Clinical trials: Tissue Repair
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Acute Myeloid Leukemia in Remission, de Novo Myelodysplastic Syndrome
Fludarabine Phosphate, Cyclophosphamide, and Total-Body Irradiation Followed by Donor Bone Marrow Transplant, Mycophenolate Mofetil, and Cyclosporine in Treating Patients With Fanconi Anemia
This phase II trial studies how well total-body irradiation (TBI) works when given together with fludarabine phosphate and cyclophosphamide followed by donor bone marrow transplant, mycophenolate mofetil, and cyclosporine in…
- Conditions
- Acute Myeloid Leukemia in Remission, de Novo Myelodysplastic Syndrome, Fanconi Anemia, Previously Treated Myelodysplastic Syndrome
- Trial name
- NCT00453388
- Testing
- Allogeneic Bone Marrow Transplantation, Cyclophosphamide, Cyclosporine
- Where
- 5 sites in United States, Brazil
- Volunteers
- 6 people
- Sponsor
- Fred Hutchinson Cancer Center
Iatrogenic Perforation of Primary Molars
Evaluation of Furcal Perforation Repair in Primary Molars With MTA Versus Bioceramics (A Randomized Clinical Trial)
Furcal perforation is one of the most challenging procedural accidents during pulpotomy of primary molars and should be sealed as soon as possible to prevent bacterial invasion at perforation site and subsequent tooth extraction.
- Trial name
- NCT04137861
- Testing
- Bioceramics
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Ahmad Elheeny
Cleft Palate, Jaw Abnormalities
Improving Informed Consent for Cleft Palate Repair
To determine if providing a written document in addition to the standard oral discussion of surgical risks improves risk recall for the parents/guardians of a child seen in consultation for cleft palate surgery, and if this has…
- Conditions
- Cleft Palate, Jaw Abnormalities, Maxillofacial Abnormalities, Mouth Abnormalities
- Trial name
- NCT02595307
- Testing
- Pamphlet
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- IWK Health Centre
Glandular Urethral Disassembly, Tubularized Incised Plate
Comparison Between Glandular Urethral Disassembly Versus Tubularized Incised Plate for Primary Distal Hypospadius Repair
To compare Glandular Urethral Disassembly technique versus Tubularized Incised Plate technique for Primary Distal Hypospadius Repair
- Conditions
- Glandular Urethral Disassembly, Tubularized Incised Plate, Distal Hypospadius Repair
- Trial name
- NCT05913128
- Testing
- Glandular Urethral Disassembly technique
- Where
- Egypt
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Benha University
Incisional Hernia
Mini- or Less-Open Sublay Operation (MILOS) of Incisional Hernias
Prospective non-randomized observational register study of all elective symptomatic incisional hernias operated on in the Hernia Center of Reference of Gross Sand Hospital using the novel endoscopic assisted Mini- or Less-Open…
- Trial name
- NCT03133000
- Volunteers
- 615 people
- Sponsor
- Gross Sand Hospital
Shoulder Pain, Shoulder Injuries
MDR SureLock All-Suture Anchor
To report the outcomes of a series of patients with recurrent anterior and/or posterior shoulder instability who underwent surgical repair of the affected labrum using the SureLock all-suture anchor.
- Conditions
- Shoulder Pain, Shoulder Injuries, Shoulder Disease, Shoulder Pain Chronic
- Trial name
- NCT04093700
- Testing
- SureLock All-Suture Anchor
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Zimmer Biomet
Hypospadias
Liposomal Bupivacaine vs Standard Penile Block for Hypospadias Repair
The investigator proposes a prospective randomized study of males with hypospadias to either bupivacaine penile block or liposomal bupivacaine block for hypospadias repair, Figure 3.
- Trial name
- NCT04479371
- Testing
- Liposomal bupivacaine, Bupivacaine
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Vesico Vaginal Fistula
Comparative Analysis of Outcome Between Extravesical and Transvesical Repair for Vesico-vaginal Fistula
In patients with vesicovaginal fistula, transvesical and extravesical repair will be compared in terms of operative time, complications and recurrence rates.
- Trial name
- NCT04676568
- Testing
- Extravesical VVF repair
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Armed Forces Institute of Urology, Rawalpindi
Ileal Pouch-Anal Anastomosis
Ileal Pouch-Anal Anastomosis Registry
Little is known about the factors that predispose patients to complications after an ileal pouch-anal anastomosis procedure (IPAA).
