Clinical trials: Tooth Disorder
Cystic Fibrosis
Improving P. Aeruginosa Detection With Breath-based Diagnostics (IMPACT-Breath)
The study is a breath biomarker validation study. It is anticipated that 300 patients with cystic fibrosis (CF) from 5 clinical sites in the USA will be enrolled.
- Trial name
- IMPACT (NCT04735952)
- Where
- 7 sites in United States, Canada
- Volunteers
- 300 people
- Sponsor
- University of British Columbia
Malocclusion, Angle Class II, Division 1
Evaluating Laser and Piezocision vs. Piezocision Alone on Root Resorption and Gingival Health During Tooth Retraction
This trial aims to determine whether using a special laser (low-level laser therapy, or LLLT) in combination with a minor surgical procedure (piezocision) can safely accelerate orthodontic treatment.
- Trial name
- NCT07442825
- Testing
- Flapless Corticotomy (Piezocision), Level Laser Therapy (LLLT), Traditional treatment
- Where
- Syria
- Volunteers
- 66 people
- Sponsor
- Damascus University
Dentin, Carious, Indirect Pulp Capping
Clinical Success of Indirect Pulp Capping: 1-Year Follow-Up
The goal of this clinical trial is to compare the clinical success of theracal pt, therabase, and biodentine indirect pulp capping on primary molars with deep dentin caries.
- Trial name
- NCT06325540
- Testing
- indirect pulp capping with theracal pt, indirect pulp capping with therabase, indirect pulp capping with biodentine
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Open Bite
Myofunctional Therapy in Open Bite - RCT
The goal of this clinical trial is to learn if myofunctional therapy in 6-10-year-old children with infant type of swallowing and open bite is effective.
- Trial name
- Myofunctional (NCT06574490)
- Testing
- Myofunctional therapy (+), Myofunctional therapy (-)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Piotr Fudalej
Black Staining
Comparison of Erythritol Air-Polishing and Conventional Polishing Following Ultrasonic Scaling on the Relapse of Chromogenic Tooth Staining in Children
The goal of this randomized clinical trial is to compare the effect of erythritol air-polishing and conventional polishing following ultrasonic scaling on the relapse of chromogenic tooth staining in children aged 4-13 years…
- Trial name
- NCT07730658
- Testing
- Guided Biofilm Therapy with erythritol, Conventional Polishing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Marmara University
Dental Caries
Comparison of Two GIC's in the Restoration of Posterior Class II Lesions in the Primary Dentition
This study will investigate the clinical performance of a novel restorative glass ionomer (DeltaFil, DMG) in comparison to an established restorative glass ionomer (Riva Self Cure HV, SDI) in the restoration of Class II cavities…
- Trial name
- NCT05965297
- Testing
- DeltaFil, Riva Self Cure HV
- Where
- 2 sites in Brazil, Portugal
- Volunteers
- 140 people
- Sponsor
- DMG Dental Material Gesellschaft mbH
Oral Health, Oral Hygiene
Effectiveness of Personalized Oral Hygiene Education in Medical and Dental Students Over Two Years
This prospective cohort study is designed to evaluate the long-term effects of individualized oral hygiene education, known as Individually Trained Oral Prophylaxis (iTOP), on oral health outcomes in medical and dental students…
- Conditions
- Oral Health, Oral Hygiene, Periodontal Health, Dental Plaque
- Trial name
- iTOP (NCT07085013)
- Testing
- Individually Trained Oral Prophylaxis (iTOP)
- Where
- Bosnia and Herzegovina
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Mostar
Class III Malocclusion
Mandibular First Molar Distalization
A clinical study to test the capability of the mini-screws inserted in the Mandibular buccal shelf area as an anchorage unit to distalize mandibular first molar for correction of mild to moderate Class III cases.
- Trial name
- NCT04229797
- Testing
- Mandibular distalization using extra-radicular miniscrews
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Occlusal ART Restorations in Primary Molars Using 3 Different GIC
The aim of this study is to evaluate the survival rate and the cost-effectiveness of occlusal-ART restorations using three GIC brands (Fuji IX, GC Europe; Maxxion R, FGM; Vitro Molar, DFL) in primary molars.
- Trial name
- NCT02377297
- Testing
- Restoration with Fuji IX, Restoration with Vitro Molar, Restoration with Maxxion R
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy, Inflammation
Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
The effectiveness of local anesthetics is reduced if inflammation is present, making it difficult to control pain during such procedures as root canals and wisdom teeth removal.
- Conditions
- Healthy, Inflammation, Mouth Disease, Pain
- Trial name
- NCT00001952
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Pain
A Study of an Acetaminophen/Naproxen Sodium Fixed Combination, Acetaminophen and Naproxen Sodium in Postoperative Dental Pain
The purpose of this study is to evaluate how well a fixed combination of acetaminophen/naproxen sodium relieves postoperative dental pain compared with acetaminophen, naproxen sodium and placebo.
