Clinical trials: Tooth Abnormalities
Charcot Marie Tooth Disease
Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT
The primary goal of this project is to develop and test a Charcot Marie Tooth disease (CMT) Pediatric Scale for use in evaluation in natural history CMT study.
- Trial name
- INC-6603 (NCT01203085)
- Where
- 14 sites in United States, Australia and 3 more
- Volunteers
- 1,201 people
- Sponsor
- University of Iowa
Dental Enamel Hypoplasia
Laser Used in the Treatment of Hypomineralized Occlusal Lesions in Teeth Enamel Affected by MIH
Background: Nowadays an increase in the incidence of teeth affected by molar incisor hypomineralisation (MIH) has been observed.
- Trial name
- NCT03614819
- Testing
- Diode laser group, Glass Ionomer Sealing Group
- Where
- Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Molar Hypomineralization, Dental Restoration Failure of Marginal Integrity
CAD-CAM or Adhesive Approaches for MIH Treatment
Aim: This randomized controlled clinical study aimed to compare direct composite resin restorations and Computer Aided Design-Computer Aided Manufacturing (CAD-CAM) supported inlay or onlay restorations in young permanent molar…
- Trial name
- NCT06456619
- Testing
- Tooth restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Baskent University
Malocclusion, Craniofacial Morphology
Research on Deep Learning-Based Intelligent Diagnosis and Treatment
This study aims to develop and evaluate deep learning-based artificial intelligence models for craniomaxillofacial multi-modal imaging analysis and clinical decision support.
- Conditions
- Malocclusion, Craniofacial Morphology, Dentofacial Deformities
- Trial name
- NCT07551622
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Molar Incisor Hypomineralization, Hypersensitivity
Intraosseous vs Infiltration Anesthesia in Molar-Incisor Hypomineralization (MIH) Children
This study aims to compare the effectiveness of intraosseous and infiltration anesthesia techniques administered using a computer-assisted anesthesia device (SleeperOne® 5; Dental HiTec, France) during restorative treatments of…
- Trial name
- MIH (NCT07352813)
- Testing
- Intraosseous anaesthesia using a computerized system, Infiltration anaesthesia using a computerized system
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ankara Yildirim Beyazıt University
Charcot-Marie-Tooth Disease
Follow up and Observation of Charcot Marie Tooth Disease in Families
The study is aimed to test the hypothesis that there is anticipation in CMT
- Trial name
- NCT00149045
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH)
Comparison of Computer-Assisted and Conventional Local Anesthesia in Children With Molar-Incisor Hypomineralization
The main questions this study aims to answer are: Does computer-controlled local anesthesia cause less pain and anxiety than conventional local anesthesia in children with molar-incisor hypomineralization (MIH)? Is there a…
- Conditions
- Molar-Incisor Hypomineralization, Molar-Incisor Hypomineralization (MIH), Computer-Controlled Local Anesthesia
- Trial name
- NCT07733011
- Testing
- Computer-Controlled Local Anesthesia, Conventional Local Anesthesia
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Marmara University
Molar Incisor Hypomineralization
Clinical Performance of Two Cad-cam Fabricated Ceramic Restoration in Teeth Affected With MIH
This study will be performed to evaluate the clinical performance (Plaque accumulation, fracture of (restoration or tooth), postoperative sensitivity, secondary caries, marginal fit and discoloration) of two CAD/CAM fabricated…
- Trial name
- NCT05434884
- Testing
- occlusal veneer restorations, endocrown restorations
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Dental Decay, Periodontal Abscess
ONE-1 Oral graNd Est 1
This study is about the assessment of two oral telemedecine tools compared to an intra oral clinical examination used as a reference among elderly persons living in nursing home.
- Conditions
- Dental Decay, Periodontal Abscess, Periodontitis, Gingivitis
- Trial name
- ONE (NCT05089214)
- Testing
- Intra oral cameras
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Molar Incisor Hypomineralization
Zirconia Reinforced Glass Ionomer in MIH
Molar-incisor hypomineralization (MIH) is a qualitative enamel defect, in which molars and incisors involved are prone to post-eruptive enamel breakdown leading to sensitivity, and caries.
- Trial name
- NCT05494749
- Testing
- zirconomer, HVGI-Equia Forte
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Hams Hamed Abdelrahman
Irregular Teeth
Comparison of the Clinical Efficacy of the Lingual Brackets and Labial Brackets in the Leveling Phase
This aim study aims to compare clinical effectiveness of customized lingual brackets and conventional labial brackets in alignment period in a sample of Class I malocclusion patients treated on a nonextraction basis.
