sought to examine the relationship between sex and outcome after thrombolysis.
- Conditions
- Ischemic Stroke, Thrombolytic (t-PA) Treatment, Gender Bias, Long Term Adverse Effects
- Trial name
- EBRICTUS (NCT03247036)
- Testing
- IV thrombolytic (t-PA) treatment vs not
- Where
- Spain
- Volunteers
- 21,000 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Deep Vein Thrombosis, Venous Thrombosis
Acute Venous Thrombosis: Thrombus Removal With Adjunctive Catheter-Directed Thrombolysis
The purpose of this study is to determine if the use of adjunctive Pharmacomechanical Catheter Directed Thrombolysis, which includes the intrathrombus administration of rt-PA--Activase (Alteplase),can prevent the post-thrombotic…
- Conditions
- Deep Vein Thrombosis, Venous Thrombosis, Postphlebitic Syndrome, Venous Thromboembolism
- Trial name
- ATTRACT (NCT00790335)
- Testing
- Recombinant tissue plasminogen activator (rt-PA)
- Where
- 56 sites in United States
- Volunteers
- 692 people
- Sponsor
- Washington University School of Medicine
Dental Malocclusion
Evaluation of Dental and Skeletal Effect of TPA and Nance as a Space Maintainers in Children: A Prospective Clinical Trial
This study will aim to evaluate the dental and skeletal effect of the Transpalatal arch and Nance holding arch as a space maintainers in children.
- Trial name
- NCT05896618
- Testing
- TPA, Nance appliance
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Space Maintenance
Efficacy of Digital Versus Conventional Nance and Transpalatal Arch Appliances for Space Maintenance
To compare the effect of digital fabricated Nance and transpalatal arch appliances versus conventional fabricated Nance and transpalatal arch appliances.
- Trial name
- TPA (NCT07593378)
- Testing
- digital fabricated nance appliance, digital TPA appliance, conventional nance appliance
- Where
- Egypt
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Pharos University in Alexandria
Central Venous Catheter Thrombosis, Central Venous Catheter Associated Bloodstream Infection
t-PA Prophylaxis to Prevent Catheter-associated Thrombosis and Infection
The purpose of this pilot study is to test feasibility of concept, consent and enrollment rates, and mechanics of study designed to assess if intra-catheter dwells of tissue plasminogen activator (t-PA) is effective in decreasing…
- Trial name
- TOPCAT (NCT03672006)
- Testing
- alteplase (recombinant t-PA), Heparin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Periodontal Diseases, Periodontal Attachment Loss
Low-level Laser Therapy as an Adjunct to Non-surgical Periodontal Treatment
The present study aimed to investigate the effects of low-level laser therapy (LLLT) as an adjunct to non-surgical periodontal treatment (NSPT) on the plasminogen-activating system in Stage 3-4, Grade C periodontitis patients.
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Periodontal Disease, AVDC Stage 3, Periodontal Inflammation
- Trial name
- NCT05233501
- Testing
- low level laser therapy, non-surgical periodontal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Acute Stroke
The CLOQS Trial - Countdown Lights to Optimize Quality in Stroke
To reduce door-to-needle times in acute stroke treatment. Using an organizational behaviour intervention (a large stopwatch), we will post a visual cue to remind all parties that "time is brain".
- Trial name
- CLOQS (NCT01148602)
- Testing
- LED stopwatch-clock timers
- Where
- 3 sites in Canada
- Volunteers
- 3,452 people
- Sponsor
- Sunnybrook Health Sciences Centre
Dental Intrusion, Mandibular Rotation
A Comparison of Two Protocol for Maxillary Molar Intrusion Buccal Miniscrew and TPA Versus Vertical Holding Appliance
this study is to compare the dental and skeletal changes caused by the intrusion of maxillary first molars buccal miniscrew and TPA versus vertical holding appliance using lateral cephalometry.
- Conditions
- Dental Intrusion, Mandibular Rotation, ANB , SNA, SNB, Openbite Teeth | Teeth and Gum | Dental
- Trial name
- NCT05433051
- Testing
- buccal miniscrew and TPA, vertical holding appliance
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Al-Azhar University
Abdominal Abscess, Tissue Plasminogen Activator
Treatment of Abdominal Abscesses With or Without Fibrinolysis
The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.