- Trial name
- NCT05761574
- Testing
- Acetaminophen/Naproxen Sodium Fixed Combination, Naproxen Sodium, Acetaminophen
- Where
- United States
- Volunteers
- 447 people
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Dental Caries, Oral Health Behavior Change
Assessing the Impact of a Social Media-Based Educational Intervention Using WhatsApp Video Messages on Dental Caries Prevention Knowledge, Oral Hygiene Practices, and Attitudes Toward Dental Health Among Primary School Children Aged 10-12 Years in Public Schools in Cairo Governorate, Egypt: A Quasi-
The goal of this study is to learn if educational videos sent through WhatsApp can improve dental health knowledge, healthy habits, and attitudes in primary school children aged 10 to 12 years in Cairo, Egypt.
- Conditions
- Dental Caries, Oral Health Behavior Change, Oral Hygiene, Oral Health, Knowledge, Attitudes, Practice
- Trial name
- NCT07363317
- Testing
- WhatsApp-Based Dental Health Education for Children
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Rana Mohamed Ahmed Farghal
Dental Caries (Diagnosis), Diagnostic Imaging
Diagnostic Performance and Children's Acceptance of Near-Infrared Light Transillumination and Bitewing Radiographs for Detecting Proximal Cavitation in Primary Molars of Patients Aged 4 to 10 Years
The goal of this observational study is to compare the diagnostic performance of three detection methods for approximal carious lesions in primary molars among pediatric patients aged 4-10 years.
- Conditions
- Dental Caries (Diagnosis), Diagnostic Imaging, Optical Imaging, Radiographic Image Interpretation, Computer-Assisted
- Trial name
- NILT (NCT07041164)
- Testing
- Bitewing radiograph, Near-infrared light transillumination
- Where
- 2 sites in Thailand
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Sawanya Prutthithaworn
Malocclusion, Dental Caries
GENOA ORAL GROWTH LONGITUDINAL STUDY (GeOrGS)
The aim of the study is to follow a group of preschool children from early permanent dentition to determine the prevalence and incidence of caries malocclusions and to investigated the related risk factors as age, gender, ethnic…
- Trial name
- GeOrGS (NCT02798809)
- Testing
- Clinical dental examination
- Where
- Italy
- Volunteers
- 270 people
- Sponsor
- University of Genova
Dental Caries
Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars
The aim of this study is to determine the effectiveness of fluoride varnishes in the prevention of dental caries lesions in erupting permanent first molars, in high-risk patients.
- Trial name
- NCT02592278
- Testing
- Fluoride Varnish, Control Group
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad Iberoamericana
Dental Caries, Dental Plaque
RCT on Effectiveness of Oral Health Preventive Programmes in School Children in Uganda
Dental caries represents a challenge for Oral Health Services in several African Countries, like Uganda. Few studies have been reported the burden of oral health, its prevention and non-operative treatment among school children…
- Conditions
- Dental Caries, Dental Plaque, Dental Diseases, Dental Caries in Children
- Trial name
- NCT06081868
- Testing
- Use of toothbrush/toothpaste/fluoride varnish, Education on nutrition/oral hygiene
- Where
- Switzerland
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dental Caries
Evaluation of the Chemo-mechanical Caries Removal Agent (BRIX3000®) in Primary Molars
Dental caries is one of the most prevalent chronic diseases in people worldwide. Traditional clinical treatment of dental decay has developed on the basis of the removal of carious tissues with high-speed handpieces and…
- Trial name
- NCT05427591
- Testing
- The chemomechanical caries removal agent "BRIX3000®" in group (1A), The traditional surgical treatment in group (1C), The chemomechanical caries removal agent "Carie-CareTM" in group (2B)
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Obesity, Type 2 Diabetes
The Influence of Simple, Low-Cost Chemistry Intervention Videos: A Randomized Trial of Children's Preferences for Sugar-Sweetened Beverages
Sugar-sweetened beverage (SSB) consumption is associated with the development of obesity, type 2 diabetes, and dental caries. The current study attempts to explore whether an educational, science-based intervention is able to…
- Conditions
- Obesity, Type 2 Diabetes, Dental Caries
- Trial name
- NCT04971317
- Testing
- Sugar-Sweetened Beverage (SSB) Video, Water Video, Control
- Where
- United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Class II Malocclusion
Clinical Effects of Electrical Stimulation on Speeding up Orthodontic Tooth Movement
Thirty two patients requiring extraction of maxillary first premolars and en-masse retraction of upper anterior teeth will participate in the study.
- Trial name
- NCT05302076
- Testing
- Low-intensity electrical current (LIEC), Traditional fixed orthodontic appliance
- Where
- Syria
- Volunteers
- 32 people
- Sponsor
- Damascus University
Dental Caries, Gingivitis
Interdental Microbiota Among Adolescents
Adolescence remains a period during which tooth decay is still very active. There are few epidemiological studies in adolescents, and the majority of them were young people aged 15 and under.
- Trial name
- MIARC (NCT03700840)
- Testing
- Interdental brushes
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université Montpellier
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