- Trial name
- IPAA (NCT01026480)
- Where
- United States
- Volunteers
- 936 people
- Sponsor
- Boston Medical Center
Epidermolysis Bullosa (EB), Epidermolysis Bullosa Dystrophica
Curcumin-Based Photodynamic Therapy in Epidermolysis Bullosa: Wound Healing, Quality of Life, and Salivary Biomarkers
Epidermolysis bullosa (EB) is a rare condition that causes extreme fragility of the skin and mucous membranes, leading to the formation of painful blisters.
- Conditions
- Epidermolysis Bullosa (EB), Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Acquisita
- Trial name
- CURE-EB (NCT07596927)
- Testing
- Curcumin-based photodynamic therapy
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Ceuma
Hypospadias
Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias Repair
Hypospadias is one of the most common congenital anomalies in childhood, requiring surgical reconstruction (1). It is a penile malformation with a more proximal or ventral location beyond the usual localization of the urethra.
- Trial name
- NCT07197203
- Testing
- Sacral ESP Block, Caudal epidural block
- Volunteers
- 66 people
- Sponsor
- Assiut University
Coarctation of Aorta
Clinical Assessment of Perfusion Techniques During Repair of Coarctation With Aortic Arch Hypoplasia in Infants
The purpose of this study is to evaluate safety and efficacy of three main perfusion methods in surgical repair of coarctation of aorta with aortic arch hypoplasia in infants.
- Trial name
- NCT02835703
- Testing
- Surgical repair of coarctation of aorta
- Where
- Russia
- Volunteers
- 45 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Skin Cancer, Mohs Micrographic Surgery
Mohs Micrographic Surgery and Reconstruction in the Optum Insurance Claims Database
Mohs micrographic surgery (MMS) followed by skin reconstruction has been widely accepted for treatment of many skin cancers. To further characterize the trends in MMS and reconstruction for skin cancer, a retrospective analysis…
- Conditions
- Skin Cancer, Mohs Micrographic Surgery, Interpolated Flap Repair
- Trial name
- NCT04117373
- Where
- United States
- Sponsor
- University of Pennsylvania
Atopic Dermatitis (AD)
Efficacy Study of a Repairing Cream in Atopic Dermatitis
The application of DermControl®, a repair cream based on hyaluronic acid, sh-oligopeptide-1 and polyphenols, in combination with topical corticosteroids, could help to improve epidermal barrier function in patients with atopic…
- Trial name
- NCT07742241
- Testing
- Dermcontrol, cream based on hyaluronic acid and sh-oligopeptide-1
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Instituto de Investigacion Biotecnologica, Farmaceutica y Medicamentos Huerfanos, S.L.
Li Fraumeni Syndrome
LIFSCREEN : Evaluation of Whole Body MRI for Early Detection of Cancers in Subjects With P53 Mutation (Li-Fraumeni Syndrome)
The purpose of this study is to compare the diagnostic efficacy of two follow-up schedules for the early detection of cancers in the population under study on cancer incidence at 3 years.
- Trial name
- LIFSCREEN (NCT01464086)
- Testing
- whole body MRI
- Where
- France
- Volunteers
- 107 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Hypospadias Repair
Hemostasis During Hypospadias Surgery
A comparison between the two hemostatic methods of hypospadias repairing operation, in terms of early and mid-term (up to 6 months) failure rate (wound dehiscence and urethral stricture needing reoperation) between the two…
- Trial name
- NCT02268019
- Testing
- tourniquet application, epinephrine injection
- Where
- Iran
- Volunteers
- 70 people
- Sponsor
- Isfahan University of Medical Sciences
Pre Proof of Concept Clinical Trial
'Pre-Proof of Concept (Pre-POC)' Clinical Trials to Optimize Lead Microbiota-directed Complementary Food (MDCF) Prototypes for Their Ability to Repair Microbiota Immaturity and Establish Their Organoleptic Acceptability
Burden: According to Bangladesh Demographic Health Survey 2014, prevalence of stunting in under-five children is 36%. Severe acute malnutrition (SAM) is prevalent in about 3% of them.
- Trial name
- MDCF (NCT03084731)
- Testing
- Microbiota Directed Complementary Food (MDCF)
- Where
- Bangladesh
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Ataxia Telangiectasia
Biomarkers for Babies and Young Children With Ataxia Telangiectasia
The goal of this observational study is to identify progressive changes of quantitative brain and lung imaging, serum and movement-related biomarkers reflecting disease progression in pre-symptomatic infants and very young…
- Trial name
- BOBCAT (NCT07709728)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Xeroderma Pigmentosum
Xeroderma Pigmentosum Patient Experiences
Xeroderma Pigmentosum (XP) is a rare skin condition that causes extreme sensitivity to the sun and an increased incidence of skin cancers.
- Trial name
- NCT01123694
- Testing
- Survey Study
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Henry Ford Health System
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