Clinical trials: Tonsil Hypertrophy
Pediatric Obstructive Sleep Apnea
Oral Corticosteroids' Role in Pediatric Obstructive Sleep Apnea
This prospective interventional clinical trial (non-randomized) aims to evaluate oral corticosteroids' role as an alternative to surgery (gold-standard) in the treatment of obstructive sleep apnea in children.
- Trial name
- NCT06917768
- Testing
- Adenotonsillectomy, Prednisolone
- Where
- Lebanon
- Volunteers
- 87 people
- Sponsor
- Hotel Dieu de France Hospital
Obstructive Sleep Apnea of Child
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep.
- Trial name
- NCT05115968
- Testing
- Tonsillectomy
- Where
- Hong Kong
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Cheilitis, Angular, Postoperative Complications
Using Dexpanthenol Cream to Prevent Lip Corner Cracks in Children After Tonsil/Adenoid Surgery
Soreness and cracking at the corners of the mouth, a condition called angular cheilitis, can be an uncomfortable problem for children after they have surgery to remove their tonsils and adenoids.
- Conditions
- Cheilitis, Angular, Postoperative Complications, Adenotonsillar Hypertrophy
- Trial name
- PrevAC-PedAT (NCT07002632)
- Testing
- Dexpanthenol 5 % Topical Ointment
- Where
- Turkey (Türkiye)
- Volunteers
- 106 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Tonsillar Hypertrophy, Sleep Apnea, Obstructive
Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
Treating sleep apnea in adults caused by tonsillar hypertrophy with intracapsular tonsillectomy by coblation
- Trial name
- NCT04314492
- Testing
- Tonsillectomy
- Where
- 2 sites in Finland
- Volunteers
- 25 people
- Sponsor
- Turku University Hospital
Obstructive Sleep Disorder, Obstructive Sleep Apnea
Topical Microporous Polysaccharide Hemospheres Versus Electrocautery for Control of Pediatric Post-Tonsillectomy Bleeding
The ultimate goal of this work is to establish a method for control bleeding after tonsillectomy in awake children. Treatment of post-tonsillectomy bleeding in children typically requires general anesthesia with currently used…
- Conditions
- Obstructive Sleep Disorder, Obstructive Sleep Apnea, Tonsillar Hypertrophy
- Trial name
- NCT00945412
- Testing
- Micropolysaccharide Hemospheres (Arista), Electrocautery (Monopolar suction cautery)
- Where
- United States
- Sponsor
- Massachusetts Eye and Ear Infirmary
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Obstructive Tonsillar Hypertrophy
Development of an Assessment Method for Obstructive Tonsillar Hypertrophy in Children by Ultrasonography
Chronic tonsillar hypertrophy is one of the most common causes of upper airway obstruction in children. Currently, several clinical staging systems are used to evaluate airway obstruction due to tonsillar hypertrophy.
- Trial name
- NCT04380272
- Testing
- The ROC analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Pamukkale University
Sleep Disorder; Breathing-Related, Snoring
Intranasal Steroid as Medical Therapy For Sleep-Disordered Breathing in Children
MIST+ is studying a nasal spray to see if it will reduce the need for surgery for snoring. Children aged 3-12 are invited to take part.
- Conditions
- Sleep Disorder; Breathing-Related, Snoring, Obstructive Sleep Apnea of Child, Sleep Disorders in Children
- Trial name
- MIST+ (NCT05382494)
- Testing
- Mometasone Furoate 50mcg Nasal Spray, Sodium Chloride 0.9 % Nasal Spray
- Where
- 2 sites in Australia
- Volunteers
- 130 people
- Sponsor
- Murdoch Childrens Research Institute
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College
Apnea, Obstructive, Tonsillitis
Evaluation of the Functional Impact of Adenotonsilectomy
Spirometric assessment of respiratory function before and after adenotonsillectomy surgery
- Conditions
- Apnea, Obstructive, Tonsillitis, Tonsillar Hypertrophy, Respiratory Function Impaired
- Trial name
- NCT05532228
- Testing
- Adenotonsillectomy
- Where
- Portugal
- Volunteers
- 78 people
- Sponsor
- Instituto de Ciências Biomédicas Abel Salazar
Adenoid Hypertrophy, Tonsillar Hypertrophy
Evaluation of the Effects of Adenoidectomy and Adenotonsillectomy on Voice in Children
This prospective study aims to evaluate the effects of adenoidectomy and adenotonsillectomy on voice and speech functions in children.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Voice Disorders in Children
- Trial name
- NCT07399041
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Adenoid Hypertrophy, Tonsillar Hypertrophy
Full-wrap Versus Conventional Suspension for Reducing Soft Palate Injury Rate in Transoral Surgery
This study aims to evaluate whether the use of full-wrap suspension, compared with the traditional double-strap suspension, can effectively reduce the risk of intraoperative and postoperative soft palate injury in…
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Nasopharyngeal Diseases, Nasopharyngeal Tumors
- Trial name
- NCT07552545
- Testing
- Intraoperative soft palate suspension using the double-strap method., Intraoperative soft palate suspension using the full-wrap method.
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Pain, Postoperative, Tonsillar Hypertrophy
Management of Post-Tonsillectomy Pain in Pediatric Patients
Single-center, randomized, open-label, non-inferiority treatment pilot study to evaluate the effectiveness of a combined acetaminophen and ibuprofen regimen for treatment of post-operative tonsillectomy pain in the pediatric…
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis
- Trial name
- NCT04551196
- Testing
- Alternating Acetaminophen and Ibuprofen, Combined Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Covid19, Immune Deficiency
The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs
We aimed to find out whether the tonsils and nasal tissues of pediatric patients are the main factors that protects the children's immune system against COVID-19 infection.
- Conditions
- Covid19, Immune Deficiency, Tonsillitis, Tonsil Hypertrophy
- Trial name
- NCT04646525
- Testing
- Physical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Selcuk University
Adenoid Hypertrophy, Tonsillar Hypertrophy
Metabolomic Profiling of Racial Disparity
Tonsillectomy ± adenoidectomy (T\&A) is one of the most common surgical operations with over 500,000 pediatric T\&As performed annually in the United States.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Surgery
- Trial name
- NCT06266429
- Testing
- Blood collection
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Nationwide Children's Hospital
Obstructive Tonsillar Hypertrophy, Tonsillitis
Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy
Study objective is to provide prospective randomized controlled data on pediatric pain levels found in PlasmaKnife tonsillectomy and monopolar tonsillectomy.
- Trial name
- jPK (NCT00466544)
- Testing
- Plasmaknife, Monopolar
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Michigan