- Trial name
- NCT01597336
- Testing
- Tissue plasminogen activator abscess flush, Saline flush of abscess
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Children's Mercy Hospital Kansas City
Short Bowel Syndrome
rtPA in in the Prevention of CVAD-Associated Thrombosis and Infection in Pediatric Patients With Short Bowel Syndrome
The primary research question is, in patients with short bowel syndrome requiring central venous access device (CVAD) for long-term total parenteral nutrition, is once weekly recombinant tissue plasminogen activator (rtPA) lock…
- Trial name
- NCT02355743
- Testing
- rtPA lock therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Lynn Malec
Intracranial Embolism, Thrombosis
Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion
The purpose of the present, randomized, controlled multicenter phase III trial is to investigate the safety and efficacy of continuous 1-hour insonation of occluded middle cerebral artery with 2 MHz TCCS in stroke patients…
- Trial name
- NCT00336596
- Testing
- transcranial ultrasound in patients treated with iv t-PA
- Where
- 6 sites in Switzerland
- Volunteers
- 400 people
- Sponsor
- University of Zurich
Empyema
Empyema Treated With tPA & DNAse
The objective of this study is to scientifically evaluate a new substrate for fibrinolysis compared to our standard tPA. The hypothesis, driven by a recent prospective trial, is that tPA may benefit from the addition of DNAse.
- Trial name
- NCT01862458
- Testing
- tPA alone, tPA plus dornase
- Where
- United States
- Sponsor
- Children's Mercy Hospital Kansas City
Embolism, Thrombophlebitis
Treatment for Blood Clots in the Veins of the Legs
Acute deep venous thrombosis (ADVT) of the lower extremity is a common disorder. Traditional treatment with anticoagulation therapy is effective in reducing the associated risk of pulmonary embolism, but is ineffective in…
- Trial name
- NCT00001713
- Testing
- Recombinant Tissue Plasminogen Activator, Heparin, Warfarin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acute Ischemic Stroke
Kanagawa Intravenous and Endvascular Treatment Registry
The K-NET registry is a prospective, multicenter, observational registry study for all consecutive patients who received intravenous tPA therapy and/or endovascular treatment for acute ischemic stroke.
- Trial name
- K-NET (NCT05213533)
- Where
- Japan
- Volunteers
- 4,000 people
- Sponsor
- St. Marianna University Toyoko Hospital
Intra-abdominal Abscess
Safety and Efficacy of the Use of Tissue Plasminogen Activator (tPA) in Intra-Abdominal Collections in Children - A Prospective Study
The objective of this study is to establish the efficacy of tPA when used in pediatric intra-abdominal abscesses immediately after percutaneous drainage, irrespective of the ultrasound appearance or consistency of the drained…
- Trial name
- NCT01576679
- Testing
- Cathflo (Alteplase), Saline
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- The Hospital for Sick Children
COVID
Nebulised Rt-PA for ARDS Due to COVID-19
Some patients infected with COVID-19 develop a severe form of a lung disease called acute respiratory distress syndrome (ARDS). In these patients, the lungs become severely inflamed because of the virus.
- Trial name
- PACA (NCT04356833)
- Testing
- Nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 1, Nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 2 IMV, Nebulised recombinant tissue-Plasminogen Activator (rt-PA) - Cohort 2 NIV
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University College, London
Thrombosis
Safety and Efficacy of Tissue Plasminogen Activator (tPA) in Neonates and Infants
The purpose of this study is to determine if alteplase is effective in dissolving a clot in a catheter in a large vein (central venous line or PICC line) or artery in infants less than 6 months of age.
- Trial name
- NCT00265005
- Testing
- alteplase
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Louisville
Stroke
Increasing Stroke Treatment Through Interventional Change Tactics Study
The purpose of this study is to evaluate a standardized, system-based, barrier assessment and interactive educational intervention to increase appropriate t-PA use for stroke.
- Trial name
- INSTINCT (NCT00349479)
- Testing
- Barrier assessment / interactive educational intervention
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Michigan
Prosthetic Valve Thrombosis
Comparison of Different TRansesophageal Echocardiography Guided thrOmbolytic Regimens for prosthetIc vAlve Thrombosis
Despite high mortality and morbidity, the best treatment strategies for prosthetic valve thrombosis (PVT) have been controversial.
- Trial name
- TROIA (NCT01451320)
- Testing
- Streptokinase, Tissue plasminogen activator
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Dysfunctional Central Venous Access Devices (CVADS)
Cathflo Activase Pediatric Study
This was a Phase IV, open-label, single-arm, multicenter trial that was to be conducted at ~60 sites in the United States. Approximately 300 pediatric subjects with dysfunctional CVADs (including catheters with valves, multiple…
- Trial name
- NCT00307580
- Testing
- Cathflo Activase (Alteplase)
- Volunteers
- 300 people
- Sponsor
- Genentech, Inc.