- Trial name
- NCT04357067
- Testing
- Lingual brackets, Labial brackets
- Volunteers
- 20 people
- Sponsor
- Aydin Adnan Menderes University
Cleft Lip and Palate
Alveolar Cleft Hard- and Soft Tissue Reconstruction With an Autogenous Tooth Derived Particulate Graft
The present study aims at clinical and radiographic evaluation of the safety and efficacy of Bonmaker ATB powder combined with a novel split thickness papilla curtain flap in the treatment of alveolar cleft defects.
- Trial name
- NCT05971914
- Testing
- Autogenous tooth derived particulate graft and a novel split thickness papilla curtain flap
- Where
- Hungary
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Molar Incisor Hypomineralization
Clinical Performance of Restorations in Teeth Affected by Molar Incisor Hypomineralization
This study evaluated the clinical performances of a glass hybrid restoration and direct posterior micro-hybrid composite restorations with short fiber reinforced composite (SFRC) after Selective Caries Removal in restorations of…
- Trial name
- NCT07733804
- Testing
- Restoration with Short Fiber-Reinforced Composite and Micro-Hybrid Composite (EverX Flow + G-ænial Posterior), Restoration with Glass Hybrid Restorative Material (EQUIA Forte HT)
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Marmara University
Vitamin D Deficiency, Obesity
D-tecting Disease - From Exposure to Vitamin D During Critical Periods of Life
Vitamin D deficiency is common among otherwise healthy pregnant women and may have consequences for them as well as the early development and long-term health of their children.
- Conditions
- Vitamin D Deficiency, Obesity, Diabetes Mellitus, Pre-Eclampsia
- Trial name
- D-tect (NCT03330301)
- Testing
- D-tect
- Where
- Denmark
- Volunteers
- 222,776 people
- Sponsor
- Bispebjerg Hospital
Molar Incisor Hypomineralization
Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization
Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment.
- Trial name
- NCT07389148
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Lokman Hekim University
Molar-Incisor Hypomineralization
Single Gene Polymorphisms Associated With Molar-Incisor Hypomineralization
The genetic factors associated with Molar-Incisor Hypomineralization (MIH), a dental condition affecting permanent molars in individuals aged 8-13.
- Trial name
- NCT06165055
- Testing
- DNA Sample Collection + DNA genotyping
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Marmara University
Orthodontics, Bracket Bonding
Comparison of Bond Failure with Resin-modified Glass Ionomer Cement and Visible Light-cure Composite Bonding Material in Adult Orthodontic Patients - a Split-Mouth, Randomized Controlled Trial
In this split mouth study design, 34 orthodontic patients coming for fixed appliance treatment will be bonded with standard light-cure composite bonding material and intervention of Resin Modified Glass Ionomer Cement (RMGIC).
- Conditions
- Orthodontics, Bracket Bonding, Malocclusion; Displaced or Missing Teeth
- Trial name
- RMGIC (NCT06602154)
- Testing
- Resin modified glass ionomer
- Where
- 2 sites in Pakistan
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Charcot-Marie-Tooth Disease
Irisin Levels in Patients With Charcot-Marie-Tooth (CMT) Disease
Irisin is an exercise-mimetic myokine secreted by skeletal muscle. Compelling evidence in animal models and humans showed that Irisin prevents onset of musculoskeletal atrophy and its low serum levels are predictive of…
- Trial name
- IRICDE (NCT04786522)
- Testing
- Bioimpedenziometry, Handgrip strenght evaluation, Evaluation on blood specimens
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Bari
Molar Incisor Hypomineralisation
Intraosseous Anesthesia in MIH-Affected Teeth
Managing MIH-affected teeth is challenging due to inflammation, sensitivity, rapid caries development, and difficulty achieving anesthesia.
- Trial name
- IO-MIH (NCT07457450)
- Testing
- Intraosseous anesthesia., Local infiltration anesthesia
- Where
- Croatia
- Volunteers
- 50 people
- Sponsor
- University of Zagreb
Hypomineralization Molar Incisor, Hypersensitivity Dentin
Photobiomodulation and New Restorative Material for Teeth With MIH on Control of Hypersensitivity and Longevity
Introduction: Molar incisor hypomineralization (MIH) is a qualitative defect of enamel development that occurs in the mineralization phase. MIH affects one or more permanent molars and, occasionally, permanent incisors.
- Trial name
- NCT06538142
- Testing
- Photobiomodulation + Restoration with Self-cure Composite Resin, Restoration with Self-cure Composite Resin, Photobiomodulation + Restoration with Photopolymerizable Bulk-fill Composite Resin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho